General

Xu Zhang     Dalian Institute of Chemical Physics

Email: zhangxu6@dicp.ac.cn

Address: 457 Zhongshan Road, Dalian, China (116023)


Research Areas

Organ on chip, Microfluidics, Tissue Engineering

Education


09/2008-01/2015   

Dalian Institute of Chemical Physics, Chinese Academy of Sciences,  Ph.D. candidate in Analytical Chemistry

09/2004-07/2008   

South China  University of Technology, B.S. candidate in Biotechnology 


Publications

   
Papers

1.      Xu Zhang, Muath Bishawi, Ge Zhang, Varun Prasad, Ellen Salmon, Jason Breithaupt, George A. Truskey* Modeling Early Stage Atherosclerosis in a Primary Human Vascular Microphysiological System, Nature Communications, (2020), DOI: 0.1038/s41467-020-19197-8    

2.      Xu Zhang, Sungmin Hong, Ringo Yen, Megan Kondash, a a Cristina E. Fernandez and George A. Truskey* C, A system to monitor statin-induced myopathy in individual engineered skeletal muscleLab on chip, (2018) Volume: 18 Issue: 18 Pages: 2787-2796 

3.      Xu Zhang#, Zhaoxu Meng#, Jingyun Ma, Yang Shi, Hui Xu, Simon Lykkemark and Jianhua Qin* Flexible Fabrication of Shape-Controlled Collagen Building Blocks for Self-Assembly of 3D Microtissues, Small, (2015) Volume: 11 Issue: 30 Pages: 3666-3675 (Cover article)   

4.      Fangchao Yin#, Xu Zhang#, Li Wang, Yaqing Wang, Yujuan Zhu, Zhongyu Li, Tingting Tao, Wenwen Chen, Hao Yu, and Jianhua Qin*HiPSC-derived multi-organoids on chip system for safety assessment of antidepressant drugLab on chip, 2020),DOI: 10.1039/D0LC00921K (#contributed equally)  

5.      Hui Wang#, Haitao Liu#, Xu Zhang#, Yaqing Wang, Mengqian Zhao, Wenwen Chen, Jianhua Qin*One-Step Generation of Aqueous-Droplet-Filled Hydrogel Fibers as Organoid Carriers Using an All-in-Water Microfluidic SystemACS Applied Materials & Interfaces,(2021 online, DOI: 10.1021/acsami.0c20434

6.      Xu Zhang, Xinghua Gao, Lei Jiang, and Jianhua Qin*, Flexible Generation of Gradient Electrospinning Nanofibers Using a Microfluidic Assisted Approach, Langmuir, (2012) 28, 10026−10032   

7.      Xu Zhang, Xinghua Gao, Lei Jiang, Xulang Zhang and Jianhua Qin* Nanofiber-modified surface directed cell migration and orientation in microsystem, Biomicrofluidics, (2011) 5, 032007

8.      Rui Gu#, Xu Zhang#, Ge Zhang, Tingting Tao, Haibo Yu, Lianqing Liu, Ying Dou, Aiping Li*, Jianhua Qin*, Probing the Bi-directional Interaction Between Microglia and Gliomas in a Tumor Microenvironment on a Microdevice. Neurochem Res. (2017), 42, 1478–1487, (#contributed equally)

9.      Jingyun Ma#, Xu Zhang #, Yang Liu, Haibo Yu, Lianqing Liu, Yang Shi, Yangfengli, Jianhua Qin, Patterning High-Throughput Multicellular Spheroids in 3D Matrix for Characterizing Invasive Hypoxic Glioma Cells. Biotechnology Journal, (2016) (#contributed equally),  

10.   Qiao Zhang, Xu Zhang, George A. Truskey*, Vascular Microphysiological Systems to Model Diseases. Cell & Gene Therapy Insights (2020); 6(1), 93–102 

11.   Min Zhang#, Peng Wang#, Ronghua Luo#, Yaqing Wang#, Zhongyu Li, Yaqiong Guo, Yulin Yao, Minghua Li, Tingting Tao, Wenwen Chen, Jianbao Han, Haitao Liu, Kangli Cui, Xu zhang, Yongtang Zheng*, Jianhua Qin1*,Biomimetic human disease model of SARS-CoV-2 induced lung injury and immune responses on organ chip system, Adv. Sci., (2020) DOI:10.1002/advs.202002928 

12.   Haitao Liu#, Yaqing Wang#, Kangli Cui, Yaqiong Guo, Xu Zhang, and Jianhua Qin* Advances in Hydrogels in Organoids and Organs-on-a-Chip, Adv. Mater (2019), DOI: 10.1002/adma.201902042 

13.   Haitao Liu#, Yaqing Wang#, Hui Wang, Mengqian Zhao, Tingting Tao, Xu Zhang, and Jianhua Qin*, A Droplet Microfluidic System to Fabricate Hybrid Capsules Enabling Stem Cell Organoid Engineering, Adv. Sci. (2020), DOI: 10.1002/advs.201903739

14.   Hui Wang#, Haitao Liu#, Fan He, Wenwen Chen, Xu Zhang, Mengqian Zhao, Jianhua Qin*, Flexible Generation of Multi-Aqueous Core Hydrogel Capsules using Microfluidic Aqueous Two-Phase System, Adv. Mater. Technol. (2020), DOI: 10.1002/admt.202000054

15.   Yaqiong Guo#, Ronghua Luo#, Yaqing Wang#, Pengwei Deng#, Tianzhang, Song#, Min Zhang, Peng Wang, Xu Zhang, Kangli Cui, Tingting Tao, Zhongyu Li, Wenwen Chen, Yongtang Zheng*, Jianhua Qin*, SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip, China Science Bulletin, (2020), DOI:10.1016/j.scib.2020.11.015.

16.   Wenwen Chen#, Rongkai Cao#, Wentao Su, Xu Zhang, Yuhai Xu, Peng Wang, Zhongqiao Gan, Yingying Xie, Hongjing Li* and Jianhua Qin*, Simple and fast isolation of circulating exosomes with a chitosan modified shuttle flow microchip for breast cancer diagnosis, Lab on chip, (2021), DOI:10.1039/d0lc01311k

17.   Xingyuan Yang, Kaiyan Li, Xu Zhang, Chang Liu, Bingkun Guo, Weijia Wen, and  Xinghua Gao*, Nanofiber membrane supported lung-on-a-chip microdevice for anti-cancer drug testing, Lab on chip, Volume: 18   Issue: 3   Pages: 486-495, 2018

18.   Zhaoxu Meng, Xu Zhang and Jianhua Qin*, A high efficiency microfluidic-based photocatalytic microreactor using electrospun nanofibrous TiO2 as a photocatalyst, Nanoscale, (2013) 5, 4687–4690 

19.   Hui Xu, Shervin Rahimpour, Cody Nesvick, Xu Zhang, Jingyun Ma, Min Zhang, Ge Zhang, Li Wang, Chunzhang Yang, Christopher Hong, Anand Germanwala, J. Elder, Abhik Ray-Chaudhury, Yu Yao, M.R. Gilbert, Russell Lonser, John Heiss, Ying Mao*, Roscoe O. Brady, Jianhua Qin* and Zhengping Zhuang*, Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy, Oncotarget, (2015) 6(14) 11882-11893 

20.   Xinghua Gao, Xu Zhang, Hui Xu, Bingpu Zhou, Weijia Wen and Jianhua Qin*, Regulation of Cell Migration and Osteogenic Differentiation in Mesenchymal Stem Cells under Extremely Low Fluidic Shear Stress , Biomicrofluidics, (2014) 8, 052008 

21.   Xinghua Gao, Xu Zhang, Huiyu Tong, Bingcheng Lin* and Jianhua Qin*, A simple elastic membrane-based microfluidic chip for the proliferation and differentiation of mesenchymal stem cells under tensile stress, Electrophoresis, (2011) 32, 3431–3436 

22.   Yang Shi, Jingyun Ma, Xu Zhang, Hongjing Li, Lei Jiang and Jianhua Qin* Hypoxia combined with spheroid culture improves cartilage specific function in chondrocytes, Integrative Biology, (2015), 7, 289-297 

      23. Kezhao Du, Qing Tu, Xu Zhang, Weiqi Han, Jie liu, Stefan Zauscher, and David B. Mitzi* Two-Dimensional Lead(II) Halide-Based Hybrid Perovskites Templated by Acene Alkylamines: Crystal Structures, Optical Properties, and Piezoelectricity, Inorganic Chemistry, (2017), 56 (15), 9291–9302 


Research Interests

Organ on chip for physiological and pathological modeling