My research interests are in biotechnology, biodegradation & biotransformation, especially in the aspect of novel strain screening; functional gene identification and systems metabolic engineering of strains for bio-based products production:

-            Understanding of microbially metabolizing persistent organic pollutants including heterocyclic aromatic compounds and hydrocarbon

-            Screening of microbes and characterization of novel enzymes with potential in industrial use

-            Reconstruction of novel metabolic pathway for bulk and high value-added fine chemicals production

Ph.D., Microbiology                            June, 2006

Shandong University                            Jinan,China

Bachelor of Sciences, Biotechnology               June, 2001

Shandong University                            Jinan,China

2016.10~   Professor/Group Leader,  Institute of Microbiology, Chinese Academy of Sciences, China

2010.10~2016.9  Associate Professor/Group Leader,  Institute of Microbiology, Chinese Academy of Sciences, China

2008.08~2010.07 German Alexander von Humboldt Fellowship for Post-doc Researcher

        2008.08~2009.12   Helmholtz Centre for Infection Research

        2010.01~2010.07   Hamburg University of Technology (TUHH), Germany

2008.01~2008.03   Senior Visiting Scholar, NIZO Food Research Institute, The Netherlands

2006.07~2008.07   Assistant Professor, Institute of Microbiology, Chinese Academy of Sciences,China

   

1. Wang Y, Cui JK, Liu Z, Zhou Y, Chen W, Gao SH, Ruchala J, Yu B*, Wang LM*. Industrial perspective validation of neutralizer-free L-lactic acid production process by engineered

acid-tolerant yeast Pichia kudriavzevii. Trends in Biotechnology, 2026, in press PDF

2. Liu FX, Zhao HL, Shang ZD, Zhang F, de Rond T, Yu B*. Rational design of D-hydantoinase from Pseudomonas aeruginosa for desymmetric synthesis of chiral intermediate

for S-pregabalin. Green Carbon, 2025, 3(3): 320-329 PDF

3. Zheng P, Ren J, Zheng J, Liu FX, Han XH, Yu B*. De novo biosynthesis of D-panthenol in engineered E. coli with rationally designed L-homoserine decarboxylase. Metabolic Engineering,

2025, 92: 63-75 PDF

4. Wang YP. Wang Y, Cui JK, Wu CC, Yu B*, Wang LM*. Non-conventional yeasts: promising cell factories for organic acid bioproduction. Trends in Biotechnology, 2025, 43(7): 1609-1626 PDF

5.  Zhang JN, Wang YH, Wang D, Yu B*. Fermentative production of 2,4-dihydroxybutyrate from glucose via a redox balanced route. ACS Sustainable Chemistry & Engineering, 2025, 13, 5101-5108 PDF

6. Hu YF, Wang ZC, Liu ZZ, Sombatmankhong K, Yu B*. Deciphering hypersaline tolerance mechanism of the pyridine-degrading strain Rhodococcus sp. PD10. Environmental Technology & Innovation, 2025, 38: 104168 PDF

7. Zhang JN, Liu ZZ, Wang YH, Yu B*. Sustainable production of L-homoserine solely from CO₂-derived acetate and formate by engineered E. coli strain. ACS Sustainable Chemistry & Engineering, 2024, 12(52): 18704-18711 PDF

8. Zheng J, Liu HX, Zhang JW*, Yu B*. De novo biosynthesis of L-azetidine-2-carboxylic acid in Escherichia coli strain for powdery mildew treatment. Journal of Agricultural and Food Chemistry, 2024, 72(41): 22736-22744 PDF

9.   郑棚，闫更轩，王丽敏，张云志，陶勇，于波*。丙酸的合成生物制造. 生物工程学报, 2024, 40(8): 2678-2694 DOI: 10.13345/j.cjb.240097

10. Liu FX^#, Ren J^#, Guo L, Liu Y, Li DF, Yu B*. Desymmetric hydrolysis of prochiral imide for S-pregabalin synthesis by rationally designed D-hydantoinase. Green Chemistry, 2022, 24: 4748-4753 (^#Equal contributors) PDF

11. Xue YB, Qiu TL, Sun Z, Liu FX, Yu B*. Mercury bioremediation by engineered Pseudomonas putida KT2440 with adaptationally optimized biosecurity circuit. Environmental Microbiology, 2022, 24(7): 3022-3036. PDF

12. Mu QX, Zhang SS, Mao XJ*, Tao Y, Yu B*. Highly efficient production of L-homoserine in Escherichia coli by engineering a redox balance route. Metabolic Engineering, 2021, 67: 321-329. PDF

已指导学生

管祥辰  硕士研究生  085238-生物工程  

朱凌峰  硕士研究生  085238-生物工程  

刘菲霞  硕士研究生  085238-生物工程  

张彩丽  硕士研究生  071010-生物化学与分子生物学  

李衍峰  硕士研究生  085238-生物工程  

刘洋  硕士研究生  085238-生物工程  

杨寒  博士研究生  071005-微生物学  

现指导学生

薛宇斌  硕士研究生  071005-微生物学  

孙智  博士研究生  071010-生物化学与分子生物学  

石雅南  硕士研究生  071005-微生物学  

牟庆璇  博士研究生  071005-微生物学  

刘洋  博士研究生  071010-生物化学与分子生物学  

孟凡康  硕士研究生  071007-遗传学