Prof. Dr. Leilei Zhu, Principle Investigator in Tianjin Institute of Industrail Biotechnology
Email: zhu_ll@tib.cas.cn
32 West 7th Avenue,
Tianjin Airport Economic Area,
Tianjin 300308
Research Areas
Protein engineering for industrial biotechnology: development of high-throughput screening methods and engineering industry and medicine relevant proteins.
Education
2009-2010 Ph.D. Institute of Biotechnology, RWTH Aachen University, Germany
2007-2009 Ph.D. study, Jacobs University Bremen, Germany
2005-2007 M.S. Department of Bioengineering, Jiangnan University, China
2001-2004 B.S. Department of Bioengineering, Jiangnan University, China
Experience
Work Experience
2016-now Principle Investigator, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China
2011-2016 Subgroup leader, Institute of Biotechnology, RWTH Aachen University, Germany
Publications
（2） A Competitive Flow Cytometry Screening System for Directed Evolution of Therapeutic Enzyme, ACS Synth Biol, 2015
（3） Directed arginine deiminase evolution for efficient inhibition of arginine-auxotrophic melanomas.，，, Appl Microbiol Biotechnol, 2015
（4） Towards understanding directed evolution: more than half of all amino acid positions contribute to ionic liquid resistance of Bacillus subtilis lipase A, ChemBioChem, 2015
（5） Protein engineering of the antitumor enzyme PpADI for improved thermal resistance, ChemBioChem, 2014
（6） Directed laccase evolution for improved ionic liquid resistance, Green Chemistry, 2013
（7） A potential antitumor drug (arginine deiminase) reengineered for efficient operation under physiological conditions, ChemBioChem, 2010
（8） Directed evolution of an antitumor drug (arginine deiminase PpADI) for increased activity at physiological pH, ChemBioChem, 2010
Book chapter
Chapter 3: Channel protein FhuA as a promising biomolecular scaffold for bioconjugates, Bio-Synthetic Hybrid Materials and Bionanoparticles: A Biological Chemical Approach Towards Material Science, Royal Society of Chemistry, 2015-09
Conferences
biobased chemicals and biorefinery, Leilei Zhu, Germany, 2015-10-06
（2）Channle protein FhuA: a versatile biomolecular scaffold for biohybrid systems, 3F-talks, Leilei Zhu, Germany, 2015-03-05
（3）Protein engineering of enzymes for improving ionic liquid resistance, Sino-Germany workshop on
biobased chemicals and biorefinery, Leilei Zhu, Germany, 2014-10-07