
电子邮件: yub@im.ac.cn
通信地址: 北京朝阳区北辰西路1号院3号 中科院微生物所F307
邮政编码: 100101
研究领域
针对生物基化学品开发相关合成生物技术体系,侧重于平台与高值化学品的微生物合成技术开发:
- 具有工业应用潜力的极端微生物的筛选与应用
- 生物基平台化学品的微生物合成技术与产业化开发
- 植源化合物的微生物合成
招生信息
工业微生物代谢工程
招生专业
招生方向
教育背景
出国学习工作
德国Hamburg University of Technology 博士后
工作经历
2006-2008 中国科学院微生物研究所,助理研究员
2010-2016 中国科学院微生物研究所,副研究员、青年研究组长
2016- 中国科学院微生物研究所,研究员、研究组长
专利与奖励
专利成果
科研活动
科研项目
指导学生
已指导学生
管祥辰 硕士研究生 085238-生物工程
朱凌峰 硕士研究生 085238-生物工程
刘菲霞 硕士研究生 085238-生物工程
张彩丽 硕士研究生 071010-生物化学与分子生物学
李衍峰 硕士研究生 085238-生物工程
刘洋 硕士研究生 085238-生物工程
杨寒 博士研究生 071005-微生物学
现指导学生
薛宇斌 硕士研究生 071005-微生物学
孙智 博士研究生 071010-生物化学与分子生物学
石雅南 硕士研究生 071005-微生物学
牟庆璇 博士研究生 071005-微生物学
刘洋 博士研究生 071010-生物化学与分子生物学
孟凡康 硕士研究生 071007-遗传学
代表性论文
1. Ma C, Mu QX, Xue YB, Xue YF, Yu B*, Ma YH*. One major facilitator superfamily transporter is responsible for propionic acid tolerance in Pseudomonas putida KT2440. Microb. Biotechnol. 2020, doi: 10.1111/1751-7915.13597
2. Ma C, Mu QX, Wang L, Shi YN, Zhu LF, Zhang SS, Xue YF, Tao Y, Ma YH*, Yu B*. Bio-production of high-purity propionate by engineering L-threonine degradation pathway in Pseudomonas putida. Appl. Microbiol. Biotechnol. 2020, online first PDF
3. Wang AX, Tian WZ, Cheng L, Xu YQ, Wang XW, Qin JY, Yu B. Enhanced ε-poly-L-lysine production by the synergistic effect of ε-poly-L-lysine synthetase overexpression and citrate in Streptomyces albulus. Front. Bioeng. Biotechnol. 2020, 8: 288. doi: 10.3389/fbioe.2020.00288 PDF
4. Liu Y, Zhu LF, Qi WP, Yu B*. Biocatalytic production of D-p-hydroxyphenylglycine by optimizing protein expression and cell wall engineering in Escherichia coli. Appl. Microbiol. Biotechnol. 2019, 103(21): 8839-8851. PDF
5. Liu FX, Malaphan M, Xing FG, Yu B*. Biodetoxification of fungal mycotoxins zearalenone by engineered probiotic bacterium Lactobacillus reuteri with surface-displayed lactonohydrolase. Appl. Microbiol. Biotechnol. 2019, 103(21): 8813-8824. PDF
6. Zheng Y#, Meng FK#, Zhu ZH, Wei WJ, Sun Z, Chen JC, Yu B*, Lou CB*, Chen GQ*. A tight cold-inducible switch built by coupling thermosensitive transcriptional and proteolytic regulatory parts. Nucleic Acids Res., 2019, 47 (12), e137 (#Equal contributors) PDF
7. Wang Y, Zhang CL, Liu GX, Ju JS, Yu B*, Wang LM*. Elucidating the role and regulation of a lactate permease as lactate transporter in Bacillus coagulans DSM1. Appl. Environ. Microbiol. 2019, 85(14): e00672-19 PDF
8. Wang LM*, Yu B, Wang RX, Xie JC. Biotechnological routes for transglutaminase production: recent achievements, perspectives and limits. Trends Food Sci. Tech. 2018, 81: 116-120. PDF
9. Yang H, Liu FX, Li Y*, Yu B*. Reconstructing biosynthetic pathway of the plant-derived cancer chemopreventive-precursor glucoraphanin in Escherichia coli. ACS Synth. Biol. 2018, 7(1): 121-131. PDF
10. Liu FX, Yang H, Wang LM, Yu B*. Biosynthesis of the high-value plant secondary product benzyl isothiocyanate via functional expression of multiple heterologous enzymes in E. coli. ACS Synth. Biol. 2016, 5(12): 1557-1565. PDF
11. Wang M#, Zhu LF#, Xu XL, Wang LM, Yin RC*, Yu B*. Efficient production of enantiomerically pure D-phenyllactate from phenylpyruvate by structure-guided design of an engineered D-lactate dehydrogenase. Appl. Microbiol. Biotechnol. 2016, 100(17): 7471-7478 (#Equal contributors) PDF
12. Sun LF, Li YF, Wang LM, Wang YP, Yu B*. Diammonium phosphate stimulates transcription of L-lactate dehydrogenase leading to increased L-lactate production in the thermotolerant Bacillus coagulans strain. Appl. Microbiol. Biotechnol. 2016, 100(15): 6653-6660 PDF
13. Hou JF, Liu FX, Wu N, Ju JS, Yu B*. Efficient biodegradation of chlorophenols in aqueous phase by magnetically immobilized aniline-degrading Rhodococcus rhodochrous strain. J. Nanobiotechnol. 2016, 14: 5. doi: 10.1186/s12951-016-0158-0 PDF
14. Zhu LF#, Guan XC#, Xie NZ, Wang LM, Yu B*, Ma YH. Fermentative production of enantiomerically pure S-1,2-propanediol from glucose by engineered E. coli strain. Appl. Microbiol. Biotechnol. 2016, 100(3): 1241-1251. (#Equal contributors) PDF
15. Zhu LF, Xu XL, Wang LM, Dong H*, Yu B*, Ma YH. NADP+-preferring D-lactate dehydrogenase from Sporolactobacillus inulinus. Appl. Environ. Microbiol. 2015, 81(18): 6294-6301. PDF
16. Liu FX, Yu B*. Efficient production of reuterin from glycerol by magnetically immobilized Lactobacillus reuterin. Appl. Microbiol. Biotechnol. 2015, 99(11): 4659-4666. PDF
17. Wang LM#, Cai YM#, Zhu LF, Guo HL, Yu B*. Major role of NAD-dependent lactate dehydrogenases in high optically pure L-lactic acid production by thermophilic Bacillus coagulans. Appl. Environ. Microbiol. 2014, 80(23): 7134-7141. (#Equal contributors) PDF
18. Peng LL, Wang LM, Che CC, Yang G, Yu B*, Ma YH. Bacillus sp. strain P38: an efficient producer of L-lactate from cellulosic hydrolysate, with high tolerance for 2-furfural. Bioresour. Technol. 2013, 149: 169-176. PDF
19. Li Y, Wang LM, Ju JS, Yu B*, Ma YH. Efficient production of polymer-grade D-lactate by Sporolactobacillus laevolacticus DSM442 with agricultural waste cottonseed as the sole nitrogen source. Bioresour. Technol. 2013, 142: 186-191. PDF
20. 于波*,曾艳,姜旭,王丽敏,马延和. 聚合级L-乳酸的非粮生物质发酵研究进展. 生物工程学报, 2013, 29(4): 411-421. (特邀综述)