Radiation biology

Cell biology

Bioengineering

2012-09--2017-07,  University of Chinese Academy of Sciences, ph.D

2007-09--2010-07,  Lanzhou University, MA.Sc

2003-09--2007-07,  Lanzhou University, B.S.

2010.07--now, Institute of Modern Physics, Chinese Academy of Sciences, Associate Professor

   

（1） Progress in heavy ion cancer therapy at IMP and future development, Malignancy Spectru, 2024, 第 9 作者
（2） Feedback loop between hypoxia and energy metabolic reprogramming aggravates the radioresistance of cancer cells, Experimental Hematology & Oncology, 2024, 第 3 作者
（3） Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy, EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2023, 第 1 作者
（4） Gadolinium Oxide Nanoparticles Reinforce the Fractionated Radiotherapy-Induced Immune Response in Tri-Negative Breast Cancer via cGAS-STING Pathway, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2023, 第 9 作者
（5） PERK Regulates the Sensitivity of Hepatocellular Carcinoma Cells to High-LET Carbon Ions via either Apoptosis or Ferroptosis, JOURNAL OF CANCER, 2022, 第 1 作者
（6） Therapeutic Efficacy of Carbon Ion Irradiation Enhanced by 11-MUA-Capped Gold Nanoparticles: An in vitro and in vivo Study, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021, 第 8 作者
（7） Hyperthermia ablation combined with transarterial chemoembolization versus monotherapy for hepatocellular carcinoma: A systematic review and meta-analysis, CANCER MEDICINE, 2021, 第 9 作者
（8） Carbon Ion Radiotherapy Acts as the Optimal Treatment Strategy for Unresectable Liver Cancer During the Coronavirus Disease 2019 Crisis, FRONTIERS IN PUBLIC HEALTH, 2021, 第 10 作者
（9） Genistein inhibits radiation-induced invasion and migration of glioblastoma cells by blocking the DNA-PKcs/Akt2/Rac1 signaling pathway, RADIOTHERAPY AND ONCOLOGY, 2021, 第 4 作者
（10） Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities, CELL DEATH DISCOVERY, 2021, 第 10 作者
（11） Inhibition of endoplasmic reticulum stress-induced autophagy promotes the killing effect of X-rays on sarcoma in mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 第 1 作者
（12） Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation, NANOSCALE RESEARCH LETTERS, 2019, 第 8 作者
（13） Different mitochondrial fragmentation after irradiation with X-rays and carbon ions in HeLa cells and its influence on cellular apoptosis, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 第 4 作者
（14） Fragmentation level determines mitochondrial damage response and subsequently the fate of cancer cells exposed to carbon ions, RADIOTHERAPY AND ONCOLOGY, 2018, 第 2 作者
（15） Caspase-9: structure, mechanisms and clinical application, Oncotarget, 2017, 第 7 作者
（16） Inhibiting autophagy with chloroquine enhances the anti-tumor effect of high-LET carbon ions via ER stress-related apoptosis, MEDICAL ONCOLOGY, 2017, 第 1 作者
（17） The synergistic radiosensitizing effect of tirapazamine-conjugated gold nanoparticles on human hepatoma HepG2 cells under X-ray irradiation, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2016, 第 5 作者
（18） Genistein sensitizes sarcoma cells in vitro and in vivo by enhancing apoptosis and by inhibiting DSB repair pathways., JOURNAL OF RADIATION RESEARCH, 2016, 
（19） Radiosensitizing effect of functionalized gold nanoparticles on human hepatoma HepG2 cells, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, 第 4 作者
（20） The Radiation Enhancement of 15 nm Citrate-Capped Gold Nanoparticles Exposed to 70 keV/mu m Carbon Ions, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2016, 第 5 作者
（21） Different Roles of CHOP and JNK in Mediating Radiation-Induced Autophagy and Apoptosis in Breast Cancer Cells, RADIATION RESEARCH, 2016, 第 2 作者
（22） The Radiation Enhancement of 15 nm Citrate-Capped Gold Nanoparticles Exposed to 70 keV/um Carbon Ions, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2016, 第 5 作者
（23） Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region, ONCOTARGET, 2016, 第 6 作者
（24） The dependence of radiation enhancement effect on the concentration of gold nanoparticles exposed to low- and high-LET radiations, PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 2015, 第 5 作者
（25） The dependence of radiation enhancement effect on the concentration of gold nanoparticles exposed to low- and high-LET radiations, PHYSICA MEDICA, 2015, 第 5 作者
（26） Carbon ions induce autophagy effectively through stimulating the unfolded protein response and subsequent inhibiting Akt phosphorylation in tumor cells, SCIENTIFIC REPORTS, 2015, 第 3 作者
（27） Role of autophagy in high linear energy transfer radiation-induced cytotoxicity to tumor cells, CANCER SCIENCE, 2014, 第 8 作者

Role of carbon ions induced ferroptosis in tumor inhibition

Relationship between ER stress and radiosensitivity of cancer

Mechanism of tumor killing and normal tissue protection by FLASH-RT