Computational Biology & Bioinformatics

• Ph.D. in Computer Science, Institute of Computing Technology, Chinese Academy of Sciences, China, 2007
• M.S. in Computer Science, Nanjing University of Science and Technology, China, 2004
• B.S. in Computer Science, Ningxia University, China, 2002

• Head of Department of Data Resources, China National Center for Bioinformation, China, 2024 - Present
• Associate Director of National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation, China, 2020 - Present
• Executive Director of BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, China, 2016 - 2020
• Professor, University of Chinese Academy of Sciences (UCAS), China, 2016 - Present
• Professor in the CAS 100-Talent Program, Beijing Institute of Genomics, Chinese Academy of Sciences, China, 2011 - Present
• Research Scientist, King Abdullah University of Science and Technology, Kingdom of Saudi Arabia, 2009 - 2011
• Postdoctoral Associate, Yale University, United States of America, 2007 - 2009

1. Yang, F., Xiong, Z., Zong, W., Kong, D., Tang, B., Chen, X., Wei, Y., Yu, X., Zhang, Y., Zou, D. et al. (2026) EWAS Open Platform 2026: a deeply integrated resource for epigenome-wide association studies. Nucleic Acids Res, 54, D1061-D1068.

2. Qi, Y., Li, Z., Zhou, X., Wang, M., Zhang, Z. and Ma, L. (2026) Charting the expression landscape of human long non-coding RNAs across diverse biological contexts with LncExpDB 2.0. Nucleic Acids Res, 54, D1184-D1189.

3. Members, C.-N. and Partners. (2026) Database resources of the National Genomics Data Center, China National Center for Bioinformation in 2026. Nucleic Acids Res, 54, D28-D47.

4. Ma, C., Li, Z., Tang, X., Li, P., Li, L., Wang, S., Wu, J., Luo, L., Liu, Y., Zhang, Z. et al. (2026) ClinMAVE: a curated database for clinical application of data from multiplexed assays of variant effect. Nucleic Acids Res, 54, D1355-D1363.

5. Hou, Y., Zou, D., Chu, Q., Zhan, B., Wang, R., Guan, D., Wang, W., Feng, X., Li, X., Zhu, X. et al. (2026) The ChickenGTEx portal: a pan-tissue catalogue of regulatory variants shaping transcriptomic and phenotypic diversity. Nucleic Acids Res, 54, D982-D993.

6. Zhu, T., Chu, Y., Niu, G., Pan, R., Chen, M., Cheng, Y., Zhang, Y., Li, Z., Jiang, S., Hao, L. et al. (2025) Editome Disease Knowledgebase v2.0: an updated resource of editome-disease associations through literature curation and integrative analysis. Bioinform Adv, 5, vbaf012.

7. Zhang, S., Chen, X., Jin, E., Wang, A., Chen, T., Zhang, X., Zhu, J., Dong, L., Sun, Y., Yu, C. et al. (2025) The GSA Family in 2025: A Broadened Sharing Platform for Multi-omics and Multimodal Data. Genomics Proteomics Bioinformatics, 23.

8. Su, Y., Han, Z., Ji, Y., Liu, A., Zou, D., Yan, L., Liu, D., Zhang, Z. and Wang, Q.F. (2025) Patterns and variations of copy number alterations in acute myeloid leukemia: insights from the LeukAtlas database. Leukemia, 39, 827-836.

9. Ma, Y., Zhao, X., Jia, Y., Han, Z., Yu, C., Fan, Z., Zhang, Z., Xiao, J., Zhao, W., Bao, Y. et al. (2025) The Updated Genome Warehouse: Enhancing Data Value, Security, and Usability to Address Data Expansion. Genomics Proteomics Bioinformatics, 23.

10. Kang, Z., Zhu, T., Zou, D., Liu, M., Zhang, Y., Wang, L., Zhang, Z. and Liu, F. (2025) HemAtlas: A Multi-omics Hematopoiesis Database. Genomics Proteomics Bioinformatics, 23.

11. Han, B., Li, H., Zheng, W., Zhang, Q., Chen, A., Zhu, S., Shi, T., Wang, F., Zou, D., Song, Y. et al. (2025) A multi-tissue single-cell expression atlas in cattle. Nat Genet, 57, 2546-2561.

12. Guan, D., Bai, Z., Zhu, X., Zhong, C., Hou, Y., Zhu, D., Chicken, G.C., Li, H., Lan, F., Diao, S. et al. (2025) Genetic regulation of gene expression across multiple tissues in chickens. Nat Genet, 57, 1298-1308.

13. CNCB-NGDC Members & Partners. (2025) Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2025. Nucleic Acids Res, 53, D30-D44.

14. Zhao, Y., Zhang, Y., Li, S., Tan, S., Cao, J., Wang, H.L., Luo, J., Guo, H., Zhang, Z. and Li, Z. (2024) Leaf Senescence Database v5.0: A Comprehensive Repository for Facilitating Plant Senescence Research. J Mol Biol, 436, 168530.

15. Zhang, Z. (2024) Expanding bioinformatics: Toward a paradigm shift from data to theory. Fundamental Research.

16. Zhang, Z. (2024) Laws of Genome Nucleotide Composition. Genomics Proteomics Bioinformatics, 22.

17. Tian, D., Xu, T., Kang, H., Luo, H., Wang, Y., Chen, M., Li, R., Ma, L., Wang, Z., Hao, L. et al. (2024) Plant genomic resources at National Genomics Data Center: assisting in data-driven breeding applications. aBIOTECH, 5, 94-106.

18. Li, Q., Zhang, Y., Luo, S., Zhang, Z., Oberg, A.L., Kozono, D.E., Lu, H., Sarkaria, J.N., Ma, L. and Wang, L. (2024) Identify Non-mutational p53 Functional Deficiency in Human Cancers. Genomics Proteomics Bioinformatics, 22.

19. Li, L., Li, C.P., Li, N., Zou, D., Zhao, W.M., Luo, H., Xue, Y.B., Zhang, Z., Bao, Y.M. and Song, S.H. (2024) Machine Learning Early Detection of SARS-CoV-2 High-Risk Variants. Advanced Science, e2405058.

20. Gao, X., Chen, K., Xiong, J., Zou, D., Yang, F., Ma, Y., Jiang, C., Gao, X., Wang, G., Gu, S. et al. (2024) The P10K database: a data portal for the protist 10 000 genomes project. Nucleic Acids Res, 52, D747-D755.

21. CNCB-NGDC Members & Partners. (2024) Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2024. Nucleic Acids Res, 52, D18-D32.

22. Chen, M., Xia, L., Tan, X., Gao, S., Wang, S., Li, M., Zhang, Y., Xu, T., Cheng, Y., Chu, Y. et al. (2024) Seeing the unseen in characterizing RNA editome during rice endosperm development. Commun Biol, 7, 1314.

23. Cao, Y., Tian, D., Tang, Z., Liu, X., Hu, W., Zhang, Z. and Song, S. (2024) OPIA: an open archive of plant images and related phenotypic traits. Nucleic Acids Res, 52, D1530-D1537.

24. Bu, C., Zheng, X., Zhao, X., Xu, T., Bai, X., Jia, Y., Chen, M., Hao, L., Xiao, J., Zhang, Z. et al. (2024) GenBase: A Nucleotide Sequence Database. Genomics Proteomics Bioinformatics, 22.

25. Zhu, T., Niu, G., Zhang, Y., Chen, M., Li, C.Y., Hao, L. and Zhang, Z. (2023) Host-mediated RNA editing in viruses. Biol Direct, 18, 12.

26. Zhang, Z., Hu, S. and Yu, J. (2023) Toward a New Paradigm of Genomics Research. Genomics, Proteomics & Bioinformatics, 21, 904-909.

27. Zhang, M., Zong, W., Zou, D., Wang, G., Zhao, W., Yang, F., Wu, S., Zhang, X., Guo, X., Ma, Y. et al. (2023) MethBank 4.0: an updated database of DNA methylation across a variety of species. Nucleic Acids Res, 51, D208-D216.

28. Wang, Z., Wang, Y.W., Kasuga, T., Lopez-Giraldez, F., Zhang, Y., Zhang, Z., Wang, Y., Dong, C., Sil, A., Trail, F. et al. (2023) Lineage-specific genes are clustered with HET-domain genes and respond to environmental and genetic manipulations regulating reproduction in Neurospora. PLoS Genet, 19, e1011019.

29. Pan, S., Kang, H., Liu, X., Lin, S., Yuan, N., Zhang, Z., Bao, Y. and Jia, P. (2023) Brain Catalog: a comprehensive resource for the genetic landscape of brain-related traits. Nucleic Acids Res, 51, D835-D844.

30. Ma, L., Zou, D., Liu, L., Shireen, H., Abbasi, A.A., Bateman, A., Xiao, J., Zhao, W., Bao, Y. and Zhang, Z. (2023) Database Commons: A Catalog of Worldwide Biological Databases. Genomics Proteomics Bioinformatics, 21, 1054-1058.

31. Ma, L. and Zhang, Z. (2023) The contribution of databases towards understanding the universe of long non-coding RNAs. Nature reviews. Molecular cell biology, 24, 601-602.

32. Liu, Y., Zhang, Y., Liu, X., Shen, Y., Tian, D., Yang, X., Liu, S., Ni, L., Zhang, Z., Song, S. et al. (2023) SoyOmics: A deeply integrated database on soybean multi-omics. Molecular plant, 16, 794-797.

33. Liu, X., Tian, D., Li, C., Tang, B., Wang, Z., Zhang, R., Pan, Y., Wang, Y., Zou, D., Zhang, Z. et al. (2023) GWAS Atlas: an updated knowledgebase integrating more curated associations in plants and animals. Nucleic Acids Res, 51, D969-D976.

34. Li, Z., Liu, L., Feng, C., Qin, Y., Xiao, J., Zhang, Z. and Ma, L. (2023) LncBook 2.0: integrating human long non-coding RNAs with multi-omics annotations. Nucleic Acids Res, 51, D186-D191.

35. Li, L., Xu, B., Tian, D., Wang, A., Zhu, J., Li, C., Li, N., Zhao, W., Shi, L., Xue, Y. et al. (2023) McAN: a novel computational algorithm and platform for constructing and visualizing haplotype networks. Brief Bioinform, 24.

36. Jiang, S., Qian, Q., Zhu, T., Zong, W., Shang, Y., Jin, T., Zhang, Y., Chen, M., Wu, Z., Chu, Y. et al. (2023) Cell Taxonomy: a curated repository of cell types with multifaceted characterization. Nucleic Acids Res, 51, D853-D860.

37. Hua, Z., Jiang, C., Song, S., Tian, D., Chen, Z., Jin, Y., Zhao, Y., Zhou, J., Zhang, Z., Huang, L. et al. (2023) Accurate identification of taxon-specific molecular markers in plants based on DNA signature sequence. Mol Ecol Resour, 23, 106-117.

38. Duan, G., Wu, G., Chen, X., Tian, D., Li, Z., Sun, Y., Du, Z., Hao, L., Song, S., Gao, Y. et al. (2023) HGD: an integrated homologous gene database across multiple species. Nucleic Acids Res, 51, D994-D1002.

39. CNCB-NGDC Members & Partners. (2023) Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2023. Nucleic Acids Res, 51, D18-D28.

40. Zhang, Z.W., Teng, X., Zhao, F., Ma, C., Zhang, J., Xiao, L.F., Wang, Y., Chang, M., Tian, Y., Li, C. et al. (2022) METTL3 regulates m(6)A methylation of PTCH1 and GLI2 in Sonic hedgehog signaling to promote tumor progression in SHH-medulloblastoma. Cell Rep, 41, 111530.

41. Zhang, Z. (2022) KaKs_Calculator 3.0: Calculating Selective Pressure on Coding and Non-coding Sequences. Genomics Proteomics Bioinformatics, 20, 536-540.

42. Zhang, Y., Zou, D., Zhu, T., Xu, T., Chen, M., Niu, G., Zong, W., Pan, R., Jing, W., Sang, J. et al. (2022) Gene Expression Nebulas (GEN): a comprehensive data portal integrating transcriptomic profiles across multiple species at both bulk and single-cell levels. Nucleic Acids Res, 50, D1016-D1024.

43. Xiong, Z., Yang, F., Li, M., Ma, Y., Zhao, W., Wang, G., Li, Z., Zheng, X., Zou, D., Zong, W. et al. (2022) EWAS Open Platform: integrated data, knowledge and toolkit for epigenome-wide association study. Nucleic Acids Res, 50, D1004-D1009.

44. Liu, L., Zhang, Y., Niu, G., Li, Q., Li, Z., Zhu, T., Feng, C., Liu, X., Zhang, Y., Xu, T. et al. (2022) BrainBase: a curated knowledgebase for brain diseases. Nucleic Acids Res, 50, D1131-D1138.

45. Liu, L., Li, Z., Liu, C., Zou, D., Li, Q., Feng, C., Jing, W., Luo, S., Zhang, Z. and Ma, L. (2022) LncRNAWiki 2.0: a knowledgebase of human long non-coding RNAs with enhanced curation model and database system. Nucleic Acids Res, 50, D190-D195.

46. Li, R., Zhang, X., Song, S., Wang, Y., Zou, D., Xiao, J., Zhao, W., Zhang, Z. and Bao, Y. (2022) Safety management and application of genomics data. Big Data Research, 8, 37-45.

47. Jiang, S., Du, Q., Feng, C., Ma, L. and Zhang, Z. (2022) CompoDynamics: a comprehensive database for characterizing sequence composition dynamics. Nucleic Acids Res, 50, D962-D969.

48. Jia, L., Li, Y., Huang, F., Jiang, Y., Li, H., Wang, Z., Chen, T., Li, J., Zhang, Z. and Yao, W. (2022) LIRBase: a comprehensive database of long inverted repeats in eukaryotic genomes. Nucleic Acids Res, 50, D174-D182.

49. Hua, Z., Tian, D., Jiang, C., Song, S., Chen, Z., Zhao, Y., Jin, Y., Huang, L., Zhang, Z. and Yuan, Y. (2022) Towards comprehensive integration and curation of chloroplast genomes. Plant Biotechnol J, 20, 2239-2241.

50. CNCB-NGDC Members & Partners. (2022) Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022. Nucleic Acids Res, 50, D27-D38.

51. Cao, J., Zhang, Y., Tan, S., Yang, Q., Wang, H.-L., Xia, X., Luo, J., Guo, H., Zhang, Z. and Li, Z. (2022) LSD 4.0: an improved database for comparative studies of leaf senescence. Molecular Horticulture, 2, 24.

52. Zhang, S.S., Chen, X., Chen, T.T., Zhu, J.W., Tang, B.X., Wang, A.K., Dong, L.L., Zhang, Z.W., Sun, Y.L., Yu, C.X. et al. (2021) GSA-Human: Genome Sequence Archive for Human. Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji, 43, 988-993.

53. Sun, C., Huang, J., Wang, Y., Zhao, X., Su, L., Thomas, G.W.C., Zhao, M., Zhang, X., Jungreis, I., Kellis, M. et al. (2021) Genus-Wide Characterization of Bumblebee Genomes Provides Insights into Their Evolution and Variation in Ecological and Behavioral Traits. Mol Biol Evol, 38, 486-501.

54. RNAcentral Consortium. (2021) RNAcentral 2021: secondary structure integration, improved sequence search and new member databases. Nucleic Acids Res, 49, D212-D220.

55. Liu, X., Wang, P., Teng, X., Zhang, Z. and Song, S. (2021) Comprehensive Analysis of Expression Regulation for RNA m6A Regulators With Clinical Significance in Human Cancers. Front Oncol, 11, 624395.

56. Li, Z., Liu, L., Jiang, S., Li, Q., Feng, C., Du, Q., Zou, D., Xiao, J., Zhang, Z. and Ma, L. (2021) LncExpDB: an expression database of human long non-coding RNAs. Nucleic Acids Res, 49, D962-D968.

57. Li, C., Tian, D., Tang, B., Liu, X., Teng, X., Zhao, W., Zhang, Z. and Song, S. (2021) Genome Variation Map: a worldwide collection of genome variations across multiple species. Nucleic Acids Res, 49, D1186-D1191.

58. CNCB-NGDC Members & Partners. (2021) Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021. Nucleic Acids Res, 49, D18-D28.

59. Chen, T., Chen, X., Zhang, S., Zhu, J., Tang, B., Wang, A., Dong, L., Zhang, Z., Yu, C., Sun, Y. et al. (2021) The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types. Genomics Proteomics Bioinformatics, 19, 578-583.

60. Chen, M., Ma, Y., Wu, S., Zheng, X., Kang, H., Sang, J., Xu, X., Hao, L., Li, Z., Gong, Z. et al. (2021) Genome Warehouse: A Public Repository Housing Genome-scale Data. Genomics Proteomics Bioinformatics, 19, 584-589.

61. Zhao, W.M., Song, S.H., Chen, M.L., Zou, D., Ma, L.N., Ma, Y.K., Li, R.J., Hao, L.L., Li, C.P., Tian, D.M. et al. (2020) The 2019 novel coronavirus resource. Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji, 42, 212-221.

62. Zhang, Z., Song, S., Yu, J., Zhao, W., Xiao, J. and Bao, Y. (2020) The Elements of Data Sharing. Genomics Proteomics Bioinformatics, 18, 1-4.

63. Yan, J., Zou, D., Li, C., Zhang, Z., Song, S. and Wang, X. (2020) SR4R: An Integrative SNP Resource for Genomic Breeding and Population Research in Rice. Genomics Proteomics Bioinformatics, 18, 173-185.

64. Xiong, Z., Li, M., Yang, F., Ma, Y., Sang, J., Li, R., Li, Z., Zhang, Z. and Bao, Y. (2020) EWAS Data Hub: a resource of DNA methylation array data and metadata. Nucleic Acids Res, 48, D890-D895.

65. Tian, D., Wang, P., Tang, B., Teng, X., Li, C., Liu, X., Zou, D., Song, S. and Zhang, Z. (2020) GWAS Atlas: a curated resource of genome-wide variant-trait associations in plants and animals. Nucleic Acids Res, 48, D927-D932.

66. Teng, X., Li, Q., Li, Z., Zhang, Y., Niu, G., Xiao, J., Yu, J., Zhang, Z. and Song, S. (2020) Compositional Variability and Mutation Spectra of Monophyletic SARS-CoV-2 Clades. Genomics Proteomics Bioinformatics, 18, 648-663.

67. Song, S., Ma, L., Zou, D., Tian, D., Li, C., Zhu, J., Chen, M., Wang, A., Ma, Y., Li, M. et al. (2020) The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR. Genomics Proteomics Bioinformatics, 18, 749-759.

68. Sang, J., Zou, D., Wang, Z., Wang, F., Zhang, Y., Xia, L., Li, Z., Ma, L., Li, M., Xu, B. et al. (2020) IC4R-2.0: Rice Genome Reannotation Using Massive RNA-seq Data. Genomics Proteomics Bioinformatics, 18, 161-172.

69. National Genomics Data Center Members & Partners. (2020) Database Resources of the National Genomics Data Center in 2020. Nucleic Acids Res, 48, D24-D33.

70. Miao, W., Song, L., Ba, S., Zhang, L., Guan, G., Zhang, Z. and Ning, K. (2020) Protist 10,000 Genomes Project. Innovation (Camb), 1, 100058.

71. Liu, L., Wang, G., Wang, L., Yu, C., Li, M., Song, S., Hao, L., Ma, L. and Zhang, Z. (2020) Computational identification and characterization of glioma candidate biomarkers through multi-omics integrative profiling. Biol Direct, 15, 10.

72. Li, Z., Zhang, Y., Zou, D., Zhao, Y., Wang, H.L., Zhang, Y., Xia, X., Luo, J., Guo, H. and Zhang, Z. (2020) LSD 3.0: a comprehensive resource for the leaf senescence research community. Nucleic Acids Res, 48, D1069-D1075.

73. Li, Q., Li, Z., Feng, C., Jiang, S., Zhang, Z. and Ma, L. (2020) Multi-omics annotation of human long non-coding RNAs. Biochem Soc Trans, 48, 1545-1556.

74. Gong, Z., Zhu, J.W., Li, C.P., Jiang, S., Ma, L.N., Tang, B.X., Zou, D., Chen, M.L., Sun, Y.B., Song, S.H. et al. (2020) An online coronavirus analysis platform from the National Genomics Data Center. Zool Res, 41, 705-708.

75. Zhao, Y., Wang, J., Liang, F., Liu, Y., Wang, Q., Zhang, H., Jiang, M., Zhang, Z., Zhao, W., Bao, Y. et al. (2019) NucMap: a database of genome-wide nucleosome positioning map across species. Nucleic Acids Res, 47, D163-D169.

76. Zhang, Z., Yu, J., Eisenhaber, F., Gao, X. and Gojobori, T. (2019) In Memory of Vladimir B. Bajic (1952–2019). Genomics, Proteomics & Bioinformatics, 17, 473-474.

77. Yin, H., Li, M., Xia, L., He, C. and Zhang, Z. (2019) Computational determination of gene age and characterization of evolutionary dynamics in human. Brief Bioinform, 20, 2141-2149.

78. Wang, G., Yin, H., Li, B., Yu, C., Wang, F., Xu, X., Cao, J., Bao, Y., Wang, L., Abbasi, A.A. et al. (2019) Characterization and identification of long non-coding RNAs based on feature relationship. Bioinformatics, 35, 2949-2956.

79. The RNAcentral Consortium. (2019) RNAcentral: a hub of information for non-coding RNA sequences. Nucleic Acids Res, 47, D221-D229.

80. Tang, B., Zhou, Q., Dong, L., Li, W., Zhang, X., Lan, L., Zhai, S., Xiao, J., Zhang, Z., Bao, Y. et al. (2019) iDog: an integrated resource for domestic dogs and wild canids. Nucleic Acids Res, 47, D793-D800.

81. Song, S. and Zhang, Z. (2019) Database Resources in BIG Data Center: Submission, Archiving, and Integration of Big Data in Plant Science. Molecular plant, 12, 279-281.

82. Pervaiz, N., Shakeel, N., Qasim, A., Zehra, R., Anwar, S., Rana, N., Xue, Y., Zhang, Z., Bao, Y. and Abbasi, A.A. (2019) Evolutionary history of the human multigene families reveals widespread gene duplications throughout the history of animals. BMC Evol Biol, 19, 128.

83. Niu, G., Zou, D., Li, M., Zhang, Y., Sang, J., Xia, L., Li, M., Liu, L., Cao, J., Zhang, Y. et al. (2019) Editome Disease Knowledgebase (EDK): a curated knowledgebase of editome-disease associations in human. Nucleic Acids Res, 47, D78-D83.

84. Ma, L., Cao, J., Liu, L., Li, Z., Shireen, H., Pervaiz, N., Batool, F., Raza, R.Z., Zou, D., Bao, Y. et al. (2019) Community Curation and Expert Curation of Human Long Noncoding RNAs with LncRNAWiki and LncBook. Curr Protoc Bioinformatics, 67, e82.

85. Ma, L., Cao, J., Liu, L., Du, Q., Li, Z., Zou, D., Bajic, V.B. and Zhang, Z. (2019) LncBook: a curated knowledgebase of human long non-coding RNAs. Nucleic Acids Res, 47, D128-D134.

86. Li, M., Zou, D., Li, Z., Gao, R., Sang, J., Zhang, Y., Li, R., Xia, L., Zhang, T., Niu, G. et al. (2019) EWAS Atlas: a curated knowledgebase of epigenome-wide association studies. Nucleic Acids Res, 47, D983-D988.

87. Li, M., Xia, L., Zhang, Y., Niu, G., Li, M., Wang, P., Zhang, Y., Sang, J., Zou, D., Hu, S. et al. (2019) Plant editosome database: a curated database of RNA editosome in plants. Nucleic Acids Res, 47, D170-D174.

88. BIG Data Center Members. (2019) Database Resources of the BIG Data Center in 2019. Nucleic Acids Res, 47, D8-D14.

89. Zhang, Z., Xue, Y. and Zhao, F. (2018) Bioinformatics Commons: The Cornerstone of Life and Health Sciences. Genomics Proteomics Bioinformatics, 16, 223-225.

90. Zhang, Y.S., Xia, L., Sang, J., Li, M., Liu, L., Li, M.W., Niu, G.Y., Cao, J.B., Teng, X.F., Zhou, Q. et al. (2018) [The BIG Data Center's database resources]. Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji, 40, 1039-1043.

91. Song, S., Tian, D., Zhang, Z., Hu, S. and Yu, J. (2018) Rice Genomics: over the Past Two Decades and into the Future. Genomics Proteomics Bioinformatics, 16, 397-404.

92. Song, S., Tian, D., Li, C., Tang, B., Dong, L., Xiao, J., Bao, Y., Zhao, W., He, H. and Zhang, Z. (2018) Genome Variation Map: a data repository of genome variations in BIG Data Center. Nucleic Acids Res, 46, D944-D949.

93. Sang, J., Wang, Z., Li, M., Cao, J., Niu, G., Xia, L., Zou, D., Wang, F., Xu, X., Han, X. et al. (2018) ICG: a wiki-driven knowledgebase of internal control genes for RT-qPCR normalization. Nucleic Acids Res, 46, D121-D126.

94. Li, R., Liang, F., Li, M., Zou, D., Sun, S., Zhao, Y., Zhao, W., Bao, Y., Xiao, J. and Zhang, Z. (2018) MethBank 3.0: a database of DNA methylomes across a variety of species. Nucleic Acids Res, 46, D288-D295.

95. International Society for Biocuration. (2018) Biocuration: Distilling data into knowledge. PLoS Biol, 16, e2002846.

96. BIG Data Center Members. (2018) Database Resources of the BIG Data Center in 2018. Nucleic Acids Res, 46, D14-D20.

97. Zhao, Z.M., Campbell, M.C., Li, N., Lee, D.S.W., Zhang, Z. and Townsend, J.P. (2017) Detection of Regional Variation in Selection Intensity within Protein-Coding Genes Using DNA Sequence Polymorphism and Divergence. Mol Biol Evol, 34, 3006-3022.

98. Xu, X., Ji, Z. and Zhang, Z. (2017) CloudPhylo: a fast and scalable tool for phylogeny reconstruction. Bioinformatics, 33, 438-440.

99. Xia, L., Zou, D., Sang, J., Xu, X., Yin, H., Li, M., Wu, S., Hu, S., Hao, L. and Zhang, Z. (2017) Rice Expression Database (RED): An integrated RNA-Seq-derived gene expression database for rice. J Genet Genomics, 44, 235-241.

100. Wang, Y., Song, F., Zhu, J., Zhang, S., Yang, Y., Chen, T., Tang, B., Dong, L., Ding, N., Zhang, Q. et al. (2017) GSA: Genome Sequence Archive<sup/>. Genomics Proteomics Bioinformatics, 15, 14-18.

101. The RNAcentral Consortium. (2017) RNAcentral: a comprehensive database of non-coding RNA sequences. Nucleic Acids Res, 45, D128-D134.

102. Salhi, A., Essack, M., Alam, T., Bajic, V.P., Ma, L., Radovanovic, A., Marchand, B., Schmeier, S., Zhang, Z. and Bajic, V.B. (2017) DES-ncRNA: A knowledgebase for exploring information about human micro and long noncoding RNAs based on literature-mining. RNA Biol, 14, 963-971.

103. BIG Data Center Members. (2017) The BIG Data Center: from deposition to integration to translation. Nucleic Acids Res, 45, D18-D24.

104. Zhao, W., Zhang, S., Tang, B., Chen, T., Hao, L., Sang, J., Li, R., Xiao, J. and Zhang, Z. (2016) Constructing the international database management system for omics big data. Big Data Research, 2, 43-52.

105. Yin, H., Wang, G., Ma, L., Yi, S.V. and Zhang, Z. (2016) What Signatures Dominantly Associate with Gene Age? Genome Biol Evol, 8, 3083-3089.

106. Yin, H., Ma, L., Wang, G., Li, M. and Zhang, Z. (2016) Old genes experience stronger translational selection than young genes. Gene, 590, 29-34.

107. Xue, Y., Lameijer, E.W., Ye, K., Zhang, K., Chang, S., Wang, X., Wu, J., Gao, G., Zhao, F., Li, J. et al. (2016) Precision Medicine: What Challenges Are We Facing? Genomics Proteomics Bioinformatics, 14, 253-261.

108. Wang, G., Sun, S. and Zhang, Z. (2016) Randomness in Sequence Evolution Increases over Time. PLoS One, 11, e0155935.

109. Tian, X., Zhang, Z., Yang, T., Chen, M., Li, J., Chen, F., Yang, J., Li, W., Zhang, B., Zhang, Z. et al. (2016) Comparative Genomics Analysis of Streptomyces Species Reveals Their Adaptation to the Marine Environment and Their Diversity at the Genomic Level. Front Microbiol, 7, 998.

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