基本信息
张娜  女  硕导  中国科学院深圳先进技术研究院
电子邮件: na.zhang@siat.ac.cn
通信地址: 广东省深圳市南山区西丽学苑大道1068号
邮政编码: 518055

研究领域

磁共振成像技术开发及其临床应用研究、医学图像处理和人工智能医学影像大数据

招生信息

生物医学工程及相关专业

招生专业
083100-生物医学工程
081104-模式识别与智能系统
招生方向
医学成像、磁共振成像
医学图像处理、人工智能与医学图像大数据
磁共振成像在心脑血管和乳腺疾病中的应用

教育背景

2013-09--2018-06   中国科学院大学   博士研究生/工学博士
2006-09--2009-06   中南大学   硕士研究生/工学硕士
2002-09--2006-07   中南大学   本科/工学学士
学历
研究生

学位
博士

工作经历



工作简历
2018-12~现在, 中国科学院深圳先进技术研究院, 副研究员
2015-11~2016-11,美国加州大学洛杉矶Cedars-Sinai医学中心, 访问学者
2011-11~2018-11,中国科学院深圳先进技术研究院, 助理研究员
2009-07~2011-10,中国科学院深圳先进技术研究院, 研究助理
社会兼职
2015-01-01-今,J Magn Reson Imaging期刊审稿人,

专利与奖励

   
奖励信息
(1) ISMRM E.K.Zavoisky Stipend, 特等奖, 其他, 2019
(2) 中国电子学会科技进步一等奖, 一等奖, 其他, 2018
(3) ISMRM《Magna Cum Laude》奖, 特等奖, 其他, 2018
专利成果
( 1 ) 磁共振血管壁成像的斑块处理方法、装置和计算设备, 发明专利, 2021, 第 4 作者, 专利号: ZL 2018 1 0818827.1

( 2 ) 一种磁共振血管壁图像分析方法、系统及计算机可读介质, 发明专利, 2020, 第 1 作者, 专利号: CN202011438072.6

( 3 ) Method and device of processing plaques in magnetic resonance imaging of vessel wall, and computer device, 发明专利, 2020, 第 3 作者, 专利号: US16/910,074

( 4 ) 磁共振血管壁成像方法、装置、设备及存储介质, 发明专利, 2020, 第 3 作者, 专利号: ZL 2018 1 0813453.4

( 5 ) 血管壁成像中脑脊液信号的抑制方法、装置、设备及介质, 发明专利, 2020, 第 3 作者, 专利号: ZL 2018 1 0813443.0

( 6 ) 一种图像处理方法、装置及计算机可读存储介质, 发明专利, 2019, 第 4 作者, 专利号: CN201910525842.1

( 7 ) 一种磁共振图像的颅内斑块和颈动脉斑块智能分割方法, 发明专利, 2018, 第 4 作者, 专利号: CN201810818059.X

( 8 ) 应用于神经外科手术的成像方法及其系统, 发明专利, 2016, 第 1 作者, 专利号: ZL 2013 1 0409624.4

( 9 ) 一种最佳m1值的获取方法、装置及医疗设备, 发明专利, 2015, 第 3 作者, 专利号: ZL 2012 1 0584523.6

( 10 ) 计算SPACE序列信号的方法和系统及主动脉信号的采集方法, 发明专利, 2015, 第 3 作者, 专利号: ZL 2012 1 0176764.7

( 11 ) 血管成像方法和系统, 发明专利, 2014, 第 3 作者, 专利号: ZL 2011 1 0459612.3

( 12 ) 一种用于下肢血管的磁共振线圈, 实用新型, 2014, 第 3 作者, 专利号: ZL 2013 2 0594623.7

( 13 ) T1加权图像的生成方法和装置, 发明专利, 2014, 第 3 作者, 专利号: ZL 2012 1 0261447.5

( 14 ) 颅脑、颈动脉和主动脉三位一体的扫描方法及扫描系统, 发明专利, 2014, 第 3 作者, 专利号: ZL 2012 1 0176865.4

( 15 ) 针对小目标的磁共振成像方法和系统, 发明专利, 2013, 第 2 作者, 专利号: ZL2012 1 0022523.7

( 16 ) 测量肿瘤组织吸入卡波金气体后氧浓度的方法及系统, 发明专利, 2012, 第 1 作者, 专利号: ZL 2010 1 0601399.0

( 17 ) 磁共振成像定量参数计算方法及系统, 发明专利, 2012, 第 1 作者, 专利号: ZL 2010 1 0234970.X

出版信息

   
发表论文
(1) Comparison of plaque characteristics of small and large subcortical infarctions in the middle cerebral artery territory using high-resolution magnetic resonance vessel wall imaging, QUANTITATIVE IMAGING IN MEDICINE AND SURGERY, 2021, 通讯作者
(2) Effects of artery input function on dynamic contrast-enhanced MRI for determining grades of gliomas, BRITISH JOURNAL OF RADIOLOGY, 2021, 通讯作者
(3) Direct and indirect parameter imaging methods for dynamic PET, Biomed. Phys. Eng. Express, 2021, 通讯作者
(4) An improved patch-based regularization method for PET image reconstruction, QUANTITATIVE IMAGING IN MEDICINE AND SURGERY, 2021, 通讯作者
(5) DPIR-Net: Direct PET Image Reconstruction Based on the Wasserstein Generative Adversarial Network, IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES, 2021, 第 5 作者
(6) Arterial culprit plaque characteristics revealed by magnetic resonance Vessel Wall imaging in patients with single or multiple infarcts, MAGNETIC RESONANCE IMAGING, 2021, 第 1 作者
(7) Plaque Morphologic Quantification Reliability of 3D Whole-Brain Vessel Wall Imaging in Patients With Intracranial Atherosclerotic Disease: A Comparison With Conventional 3D Targeted Vessel Wall Imaging, JOURNAL OF MAGNETIC RESONANCE IMAGING, 2021, 第 1 作者
(8) PET Image Reconstruction Using a Cascading Back-Projection Neural Network, IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING, 2020, 第 4 作者
(9) A Comparative Study of Chest Computed Tomography Features in Young and Older Adults With Corona Virus Disease (COVID-19), JOURNAL OF THORACIC IMAGING, 2020, 第 4 作者
(10) A 3D attention residual encoder–decoder least-square GAN for low-count PET denoising, NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2020, 通讯作者
(11) Joint intracranial and carotid vessel wall imaging in 5 minutes using compressed sensing accelerated DANTE-SPACE, EUROPEAN RADIOLOGY, 2020, 第 6 作者
(12) Three-dimensional intra- and extracranial arterial vessel wall joint imaging in patients with cerebrovascular disease, EUROPEAN JOURNAL OF RADIOLOGY, 2020, 第 2 作者
(13) Association between basilar artery configuration and Vessel Wall features: a prospective high-resolution magnetic resonance imaging study, BMC MEDICAL IMAGING, 2019, 第 5 作者
(14) Cerebral Venous Thrombosis: MR Black-Blood Thrombus Imaging with Enhanced Blood Signal Suppression, AMERICAN JOURNAL OF NEURORADIOLOGY, 2019, 
(15) 高分辨全脑MR血管壁成像技术的可重复性研究, Reproducibility of high-resolution whole-brain MR vascular wall imaging, 广东医科大学学报, 2019, 第 2 作者
(16) Reproducibility of simultaneous imaging of intracranial and extracranial arterial vessel walls using an improved T1-weighted DANTE-SPACE sequence on a 3 T MR system, MAGNETIC RESONANCE IMAGING, 2019, 第 2 作者
(17) 面向脑血管病早期精确诊疗的磁共振血管壁成像研究, 2018, 第 1 作者
(18) 3d whole-brain vessel wall cardiovascular magnetic resonance imaging: a study on the reliability in the quantification of intracranial vessel dimensions, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 2018, 第 1 作者
(19) An improved statistical iterative algorithm for sparse-view and limited-angle CT image reconstruction., SCIENTIFIC REPORTS, 2017, 第 3 作者
(20) MRI定量分析颈动脉粥样硬化斑块脂质坏死核:与手术病理对照, MRI quantitative analysis of lipid-rich necrotic core of carotid atherosclerotic plaque:Compared with histopathology, 中国医学影像技术, 2017, 第 2 作者
(21) Geometric calibration of a stationary digital breast tomosynthesis system based on distributed carbon nanotube X-ray source arrays, PLOS ONE, 2017, 第 2 作者
(22) High resolution simultaneous imaging of intracranial and extracranial arterial wall with improved cerebrospinal fluid suppression, MAGNETIC RESONANCE IMAGING, 2017, 第 2 作者
(23) A fast screening protocol for carotid plaques imaging using 3D multi-contrast MRI without contrast agent, MAGNETIC RESONANCE IMAGING, 2017, 第 1 作者
(24) Non-Contrast-Enhanced MR Angiography (NCE-MRA) of the Hand Using Flow-Sensitive Dephasing (FSD)-Prepared Steady-State Free Precession (SSFP) in Patients with Rheumatoid Arthritis, APPLIED MAGNETIC RESONANCE, 2016, 第 5 作者
(25) 基于快速梯度回波序列的氨基质子转移成像, Amide Proton Transfer Imaging with Fast Gradient Echo Sequence, 集成技术, 2016, 第 2 作者
(26) Image reconstruction from few-view CT data by gradient-domain dictionary learning, JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY, 2016, 第 3 作者
(27) FSD-bSSFP非增强MRA手部动脉病变诊断的初步研究, Non-contrast MR angiography with balanced steady-state free precession based on flow-sensitive dephasing:a preliminary study in hand arterial diseases, 中华生物医学工程杂志, 2016, 第 5 作者
(28) epsilon-Caprolactone-Modified Polyethylenimine as Efficient Nanocarriers for siRNA Delivery in Vivo, ACS APPLIED MATERIALS & INTERFACES, 2016, 第 5 作者
(29) Noncontrast MRA of pedal arteries in type II diabetes: effect of disease load on vessel visibility., ACADEMIC RADIOLOGY, 2015, 第 4 作者
(30) High resolution three dimensional intracranial arterial wall imaging at 3 T using T1 weighted SPACE, MAGNETIC RESONANCE IMAGING, 2015, 第 2 作者
(31) Non-Contrast Enhanced MR Angiography (NCE-MRA) of the Calf: A Direct Comparison between Flow-Sensitive Dephasing (FSD) Prepared Steady-State Free Precession (SSFP) and Quiescent-Interval Single-Shot (QISS) in Patients with Diabetes, PLOS ONE, 2015, 第 1 作者
(32) Undersampling trajectory design for compressed sensing based dynamic contrast-enhanced magnetic resonance imaging, JOURNAL OF ELECTRONIC IMAGING, 2015, 第 3 作者
(33) Efficient Method for Analyzing MR Real-Time Cines: Toward Accurate Quantification of Left Ventricular Function, JOURNAL OF MAGNETIC RESONANCE IMAGING, 2015, 第 3 作者
(34) Detection of Infragenual Arterial Disease Using Non-Contrast-Enhanced MR Angiography in Patients With Diabetes, JOURNAL OF MAGNETIC RESONANCE IMAGING, 2014, 第 2 作者
(35) Unenhanced MR Angiography of the Foot: Initial Experience of Using Flow-Sensitive Dephasing–prepared Steady-State Free Precession in Patients with Diabetes, RADIOLOGY, 2014, 第 3 作者
(36) 手动脉非增强磁共振血管成像的初步临床应用, Non-contrast-enhanced MR Angiography of Hand:Preliminary Clinical Experience, 中国医学影像学杂志, 2014, 第 8 作者
(37) 三维快速自旋回波(SPACE)——序列原理及其应用, 集成技术, 2013, 第 2 作者
(38) 非增强磁共振血管成像对糖尿病下肢动脉狭窄的诊断价值, Diagnostic Value of Non-contrast Enhanced Magnetic Resonance Angiography for Diabetic Lower Extremity Arterial Stenosis, 中国医学影像学杂志, 2013, 第 6 作者
(39) Noise Behavior of MR Brain Reconstructions Using Compressed Sensing, 2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2013, 第 3 作者
(40) Correlation of Volume Transfer Coefficient K trans with Histopathologic Grades of Gliomas, JOURNAL OF MAGNETIC RESONANCE IMAGING, 2012, 第 1 作者
(41) 扩散加权成像对诊断前列腺癌的初步研究, Preliminary Research for the Diagnosis of Prostate Cancer by Using Diffusion-weighted Imaging, 中国医学影像学杂志, 2012, 第 3 作者
(42) Interactive Quantitative Measurement of Blood Vessel of Brain and Human Skeleton Visualization from Non-Enhanced MR Angiography and CT Data, ADVANCED SCIENCE LETTERS, 2011, 第 2 作者
(43) 高斯噪声对DTI参数MD和FA的影响, The Effect of Gaussian Noise on the DTI parameters of MD and FA, 北京生物医学工程, 2010, 第 3 作者
(44) 利用T1加权DCE-MⅪ技术对脑胶质瘤分级, Study of Glioma's Grades Using T1-weighted DCE-MRI Technique, 中国生物医学工程学报, 2010, 第 2 作者
(45) Region of Interest Three-dimensional Visualization in Clinical Human CT Images Sequence, 2010 3RD INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING AND INFORMATICS (BMEI 2010), VOLS 1-7, 2010, 第 2 作者
(46) MRI检测易损斑块的优势与不足, Advantage and disadvantage of MR imaging for vulnerable plaque, 磁共振成像, 2010, 第 1 作者
(47) The effect of different number of diffusion gradients on SNR of diffusion tensor-derived measurement maps, J. Biomed Sci & Engin, 2009, 第 1 作者
(48) Time-Varying Under-sampling Trajectory Design for Compressed Sensing Based DCE-MRI, 

科研活动

   
科研项目
( 1 ) 动态对比增强MRI对动脉粥样硬化斑块炎症定量分析的研究, 负责人, 国家任务, 2014-01--2016-12
( 2 ) 用于头颈动脉斑块一体化早期诊断的磁共振血管壁成像研究, 负责人, 地方任务, 2018-05--2021-04
( 3 ) 用于缺血性脑卒中病因精准分型的头颈高分辨磁共振成像关键技术研发, 负责人, 地方任务, 2019-03--2021-03
( 4 ) 脑卒中相关血管床粥样硬化斑块的快速磁共振成像及智能诊断研究, 参与, 国家任务, 2019-01--2023-12
( 5 ) 磁共振高分辨脑血管壁成像技术研究, 负责人, 企业委托, 2019-08--2021-07
( 6 ) 专2019N011 脑卒中血管斑块磁共振成像多中心临床研究及应用示范, 参与, 地方任务, 2020-10--2023-09
参与会议
(1)Automatic analysis of carotid vessel wall in MR black blood images using custom convolutional trajectories   2022-05-07
(2)3D Automatic segmentation of breast lesion in dynamic contrast enhanced MRI using deep convolutional neural network.   2022-05-07
(3)Effects of Contrast Agents on Diffusion-Weighted Imaging and T2-Weighted Imaging for diagnosis of Breast tumor   2022-05-07
(4)A Semantic Segmentation Method with Emphasizing Edge information for Automatic Vessel Wall Analysis   2022-05-07
(5)Super-resolution MR Vessel Wall Images Using deep learning   2022-05-07
(6)Non-contrast enhanced MR vessel wall image acquisition based on generation adversarial network   2022-05-07
(7)Combination of pharmacokinetic parameters and texture features of DCE-MRI for predicting preoperative classification of breast cancer   2021-05-15
(8)Automatic segmentation of arterial vessel wall on undersampled MR image using deep learning   2021-05-15
(9)Deep Learning for MR Vessel Wall Imaging: Automated Detection of arterial vessel wall and plaque   2021-05-15
(10)Automatic segmentation of glioma based on MRI K-space data   2021-05-15
(11)Automatic segmentation of middle cerebral artery plaque based on deep learning   2021-05-15
(12)Automated Morphology Analysis of Intracranial and Extracranial Vessel Wall Using Convolutional Neural Network   2020-08-08
(13)Comparison of plaque characteristics between patients with small and large subcortical infarction using high resolution MR vessel wall imaging   2020-08-08
(14)Clinical reliability of 3D whole-brain vessel wall imaging in patients with intracranial atherosclerotic disease: a comparison with conventional targeted imaging   2019-05-11
(15)Three Dimensional Intra- and Extra-cranial Arterial Vessel Wall Joint Imaging in Patients with ischemic stroke   2018-06-16
(16)Infarct Pattern and Large Artery Atherosclerosis Features Revealed by Combined Intra- and Extra-cranial Vessel Wall Imaging in Patients with Non-cardiac Acute and Sub-acute Ischemic Stroke   2018-06-16
(17)Whole-Brain Vessel Wall MR Imaging Using Inversion- Recovery Prepared SPACE: Reproducibility and Accuracy of Intracranial Artery Morphology   2017-04-22
(18)Comparison of 3D non-contrast enhanced foot MR angiography using steady-state free precession with single and multi-directional FSD modules preparation   2015-05-30
(19)Noncontrast-enhanced MR angiography in the calf: A comparison between Flow-sensitive dephasing prepared steady-state free precession and quiescent-interval single-shot in patients with diabetes   2015-05-30
(20)Detection of peripheral arterial disease using non-contrast enhanced MR angiography (NCE-MRA) in patients with diabetes   2012-12-14
(21)Clinical evaluation of peripheral non-contrast enhanced MR angiography (NCE-MRA) using steady-state free precession (SSFP) and flow sensitive dephasing (FSD) in diabetes   2012-05-05
(22)A New Approach for Noncontrast MR Imaging of Carotid Artery Disease   2012-05-05
(23)Accelerating Dynamic Contrast-Enhanced MRI Using K-T ISD   2012-05-05
(24)Evaluation of non-contrast MR angiography using steady-state free precession and flow sensitive dephasing for detecting peripheral arterial disease in patients with diabetes   2011-11-27
(25)Effects of artery input function on dynamic contrast enhanced MRI for determining grades of gliomas   2011-05-07
(26)Quantitative correlation of volume transfer coefficient Ktrans with histopathologic grade of gliomas   2010-05-01

合作情况

与上海联影医疗科技有限公司及国内多家三级甲等医院长期合作,开展心脑血管疾病和乳腺疾病的磁共振成像新技术研发、相应的图像后处理软件研发,以及在临床的应用研究

指导学生

已指导学生

冷清谱  硕士研究生  085210-控制工程  

现指导学生

王国帅  硕士研究生  085400-电子信息  

刘嘉敏  硕士研究生  083100-生物医学工程  

梁港林  硕士研究生  085400-电子信息  

黄正勇  硕士研究生  085400-电子信息