基本信息
章张  男  博导  中国科学院北京基因组研究所(国家生物信息中心)
电子邮件: zhangzhang@big.ac.cn
通信地址: 北京市朝阳区北辰西路1号院中国科学院北京基因组研究所
邮政编码: 100101

研究领域

生物信息学/计算生物学

招生信息

欢迎生物信息学、计算机科学、数学、物理等专业背景学生报考。


招生专业
0710J3-生物信息学
0710Z2-计算生物学
0710Z1-基因组学
招生方向
生物大数据整合挖掘
计算健康基因组学

教育背景

2004-09--2007-07   中国科学院计算技术研究所   计算机科学博士
2002-09--2004-07   南京理工大学   计算机科学硕士
1998-09--2002-07   宁夏大学   计算机科学学士

教授课程

基因组学
生命组学
基因组学概述
大数据科学
基因组技术与健康大数据
健康数据与基因组技术
生物信息学前沿讲座
基因组学前沿

科研活动

科研项目
( 1 ) 生物大数据知识挖掘理论及应用, 负责人, 国家任务, 2021-01--2025-12
( 2 ) 基于多层次微进化特征的自然选择压力检测研究, 负责人, 国家任务, 2019-01--2022-12
( 3 ) 生物多样性组学数据平台和数据库系统, 负责人, 中国科学院计划, 2018-01--2022-12
( 4 ) 中国人群全基因组测序与系统分析, 负责人, 国家任务, 2017-07--2020-12
( 5 ) 分子模块组学数据整合与辞海系统建设, 负责人, 中国科学院计划, 2016-01--2017-12
( 6 ) ****(择优), 负责人, 中国科学院计划, 2014-01--2017-12
( 7 ) 动物复杂性状的进化解析与调控—动物复杂性状多组学数据的存储与访问平台建设, 负责人, 中国科学院计划, 2014-01--2019-12
( 8 ) 生物信息技术共享、转化研究平台建设, 参与, 国家任务, 2012-01--2016-12
参与会议
(1)From data to theory: three laws of genome nucleotide composition   2023-10-27
(2)Towards a Universe of Human Long Non-coding RNAs   2022-07-22
(3)Biological Big Data Deposition, Public Sharing and Database Resources   2021-10-25
(4)RiceWiki: a wiki-based database for community curation of rice genes.   Zhang Zhang   2014-04-06
(5)Big biological data integration and curation   2014中国科学数据大会—科研大数据和数据科学   Zhang Zhang   2014-02-24
(6)Biocuration in the era of big data.   Zhang Zhang   2014-02-09
(7)Biological databases: wikify or die.   Zhang Zhang   2013-10-28
(8)Community curation in biological knowledge wikis   Zhang Zhang   2013-04-07
(9)Next-Generation Bioinformatics: harnessing collective resources for large-scale data manipulation   Zhang Zhang   2012-03-19
(10)Estimating codon usage bias and its statistical significance by accounting for background nucleotide composition   Zhang Zhang   2011-10-22

指导学生

已指导学生

孙世翔  博士研究生  0710J3-生物信息学  

殷红彦  博士研究生  0710J3-生物信息学  

于春蕾  硕士研究生  0710J3-生物信息学  

徐行健  博士研究生  0710J3-生物信息学  

王光煜  博士研究生  0710J3-生物信息学  

夏琳  博士研究生  0710J3-生物信息学  

李漫  硕士研究生  0710J3-生物信息学  

曹佳宝  硕士研究生  085238-生物工程  

桑健  博士研究生  0710J3-生物信息学  

王佩  硕士研究生  0710J3-生物信息学  

连明  硕士研究生  0710Z1-基因组学  

张阳  硕士研究生  085211-计算机技术  

刘琳  博士研究生  0710J3-生物信息学  

刘晓楠  博士研究生  0710J3-生物信息学  

牛广艺  博士研究生  0710J3-生物信息学  

高纯纯  博士研究生  0710J3-生物信息学  

张源笙  硕士研究生  085238-生物工程  

陈茹茹  硕士研究生  0710J3-生物信息学  

程远  硕士研究生  0710J3-生物信息学  

杜强  硕士研究生  0710J3-生物信息学  

冯昶瑞  硕士研究生  0710J3-生物信息学  

李乾鹏  博士研究生  0710J3-生物信息学  

滕徐菲  博士研究生  0710J3-生物信息学  

刘畅  硕士研究生  0710Z1-基因组学  

潘榕  硕士研究生  0710J3-生物信息学  

罗思成  硕士研究生  0710J3-生物信息学  

现指导学生

朱彤彤  博士研究生  0710J3-生物信息学  

陈铭  博士研究生  0710J3-生物信息学  

张阳  博士研究生  0710J3-生物信息学  

李昭  博士研究生  0710J3-生物信息学  

荆蔚  硕士研究生  0710J3-生物信息学  

程源源  硕士研究生  0710J3-生物信息学  

覃煜鑫  硕士研究生  0710J3-生物信息学  

褚原  硕士研究生  0710J3-生物信息学  

周新羽  博士研究生  0710J3-生物信息学  

郑兴  博士研究生  0710J3-生物信息学  

成文卓  硕士研究生  0710J3-生物信息学  

汪诗婷  硕士研究生  0710J3-生物信息学  

王苗苗  硕士研究生  0710J3-生物信息学  

齐跃  博士研究生  0710J3-生物信息学  

詹怡然  硕士研究生  0710J3-生物信息学  

马克华  博士研究生  0710J3-生物信息学  

罗政  硕士研究生  0710J3-生物信息学  

王紫晗  硕士研究生  0710J3-生物信息学  

工作经历

  • 2020至今 中国科学院北京基因组研究所/国家生物信息中心 国家基因组科学数据中心 副主任
  • 2016—2020 中国科学院北京基因组研究所 生命与健康大数据中心 执行主任
  • 2011至今 中国科学院大学 教授
  • 2011至今 中国科学院北京基因组研究所  研究员,博士生导师
  • 2009—2011 沙特阿卜杜拉国王理工大学(King Abdullah University of Science and Technology) 研究科学家
  • 2007—2009 美国耶鲁大学(Yale University) 博士后

发表论著

https://ngdc.cncb.ac.cn/people/zhang-zhang

  1. Zhang Z: KaKs_Calculator 3.0: Calculating selective pressure on coding and non-coding sequences. Genomics Proteomics Bioinformatics 2022. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34990803

  2. Zhang Y, Zou D, Zhu T, Xu T, Chen M, Niu G, Zong W, Pan R, Jing W, Sang J, Liu C, Xiong Y, Sun Y, Zhai S, Chen H, Zhao W, Xiao J, Bao Y, Hao L, Zhang Z: Gene Expression Nebulas (GEN): a comprehensive data portal integrating transcriptomic profiles across multiple species at both bulk and single-cell levels. Nucleic Acids Res 2022, 50(D1):D1016-D1024. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34591957

  3. Xiong Z, Yang F, Li M, Ma Y, Zhao W, Wang G, Li Z, Zheng X, Zou D, Zong W, Kang H, Jia Y, Li R, Zhang Z, Bao Y: EWAS Open Platform: integrated data, knowledge and toolkit for epigenome-wide association study. Nucleic Acids Res 2022, 50(D1):D1004-D1009. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718752

  4. Liu L, Zhang Y, Niu G, Li Q, Li Z, Zhu T, Feng C, Liu X, Zhang Y, Xu T, Chen R, Teng X, Zhang R, Zou D, Ma L, Zhang Z: BrainBase: a curated knowledgebase for brain diseases. Nucleic Acids Res 2022, 50(D1):D1131-D1138. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718720

  5. Liu L, Li Z, Liu C, Zou D, Li Q, Feng C, Jing W, Luo S, Zhang Z, Ma L: LncRNAWiki 2.0: a knowledgebase of human long non-coding RNAs with enhanced curation model and database system. Nucleic Acids Res 2022, 50(D1):D190-D195. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34751395

  6. Jiang S, Du Q, Feng C, Ma L, Zhang Z: CompoDynamics: a comprehensive database for characterizing sequence composition dynamics. Nucleic Acids Res 2022, 50(D1):D962-D969. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718745

  7. Jia L, Li Y, Huang F, Jiang Y, Li H, Wang Z, Chen T, Li J, Zhang Z, Yao W: LIRBase: a comprehensive database of long inverted repeats in eukaryotic genomes. Nucleic Acids Res 2022, 50(D1):D174-D182. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34643715

  8. CNCB-NGDC Members & Partners: Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022. Nucleic Acids Res 2022, 50(D1):D27-D38. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34718731

  9. Chen T, Chen X, Zhang S, Zhu J, Tang B, Wang A, Dong L, Zhang Z, Yu C, Sun Y, Chi L, Chen H, Zhai S, Sun Y, Lan L, Zhang X, Xiao J, Bao Y, Wang Y, Zhang Z, Zhao W: The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types. Genomics Proteomics Bioinformatics 2022:doi: 10.1016/j.gpb.2021.1008.1001. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34400360

  10. Chen M, Ma Y, Wu S, Zheng X, Kang H, Sang J, Xu X, Hao L, Li Z, Gong Z, Xiao J, Zhang Z, Zhao W, Bao Y: Genome Warehouse: A Public Repository Housing Genome-scale Data. Genomics Proteomics Bioinformatics 2022:doi: 10.1016/j.gpb.2021.1004.1001. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34175476

  11. The RNAcentral Consortium: RNAcentral 2021: secondary structure integration, improved sequence search and new member databases. Nucleic Acids Res 2021, 49(D1):D212-D220. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33106848

  12. Liu X, Wang P, Teng X, Zhang Z, Song S: Comprehensive Analysis of Expression Regulation for RNA m6A Regulators With Clinical Significance in Human Cancers. Front Oncol 2021, 11:624395. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33718187

  13. Li Z, Liu L, Jiang S, Li Q, Feng C, Du Q, Zou D, Xiao J, Zhang Z, Ma L: LncExpDB: an expression database of human long non-coding RNAs. Nucleic Acids Res 2021, 49(D1):D962-D968. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33045751

  14. Li C, Tian D, Tang B, Liu X, Teng X, Zhao W, Zhang Z, Song S: Genome Variation Map: a worldwide collection of genome variations across multiple species. Nucleic Acids Res 2021, 49(D1):D1186-D1191. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33170268

  15. CNCB-NGDC Members & Partners: Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021. Nucleic Acids Res 2021, 49(D1):D18-D28. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33175170

  16. Zhao WM, Song SH, Chen ML, Zou D, Ma LN, Ma YK, Li RJ, Hao LL, Li CP, Tian DM, Tang BX, Wang YQ, Zhu JW, Chen HX, Zhang Z, Xue YB, Bao YM: The 2019 novel coronavirus resource. Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji 2020, 42(2):212-221. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32102777

  17. Zhang Z, Song S, Yu J, Zhao W, Xiao J, Bao Y: The Elements of Data Sharing. Genomics Proteomics Bioinformatics 2020, 18(1):1-4. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32360769

  18. Yan J, Zou D, Li C, Zhang Z, Song S, Wang X: SR4R: An Integrative SNP Resource for Genomic Breeding and Population Research in Rice. Genomics Proteomics Bioinformatics 2020, 18(2):173-185. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32619768

  19. Xiong Z, Li M, Yang F, Ma Y, Sang J, Li R, Li Z, Zhang Z, Bao Y: EWAS Data Hub: a resource of DNA methylation array data and metadata. Nucleic Acids Res 2020, 48(D1):D890-D895. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31584095

  20. Tian D, Wang P, Tang B, Teng X, Li C, Liu X, Zou D, Song S, Zhang Z: GWAS Atlas: a curated resource of genome-wide variant-trait associations in plants and animals. Nucleic Acids Res 2020, 48(D1):D927-D932. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31566222

  21. Teng X, Li Q, Li Z, Zhang Y, Niu G, Xiao J, Yu J, Zhang Z, Song S: Compositional Variability and Mutation Spectra of Monophyletic SARS-CoV-2 Clades. Genomics Proteomics Bioinformatics 2020, 18(6):648-663. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33581339

  22. Song S, Ma L, Zou D, Tian D, Li C, Zhu J, Chen M, Wang A, Ma Y, Li M, Teng X, Cui Y, Duan G, Zhang M, Jin T, Shi C, Du Z, Zhang Y, Liu C, Li R, Zeng J, Hao L, Jiang S, Chen H, Han D, Xiao J, Zhang Z, Zhao W, Xue Y, Bao Y: The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR. Genomics Proteomics Bioinformatics 2020, 18(6):749-759. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33704069

  23. Sang J, Zou D, Wang Z, Wang F, Zhang Y, Xia L, Li Z, Ma L, Li M, Xu B, Liu X, Wu S, Liu L, Niu G, Li M, Luo Y, Hu S, Hao L, Zhang Z: IC4R-2.0: Rice Genome Reannotation Using Massive RNA-seq Data. Genomics Proteomics Bioinformatics 2020, 18(2):161-172. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32683045

  24. National Genomics Data Center Members & Partners: Database Resources of the National Genomics Data Center in 2020. Nucleic Acids Res 2020, 48(D1):D24-D33. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31702008

  25. Miao W, Song L, Ba S, Zhang L, Guan G, Zhang Z, Ning K: Protist 10,000 Genomes Project. Innovation (N Y) 2020, 1(3):100058. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-34557722

  26. Liu L, Wang G, Wang L, Yu C, Li M, Song S, Hao L, Ma L, Zhang Z: Computational identification and characterization of glioma candidate biomarkers through multi-omics integrative profiling. Biol Direct 2020, 15(1):10. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32539851

  27. Li Z, Zhang Y, Zou D, Zhao Y, Wang HL, Zhang Y, Xia X, Luo J, Guo H, Zhang Z: LSD 3.0: a comprehensive resource for the leaf senescence research community. Nucleic Acids Res 2020, 48(D1):D1069-D1075. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31599330

  28. Li Q, Li Z, Feng C, Jiang S, Zhang Z, Ma L: Multi-omics annotation of human long non-coding RNAs. Biochem Soc Trans 2020, 48(4):1545-1556. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-32756901

  29. Gong Z, Zhu JW, Li CP, Jiang S, Ma LN, Tang BX, Zou D, Chen ML, Sun YB, Song SH, Zhang Z, Xiao JF, Xue YB, Bao YM, Du ZL, Zhao WM: An online coronavirus analysis platform from the National Genomics Data Center. Zool Res 2020, 41(6):705-708. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-33045776

  30. Zhao Y, Wang J, Liang F, Liu Y, Wang Q, Zhang H, Jiang M, Zhang Z, Zhao W, Bao Y, Zhang Z, Wu J, Asmann YW, Li R, Xiao J: NucMap: a database of genome-wide nucleosome positioning map across species. Nucleic Acids Res 2019, 47(D1):D163-D169. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30335176

  31. Zhang Z, Yu J, Eisenhaber F, Gao X, Gojobori T: In Memory of Vladimir B. Bajic (1952-2019). Genomics Proteomics & Bioinformatics 2019, 17(5):473-474. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-WOS:000518438500001

  32. Yin H, Li M, Xia L, He C, Zhang Z: Computational determination of gene age and characterization of evolutionary dynamics in human. Brief Bioinform 2019, 20(6):2141-2149. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30184145

  33. Wang G, Yin H, Li B, Yu C, Wang F, Xu X, Cao J, Bao Y, Wang L, Abbasi AA, Bajic VB, Ma L, Zhang Z: Characterization and identification of long non-coding RNAs based on feature relationship. Bioinformatics 2019, 35(17):2949-2956. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30649200

  34. The RNAcentral Consortium: RNAcentral: a hub of information for non-coding RNA sequences. Nucleic Acids Res 2019, 47(D1):D221-D229. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30395267

  35. Tang B, Zhou Q, Dong L, Li W, Zhang X, Lan L, Zhai S, Xiao J, Zhang Z, Bao Y, Zhang YP, Wang GD, Zhao W: iDog: an integrated resource for domestic dogs and wild canids. Nucleic Acids Res 2019, 47(D1):D793-D800. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30371881

  36. Song S, Zhang Z: Database Resources in BIG Data Center: Submission, Archiving, and Integration of Big Data in Plant Science. Molecular plant 2019, 12(3):279-281. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30716410

  37. Pervaiz N, Shakeel N, Qasim A, Zehra R, Anwar S, Rana N, Xue Y, Zhang Z, Bao Y, Abbasi AA: Evolutionary history of the human multigene families reveals widespread gene duplications throughout the history of animals. BMC Evol Biol 2019, 19(1):128. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31221090

  38. Niu G, Zou D, Li M, Zhang Y, Sang J, Xia L, Li M, Liu L, Cao J, Zhang Y, Wang P, Hu S, Hao L, Zhang Z: Editome Disease Knowledgebase (EDK): a curated knowledgebase of editome-disease associations in human. Nucleic Acids Res 2019, 47(D1):D78-D83. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30357418

  39. Ma L, Cao J, Liu L, Li Z, Shireen H, Pervaiz N, Batool F, Raza RZ, Zou D, Bao Y, Abbasi AA, Zhang Z: Community Curation and Expert Curation of Human Long Noncoding RNAs with LncRNAWiki and LncBook. Curr Protoc Bioinformatics 2019, 67(1):e82. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-31524988

  40. Ma L, Cao J, Liu L, Du Q, Li Z, Zou D, Bajic VB, Zhang Z: LncBook: a curated knowledgebase of human long non-coding RNAs. Nucleic Acids Res 2019, 47(D1):D128-D134. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30329098

  41. Li M, Zou D, Li Z, Gao R, Sang J, Zhang Y, Li R, Xia L, Zhang T, Niu G, Bao Y, Zhang Z: EWAS Atlas: a curated knowledgebase of epigenome-wide association studies. Nucleic Acids Res 2019, 47(D1):D983-D988. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30364969

  42. Li M, Xia L, Zhang Y, Niu G, Li M, Wang P, Zhang Y, Sang J, Zou D, Hu S, Hao L, Zhang Z: Plant editosome database: a curated database of RNA editosome in plants. Nucleic Acids Res 2019, 47(D1):D170-D174. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30364952

  43. BIG Data Center Members: Database Resources of the BIG Data Center in 2019. Nucleic Acids Res 2019, 47(D1):D8-D14. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30365034

  44. Zhang Z, Xue Y, Zhao F: Bioinformatics Commons: The Cornerstone of Life and Health Sciences. Genomics Proteomics Bioinformatics 2018, 16(4):223-225. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30268933

  45. Song S, Tian D, Zhang Z, Hu S, Yu J: Rice Genomics: over the Past Two Decades and into the Future. Genomics Proteomics Bioinformatics 2018, 16(6):397-404. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-30771506

  46. Song S, Tian D, Li C, Tang B, Dong L, Xiao J, Bao Y, Zhao W, He H, Zhang Z: Genome Variation Map: a data repository of genome variations in BIG Data Center. Nucleic Acids Res 2018, 46(D1):D944-D949. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-29069473

  47. Sang J, Wang Z, Li M, Cao J, Niu G, Xia L, Zou D, Wang F, Xu X, Han X, Fan J, Yang Y, Zuo W, Zhang Y, Zhao W, Bao Y, Xiao J, Hu S, Hao L, Zhang Z: ICG: a wiki-driven knowledgebase of internal control genes for RT-qPCR normalization. Nucleic Acids Res 2018, 46(D1):D121-D126. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-29036693

  48. Li R, Liang F, Li M, Zou D, Sun S, Zhao Y, Zhao W, Bao Y, Xiao J, Zhang Z: MethBank 3.0: a database of DNA methylomes across a variety of species. Nucleic Acids Res 2018, 46(D1):D288-D295. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-29161430

  49. International Society for Biocuration: Biocuration: Distilling data into knowledge. PLOS Biology 2018, 16(4):e2002846. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-29659566

  50. BIG Data Center Members: Database Resources of the BIG Data Center in 2018. Nucleic Acids Research 2018, 46(D1):D14-D20. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-29036542

  51. Zhao ZM, Campbell MC, Li N, Lee DSW, Zhang Z, Townsend JP: Detection of Regional Variation in Selection Intensity within Protein-Coding Genes Using DNA Sequence Polymorphism and Divergence. Mol Biol Evol 2017, 34(11):3006-3022. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-28962009

  52. Xu X, Ji Z, Zhang Z: CloudPhylo: a fast and scalable tool for phylogeny reconstruction. Bioinformatics 2017, 33(3):438-440. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-28172557

  53. Xia L, Zou D, Sang J, Xu X, Yin H, Li M, Wu S, Hu S, Hao L, Zhang Z: Rice Expression Database (RED): An integrated RNA-Seq-derived gene expression database for rice. J Genet Genomics 2017, 44(5):235-241. https://ngdc.cncb.ac.cn/openlb/publication/OLB-PM-28529082

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