基本信息
郑小刚  男  硕导  中国科学院近代物理研究所
电子邮件: zhengxg@impcas.ac.cn
通信地址: 甘肃省兰州市城关区雁北路99号
邮政编码: 730000

研究领域

放射生物学

细胞生物学

招生信息

   
招生专业
071011-生物物理学
086000-生物与医药
招生方向
重离子诱导的铁死亡在肿瘤抑制中的作用研究
内质网应激与肿瘤辐射敏感性的关系研究

教育背景

2012-09--2017-07   中国科学院大学   博士
2007-09--2010-07   兰州大学   硕士
2003-09--2007-07   兰州大学   学士
学历
博士研究生

学位
理学博士

专利与奖励

   
专利成果
( 1 ) 金雀异黄酮在制备重离子辐射增敏药物中的应用, 发明专利, 2018, 第 8 作者, 专利号: CN107693512A

( 2 ) 利用自噬抑制剂氯喹提高离子束治疗肿瘤疗效的方法, 发明专利, 2016, 第 1 作者, 专利号: CN105250296A

出版信息

   
发表论文
(1) PERK Regulates the Sensitivity of Hepatocellular Carcinoma Cells to High-LET Carbon Ions via either Apoptosis or Ferroptosis, Journal of Cancer, 2022, 第 1 作者
(2) Therapeutic Efficacy of Carbon Ion Irradiation Enhanced by 11-MUA-Capped Gold Nanoparticles: An in vitro and in vivo Study, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021, 第 8 作者
(3) Hyperthermia ablation combined with transarterial chemoembolization versus monotherapy for hepatocellular carcinoma: A systematic review and meta-analysis, CANCER MEDICINE, 2021, 第 9 作者
(4) Carbon Ion Radiotherapy Acts as the Optimal Treatment Strategy for Unresectable Liver Cancer During the Coronavirus Disease 2019 Crisis, FRONTIERS IN PUBLIC HEALTH, 2021, 第 10 作者
(5) Genistein inhibits radiation-induced invasion and migration of glioblastoma cells by blocking the DNA-PKcs/Akt2/Rac1 signaling pathway, RADIOTHERAPY AND ONCOLOGY, 2021, 第 4 作者
(6) Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities, CELL DEATH DISCOVERY, 2021, 第 10 作者
(7) Inhibition of endoplasmic reticulum stress-induced autophagy promotes the killing effect of X-rays on sarcoma in mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 第 1 作者
(8) Radiosensitizing Effect of Gadolinium Oxide Nanocrystals in NSCLC Cells Under Carbon Ion Irradiation, Nanoscale Research Letters, 2019, 第 8 作者
(9) Different mitochondrial fragmentation after irradiation with X-rays and carbon ions in HeLa cells and its influence on cellular apoptosis, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 第 4 作者
(10) Fragmentation level determines mitochondrial damage response and subsequently the fate of cancer cells exposed to carbon ions, RADIOTHERAPY AND ONCOLOGY, 2018, 第 2 作者
(11) Caspase-9: structure, mechanisms and clinical application, ONCOTARGET, 2017, 第 7 作者
(12) 抑制自噬促进内质网应激引起的凋亡增强高LET碳离子抑癌效应的研究, Study on the enhancement of anti-tumor effect of high-LET carbon ions combined with autophagy inhibition via promoting ER stress-related apoptosis, 2017, 第 1 作者
(13) Inhibiting autophagy with chloroquine enhances the anti-tumor effect of high-LET carbon ions via ER stress-related apoptosis, MEDICAL ONCOLOGY, 2017, 第 1 作者
(14) The synergistic radiosensitizing effect of tirapazamine-conjugated gold nanoparticles on human hepatoma HepG2 cells under X-ray irradiation, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2016, 
(15) Genistein sensitizes sarcoma cells in vitro and in vivo by enhancing apoptosis and by inhibiting DSB repair pathways., JOURNAL OF RADIATION RESEARCH, 2016, 
(16) Radiosensitizing effect of functionalized gold nanoparticles on human hepatoma HepG2 cells, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, 第 4 作者
(17) The Radiation Enhancement of 15 nm Citrate-Capped Gold Nanoparticles Exposed to 70 keV/mu m Carbon Ions, JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2016, 第 5 作者
(18) Different Roles of CHOP and JNK in Mediating Radiation-Induced Autophagy and Apoptosis in Breast Cancer Cells, RADIATION RESEARCH, 2016, 第 2 作者
(19) The Radiation Enhancement of 15 nm Citrate-Capped Gold Nanoparticles Exposed to 70 keV/μm Carbon Ions, Journal of Nanoscience and Nanotechnology, 2016, 第 5 作者
(20) Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region, ONCOTARGET, 2016, 第 6 作者
(21) The dependence of radiation enhancement effect on the concentration of gold nanoparticles exposed to low- and high-LET radiations, PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS, 2015, 第 5 作者
(22) The dependence of radiation enhancement effect on the concentration of gold nanoparticles exposed to low- and high-LET radiations, Physica Medica, 2015, 第 5 作者
(23) Carbon ions induce autophagy effectively through stimulating the unfolded protein response and subsequent inhibiting Akt phosphorylation in tumor cells, SCIENTIFIC REPORTS, 2015, 第 3 作者
(24) Role of autophagy in high linear energy transfer radiation-induced cytotoxicity to tumor cells, CANCER SCIENCE, 2014, 第 8 作者

科研活动

   
科研项目
( 1 ) 氨基酸转运与乏氧识别的双重靶向新型硼药研制与生物自适形剂量调强, 负责人, 国家任务, 2017-07--2020-06
( 2 ) UPR调控肝癌细胞碳离子辐射敏感性的作用机制研究, 负责人, 中国科学院计划, 2019-01--2021-12
( 3 ) PERK调控肝癌细胞对碳离子辐射敏感性的机理研究, 负责人, 国家任务, 2021-01--2023-12
( 4 ) 重离子辐射诱导肝癌细胞内质网应激的机制研究, 负责人, 地方任务, 2020-10--2022-12
( 5 ) 碳离子辐射诱导的铁死亡在肿瘤抑制中的作用研究, 负责人, 其他任务, 2021-07--2021-12