基本信息
杨开广 男 博导 中国科学院大连化学物理研究所
电子邮件： yangkaiguang@dicp.ac.cn
通信地址： 辽宁省大连市中山路457号 大连化物所1810组
邮政编码： 116023
电子邮件： yangkaiguang@dicp.ac.cn
通信地址： 辽宁省大连市中山路457号 大连化物所1810组
邮政编码： 116023
研究领域
蛋白质组学新技术新方法；功能材料；载体交联；蛋白质复合物原位分析
教育背景
2007-09--2009-02 Lund University 联合培养博士生2003-09--2009-06 四川大学 博士1999-09--2003-06 成都理工大学 学士
专利与奖励
专利：
已授权发明专利103项。
获奖：
中国科学院“青年创新促进会”优秀会员（2022年）
大连化物所“张大煜青年学者”（2022年）
大连化物所冠名奖“青年优秀奖” （2016年）
代表性专利成果：
（ 1 ） 一种聚乙二醇偶联结合超滤离心分离富集糖肽的方法, 发明, 2011, 专利号: 201110104461.X
（ 2 ） 一种亲水性金属离子固定化亲和纳米磁球的制备方法, 发明, 2011, 专利号: 201110103667.0
（ 3 ） 多种蛋白质肽段同时印迹聚合物微球材料及其制备和应用, 发明, 2016, 专利号: 201310240284.7
（ 4 ） 基于RAFT策略蛋白质表面分子印迹材料及制备和应用, 发明, 2016, 专利号: 201310240303.6
（ 5 ） 一种生物样品纯化的装置及其应用, 发明, 2017, 专利号: 201310237476.2
（ 6 ） 一种聚合物纳米微球的制备方法, 发明, 2017, 专利号: 201410040748.4
（ 7 ） 一种核壳结构的聚合物微球及其制备和应用, 发明, 2018, 专利号: 201410749219.1
（ 8 ） 一种有机无机杂化微球颗粒及其制备和应用, 发明, 2018, 专利号: 201410748234.4
（ 9 ） 基于质谱的氧连接氮乙酰葡糖胺修饰糖蛋白质的分析方法, 发明, 2019, 专利号: 201410397766.8
（ 10 ） 赖氨酸氮连接磷酸化翻译后修饰富集和鉴定的方法, 发明, 2019, 专利号: 201610396820.6
出版信息
申请人已在Nature Communications, Advanced Materials, Science Bulletin, Small, Anal. Chem.，ACS Appl. Mater.Interfaces，Nanoscale，Macromolecules，Chem. Commun.，等杂志发表SCI 文章104余篇，他引2700 余次，H 因子34(截至2024年5月24日)。
发表论文
[1] Chen, Yuwan, Zhou, Wen, Xia, Yufei, Zhang, Weijie, Zhao, Qun, Li, Xinwei, Gao, Hang, Liang, Zhen, Ma, Guanghui, Yang, Kaiguang, Zhang, Lihua, Zhang, Yukui. Targeted cross-linker delivery for the in situ mapping of protein conformations and interactions in mitochondria. NATURE COMMUNICATIONS[J]. 2023, 14(1): http://dx.doi.org/10.1038/s41467-023-39485-3.[2] Li, Xinwei, Chen, Yuwan, Jiang, Jing, Zhou, Wen, Gao, Hang, Zhao, Qun, Liang, Zhen, Cao, Xupeng, Yang, Kaiguang, Zhang, Lihua, Zhang, Yukui. Crosslinker Nanocarriers Delivery to Chloroplasts for In Vivo Mapping of Photosynthetic Membrane Protein Complexes in Living Chlamydomonas reinhardtii Cells. ANALYTICAL CHEMISTRY. 2023, http://dx.doi.org/10.1021/acs.analchem.3c01009.[3] Ma, Baofu, Zhang, Kun, Sun, Zhen, Pan, Hui, Yang, Kaiguang, Jiang, Bo, Zhao, Baofeng, Liang, Zhen, Zhang, Yukui, Zhang, Lihua. Pushpin-like nanozyme for plasmon-enhanced tumor targeted therapy. ACTA BIOMATERIALIA[J]. 2023, 158: 673-685, http://dx.doi.org/10.1016/j.actbio.2022.12.069.[4] Zhou, Wen, Sui, Zhigang, Liu, Jianhui, He, Yingyun, Yuan, Huiming, Sun, Yue, Liang, Zhen, Yang, Kaiguang, Zhang, Lihua, Zhang, Yukui. High-Sensitivity Detection toward SARS-CoV-2 S1 Glycoprotein by Parallel Reaction Monitoring Mass Spectrometry. ANALYTICAL CHEMISTRY[J]. 2023, 95(23): 8752-8757, http://dx.doi.org/10.1021/acs.analchem.2c05770.[5] Liu, Lukuan, Liu, Jianhui, Zhou, Wen, Sui, Zhigang, Liu, Jing, Yang, Kaiguang, Zhang, Lihua, Liang, Zhen, Zhang, Yukui. An artificial antibody for exosome capture by dull template imprinting technology. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2022, 10(35): 6655-6663, http://dx.doi.org/10.1039/d2tb00494a.[6] Chu, Hongwei, Zhao, Qun, Liu, Ju, Yang, Kaiguang, Wang, Yanlei, Liu, Jianhui, Zhang, Kun, Zhao, Baofeng, He, Hongyan, Zheng, Yong, Zhong, Shijun, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. Ionic Liquid-Based Extraction System for In-Depth Analysis of Membrane Protein Complexes. ANALYTICAL CHEMISTRY[J]. 2022, 94(2): 758-767, http://dx.doi.org/10.1021/acs.analchem.1c03195.[7] 周雯, 杨开广, 张丽华, 梁振, 张玉奎. 基于成簇的规则间隔短回文重复序列的严重急性呼吸综合征冠状病毒2检测的最新进展. 色谱[J]. 2022, 40(9): 773-781, http://lib.cqvip.com/Qikan/Article/Detail?id=7108017435.[8] Wang, ZiXuan, Chu, HongWei, Yang, KaiGuang, Zhao, BaoFeng, Liang, Zhen, Zhang, LiHua, Zhang, YuKui. Label-Free Quantitative Proteomics Analysis of the Sorafenib Resistance in HepG2 Cells. JOURNAL OF ANALYSIS AND TESTING. 2021, [9] Li, Yilan, Yang, Kaiguang, Yuan, Huiming, Zhang, Weijie, Sui, Zhigang, Wang, Nan, Lin, Hongli, Zhang, Lihua, Zhang, Yukui. Surface Nanosieving Polyether Sulfone Particles with Graphene Oxide Encapsulation for the Negative Isolation toward Extracellular Vesicles. ANALYTICAL CHEMISTRY[J]. 2021, 93(50): 16835-16844, [10] 周雯, 杨开广, 赵宝锋, 张丽华, 张玉奎. 活性氧刺激响应纳米载体. 色谱[J]. 2021, 39(2): 118-124, http://lib.cqvip.com/Qikan/Article/Detail?id=7103766298.[11] Chu, Hongwei, Zhao, Qun, Liu, Ju, Yang, Kaiguang, Wang, Yanlei, Liu, Jianhui, Zhang, Kun, Zhao, Baofeng, He, Hongyan, Zheng, Yong, Zhong, Shijun, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. Ionic Liquid-Based Extraction System for In-Depth Analysis of Membrane Protein Complexes. ANALYTICAL CHEMISTRY[J]. 2021, [12] Hu, Yechen, Jiang, Hao, Zhao, Baofeng, Yang, Kaiguang, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. Quantitative proteomics of epigenetic histone modifications in MCF-7 cells under estradiol stimulation. ANALYTICAL METHODS[J]. 2021, 13(4): 469-476, http://dx.doi.org/10.1039/d0ay02146f.[13] Deng, Nan, Chen, Yuanbo, Liang, Zhen, Bian, Yangyang, Wang, Bing, Sui, Zhigang, Zhang, Xiaodan, Yang, Kaiguang, Zhang, Lihua, Zhang, Yukui. Ampholine immobilized polymer microspheres for increasing coverage of human urinary proteome. TALANTA[J]. 2020, 215: http://dx.doi.org/10.1016/j.talanta.2020.120931.[14] Sun, Mingwei, Liang, Yu, Li, Yang, Yang, Kaiguang, Zhao, Baofeng, Yuan, Huiming, Li, Xiao, Zhang, Xiaodan, Liang, Zhen, Shan, Yichu, Zhang, Lihua, Zhang, Yukui. Comprehensive Analysis of Protein N-Terminome by Guanidination of Terminal Amines. ANALYTICAL CHEMISTRY[J]. 2020, 92(1): 567-572, https://www.webofscience.com/wos/woscc/full-record/WOS:000506719400033.[15] 周雯, 杨开广, 赵宝锋, 张丽华, 张玉奎. 活性氧刺激响应纳米载体. 色谱. 2020, 118-124, https://nxgp.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKMypi3qVj28LEUDxQXHYyS3fbyEOrIfBzJ9ZGvXuXMTJdt94RmuLHeRHLJC-FkxMhZc1qMGXZOlM&uniplatform=NZKPT.[16] Lukuan Liu, Chengyong Dong, Xinwei Li, Senwu Li, Baofu Ma, Baofeng Zhao, Xiao Li, Zhen Liang, Kaiguang Yang, Lihua Zhang, Yukui Zhang. Antibody‐Free Hydrogel with the Synergistic Effect of Cell Imprinting and Boronate Affinity: Toward the Selective Capture and Release of Undamaged Circulating Tumor Cells. Small[J]. 2020, 16(7): https://www.doi.org/10.1002/smll.201904199.[17] Yang, Kaiguang, Li, Senwu, Liu, Lukuan, Chen, Yuwan, Zhou, Wen, Pei, Jiaqi, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. Epitope Imprinting Technology: Progress, Applications, and Perspectives toward Artificial Antibodies. ADVANCED MATERIALS[J]. 2019, 31(50): https://www.webofscience.com/wos/woscc/full-record/WOS:000481819300001.[18] Liu, Lukuan, Yang, Kaiguang, Li, Senwu, Zhang, Lihua, Zhang, Yukui. Poly(ether sulfone) nanoparticles and controllably modified nanoparticles obtained through temperature-dependent cryogelation. JOURNAL OF APPLIED POLYMER SCIENCE[J]. 2019, 136(20): http://www.corc.org.cn/handle/1471x/2372793.[19] Liang, Yantao, Wang, Long, Wang, Zengmeng, Zhao, Jiulong, Yang, Qingwei, Wang, Min, Yang, Kaiguang, Zhang, Lihua, Jiao, Nianzhi, Zhang, Yongyu. Metagenomic Analysis of the Diversity of DNA Viruses in the Surface and Deep Sea of the South China Sea. FRONTIERS IN MICROBIOLOGY[J]. 2019, 10: https://doaj.org/article/9559b54a7d8f44b69ae50aaa07a607f7.[20] Liu, Lukuan, Yang, Kaiguang, Gao, Hang, Li, Xiao, Chen, Yuanbo, Zhang, Lihua, Peng, Xiaojun, Zhang, Yukui. Artificial Antibody with Site-Enhanced Multivalent Aptamers for Specific Capture of Circulating Tumor Cells. ANALYTICAL CHEMISTRY[J]. 2019, 91(4): 2591-2594, http://cas-ir.dicp.ac.cn/handle/321008/165976.[21] 杨开广, 李森武, 刘路宽, 陈玉宛, 周雯, 张丽华, 张玉奎. 抗原决定基印迹材料及其应用. 科学通报[J]. 2019, 1368-1379, https://www.sciengine.com/doi/10.1360/N972018-01033.[22] 刘路宽, 杨开广, 梁振, 张丽华, 张玉奎. 循环肿瘤细胞捕获方法的研究进展. 色谱[J]. 2019, 37(4): 358-366, http://lib.cqvip.com/Qikan/Article/Detail?id=7001511997.[23] Liu, Lukuan, Yang, Kaiguang, Dai, Zhongpeng, Liang, Zhen, Zhang, Lihua, Peng, Xiaojun, Zhang, Yukui. Cell-imprinted polydimethylsiloxane for the selective cell adhesion. CHINESE CHEMICAL LETTERS[J]. 2019, 30(3): 672-675, http://lib.cqvip.com/Qikan/Article/Detail?id=7001849614.[24] Hou, Rui, Li, Yilan, Sui, Zhigang, Yuan, Huiming, Yang, Kaiguang, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. Advances in exosome isolation methods and their applications in proteomic analysis of biological samples. ANALYTICAL AND BIOANALYTICAL CHEMISTRYnull. 2019, 411(21): 5351-5361, [25] Lukuan Liu, Kaiguang Yang, Zhongpeng Dai, Zhen Liang, Lihua Zhang, Xiaojun Peng, Yukui Zhang. Cell-imprinted polydimethylsiloxane for the selective cell adhesion. 中国化学快报:英文版[J]. 2019, 30(3): 672-675, http://lib.cqvip.com/Qikan/Article/Detail?id=7001849614.[26] Wu, Qiong, Jiang, Bo, Weng, Yejing, Liu, Jianxi, Li, Senwu, Hu, Yechen, Yang, Kaiguang, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. 3-Carboxybenzoboroxole Functionalized Polyethylenimine Modified Magnetic Graphene Oxide Nanocomposites for Human Plasma Glycoproteins Enrichment under Physiological Conditions. ANALYTICAL CHEMISTRY[J]. 2018, 90(4): 2671-2677, http://cas-ir.dicp.ac.cn/handle/321008/168820.[27] Han, Shuai, Yang, Kaiguang, Zhu, Hong, Liu, Jianhui, Zhang, Lihua, Zhao, Jiuyang. Proteomics investigation of the changes in serum proteins after high- and low-flux hemodialysis. RENAL FAILURE[J]. 2018, 40(1): 506-513, http://cas-ir.dicp.ac.cn/handle/321008/166966.[28] Li, Senwu, Yang, Kaiguang, Liu, Lukuan, Zhao, Baofeng, Chen, Yuanbo, Li, Xiao, Zhang, Lihua, Zhang, Yukui. Surface sieving coordinated IMAC material for purification of His-tagged proteins. ANALYTICA CHIMICA ACTA[J]. 2018, 997: 9-15, http://dx.doi.org/10.1016/j.aca.2017.10.021.[29] Shao, Wenya, Liu, Jianxi, Liang, Yu, Yang, Kaiguang, Min, Yi, Zhang, Xiaodan, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. "Thiol-ene" grafting of silica particles with three-dimensional branched copolymer for HILIC/cation-exchange chromatographic separation and N-glycopeptide enrichment. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2018, 410(3): 1019-1027, http://cas-ir.dicp.ac.cn/handle/321008/168532.[30] Liu, Lukuan, Yang, Kaiguang, Zhu, Xudong, Liang, Yu, Chen, Yuanbo, Fang, Fei, Zhao, Qun, Zhang, Lihua, Zhang, Yukui. Aptamer-immobilized open tubular capillary column to capture circulating tumor cells for proteome analysis. TALANTA[J]. 2017, 175: 189-193, http://dx.doi.org/10.1016/j.talanta.2017.07.041.[31] Yang, Kaiguang, Liu, Jianhui, Sun, Jingdi, Zhou, Yuan, Zhao, Qun, Li, Senwu, Liu, Lukuan, Zhang, Lihua, Zhao, Jiuyang, Zhang, Yukui. Proteomic study provides new clues for complications of hemodialysis caused by dialysis membrane. SCIENCE BULLETIN[J]. 2017, 62(18): 1251-1255, http://dx.doi.org/10.1016/j.scib.2017.08.026.[32] Han, Shuai, Yang, Kaiguang, Sun, Jingdi, Liu, Jianhui, Zhang, Lihua, Zhao, Jiuyang. Proteomics Investigations into Serum Proteins Adsorbed by High-Flux and Low-Flux Dialysis Membranes. PROTEOMICS CLINICAL APPLICATIONS[J]. 2017, 11(11-12): http://cas-ir.dicp.ac.cn/handle/321008/168442.[33] Chen, Yuanbo, Deng, Nan, Wu, Ci, Liang, Yu, Jiang, Bo, Yang, Kaiguang, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. Aptamer functionalized hydrophilic polymer monolith with gold nanoparticles modification for the sensitive detection of human alpha-thrombin. TALANTA[J]. 2016, 154: 555-559, http://cas-ir.dicp.ac.cn/handle/321008/170974.[34] Li, Senwu, Yang, Kaiguang, Zhao, Baofeng, Li, Xiao, Liu, Lukuan, Chen, Yuanbo, Zhang, Lihua, Zhang, Yukui. Epitope imprinting enhanced IMAC (EI-IMAC) for highly selective purification of His-tagged protein (vol 4, pg 1960, 2016). JOURNAL OF MATERIALS CHEMISTRY B. 2016, 4(15): 2739-2739, http://cas-ir.dicp.ac.cn/handle/321008/170734.[35] Li, Senwu, Yang, Kaiguang, Deng, Nan, Min, Yi, Liu, Lukuan, Zhang, Lihua, Zhang, Yukui. Thermoresponsive Epitope Surface-Imprinted Nanoparticles for Specific Capture and Release of Target Protein from Human Plasma. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(9): 5747-5751, http://cas-ir.dicp.ac.cn/handle/321008/148410.[36] Shao, Wenya, Liu, Jianxi, Yang, Kaiguang, Liang, Yu, Weng, Yejing, Li, Senwu, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. Hydrogen-bond interaction assisted branched copolymer HILIC material for separation and N-glycopeptides enrichment. TALANTA[J]. 2016, 158: 361-367, http://dx.doi.org/10.1016/j.talanta.2016.05.034.[37] Liu, Jianxi, Yang, Kaiguang, Shao, Wenya, Qu, Yanyan, Li, Senwu, Wu, Qi, Zhang, Lihua, Zhang, Yukui. Boronic Acid-Functionalized Particles with Flexible Three-Dimensional Polymer Branch for Highly Specific Recognition of Glycoproteins. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(15): 9552-9556, http://dx.doi.org/10.1021/acsami.6b01829.[38] Wu, Ci, Liang, Yu, Yang, Kaiguang, Min, Yi, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. Clickable Periodic Mesoporous Organosilica Monolith for Highly Efficient Capillary Chromatographic Separation. ANALYTICAL CHEMISTRY[J]. 2016, 88(3): 1521-1525, http://cas-ir.dicp.ac.cn/handle/321008/148420.[39] Liu, Lukuan, Yang, Kaiguang, Zhang, Lihua, Zhang, Yukui. Protein-imprinted material for the treatment of antibiotic-resistant bacteria. SCIENCE BULLETIN[J]. 2016, 61(24): 1890-1891, http://dx.doi.org/10.1007/s11434-016-1207-7.[40] Nan Deng, Bo Jiang, Yuanbo Chen, Zhen Liang, Lihua Zhang, Yu Liang, Kaiguang Yang, Yukui Zhang. Aptamer-conjugated gold functionalized graphene oxide nanocomposites for human α-thrombin specific recognition. JOURNAL OF CHROMATOGRAPHY A. 2016, 1427: 16-21, http://dx.doi.org/10.1016/j.chroma.2015.12.018.[41] Deng, Nan, Jiang, Bo, Chen, Yuanbo, Liang, Zhen, Zhang, Lihua, Liang, Yu, Yang, Kaiguang, Zhang, Yukui. Aptamer-conjugated gold functionalized graphene oxide nanocomposites for human alpha-thrombin specific recognition. JOURNAL OF CHROMATOGRAPHY A[J]. 2016, 1427: 16-21, http://cas-ir.dicp.ac.cn/handle/321008/148426.[42] Fang, Fei, Zhao, Qun, Sui, Zhigang, Liang, Yu, Jiang, Hao, Yang, Kaiguang, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. Glycan Moieties as Bait to Fish Plasma Membrane Proteins. ANALYTICAL CHEMISTRY[J]. 2016, 88(10): 5065-5071, http://dx.doi.org/10.1021/acs.analchem.6b01082.[43] Yang, Kaiguang, Li, Senwu, Liu, Jianxi, Liu, Lukuan, Zhang, Lihua, Zhang, Yukui. Multiepitope Templates Imprinted Particles for the Simultaneous Capture of Various Target Proteins. ANALYTICAL CHEMISTRY[J]. 2016, 88(11): 5621-5625, http://dx.doi.org/10.1021/acs.analchem.6b01247.[44] 李沁然, 杨开广, 梁玉, 江波, 刘健熙, 张丽华, 梁振, 张玉奎. Surface Protein Imprinted Core−Shell Particles for High Selective. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 6: 21954-, http://cas-ir.dicp.ac.cn/handle/321008/148325.[45] Li, Senwu, Yang, Kaiguang, Zhao, Baofeng, Li, Xiao, Liu, Lukuan, Chen, Yuanbo, Zhang, Lihua, Zhang, Yukui. Epitope imprinting enhanced IMAC (EI-IMAC) for highly selective purification of His-tagged protein. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2016, 4(11): 1960-1967, http://cas-ir.dicp.ac.cn/handle/321008/148415.[46] Li, Qinran, Yang, Kaiguang, Li, Senwu, Liu, Lukuan, Zhang, Lihua, Liang, Zhen, Zhang, Yukui. Preparation of surface imprinted core-shell particles via a metal chelating strategy: specific recognition of porcine serum albumin. MICROCHIMICA ACTA[J]. 2016, 183(1): 345-352, http://cas-ir.dicp.ac.cn/handle/321008/148438.[47] 陈远波, 邓楠, 吴慈, 梁玉, 江波, 杨开广, 梁振, 张丽华, 张玉奎. Aptamer Functionalized Hydrophilic Polymer Monolith with Gold Nanoparticles Modification for Zhodification for the Sensitive Detection of Human Alpha-thrombin. TALANTA[J]. 2016, 154: 555-, http://cas-ir.dicp.ac.cn/handle/321008/148423.[48] Liu, Jianxi, Yang, Kaiguang, Shao, Wenya, Li, Senwu, Wu, Qi, Zhang, Shen, Qu, Yanyan, Zhang, Lihua, Zhang, Yukui. Synthesis of Zwitterionic Polymer Particles via Combined Distillation Precipitation Polymerization and Click Chemistry for Highly Efficient Enrichment of Glycopeptide. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(34): 22018-22024, http://cas-ir.dicp.ac.cn/handle/321008/170092.[49] Weng, Yejing, Jiang, Bo, Yang, Kaiguang, Sui, Zhigang, Zhang, Lihua, Zhang, Yukui. Polyethyleneimine-modified graphene oxide nanocomposites for effective protein functionalization. NANOSCALE[J]. 2015, 7(34): 14284-14291, http://cas-ir.dicp.ac.cn/handle/321008/143725.[50] Wu, Shuaibin, Zhang, Hongfei, Yang, Kaiguang, Ma, Junfeng, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. A rapid protein sample preparation method based on organic-aqueous microwave irradiation technique. SCIENCE CHINA. CHEMISTRY[J]. 2015, 58(3): 526-531, http://159.226.238.44/handle/321008/143707.[51] Qu, Yanyan, Liu, Jianxi, Yang, Kaiguang, Wu, Qi, Shan, Yichu, Zhang, Lihua, Liang, Zhen, Zhang, Yukui. Glycoprotein recognition by water-compatible core-shell polymeric submicron particles. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2015, 3(19): 3927-3930, http://159.226.238.44/handle/321008/143714.[52] Min, Yi, Yang, Kaiguang, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. Dandelion-like core-shell silica microspheres with hierarchical pores. RSC ADVANCES[J]. 2015, 5(33): 26269-26272, http://159.226.238.44/handle/321008/143711.[53] Liu, Jianxi, Yang, Kaiguang, Qu, Yanyan, Li, Senwu, Wu, Qi, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. An efficient approach to prepare boronate core-shell polymer nanoparticles for glycoprotein recognition via combined distillation precipitation polymerization and RAFT media precipitation polymerization. CHEMICAL COMMUNICATIONS[J]. 2015, 51(18): 3896-3898, http://159.226.238.44/handle/321008/143717.[54] Li, Senwu, Yang, Kaiguang, Liu, Jianxi, Jiang, Bo, Zhang, Lihua, Zhang, Yukui. Surface-Imprinted Nanoparticles Prepared with a His-Tag-Anchored Epitope as the Template. ANALYTICAL CHEMISTRY[J]. 2015, 87(9): 4617-4620, http://159.226.238.44/handle/321008/143715.[55] Jiang, Bo, Yang, Kaiguang, Zhang, Lihua, Liang, Zhen, Peng, Xiaojun, Zhang, Yukui. Dendrimer-grafted graphene oxide nanosheets as novel support for trypsin immobilization to achieve fast on-plate digestion of proteins. TALANTA[J]. 2014, 122: 278-284, http://dx.doi.org/10.1016/j.talanta.2014.01.056.[56] Yang, Kaiguang, Liu, Jianxi, Li, Senwu, Li, Qinran, Wu, Qi, Zhou, Yuan, Zhao, Qun, Deng, Nan, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. Epitope imprinted polyethersulfone beads by self-assembly for target protein capture from the plasma proteome. CHEMICAL COMMUNICATIONS[J]. 2014, 50(67): 9521-9524, http://cas-ir.dicp.ac.cn/handle/321008/144465.[57] 李森武, 杨开广, 张丽华, 张玉奎. His-tag as an anchor for epitope-oriented surface imprinting. the 8th international conference on molecular imprintingnull. 2014, http://cas-ir.dicp.ac.cn/handle/321008/143644.[58] Li, Qinran, Yang, Kaiguang, Liang, Yu, Jiang, Bo, Liu, Jianxi, Zhang, Lihua, Liang, Zhen, Zhang, Yukui. Surface Protein Imprinted Core-Shell Particles for High Selective Lysozyme Recognition Prepared by Reversible Addition-Fragmentation Chain Transfer Strategy. ACS APPLIED MATERIALS & INTERFACES[J]. 2014, 6(24): 21954-21960, http://cas-ir.dicp.ac.cn/handle/321008/145522.[59] 刘健熙, 杨开广, 张丽华, 张玉奎. HYDROPHILIC BORONIC ACID FUNCTIONAL CORE-SHELL PARTICLES FOR PH-RESPONSIVE RECOGNITION OF GLYCOPROTEINS BASED ON ‘THIOL-ENE’ CHEMISTRY. 30th International Symposium on Microscale Bioseparationsnull. 2014, http://cas-ir.dicp.ac.cn/handle/321008/143650.[60] 江波, 杨开广, 张丽华, 梁振, 张玉奎. CONTROL SYNTHESIS OF GO/FE3O4/AU/PEG COMPOSITES FOR THE HIGHLY SELECTIVE ENRICHMENT OF N-LINKED GLYCOPEPTIDES FROM BIOLOGICAL SAMPLES. 30th international symposium on microscale bioseparationsnull. 2014, http://cas-ir.dicp.ac.cn/handle/321008/143651.[61] 杨开广, 刘健熙, 李森武, 李沁然, 吴琪, 张丽华, 张玉奎. Protein imprinted materials for the target protein capture in human plasma proteome. the 8th international conference on molecular imprintingnull. 2014, http://cas-ir.dicp.ac.cn/handle/321008/143645.[62] 杨开广, 李森武, 张丽华, 张玉奎. Protein imprinted materials in the proteomics study. the 8th international conference on molecular imprintingnull. 2014, http://cas-ir.dicp.ac.cn/handle/321008/143646.[63] Liu, Jinxiang, Deng, Qiliang, Tao, Dingyin, Yang, Kaiguang, Zhang, Lihua, Liang, Zhen, Zhang, Yukui. Preparation of protein imprinted materials by hierarchical imprinting techniques and application in selective depletion of albumin from human serum. SCIENTIFIC REPORTS[J]. 2014, 4(1): http://cas-ir.dicp.ac.cn/handle/321008/144458.[64] Liu, Jianxi, Qu, Yanyan, Yang, Kaiguang, Wu, Qi, Shan, Yichu, Zhang, Lihua, Liang, Zhen, Zhang, Yukui. Monodisperse Boronate Polymeric Particles Synthesized by a Precipitation Polymerization Strategy: Particle Formation and Glycoprotein Response from the Standpoint of the Flory-Huggins Model. ACS APPLIED MATERIALS & INTERFACES[J]. 2014, 6(3): 2059-2066, http://cas-ir.dicp.ac.cn/handle/321008/144460.[65] 李沁然, 杨开广, 李森武, 刘键熙, 张丽华, 梁振, 张玉奎. 可逆加成-断裂链转移策略制备可识别转铁蛋白的抗原决定基印迹微球. 色谱[J]. 2014, 32(10): 1029-1033, http://lib.cqvip.com/Qikan/Article/Detail?id=662825445.[66] Zhao, Qun, Fang, Fei, Liang, Yu, Yuan, Huiming, Yang, Kaiguang, Wu, Qi, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. 1-Dodecyl-3-Methylimidazolium Chloride-Assisted Sample Preparation Method for Efficient Integral Membrane Proteome Analysis. ANALYTICAL CHEMISTRY[J]. 2014, 86(15): 7544-7550, http://cas-ir.dicp.ac.cn/handle/321008/144459.[67] 杨开广, 李沁然, 刘晋湘, 李森武, 张丽华, 刘健熙. PROTEIN IMPRINTED MATERIALS FOR THE TARGET PROTEIN CAPTURE IN THE PROTEOMIC SAMPLE. 30th international symposium on microscale bioseparationsnull. 2014, http://cas-ir.dicp.ac.cn/handle/321008/143652.[68] Deng, Nan, Zhu, Guijie, Chen, Yuanbo, Wu, Qi, Liang, Zhen, Sui, Zhigang, Zhang, Lihua, Yang, Kaiguang, Zhang, Yukui. Decrease of dynamic range of proteins in human plasma by ampholine immobilized polymer microspheres. ANALYTICA CHIMICA ACTA[J]. 2014, 826: 43-50, http://dx.doi.org/10.1016/j.aca.2014.04.004.[69] Jiang, Bo, Liang, Yu, Wu, Qi, Jiang, Hao, Yang, Kaiguang, Zhang, Lihua, Liang, Zhen, Peng, Xiaojun, Zhang, Yukui. New GO-PEI-Au-L-Cys ZIC-HILIC composites: synthesis and selective enrichment of glycopeptides. NANOSCALE[J]. 2014, 6(11): 5616-5619, http://cas-ir.dicp.ac.cn/handle/321008/144466.[70] Deng, Nan, Liang, Zhen, Liang, Yu, Sui, Zhigang, Zhang, Liyuan, Wu, Qi, Yang, Kaiguang, Zhang, Lihua, Zhang, Yukui. Aptamer Modified Organic Inorganic Hybrid Silica Monolithic Capillary Columns for Highly Selective Recognition of Thrombin (vol 84, pg 10186, 2012). ANALYTICAL CHEMISTRYnull. 2013, 85(7): 3794-3794, https://www.webofscience.com/wos/woscc/full-record/WOS:000317173200049.[71] 江波, 杨开广, 梁振, 张丽华, 张玉奎. Boronic acid functionalized graphene oxide composites for specific recognition of N-linked glycopeptides. 22nd international symposium on glycoconjugatesnull. 2013, 366-, http://159.226.238.44/handle/321008/120130.[72] Li, Qinran, Yang, Kaiguang, Liu, Jinxiang, Zhang, Lihua, Liang, Zhen, Zhang, Yukui. Transferrin recognition based on a protein imprinted material prepared by hierarchical imprinting technique. MICROCHIMICA ACTA[J]. 2013, 180(15-16): 1379-1386, http://www.irgrid.ac.cn/handle/1471x/858176.[73] 乔晓强, 周愿, 侯春彦, 张晓丹, 杨开广, 张丽华, 张玉奎. 溴化1-丁基，3-（3-氨丙基）咪唑用于羧基衍生：潜在应用于肽段的高灵敏度质谱鉴定. 中国科学: 生命科学[J]. 2013, 43(1): 96-, http://159.226.238.44/handle/321008/119611.[74] 刘健熙, 杨开广, 曲焱焱, 张丽华, 梁振, 张玉奎. An efficient approach to prepare boronic acid functional core-shell polymer nanoparticles for enrichment of glycoproteins viaRAFTmedia precipitation polymerization. 22nd international symposium on glycoconjugatesnull. 2013, 365-, http://159.226.238.44/handle/321008/120132.[75] Qiao XiaoQiang, Zhou Yuan, Hou ChunYan, Zhang XiaoDan, Yang KaiGuang, Zhang LiHua, Zhang YuKui. 1-(3-Aminopropyl)-3-butylimidazolium bromide for carboxyl group derivatization: potential applications in high sensitivity peptide identification by mass spectrometry. SCIENCE CHINA-LIFE SCIENCES[J]. 2013, 56(3): 240-245, http://159.226.238.44/handle/321008/137821.[76] 曲焱焱, 翁叶靖, 杨开广, 张丽华, 张丽华, 张玉奎. Tandem dimethyl and solid-phase 18O stable isotope labeling for N-glycoproteome quantitation. 22nd international symposium on glycoconjugatesnull. 2013, 367-, http://159.226.238.44/handle/321008/120127.[77] 杨开广, 刘建熙, 李沁然, 张丽华, 张玉奎. Protein imprinted materials for Proteomic Study. 7TH INTERNATIONAL CONFERENCE ON MOLECULARLY IMPRINTED POLYMERS SCIENCE AND TECHNOLOGYnull. 2012, 62-, http://159.226.238.44/handle/321008/117085.[78] Qu Yanyan, Liu Jianxi, Yang Kaiguang, Yuan Huiming, Zhang Lihua, Liang Zhen, Zhang Yukui. Boronic Acid Functionalized Core-shell Polymer Nanoparticles for Selective Enrichment of Glycopeptides. ASIA OCEANIA HUMAN PROTEOME ORGANIZATION 6TH CONGRESSnull. 2012, 282-, http://159.226.238.44/handle/321008/117093.[79] Yang, Kaiguang, Zhang, Lihua, Liang, Zhen, Zhang, Yukui. Protein-imprinted materials: rational design, application and challenges. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2012, 403(8): 2173-2183, http://www.irgrid.ac.cn/handle/1471x/721602.[80] Wu, Shuaibin, Zhang, Lei, Yang, Kaiguang, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. Preparing a metal-ion chelated immobilized enzyme reactor based on the polyacrylamide monolith grafted with polyethylenimine for a facile regeneration and high throughput tryptic digestion in proteomics. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2012, 402(2): 703-710, http://www.irgrid.ac.cn/handle/1471x/721704.[81] 曲焱焱, 刘建熙, 杨开广, 张丽华, 梁振, 张玉奎. Boronic Acid Functionalized Core-Shell Polymer Nanoparticles Prepared by Distillation Precipitation Polymerization for Selective Enrichment of Glycopeptides. 38TH INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2012, 256-, http://159.226.238.44/handle/321008/117087.[82] 张丽媛, 张丽华, 梁振, 杨开广, 张玉奎. Novel Functionalized Materials for Phosphopeptides Enrichment with Improved Selectivity and Binding Capacity. 38TH INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2012, 274-, http://159.226.238.44/handle/321008/117086.[83] Zhang, Liyuan, Liang, Zhen, Yang, Kaiguang, Xia, Simin, Wu, Qi, Zhang, Lihua, Zhang, Yukui. Mesoporous TiO2 aerogel for selective enrichment of phosphopeptides in rat liver mitochondria. ANALYTICA CHIMICA ACTA[J]. 2012, 729: 26-35, http://dx.doi.org/10.1016/j.aca.2012.04.005.[84] Zhang, Liyuan, Zhao, Qun, Liang, Zhen, Yang, Kaiguang, Sun, Liangliang, Zhang, Lihua, Zhang, Yukui. Synthesis of adenosine functionalized metal immobilized magnetic nanoparticles for highly selective and sensitive enrichment of phosphopeptides. CHEMICAL COMMUNICATIONS[J]. 2012, 48(50): 6274-6276, http://www.irgrid.ac.cn/handle/1471x/721355.[85] Deng, Nan, Liang, Zhen, Liang, Yu, Sui, Zhigang, Zhang, Liyuan, Wu, Qi, Yang, Kaiguang, Zhang, Lihua, Zhang, Yukui. Aptamer Modified Organic-Inorganic Hybrid Silica Monolithic Capillary Columns for Highly Selective Recognition of Thrombin. ANALYTICAL CHEMISTRY[J]. 2012, 84(23): 10186-10190, http://159.226.238.44/handle/321008/142981.[86] Jiang, Bo, Yang, Kaiguang, Zhao, Qun, Wu, Qi, Liang, Zhen, Zhang, Lihua, Peng, Xiaojun, Zhang, Yukui. Hydrophilic immobilized trypsin reactor with magnetic graphene oxide as support for high efficient proteome digestion. JOURNAL OF CHROMATOGRAPHY A[J]. 2012, 1254: 8-13, http://dx.doi.org/10.1016/j.chroma.2012.07.030.[87] 杨开广, 张丽华, 张玉奎. 蛋白质分离和鉴定的新技术新方法研究进展. 郑州轻工业学院学报：自然科学版[J]. 2012, 27(5): 1-7, http://lib.cqvip.com/Qikan/Article/Detail?id=44273370.[88] Qu, Yanyan, Liu, Jianxi, Yang, Kaiguang, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. Boronic Acid Functionalized Core-Shell Polymer Nanoparticles Prepared by Distillation Precipitation Polymerization for Glycopeptide Enrichment. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2012, 18(29): 9056-9062, http://www.irgrid.ac.cn/handle/1471x/721422.[89] Liu, Jinxiang, Yang, Kaiguang, Deng, Qiliang, Li, Qinran, Zhang, Lihua, Liang, Zhen, Zhang, Yukui. Preparation of a new type of affinity materials combining metal coordination with molecular imprinting. CHEMICAL COMMUNICATIONS[J]. 2011, 47(13): 3969-3971, http://www.irgrid.ac.cn/handle/1471x/456668.[90] Zhang, Liyuan, Wang, Hui, Liang, Zhen, Yang, Kaiguang, Zhang, Lihua, Zhang, Yukui. Facile preparation of monolithic immobilized metal affinity chromatography capillary columns for selective enrichment of phosphopeptides. JOURNAL OF SEPARATION SCIENCE[J]. 2011, 34(16-17): 2122-2130, http://www.irgrid.ac.cn/handle/1471x/456667.[91] 江波, 杨开广, 张丽华, 梁振, 彭小军, 张玉奎. Covalent Bonding Fe3o4 Nanoparticles on Graphene Oxide and Used as Substrate for Microwave-assisted Digestion of Protein. 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2011, 479-, http://159.226.238.44/handle/321008/117400.[92] WU ShuaiBin, MA JunFeng, YANG KaiGuang, LIU JinXiang, LIANG Zhen, ZHANG LiHua, ZHANG YuKui. A novel organic-inorganic hybrid monolith for trypsin immobilization. 中国科学：生命科学英文版[J]. 2011, 54(1): 54-59, http://lib.cqvip.com/Qikan/Article/Detail?id=36441417.[93] 吴帅斌, 张磊, 杨开广, 梁振, 张丽华, 张玉奎. Rapid regeneration of metal ion chelated immobilized enzyme reactor for high throughput digestion. 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2011, 477-, http://159.226.238.44/handle/321008/117402.[94] Sun, Liangliang, Zhao, Qun, Zhu, Guijie, Zhou, Yuan, Wang, Tingting, Shan, Yichu, Yang, Kaiguang, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. Octyl-functionalized hybrid magnetic mesoporous microspheres for enrichment of low-concentration peptides prior to direct analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY[J]. 2011, 25(9): 1257-1265, http://www.irgrid.ac.cn/handle/1471x/456671.[95] 刘键熙, 曲焱焱, 杨开广, 吴琪, 张丽华, 张玉奎. Boronic Acid Functionalized Core-shell Polymer Nanoparticles for Selective Enrichment of Glycopeptides. 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2011, 402-0, http://159.226.238.44/handle/321008/116003.[96] Qiao, Xiaoqiang, Sun, Liangliang, Chen, Lingfan, Zhou, Yuan, Yang, Kaiguang, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. Piperazines for peptide carboxyl group derivatization: effect of derivatization reagents and properties of peptides on signal enhancement in matrix-assisted laser desorption/ionization mass spectrometry. RAPID COMMUNICATIONS IN MASS SPECTROMETRY[J]. 2011, 25(5): 639-646, http://www.irgrid.ac.cn/handle/1471x/456676.[97] 李沁然, 杨开广, 刘晋湘, 张丽华, 梁振, 张玉奎. Preparation and Application of Surface Imprintiong Particles with Metal Chelating for Recognition of Albumin. 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2011, 398-, http://159.226.238.44/handle/321008/117408.[98] 杨开广, 刘键熙, 曲焱焱, 张丽华, 张玉奎. Preparation of epitope imprinted polyethersulfone particles through self-assembly for protein recognition. THE 11TH ASIAN CONFERENCE ON ANALYTICAL SCIENCESnull. 2011, 67-, http://159.226.238.44/handle/321008/117382.[99] Wu, Shuaibin, Sun, Liangliang, Ma, Junfeng, Yang, Kaiguang, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. High throughput tryptic digestion via poly (acrylamide-co-methylenebisacrylamide) monolith based immobilized enzyme reactor. TALANTA[J]. 2011, 83(5): 1748-1753, http://dx.doi.org/10.1016/j.talanta.2010.12.011.[100] 杨开广, 刘键熙, 曲焱焱, 张丽华, 梁振, 张玉奎. Fabrication of Epitope Imprinted Polyethersulfone Particles through Self-assembly for Protein Recogintion. 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2011, 476-, http://159.226.238.44/handle/321008/117403.[101] Zhang, Liyuan, Xu, Jin, Sun, Liangliang, Ma, Junfeng, Yang, Kaiguang, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. Zirconium oxide aerogel for effective enrichment of phosphopeptides with high binding capacity. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2011, 399(10): 3399-3405, http://www.irgrid.ac.cn/handle/1471x/456675.[102] 邓楠, 张丽华, 杨开广, 张丽华, 张玉奎. Organci-Inorganic Hybrid Silica Monolith Based Covalently Bonded Aptamer Affinity Chromatography Column for Thrombin Detection. 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2011, 405-, http://159.226.238.44/handle/321008/117284.[103] Wu ShuaiBin, Ma JunFeng, Yang KaiGuang, Liu JinXiang, Liang Zhen, Zhang LiHua, Zhang YuKui. A novel organic-inorganic hybrid monolith for trypsin immobilization. SCIENCE CHINA-LIFE SCIENCES[J]. 2011, 54(1): 54-59, http://www.irgrid.ac.cn/handle/1471x/456681.[104] Wu, Shuaibin, Yang, Kaiguang, Liang, Zhen, Zhang, Lihua, Zhang, Yukui. Urea free and more efficient sample preparation method for mass spectrometry based protein identification via combining the formic acid-assisted chemical cleavage and trypsin digestion. TALANTA[J]. 2011, 86(待补充): 429-435, http://dx.doi.org/10.1016/j.talanta.2011.08.052.[105] Liu, Jinxiang, Deng, Qiliang, Yang, Kaiguang, Zhang, Lihua, Liang, Zhen, Zhang, Yukui. Macroporous molecularly imprinted monolithic polymer columns for protein recognition by liquid chromatography. JOURNAL OF SEPARATION SCIENCE[J]. 2010, 33(17-18): 2757-2761, http://159.226.238.44/handle/321008/103559.[106] 杨开广, 刘晋湘, 李沁然, 梁振, 张丽华, 张玉奎. Selective Depletion of High Abundance Proteins from Human Plasma by Imprinting Techniques. mip2010: the 6th international conference on molecular imprintingnull. 2010, 附2/2-, http://159.226.238.44/handle/321008/114126.[107] 吴帅宾, 马俊锋, 杨开广, 刘晋湘, 梁振, 张丽华, 张玉奎. 基于环氧功能基团的杂化硅胶固定化酶反应器. 中国科学：生命科学[J]. 2010, 874-879, http://lib.cqvip.com/Qikan/Article/Detail?id=35553912.[108] Cao, Fuming, Liao, Jia, Yang, Kaiguang, Bai, Pengli, Wei, Qiang, Zhao, Changsheng. Self-Assembly Molecularly Imprinted Nanofiber for 4-HA Recognition. ANALYTICAL LETTERS[J]. 2010, 43(17): 2790-2797, http://www.corc.org.cn/handle/1471x/1911291.[109] Yang, Kaiguang, Berg, Martin Mingarini, Zhao, Changsheng, Ye, Lei. 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JOURNAL OF APPLIED POLYMER SCIENCE[J]. 2008, 108(6): 3859-3866, https://www.webofscience.com/wos/woscc/full-record/WOS:000255339200055.[113] Zhao, Changsheng, Yu, Binyu, Qian, Bosi, Wei, Qiang, Yang, Kaiguang, Zhang, Aimin. BPA transfer rate increase using molecular imprinted polyethersulfone hollow fiber membrane. JOURNAL OF MEMBRANE SCIENCE[J]. 2008, 310(1-2): 38-43, http://dx.doi.org/10.1016/j.memsci.2007.10.042.[114] Yang, Kaiguang, Li, Bingquan, Zhou, Hui, Ma, Jiaojiao, Bai, Pengli, Zhao, Changsheng. Preparation and selective binding characterization of bisphenol a imprinted polyethersulfone particles. JOURNAL OF APPLIED POLYMER SCIENCE[J]. 2007, 106(4): 2791-2799, http://www.corc.org.cn/handle/1471x/1994178.[115] Mao, M, Liu, ZB, Wang, T, Yu, BY, Wen, X, Yang, KG, Zhao, CS. Polysulfone-activated carbon hybrid particles for the removal of BPA. SEPARATION SCIENCE AND TECHNOLOGY[J]. 2006, 41(3): 515-529, http://www.corc.org.cn/handle/1471x/1994041.[116] 赵长生, 毛矛, 刘宗彬, 杨开广. 包埋活性炭的聚砜微球去除双酚A的研究. 水处理技术[J]. 2006, 32(5): 52-54, http://lib.cqvip.com/Qikan/Article/Detail?id=21808753.[117] Long, Li, Liu, Zongbin, Wang, Ting, Deng, Xiaopei, Yang, Kaiguang, Li, Longjiang, Zhao, Changsheng. Polyethersulfone dead-end tube as a scaffold for artificial lacrimal glands in vitro. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS[J]. 2006, 78B(2): 409-416, https://www.webofscience.com/wos/woscc/full-record/WOS:000239300000027.[118] 赵长生, 刘宗彬, 杨开广, 张小华, 常津. 功能高分子微球选择性清除环境毒素. 高分子通报[J]. 2006, 65-69, http://lib.cqvip.com/Qikan/Article/Detail?id=21658239.[119] Zhao, CS, Sun, SD, Yang, KG, Nomizu, M, Nishi, N. DNA-loaded porous polyethersulfone particles for environmental applications I. Preparation. 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发表著作
（1） 蛋白质组学研究-概念、技术及应用, Proteome Research--Concepts, Technology and Application, 科学出版社, 2010-05, 第 5 作者
科研活动
科研项目
（ 1 ） 用于血浆高丰度蛋白质选择性去除的多抗原决定基表面印迹磁球的研究, 主持, 国家级, 2011-01--2013-12（ 2 ） 基于相反转自组装技术的蛋白质 C-末端肽印迹材料制备及机理研究, 主持, 国家级, 2014-01--2017-12（ 3 ） 针对细胞识别的人工抗体材料制备及其在循环肿瘤细胞捕获中的应用, 主持, 国家级, 2016-01--2019-12（ 4 ） 蛋白质组富集分离与修饰鉴定的关键技术研究与开发, 参与, 国家级, 2012-01--2015-12（ 5 ） 质谱鉴定新方法研究, 参与, 国家级, 2016-07--2019-12（ 6 ） 中国科学院青年创新促进会第七批会员资助, 主持, 部委级, 2017-01--2020-12（ 7 ） 基于交联剂跨膜靶向转运载体的细胞内蛋白质复合物原位靶向分析方法, 主持, 国家级, 2019-01--2022-12