General

Prof. Dr. Yu Zhang

Research Areas

Chemistry and bioactivity of plant natural products especially various types of alkaloids

Education

2001.09-2005.07, Guizhou University, BS.

2005.09-2010.07, Kunming Institute of Botany, Chinese Academy of Sciences

Experience

2010.07-2014.01, Kunming Institute of Botany, Chinese Academy of Sciences, Research Assistant

2014.01-2020.11, Kunming Institute of Botany, Chinese Academy of Sciences, Associate Professor

2015.06-2016.06, The University of North Carolina at Chapel Hill, Visting Scholar

2020.11- now, Kunming Institute of Botany, Chinese Academy of Sciences, Professor

Publications

(1) Cytotoxic Monoterpenoid Indole Alkaloids from Tabernaemontana corymbosa as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification, Journal of Natural Products, 2020
(2) Stemtuberolines A-G, new alkaloids from Stemona tuberosa and their anti- TMV activity, Fitoterapia, 2020
(3) Bousangine A, a novel C-17-nor aspidosperma-type monoterpenoid indole alkaloid from Bousigonia angustifolia, Fitoterapia, 2020
(4) Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization, Molecules, 2019
(5) Alkaloids from the roots of Stemona tuberosa and their anti-tobacco mosaic virus activities, Tetrahedron, 2019
(6) Five new alkaloids from Aconitum apetalum (Ranunculaceae), Phytochemistry Letters, 2019
(7) Two new monoterpenoid indole alkaloids from Tabernaemontana divaricata, Natural Product Research, 2019
(8) Fluevirines E and F, two new alkaloids from Flueggea virosa, Natural Product Research, 2019
(9) A new highly oxygenated abietane diterpenoid and a new lysosome generating phorbol ester from the roots of Euphorbia fischeriana Steud, Natural Product Research, 2019
(10) Melocochines A and B, Two Alkaloids from the Fruits of Melodinus cochinchinensis, Organic Letters, 2019
(11) Acoapetaludines A-K, C20 and C19-diterpenoid alkaloids from the whole plants of Aconitum apetalum (Huth) B.Fedtsch, Phytochemistry, 2019
(12) Taburnaemines A-I, cytotoxic vobasinyl-ibogan-type bisindole alkaloids from Tabernaemontana corymbosa, Journal of Natural Products, 2018
(13) Seven new anthranilamide derivatives from Aconitum apetalum, Fitoterapia, 2018
(14) Modified abietane diterpenoids from whole plants of Selaginella moellendorffii, Journal of Natural Products, 2018
(15) Two new monoterpenoid indole alkaloids from Alstonia rostrata, Natural Product Research, 2018
(16) C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death, Protein Cell, 2018
(17) Tabercorymines A and B, two vobasinyl-ibogan-type bisindole alkaloids from Tabernaemontana corymbosa, Organic Letters, 2017
(18) Polycyclic monoterpenoid indole alkaloids from Alstonia rostrata and their reticulate derivation, Phytochemistry Letters, 2017
(19) Melohenryines A and B, two new indole alkaloids from Melodinus henryi, Phytochemistry Letters, 2017
(20) Three new alkaloids from Myrioneuron faberi, Tetrahedron Letters, 2016
(21) (–)-Evodiakine, A Pair of Rearranged Rutaecarpine-Type Alkaloids From Evodia rutaecarpa, Nat. Prod. Bioprospect., 2016
(22) Schoberine B, an alkaloid with an unprecedented straight C5 side chain, and myriberine B from Myrioneuron faberi, RSC Advances, 2016
(23) Myritonines A−C, Alkaloids from Myrioneuron tonkinensis Based on a Novel Hexacyclic Skeleton, Journal of Natural Products, 2016
(24) Bioactive Limonoid Constituents of Munronia henryi, Journal of Natural Products, 2015
(25) New vobasinyl-ibogan type bisindole alkaloids from Tabernaemontana corymbosa, Fitoterapia, 2015
(26) Alkaloids with Different Carbon Units from Myrioneuron faberi, Journal of Natural Products, 2015
(27) Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforata, Angew. Chem. Int. Ed., 2015
(28) Myrifabine, the first dimeric Myrioneuron alkaloid from Myrioneuron faberi, Organic Letters, 2014
(29) Anguistifonines A and B, cytotoxic bisindole alkaloids from Bousigonia angustifolia, Journal of Natural Products, 2014
(30) Myriberine A, a new alkaloid with an unprecedented heteropentacyclic skeleton from Myrioneuron faberi, Organic Letters, 2013
(31) Indole alkaloids from Ervatamia chinensis, Phytochemistry, 2012


Research Interests

My major research interests focus on the chemistry and biological functions of plant natural products especially terpenoid alkaloids.


Students

已指导学生

霍宗庆  硕士研究生  105500-药学  

赵倩  硕士研究生  078001-药物化学  

马叶含  硕士研究生  105500-药学  

现指导学生

魏银铃  硕士研究生  078001-药物化学  

李晓宇  硕士研究生  105500-药学  

张伯斗  博士研究生  100701-药物化学  

张信笺  硕士研究生  105500-药学