基本信息

张于  男  博士生导师  中国科学院昆明植物研究所
办公电话: 0871-65223263
电子邮件: zhangyu@mail.kib.ac.cn
通信地址: 云南省昆明市蓝黑路132号

邮政编码: 650201

研究领域

主要研究方向为以具有重要生理功能的活性生物碱为研究目标,利用植物化学、化学合成、生物学等手段探讨其结构、活性、作用机制以及成药性研究等。

教育背景

2005-09--2010-07   中国科学院昆明植物研究所   博士
2001-09--2005-07   贵州大学   学士

工作经历


2020-11~现在, 中国科学院昆明植物研究所, 研究员
2015-06~2016-06,University of North Carolina at Chapel Hill, Visiting Scholar
2014-01~2020-11,中国科学院昆明植物研究所, 副研究员
2010-07~2014-01,中国科学院昆明植物研究所, 助理研究员

教授课程

ECD在天然产物结构鉴定中的应用
ECD在天然产物结构鉴定中的作用
CD/ORD在天然产物绝对构型

专利与奖励

1. 2009年度云南省自然科学一等奖(第六获奖人)
专利成果
[1] 张于, 罗荣灿, 郝小江, 姚永刚. 吲哚生物碱类化合物及其制备方法和其药物组合物与应用. 202210007290.7, 2022-01-06.
[2] 张于, 郝小江, 郭伶俐, 白雪. 一种吲哚生物碱或其药学上可接受的盐及制备方法和应用、吲哚生物碱药物组合物及其应用. CN: CN110437255B, 2020-08-21.
[3] 张于, 郝小江, 郭伶俐, 白雪. 依波加生物碱或其药学上可接受的盐以及制备方法和应用、依波加生物碱药物组合物及应用. CN: CN110483515B, 2020-08-07.
[4] 李洋, 张于, 郝小江, 杨崇林. 一种天然小分子HEC-23在制备用于促进溶酶体介导的细胞死亡的药物中用途. 中国: CN108478809A, 2018-09-04.
[5] 郝小江, 陈铎之, 尹俊林, 彭宗根, 何红平, 蒋建东, 邸迎彤, 张于, 李顺林. 菲啶类衍生物及其药物组合物和其制备方法与应用. 中国: CN103145617A, 2013.06.12.
[6] 郝小江, 张于, 何红平, 李艳, 郭伶俐, 邸迎彤. 抗肿瘤生物碱类化合物,其药物组合物及其制备方法和应用. 中国: CN102225937A, 2011-10-26.
[7] 陈刚, 郝小江, 何红平, 李顺林, 高锁, 张于. 3-丙酮基-3-羟基羟吲哚的制备方法. 中国: CN101979379A, 2011-02-23.

出版信息

   
发表论文
[1] Chen, YanNi, Ding, Xiao, Li, DongMei, Sun, Mao, Yang, Lei, Zhang, Yu, Di, YingTong, Fang, Xin, Hao, XiaoJiang. Diterpenoids with an unprecedented ring system from Euphorbia peplus and their activities in the lysosomal-autophagy pathway. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2021, 19(7): 1541-1545, https://www.webofscience.com/wos/woscc/full-record/WOS:000621563000010.
[2] Zhao, NingDong, Li, YuLin, Song, Yu, Yang, BaoJia, Ding, Xiao, Gao, Fang, Ye, Jian, Hao, XiaoJiang, Zhang, Yu, Li, ShunLin. Ten new nortriterpenes from Euphorbia resinifera and their anti-tomato yellow leaf curl virus activities. FITOTERAPIA[J]. 2021, 153: http://dx.doi.org/10.1016/j.fitote.2021.104989.
[3] Zhang, Yu, Bai, Xue, Yuwen, HuanSha, Guo, LingLi, Liu, JianWen, Hao, XiaoJiang. Alkaloids from Tabernaemontana divaricata combined with fluconazole to overcome fluconazole resistance in Candida albicans. BIOORGANIC CHEMISTRY[J]. 2021, 107: http://dx.doi.org/10.1016/j.bioorg.2020.104515.
[4] Zhao, Qian, Zhu, WenTao, Ding, Xiao, Huo, ZongQing, Donkor, Paul O, Adelakun, Tiwalade A, Hao, XiaoJiang, Zhang, Yu. Voacafrines A-N, aspidosperma-type monoterpenoid indole alkaloids from Voacanga africana with AChE inhibitory activity. PHYTOCHEMISTRY[J]. 2021, 181: http://dx.doi.org/10.1016/j.phytochem.2020.112566.
[5] Zhu, WenTao, Chen, Chen, Zhao, Qian, Han, LingLing, Yang, Min, Hao, XiaoJiang, Zhang, Yu. Isolation and structure elucidation of tabercetimines A-D, four new quaternary monoterpenoid indole alkaloids from Tabernaemontana divaricata. TETRAHEDRON LETTERS[J]. 2021, 78: http://dx.doi.org/10.1016/j.tetlet.2021.153289.
[6] Li, YuLin, Zhang, Yu, Zhao, PingZhi, Hu, ZhanXing, Gu, YuCheng, Ye, Jian, Hao, XiaoJiang. Two new steroidal alkaloids from the rhizomes of Veratrum nigrum L. and their anti-TYLCV activity. FITOTERAPIA[J]. 2020, 147: http://dx.doi.org/10.1016/j.fitote.2020.104731.
[7] Wu, Ya, Lin, Zhiwei, Bai, Yun, Zhang, Yu, Cai, Qing, Mu, Shuzhen, Han, Weiwei, Hao, Xiaojiang, Chen, Gang. Synthesis and PDE-10 Inhibition of 3-substituted Phenylimino-indolin-2-ones. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGYnull. 2020, 126: 34-34, https://www.webofscience.com/wos/woscc/full-record/WOS:000509492400044.
[8] Yuan, WenJuan, Gao, WenFen, Zhao, JiangYu, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Diterpenes with potential treatment of vitiligo from the aerials parts of Euphorbia antiquorum L. FITOTERAPIA[J]. 2020, 144: http://ir.kib.ac.cn/handle/151853/72049, http://www.irgrid.ac.cn/handle/1471x/6927915, http://ir.kib.ac.cn/handle/151853/72050, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000537596000004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[9] Huo, ZongQing, Zhao, Qian, Liu, JianWen, Zhu, WenTao, Hao, XiaoJiang, Zhang, Yu. Bousangine A, a novel C-17-nor aspidosperma-type monoterpenoid indole alkaloid from Bousigonia angustifolia. FITOTERAPIA[J]. 2020, 142: http://dx.doi.org/10.1016/j.fitote.2020.104491.
[10] Zhu, WenTao, Zhao, Qian, Huo, ZongQing, Hao, XiaoJiang, Yang, Min, Zhang, Yu. Taberdivamines A and B, two new quaternary indole alkaloids from Tabernaemontana divaricata. TETRAHEDRON LETTERS[J]. 2020, 61(44): http://dx.doi.org/10.1016/j.tetlet.2020.152400.
[11] Adelakun, Tiwalade A, Ding, Xiao, Ombati, Rose M, Zhao, NingDong, ObodozieOfoegbu, Obiageri, Di, YingTong, Zhang, Yu, Hao, XiaoJiang. A new highly oxygenated abietane diterpenoid and a new lysosome generating phorbol ester from the roots of Euphorbia fischeriana Steud. NATURAL PRODUCT RESEARCH[J]. 2020, 34(21): 3027-3035, https://www.webofscience.com/wos/woscc/full-record/WOS:000469633400001.
[12] Hao Xiaojiang. Cytotoxic Monoterpenoid Indole Alkaloids from Tabernaemontana corymbosa as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification. Journal of Natural Products. 2020, [13] Zhang, Yu, Ding, Xiao, Yuan, YuXi, Guo, LingLi, Hao, XiaoJiang. Cytotoxic Monoterpenoid Indole Alkaloids from Tabernaemontana corymbosa as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 83(5): 1432-1439, http://ir.kib.ac.cn/handle/151853/72090, http://www.irgrid.ac.cn/handle/1471x/6927926, http://ir.kib.ac.cn/handle/151853/72091, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000537539300010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[14] Si, Yu, Ding, Xiao, Adelakuna, Tiwalade A, Zhang, Yu, Hao, XiaoJiang. Acotarines A-G, new diterpenoid alkaloids from Aconitum taronense induce lysosomal biogenesis. FITOTERAPIA[J]. 2020, 147: http://dx.doi.org/10.1016/j.fitote.2020.104738.
[15] Hu, ZhanXing, An, Qiao, Tang, HongYu, Yuan, ChunMao, Li, YaNan, Zhang, Yu, Hao, XiaoJiang. Stemtuberolines A-G, new alkaloids from Stemona tuberosa and their anti-TMV activity. FITOTERAPIA[J]. 2020, 143: http://dx.doi.org/10.1016/j.fitote.2020.104572.
[16] Yi, WenFang, Ding, Xiao, Chen, YuanZhi, Adelakun, Tiwalade A, Zhang, Yu, Hao, XiaoJiang. Tabernaesines A-I, Cytotoxic Aspidosperma-Aspidosperma-Type Bisindole Alkaloids from Tabernaemontana pachysiphon. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 83(11): 3215-3222, https://www.webofscience.com/wos/woscc/full-record/WOS:000595546200001.
[17] Zhang, Yu, Goto, Masuo, Oda, Akifumi, Hsu, PeiLing, Guo, LingLi, Fu, YanHui, MorrisNatschke, Susan L, Hamel, Ernest, Lee, KuoHsiung, Hao, XiaoJiang. Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization. MOLECULES[J]. 2019, 24(7): https://www.webofscience.com/wos/woscc/full-record/WOS:000464962900002.
[18] Yuwen, Huansha, Yuan, Yuxi, Hao, Xiaojiang, He, Hongping, Zhang, Yu. Two new monoterpenoid indole alkaloids from Tabernaemontana divaricata. NATURAL PRODUCT RESEARCH[J]. 2019, 33(15): 2139-2144, https://www.webofscience.com/wos/woscc/full-record/WOS:000476549900002.
[19] Zhang, Jiahui, Cao, Pei, Ma, Yuanliang, Fang, Xin, Yang, Jing, Zhang, Yu, Chen, Duozhi, Gu, Yucheng, Di, Yingtong, Hao, Xiaojiang. Structural Revision of Macropodumine A and Structure of 2-Deoxymacropodumine A, Daphniphyllum Alkaloids with 11-Membered Macrolactone Rings. JOURNAL OF NATURAL PRODUCTS[J]. 2019, 82(3): 427-430, http://dx.doi.org/10.1021/acs.jnatprod.8b00232.
[20] Hong, Wei, Zhang, Yu, Yang, Jun, Xia, MengYuan, Luo, JiFeng, Li, XiaoNian, Wang, YueHu, Wang, JunSong. Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius. JOURNAL OF NATURAL PRODUCTS[J]. 2019, 82(12): 3221-3226, [21] Yu Zhang, Masuo Goto, Akifumi Oda, PeiLing Hsu, LingLi Guo, YanHui Fu, Susan L MorrisNatschke, Ernest Hamel, KuoHsiung Lee, XiaoJiang Hao. Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization. Molecules[J]. 2019, 24(7): https://doaj.org/article/24b59580fb8c4df8be77fe23a564b2ac.
[22] Hu, ZhanXing, An, Qiao, Tang, HongYu, Chen, ZhengHong, Aisa, Haji Aker, Zhang, Yu, Hao, XiaoJiang. Acoapetaludines A-K, C-20 and C-19-diterpenoid alkaloids from the whole plants of Aconitum apetalum (Huth) B.Fedtsch. PHYTOCHEMISTRY[J]. 2019, 167: http://dx.doi.org/10.1016/j.phytochem.2019.112111.
[23] Liu, JianWen, Huo, ZongQing, Zhao, Qian, Hao, XiaoJiang, He, HongPing, Zhang, Yu. Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus. FITOTERAPIA[J]. 2019, 138: http://dx.doi.org/10.1016/j.fitote.2019.104347.
[24] Feng, Ling, Zhang, Yu, Liu, YanChun, Liu, Yan, Luo, ShiHong, Huang, ChunShuai, Li, ShengHong. Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2019, 27(2): 442-446, http://dx.doi.org/10.1016/j.bmc.2018.12.023.
[25] Zhang, Yu, Ding, Xiao, Shao, Shun, Guo, LingLi, Zhao, Qing, Hao, XiaoJiang, He, HongPing. Melocochines A and B, Two Alkaloids from the Fruits of Melodinus cochinchinensis. ORGANIC LETTERS[J]. 2019, 21(22): 9272-9275, https://www.webofscience.com/wos/woscc/full-record/WOS:000497259500086.
[26] Zhang Yu. Fluevirines E and F, two new alkaloids from Flueggea virosa. Natural Product Research. 2019, [27] Hu, ZhanXing, Tang, HongYu, Guo, Jie, Aisa, Haji Aker, Zhang, Yu, Hao, XiaoJiang. Alkaloids from the roots of Stemona tuberosa and their anti-tobacco mosaic virus activities. TETRAHEDRON[J]. 2019, 75(12): 1711-1716, http://ir.xjipc.cas.cn/handle/365002/5708.
[28] Hu, ZhanXing, Tang, HongYu, Yan, XiaoHui, Zeng, YanRong, Aisa, Haji Aker, Zhang, Yu, Hao, XiaoJiang. Five new alkaloids from Aconitum apetalum (Ranunculaceae). PHYTOCHEMISTRY LETTERS[J]. 2019, 29(2): 6-11, http://ir.xjipc.cas.cn/handle/365002/5665.
[29] Chen, Duozhi, Yang, Bijuan, He, Xiaoli, Fan, Shirui, Cai, Jieyun, Jing, Chenxu, Zhang, Heng, Zhang, Yu, Li, Lin, Hao, Xiaojiang. Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/beta-catenin signalling pathway agonists. BIOORGANIC CHEMISTRY[J]. 2019, 84: 285-294, http://ir.kib.ac.cn/handle/151853/64207.
[30] Ke, LeiYu, Zhang, Yu, Xia, MengYuan, Zhuo, JingXian, Wang, YueHu, Long, ChunLin. Modified Abietane Diterpenoids from Whole Plants of Selaginella moellendorffii. JOURNAL OF NATURAL PRODUCTS[J]. 2018, 81(2): 418-422, http://dx.doi.org/10.1021/acs.jnatprod.7b00909.
[31] Yi, Wenfang, Chen, Duozhi, Ding, Xiao, Li, Xiaonian, Li, Shunlin, Di, Yingtong, Zhang, Yu, Hao, Xiaojiang. Cytotoxic indole alkaloids from Melodinus khasianus and Melodinus tenuicaudatus. FITOTERAPIA[J]. 2018, 128: 162-168, http://dx.doi.org/10.1016/j.fitote.2018.05.015.
[32] Yan, Ying, Tang, Lei, Hu, Jiaqi, Wang, Jianta, Adelakun, Tiwalade Adegoke, Yang, Dongqiong, Di, Yingtong, Zhang, Yu, Hao, Xiaojiang. Munronin O, a potential activator for plant resistance. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY[J]. 2018, 146: 13-18, http://dx.doi.org/10.1016/j.pestbp.2018.02.001.
[33] Chen, Gang, Lin, Jiao, Zhang, Jie, Wu, Ya, Gu, Xuefan, Hao, Xiaojiang, Zhang, Yu. Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation. COMPTES RENDUS CHIMIE[J]. 2018, 21(5): 471-474, http://ir.kib.ac.cn/handle/151853/64766.
[34] Zhang Yu. Taburnaemines A-I, cytotoxic vobasinyl-ibogan-type bisindole alkaloids from Tabernaemontana corymbosa. Journal of Natural Products. 2018, [35] Li, Yang, Liang, Jingjing, Tang, Guihua, Ding, Xiao, Xu, Meng, Gan, Qiwen, Zhang, Yu, Yang, Chonglin, Hao, Xiaojiang, Gao, Zhiyang, Guo, Lingli, Wang, Xin, Liu, Xuezhao, Liu, Kai. C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT[J]. 2018, 54(6): 606-611, http://ir.kib.ac.cn/handle/151853/63281.
[36] Li, Yang, Zhang, Yu, Gan, Qiwen, Xu, Meng, Ding, Xiao, Tang, Guihua, Liang, Jingjing, Liu, Kai, Liu, Xuezhao, Wang, Xin, Guo, Lingli, Gao, Zhiyang, Hao, Xiaojiang, Yang, Chonglin. C. elegans-based screen identifies lysosome-damaging alkaloids that induce STAT3-dependent lysosomal cell death. PROTEIN & CELL[J]. 2018, 9(12): 1013-1026, http://lib.cqvip.com/Qikan/Article/Detail?id=6100018010.
[37] Zhao, NingDong, Ding, Xiao, Song, Yu, Yang, DongQiong, Adelakun, Tiwalade Adegoke, Qian, WenDan, Zhang, Yu, Di, YingTong, Gao, Fang, Hao, XiaoJiang, Li, ShunLin. Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis. JOURNAL OF NATURAL PRODUCTS[J]. 2018, 81(5): 1209-1218, https://www.webofscience.com/wos/woscc/full-record/WOS:000433635500010.
[38] Xia, Fan, Zhang, DaWei, Wu, ChunYan, Geng, HuiChun, Xu, WenDan, Zhang, Yu, Yang, XingWei, Qin, HongBo, Xu, Gang. Isolation, structural elucidation, and synthetic study of salviyunnanone A, an abietane derived diterpenoid with a 7/5/6/3 ring system from Salvia yunnanensis. ORGANIC CHEMISTRY FRONTIERS[J]. 2018, 5(8): 1262-1266, http://ir.kib.ac.cn/handle/151853/63377.
[39] Hu, ZhanXing, Zhao, LiHua, Tang, HongYu, Aisa, Haji Aker, Zhang, Yu, Hao, XiaoJiang. Seven new anthranilamide derivatives from Aconitum apetalum. FITOTERAPIA[J]. 2018, 128(7): 73-78, http://dx.doi.org/10.1016/j.fitote.2018.05.008.
[40] Yuan, YuXi, Guo, Feng, He, HongPing, Zhang, Yu, Hao, XiaoJiang. Two new monoterpenoid indole alkaloids from Alstonia rostrata. NATURAL PRODUCT RESEARCH[J]. 2018, 32(7): 844-848, https://www.webofscience.com/wos/woscc/full-record/WOS:000426946900017.
[41] Gu, Xuefan, Zhang, Yu, Hao, Xiaojiang, Chen, Gang, Lin, Jiao, Zhang, Jie, Wu, Ya. Autocatalytic synthesis of 3-ethyl-3-hydroxy-indole-2-ones and their neuroprotection and antitumor activities' evaluation. MOLECULES[J]. 2018, 23(5): 1015-, http://www.irgrid.ac.cn/handle/1471x/1781753.
[42] Zhao, Qing, Yu, Qian, He, Li, Ma, Xiao, An, Lin-Kun, Liu, Hai-Yang, Liu, Hui, Zhang, Yu, Yan, Huan, Zhi, Yin-E., Qin, Xu-Jie, Wang, Shan. Baeckfrutones A-L, polymethylated phloroglucinol meroterpenoids from the twigs and leaves of Baeckea frutescens. INDUSTRIAL CROPS AND PRODUCTS[J]. 2018, 124: 186-191, http://www.irgrid.ac.cn/handle/1471x/1781667.
[43] Zhong, XiuHong, Bao, MeiFen, Zeng, ChunXia, Zhang, BingJie, Wu, Jing, Zhang, Yu, Cai, XiangHai. Polycyclic monoterpenoid indole alkaloids from Alstonia rostrata and their reticulate derivation. PHYTOCHEMISTRY LETTERS[J]. 2017, 20: 77-83, http://dx.doi.org/10.1016/j.phytol.2017.04.008.
[44] Guo, LingLi, Yuan, YuXi, He, HongPing, Li, ShunLin, Zhang, Yu, Hao, XiaoJiang. Melohenryines A and B, two new indole alkaloids from Melodinus henryi. PHYTOCHEMISTRY LETTERS[J]. 2017, 21: 179-182, http://dx.doi.org/10.1016/j.phytol.2017.07.001.
[45] Yuan, WenJuan, Gao, WenFen, Zhang, JiaHui, Cao, Pei, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. (+/-)-Perforison A, A Pair of New Chromone Enantiomers from Harrisonia perforata. NATURAL PRODUCT COMMUNICATIONS[J]. 2017, 12(1): 63-65, http://ir.kib.ac.cn/handle/151853/41892.
[46] Yuan, YuXi, Zhang, Yu, Guo, LingLi, Wang, YueHu, Goto, Masuo, MorrisNatschke, Susan L, Lee, KuoHsiung, Hao, XiaoJiang. Tabercorymines A and B, Two Vobasinyl-Ibogan-Type Bisindole Alkaloids from Tabernaemontana corymbosa. ORGANIC LETTERS[J]. 2017, 19(18): 4964-4967, https://www.webofscience.com/wos/woscc/full-record/WOS:000411304300066.
[47] Zhong XiuHong, Bao MeiFen, Zeng ChunXia, Zhang BingJie, Wu Jing, Zhang Yu, Cai XiangHai. Polycyclic monoterpenoid indole alkaloids from Alstonia rostrata and their reticulate derivation. Phytochemistry Letters[J]. 2017, [48] Cai, Cancan, Zhang, Yu, Yang, Dongqiong, Hao, Xiaojiang, Li, Shunlin. Two new kaurane-type diterpenoids from Wedelia chinensis (Osbeck.) Merr. NATURAL PRODUCT RESEARCH[J]. 2017, 31(21): 2531-2536, https://www.webofscience.com/wos/woscc/full-record/WOS:000412458800012.
[49] Chen, Jia, Zheng, Guowei, Zhang, Yu, Aisa, Haji A, Hao, XiaoJiang. Phytotoxic Terpenoids from Ligularia cymbulifera Roots. FRONTIERS IN PLANT SCIENCE[J]. 2017, 7(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000412806900001.
[50] Yuan, WenJuan, Ding, Xiao, Wang, Zhe, Yang, BiJuan, Li, XiaoNian, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Chen, Quan, Di, YingTong, Aisa, Haji Akber, Hao, XiaoJiang. Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/e37a28dc25a9453b84cb871969fa2f32.
[51] Guo LingLi, Yuan YuXi, He HongPing, Li ShunLin, Zhang Yu, Hao XiaoJiang. Melohenryines A and B, two new indole alkaloids from Melodinus henryi. Phytochemistry Letters[J]. 2017, [52] Li, XiaoHui, Zhang, Yu, Zhang, JiaHui, Li, XiaoNian, Cao, MingMing, Di, YingTong, Peng, ZongGen, Jiang, JianDong, Hao, XiaoJiang. Myritonines A-C, Alkaloids from Myrioneuron tonkinensis Based on a Novel Hexacyclic Skeleton. JOURNAL OF NATURAL PRODUCTS[J]. 2016, 79(4): 1203-1207, http://ir.kib.ac.cn/handle/151853/26223.
[53] Yuan, WenJuan, Yang, GuoPing, Zhang, JiaHui, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Three new diterpenes with cytotoxic activity from the roots of Euphorbia ebracteolata Hayata. PHYTOCHEMISTRY LETTERS[J]. 2016, 18(1): 176-179, http://dx.doi.org/10.1016/j.phytol.2016.10.008.
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[124] Zhang, Zhen, Zhang, Yu, Wang, YueHu, Zhang, Qiang, Yan, XiaoHui, Di, YingTong, He, HongPing, Hao, XiaoJiang. Three novel beta-carboline alkaloids from Gelsemium elegans. FITOTERAPIA[J]. 2012, 83(4): 704-708, http://www.irgrid.ac.cn/handle/1471x/832348.
[125] Zhang, Qiang, Zhang, Yu, He, HongPing, Di, YingTong, Hao, XiaoJiang. Trichilone, a New C-21 Steroid from Trichilia connaroides. NATURAL PRODUCT COMMUNICATIONS[J]. 2012, 7(10): 1267-1268, http://www.irgrid.ac.cn/handle/1471x/544322.
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[129] Li, XiaoNing, Zhang, Yu, Cai, XiangHai, Feng, Tao, Liu, YaPing, Li, Yan, Ren, Jie, Zhu, HuaJie, Luo, XiaoDong. Psychotripine: A New Trimeric Pyrroloindoline Derivative from Psychotria pilifera. ORGANIC LETTERS[J]. 2011, 13(21): 5896-5899, http://www.irgrid.ac.cn/handle/1471x/392897.
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科研活动

   
科研项目
( 1 ) 影响自噬-溶酶体通路的vobasinyl-ibogan类型生物碱的发现及其抗肿瘤机制研究, 主持, 国家级, 2015-01--2018-12
( 2 ) 三种植物中抗肿瘤二聚单萜吲哚生物碱活性成分研究, 主持, 国家级, 2012-01--2014-12
( 3 ) 密脉木属植物中抗丙肝病毒生物碱活性成分及其分子设计, 主持, 省级, 2014-10--2017-09
( 4 ) 中国科学院青年创新促进会人才项目, 主持, 部委级, 2015-01--2018-12
( 5 ) 密脉木生物碱抗HCV活性及其分子设计, 主持, 部委级, 2012-10--2015-10
( 6 ) 天然翠雀花中二萜类生物碱的分离分析及结构修饰, 主持, 部委级, 2013-01--2014-12
( 7 ) 具有重要活性的新结构生物碱的发现, 主持, 部委级, 2016-10--2019-09
( 8 ) Aspidosperma-eburnea类生物碱促溶酶体生成的构效关系与作用机制 研究, 主持, 国家级, 2019-01--2022-12
( 9 ) 抑制微管蛋白聚合活性的白坚木类型生物碱的发现、构 效关系以及机制研究, 主持, 省级, 2018-06--2021-05
( 10 ) 云南省万人计划青年拔尖人才, 主持, 省级, 2019-01--2023-12

指导学生

已指导学生

霍宗庆  硕士研究生  105500-药学  

现指导学生

赵倩  硕士研究生  078001-药物化学  

马叶含  硕士研究生  105500-药学