General
   

Research Areas

Development of novel magnetic resonance imaging (MRI) techniques and its clinical applications in cerebrovascular diseases and breast diseases


Education

Nov. 2015~ Nov. 2016: Visiting Grad. Student

Biomedical Science

Biomedical Imaging Research Institute

Cedars-Sinai Medical Center

Los Angeles, USA

Sep. 2013~ Jun. 2018: PhD Degree

Lauterbur Research Center for Biomedical Imaging

Shenzhen Institutes of Advanced Technology

University of Chinese Academy of Sciences

Shenzhen, China

Sep. 2006~ May. 2009: M.Sc. Degree

Department of Biomedical Engineering

Central South University

Changsha, China

Sep. 2002~ Jun. 2006: B.Sc Degree

Department of Biomedical Engineering

Central South University

Changsha, China


Experience

   
Work Experience

Dec. 2018~ present: Associate Professor

Lauterbur Research Center for Biomedical Imaging

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

Oct. 2011~ Nov. 2018: Assistant Professor

Lauterbur Research Center for Biomedical Imaging

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

Jul. 2009~ Sep. 2011: Research Assistant

Lauterbur Research Center for Biomedical Imaging

Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China


Publications

   
Papers

1.    Jia L#, Zhang N#, Kukun H, Ren L, Zhang L, Lyu J, Liang D, Li Y, Zheng H, Jia W, Liu X, Three-dimensional Intra- and Extracranial Arterial Vessel Wall Joint Imaging in Patients with Cerebrovascular Disease, Eur J Radiol. 2020; doi: https://doi.org/10.1016/j.ejrad.2020.108921

2.    Jia S, Zhang L, Ren L, Qi Y, Ly J, Zhang N, Li Y, Liu X, Zheng H, Liang D, Chung YC. Joint intracranial and carotid vessel wall imaging in 5 minutes using compressed sensing accelerated DANTE-SPACE. Eur Radiol. 2020 Jan;30(1):119-127.

3.    Wan L#, Zhang N#, Zhang L, Long X, Jia S, Li Y, Liang D, Zheng H, Liu X. Reproducibility of simultaneous imaging of intracranial and extracranial arterial vessel walls using an improved T1-weighted DANTE-SPACE sequence on a 3 T MR system. Magn Reson Imaging. 2019 Oct; 62:152-158.

4.    Zhang N, Zhang F, Deng Z, Yang Q, Diniz M, Song S, Schlick K, Maya M, Gonzalez N, Li D, Zheng H, Liu X, Fan Z. 3D whole-brain vessel wall MR imaging: A study on the reliability in the quantification of intracranial vessel dimensions. J Cardiovasc Magn Reson 2018 Jun 14;20(1):39.

5.    Zhang N, Zhang L, Yang Q, Pei A, Tong X, Chung YC, Liu X*. A Fast Screening Protocol for Carotid Plaques Imaging Using 3D Multi-contrast MRI without Contrast Agent. Magn Reson Imaging. 2017 Jun;39:89-97.

6.    Jiang C#, Zhang N#, Gao J, Hu Z. Geometric calibration of a stationary digital breast tomosynthesis system based on distributed carbon nanotube X-ray source arrays. PLoS One. 2017 Nov 29;12(11):e0188367.

7.    Hu Z, Gao J, Zhang N#, Yang Y, Liu X, Zheng H, Liang D. An improved statistical iterative algorithm for sparse-view and limited-angle CT image reconstruction. Sci Rep. 2017 Sep 6; 7(1):10747. doi: 10.1038/s41598-017-11222-z.

8.    Zhang L, Zhang N, Wu J, Liu X, Chung YC. High resolution simultaneous imaging of intracranial and extracranial arterial wall with improved cerebrospinal fluid suppression. Magn Reson Imaging. 2017 Dec;44:65-71.

9.    Xie L, Tan Y, Wang Z, Liu H, Zhang N, Zou C, Liu X, Liu G, Lu J, Zheng H. ε-Caprolactone-Modified Polyethylenimine as Efficient Nanocarriers for siRNA Delivery in Vivo. ACS Appl Mater Interfaces. 2016 Nov 2;8(43):29261-29269.

10.  Wang L, He L, Zhi W, Tang Y, Zhang N, Feng F. Non-Contrast-Enhanced MR Angiography (NCE-MRA) of the Hand Using Flow-Sensitive Dephasing (FSD)-Prepared Steady-State Free Precession (SSFP) in Patients with Rheumatoid Arthritis. Applied Magnetic Resonance 2016 Aug;47(8):835–845.

11.  Hu Z, Liu Q, Zhang N, Zhang Y, Peng X, Wu PZ, Zheng H, Liang D. Image Reconstruction from Few-view CT Data by Gradient-domain Dictionary Learning. J Xray Sci Technol. 2016 May 21;24(4):627-38.

12.  Zhang N, Zou L, Huang Y, Liu D, Tang Y, Fan Z, Chen H, Liu X*. Non-Contrast Enhanced MR Angiography (NCE-MRA) of the Calf: A Direct Comparison between Flow-Sensitive Dephasing (FSD) Prepared Steady-State Free Precession (SSFP) and Quiescent-Interval Single-Shot (QISS) in Patients with Diabetes. PLoS One. 2015 Jun 2;10(6):e0128786-1~14.

13.  Zhang L, Zhang N, Wu J, Zhang L, Huang Y, Liu X, Chung YC*. High resolution three dimensional intracranial arterial wall imaging at 3T using T1 weighted SPACE. Magn Reson Imaging. 2015 Nov;33(9):1026-34.

14.  Wu Y, Jiang K, Zhang N, Gao Y, Chen Y, Zheng H, Liu X, Chung YC. An Efficient Method for Analysis of MR Real-time Cines: Toward Accurate Quantification of Left Ventricular Function. J Magn Reson Imaging. 2015 Oct;42(4):972-80.

15.  Tan Y, Xie L, Wang Z, Zhang N, Zou C, Chen Z, Liu X, Lu J, Liu G, Zheng H. Epsilon-caprolactone modified polyethylenimine for highly efficient antigen delivery and chemical exchange saturation transfer functional MR imaging. Biomaterials. 2015 Jul;56:219-28.

16.  Zhang L, Liu X, Fan Z, Zhang N, Chung YC, Liao W, Zheng H, Li D3. Noncontrast MRA of Pedal Arteries in Type II Diabetes: Effect of Disease Load on Vessel Visibility. Acad Radiol. 2015 Apr;22(4):513-9.

17.  Liu D, Liang D, Zhang N, Liu X, Zhang YT. Under-sampling trajectory design for compressed sensing based DCE-MRI. J. Electron. Imaging. 2015 Jan 20;24(1):013017-1~10. doi: 10.1117/1.JEI.24.1.013017

18.  Liu X, Zhang N, Fan Z, Feng F, Yang Q, Zheng H, Liu P*, Li D*. Detection of infragenual arterial disease using non-contrast-enhanced MR angiography in patients with diabetes. J Magn Reson Imaging 2014 Dec; 40(6):1422-9.

19.  Liu X, Fan Z, Zhang N, Yang Q, Feng F, Liu P, Zheng H*, Li D. Unenhanced MR angiography of the foot: initial experience of using flow-sensitive dephasing-prepared steady-state free precession in patients with diabetes. Radiology 2014 Sep; 272(3):885-94.

20. Zhang N, Zhang L, Qiu B, Meng L, Wang X, Hou BL*. Correlation of volume transfer coefficient Ktrans with histopathologic grades of gliomas. J Magn Reson Imaging 2012 Aug; 36(2):355-63.

21.  Hu Z, Zhang N, Liu Y, Gui J, Rong J, Zou J, Zhang Q, Zheng H. Interactive quantitative measurement of blood vessel of brain and human skeleton visualization from non-enhanced MR angiography and CT data. Advanced Science Letters. 2011;4(2):363-367.

22.  Zhang N, Deng Z*, Wang F, Wang X. The effect of different number of diffusion gradients on SNR of diffusion tensor-derived measurement maps. J. Biomed Sci & Engin 2009 Apr; 2(2):96-101.


Patents

1. Magnetic resonance (MR) vessel wall imaging method, device, equipment and storage medium. PCT/CN2019/088327

2.  Method, device, equipment and medium for suppression of cerebrospinal fluid signal in MR vessel wall imaging. PCT/CN2019/088331


Research Interests

Non-contrast enhanced MRA and its clinical application

MR vessel wall imaging and its clinical application

Breast MRI and its clinical application


Conferences

1.      Na Zhang, Tingting Zhu, Lijie Ren, Lei Zhang, Zhangyan Fan, Liwen Wan, Hairong Zheng, Xin Liu. Comparison of plaque characteristics between patients with small and large subcortical infarction using high resolution MR vessel wall imaging. ISMRM 28th Annual Meeting, e-poster presentation, 18-23 April 2020, Sydney, Australia.

2.      Na Zhang, Xinfeng Liu, Qi Yang, Shlee Song, Zhenliang Xiong, Lei Zhang, Hairong Zheng, Xin Liu, Zhaoyang Fan. Clinical reliability of 3D whole-brain vessel wall imaging in patients with intracranial atherosclerotic disease: a comparison with conventional targeted imaging. ISMRM 27th Annual Meeting, e-poster presentation, 11-16 May 2019, Montréal, Canada. P.3240.

3.      Lei Zhang, Yanjie Zhu, Yiu-cho Chung, Lijie Ren, Na Zhang, Xin Liu. T2 Weighted Whole-Brain Intracranial Vessel Wall Imaging at 3 Tesla with Cerebrospinal Fluid suppression. ISMRM 27th Annual Meeting, e-poster presentation, 11-16 May 2019, Montréal, Canada. P.1044.

4.      Na Zhang, Lin Jia, Lei Zhang, Jinhao Lyu, Wenxiao Jia, Hairong Zheng, Xin Liu. Three Dimensional Intra- and Extra-cranial Arterial Vessel Wall Joint Imaging in Patients with ischemic stroke. ISMRM 26th Annual Meeting, oral presentation, 16-21 June 2018, Paris, France. P.377.

5.      Na Zhang, Jinhao Lyu, Lei Zhang, Lin Jia, Wenxiao Jia, Hairong Zheng, Xin Liu. Infarct Pattern and Large Artery Atherosclerosis Features Revealed by Combined Intra- and Extra-cranial Vessel Wall Imaging in Patients with Non-cardiac Acute and Sub-acute Ischemic Stroke. ISMRM 26th Annual Meeting, e-poster presentation, 16-21 June 2018, Paris, France. P.3477.

6.      Liwen Wan, Na Zhang, Lei Zhang, Xiaojing Long, Hairong Zheng, Xin Liu Reproducibility of Simultaneous Intracranial and Extracranial Arterial Vessel Wall MR Imaging based on T1 weighted DANTE-SPACE. ISMRM 26th Annual Meeting, traditional poster presentation, 16-21 June 2018, Paris, France. P.3002.

7.      Na Zhang, Fan Zhang, Zixin Deng, Qi Yang, Xiaoming Bi, Debiao Li, Xin Liu, Zhaoyang Fan. Whole-Brain Vessel Wall MR Imaging Using Inversion- Recovery Prepared SPACE: Reproducibility and Accuracy of Intracranial Artery Morphology. Proc. ISMRM 25th Annual Meeting, oral power pitch presentation, 22-27 April 2017, Hawaii, USA. P.333.

8.      Na Zhang, Zhaoyang Fan, Xin Liu. Comparison of 3D non-contrast enhanced foot MR angiography using steady-state free precession with single and multi-directional FSD modules preparation. ISMRM 23rd Annual Meeting, e-poster presentation, 30 May-5 June 2015, Toronto, Ontario, Canada. P.4499.

9.      Hanwei Chen, Na Zhang, Xin Liu. Noncontrast-enhanced MR angiography in the calf: A comparison between Flow-sensitive dephasing prepared steady-state free precession and quiescent-interval single-shot in patients with diabetes. ISMRM 23rd Annual Meeting, oral presentation, 30 May-5 June 2015, Toronto, Ontario, Canada. P.975.

10.    Yin Wu, Na Zhang, Fan Yang, Yucheng Chen, Yiu-Cho Chung. An Efficient Approach for Analysis of Real-Time Cine for LV Function Quantification. ISMRM 21th Annual Meeting, e-poster presentation, 20-26 April 2013, Salt Lake City, USA. P. 4499.

11.    Lei Zhang, Qing Zhai, Na Zhang, XiaoXin Tong, Xin Liu, Yiu-cho Chung. High Resolution Three Dimensional Intracranial Arterial Wall Imaging at 3T Using SNR-Optimized T1 Weighted SPACE. ISMRM 21th Annual Meeting, e-poster presentation, 20-26 April 2013, Salt Lake City, USA. P. 4537.

12.    Zhaoyang Fan, Xin Liu, Na Zhang, Qi Yang, Fei Feng, Pengcheng Liu, Dehe Weng, and Debiao Li. Non-Contrast Enhanced MR Angiography (NCE-MRA) of the Foot Using Flow Sensitive Dephasing (FSD) Prepared Steady-State Free Precession (SSFP) in Patients with Diabetes. ISMRM 21th Annual Meeting, e-poster presentation, 20-26 April 2013, Salt Lake City, USA. P. 4476.

13.    Na Zhang, Zhaoyang Fan, Fei Feng, Pengcheng Liu, Xin Liu, Dehe Weng, Renate Jerecic, Yongming Dai, Hairong Zheng, and Debiao Li. Clinical evaluation of peripheral non-contrast enhanced MR angiography (NCE-MRA) using steady-state free precession (SSFP) and flow sensitive dephasing (FSD) in diabetes. ISMRM 20th Annual Meeting, oral presentation, 5-11 May 2012, Melbourne, Australia. P.0528.

14.    Na Zhang, Anqi Pei, Lei Zhang, Xiaoxin Tong, Xin Liu, and Yiu-Cho Chung. A New Approach for Noncontrast MR Imaging of Carotid Artery Disease. ISMRM 20th Annual Meeting, e-poster presentation, 5-11 May 2012, Melbourne, Australia. P.3828.

15.    Na Zhang, Guanghua Song, Weiqi Liao, Weijie Tao, Leslie Ying, and Dong Liang. Accelerating Dynamic Contrast-Enhanced MRI Using K-T ISD. ISMRM 20th Annual Meeting, e-poster presentation, 5-11 May 2012, Melbourne, Australia. P.4221.

16.    Na Zhang, Zhaoyang Fan, Fei Feng, Pengcheng Liu, Qi Yang, Dehe Weng, Renate Jerecic, Xin Liu, Hairong Zheng, Debiao Li. Detection of peripheral arterial disease using non-contrast enhanced MR angiography (NCE-MRA) in patients with diabetes. CSMRM & OCSMRM Joint Meeting 2012 and ISMRM Workshop, oral presentation, 14-16 Dec 2012, Xiamen, China. P.2.9.

17.    Lijuan Zhang, Na Zhang, Weiqi Liao, Xin Liu, Yang Liu, Dehe Weng, Renate Jerecic, Fei Feng, Zhaoyang Fan, and Debiao Li. Non-Contrast MRA of Pedal Arteries in Type II Diabetes: Effect of Disease Load on Vessel Visibility. 20th Annual Meeting, e-poster presentation, 5-11 May 2012, Melbourne, Australia. P.3882.

18.    Na Zhang, L. Zhang, X. Liu, H. Zheng, J. Carpenter, B. L. Hou. Effects of artery input function on dynamic contrast enhanced MRI for determining grades of gliomas. ISMRM 19th Annual Meeting, e-poster presentation, 7-13 May 2011, Montreal, Canada. P.3901.

19.    Na Zhang, Zhaoyang Fan, Dehe Weng, Lixin Jin, Fei Feng, Xin Liu, Debiao Li. Evaluation of non-contrast MR angiography using steady-state free precession and flow sensitive dephasing for detecting peripheral arterial disease in patients with diabetes. RSNA 97th annual meeting, oral presentation, 27 Nov-2 Dec 2011, Chicago, USA.

20.    Yin Wu, Chao Zou, Lijuan Zhang, Wei Liu, Rui-Bin Dai, Na Zhang, and Xin Liu. Impact of b-value on DTI indices of left ventricular porcine myocardium: a preliminary study. ISMRM 19th Annual Meeting, e-poster presentation, 7-13 May 2011, Montreal, Canada. P.3401.

21.    Na Zhang, Zhensheng Deng, Li Meng, Xiaoyi Wang, Weihua Liao, Bob L. Hou. Quantitative correlation of volume transfer coefficient Ktrans with histopathologic grade of gliomas. ISMRM 18th Annual Meeting, e-poster presentation, 1-7 May 2010, Stockholm, Sweden. P.4809.


Students

现指导学生

王国帅  硕士研究生  085400-电子信息  

黄正勇  硕士研究生  085400-电子信息  

冷清谱  硕士研究生  085210-控制工程  

Honors & Distinctions

1.      ISMRM E. K. Zavoisky Stipend (2019, 2020)

2.      First Prize of Science and Technology Progress Award of Chinese Institute of Electronics “Cerebrovascular magnetic resonance imaging technology and its application” (2018)

3.      High-Level Professional Reserve Talent in Shenzhen (2017-2022)

4.      Overseas High-Caliber Personnel (Level C) (2018-2023)

5.      High-Level Talent in Nanshan District of Shenzhen (Level C) (2018-2023)

6.      ISMRM Educational Stipend (2012, 2018)

7.      ISMRM MERIT AWARD: Magna Cum Laude (2018)

8.      ISMRM MERIT AWARD: Summa Cum Laude (top 3%) (2012)

9.      CSMRM & OCSMRM Oral Presentation Award (2012)

10.   Radiology Branch of Chinese Medical Association Oral Presentation Award (2012)