General

Prof. Dr. Leilei Zhu, Principle Investigator in Tianjin Institute of Industrail Biotechnology

Email: zhu_ll@tib.cas.cn

32 West 7th Avenue,

Tianjin Airport Economic Area,

Tianjin 300308

Research Areas

Protein engineering for industrial biotechnology: development of high-throughput screening methods and engineering industry and medicine relevant proteins.


Education

2009-2010         Ph.D. Institute of Biotechnology, RWTH Aachen University, Germany

2007-2009         Ph.D. study, Jacobs University Bremen, Germany

2005-2007         M.S. Department of Bioengineering, Jiangnan University, China

2001-2004         B.S. Department of Bioengineering, Jiangnan University, China


Experience

   
Work Experience

2016-now            Principle Investigator, Tianjin Institute of Industrial Biotechnology,  Chinese Academy of Sciences, Tianjin, China

2011-2016         Subgroup leader, Institute of Biotechnology, RWTH Aachen University, Germany


Publications

(1) Directed evolution 2.0: improving and deciphering enzyme properties, Chem Commun, 2015
(2) A Competitive Flow Cytometry Screening System for Directed Evolution of Therapeutic Enzyme, ACS Synth Biol, 2015
(3) Directed arginine deiminase evolution for efficient inhibition of arginine-auxotrophic melanomas.,,, Appl Microbiol Biotechnol, 2015
(4) Towards understanding directed evolution: more than half of all amino acid positions contribute to ionic liquid resistance of Bacillus subtilis lipase A, ChemBioChem, 2015
(5) Protein engineering of the antitumor enzyme PpADI for improved thermal resistance, ChemBioChem, 2014
(6) Directed laccase evolution for improved ionic liquid resistance, Green Chemistry, 2013
(7) A potential antitumor drug (arginine deiminase) reengineered for efficient operation under physiological conditions, ChemBioChem, 2010

(8) Directed evolution of an antitumor drug (arginine deiminase PpADI) for increased activity at physiological pH, ChemBioChem, 2010


Book chapter

Chapter 3: Channel protein FhuA as a promising biomolecular scaffold for bioconjugates, Bio-Synthetic Hybrid Materials and Bionanoparticles: A Biological Chemical Approach Towards Material Science, Royal Society of Chemistry, 2015-09




Conferences

(1)Directed evolution of arginine deiminase for anti-­tumor application, Sino-Germany workshop on
biobased chemicals and biorefinery,   Leilei Zhu,   Germany, 2015-10-06
(2)Channle protein FhuA: a versatile biomolecular scaffold for biohybrid systems, 3F-talks,   Leilei Zhu, Germany,   2015-03-05
(3)Protein engineering of enzymes for improving ionic liquid resistance,   Sino-Germany workshop on
biobased chemicals and biorefinery,   Leilei Zhu,   Germany, 2014-10-07