Hi, I am Yajing Hao, PI in Beijing Institute of Genomics, Chinese Academy of Science/ China National Center for Bioinformatics. My research focuses on RNA regulation and Genomics. I have extensive experience in using both experimental and computational methods to uncover the detailed mechanism principle of RNA regulation in pathological and physiological processes at both co-transcriptional and post-transcriptional levels. 

Ph.D training:

During my Ph.D. study, non-coding RNAs (ncRNAs) had just begun to attract broad attention in the field of RNA biology, and several star ncRNAs have been shown to play important roles in some key physiological and/or pathological processes. I was fascinated by this new edge of biology and thus decided to devote myself to ncRNA research. In the first two years of my Ph.D. training, I concentrated on constructing and updating a series of ncRNA databases, which have been well-received to date by the research community (NONCODE 2016, NPInter 2016, LncVar 2017 & SmProt 2018). Systematically sorting and organizing ncRNA-related data, I naturally moved to their functional studies in collaboration with my co-workers in the lab. Together, we discovered and validated several key ncRNAs in different tumor metastasis (Gene, 2017, Clinical Cancer Res 2017, J Hematol Oncol, 2019, J Hepatol, 2019). Through these efforts, I was awarded 6 significant research articles in which I was either the first or co-first author, and together 5 other co-authored research papers. My findings earned me a prestigious national scholarship, a “The Di’ao First Prize Scholarship”, and an “Outstanding Graduate Award of Beijing City” in 2018.


PostDoc training:

With a strong desire to pursue a career in academia, I joined the laboratory of Dr. Xiang-Dong Fu at UCSD as a postdoctoral fellow. Even before physically joining UCSD, I already began to tackle their data generated by GRID-seq, a technology designed to deduce the DNA-RNA interactome in higher eukaryotic cells. This allowed me to quickly dive into the project after coming to UCSD and publishing my first-author paper on the contribution of repeats-derived ncRNA to the formation of constitutive heterochromatin in Drosophila (Genome Research 2020). In this study, we demonstrated for the first time that a set of active retrotransposons is critical for cell division by helping maintain heterochromatic centromeres. I have also extended this concept to mammalian cells and elucidation a novel lncRNA CCTT in kinetochore assemble and maintain genome stability at the centromere (Molecular Cell 2022). Meanwhile, I have also been driving the development of multiple RNA binding proteins-related projects, including the elucidation of the contribution of regulated RNA editing to brain tumor development and adaptive immunology, the contribution of RBPs to heart failure and spermiogenesis, earning me co-first (JCI 2022, Nature Immunology, under review) and co-author (PNAS 2019, Cell 2020) publications in these studies.

Another main research project of mine is to attack a fundamental problem in the RNA field. That is, how many genes in mammalian genomes are directly involved in the regulation of alternative splicing? This question has been plaguing the field for many years. I have developed a new high-throughput high- multiplexed screening technology called HTS2, which enables profiling many endogenous alternative splicing events in response to the knockdown of each protein-coding gene in the genome. As the dimensions of data increase, all previous statistic models fail because of the accumulation of noise. I then developed a new statistic called Zeta to process such two-dimensional high throughput data, leading to the identification of a large set of splicing factors that have escaped detection from previous efforts. I have further packaged Zeta into a plug-and-play ZetaSuite software and applied it to the analysis of cancer dependency and single-cell transcriptome analysis. These findings have been packaged into two manuscripts for publication (Cell 2023, under revision & Genome Biology 2022).


That’s all. If you want to know more about our lab, please don’t hesitate to contact me through Email: haoyajing@big.ac.cn.




 


Research Areas

In my lab, the short-term goal is to apply the approach to APA regulation, an underdetermined but major post-transcriptional regulation that has been linked to variable physiological and pathological biological. Specifically, I aim to 1) Systematically qualify and quantify alternative polyadenylation (APA) regulators in the human genome, 2) Dissect pathways for APA regulation, and 3) Pursue APA as an intrinsic antiviral immunity mechanism.  The long-term goal is to further use this new technology platform coupled with other large-scale datasets to dissect human disease mechanisms at the RNA regulatory levels. This research will provide novel insights into different biological processes from RNA regulatory aspects and will have significant implications for the development of innovative therapies.


Education

September 2013 ~ June 2018 PhD. In Bioinformatics. Supervisor: Runsheng Chen

Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, P.R. China

Thesis Topic: Functional Studies of Non-coding RNAs in the organization of constitutive heterochromatin


September, 2008 ~ June, 2013 B.E. In Biotechnology

College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, P.R. China
Thesis Topic: Characterized of gene fusion events in glioblastoma. 


Experience

   
Work Experience

August 2023 ~ Current  PI

CAS Key laboratory of Genome Sciences & Information

Beijing Institute of Genomics Chinese Academy of Sciences/China National Center for Bioinformatics

Research Interests:RNA Biology, Genomics, Cancer, Heterochromatin, Immunology 


September 2018 ~ July 2023 PostDoc. In RNA biology.  Supervisor: Xiang-Dong Fu

Dept. of Cellular and Molecular Medicine, University of California, San Diego

​


Publications

   
Papers
    • [1] Hao, Yajing, Cai, Ting, Liu, Chang, Zhang, Xuan, Fu, XiangDong. Sequential Polyadenylation to Enable Alternative mRNA3' End Formation. MOLECULES AND CELLS null. 2023, 46(1): 57-64, http://dx.doi.org/10.14348/molcells.2023.2176. (First author)
      [2] Kanbar, Jad N, Ma, Shengyun, Kim, Eleanor S, Kurd, Nadia S, Tsai, Matthew S, Tysl, Tiffani, Widjaja, Christella E, Limary, Abigail E, Yee, Brian, He, Zhaoren, Hao, Yajing, Fu, XiangDong, Yeo, Gene W, Huang, Wendy J, Chang, John T. The long noncoding RNA Malat1 regulates CD8(+) T cell differentiation by mediating epigenetic repression. JOURNAL OF EXPERIMENTAL MEDICINE[J]. 2022, 219(6): http://dx.doi.org/10.1084/jem.20211756.
      [3] Li Jiang, Yajing Hao, Changwei Shao, Qiulian Wu, Briana C Prager, Ryan C Gimple, Gabriele Sulli, Leo JY Kim, Guoxin Zhang, Zhixin Qiu, Zhe Zhu, XiangDong Fu, Jeremy N Rich. ADAR1-mediated RNA editing links ganglioside catabolism to glioblastoma stem cell maintenance. THE JOURNAL OF CLINICAL INVESTIGATION[J]. 2022, 132(6): https://doaj.org/article/9e343997925d42dba86e8ff866779674.(      Co-First author)
      [4] Hao, Yajing, Zhang, Shuyang, Shao, Changwei, Li, Junhui, Zhao, Guofeng, Zhang, DongEr, Fu, XiangDong. ZetaSuite: computational analysis of two-dimensional high-throughput data from multi-target screens and single-cell transcriptomics. GENOME BIOLOGY[J].  2022, 23(1):  http://dx.doi.org/10.1186/s13059-022-02729-4.(First author)
      [5] Chong Zhang, Dongpeng Wang, Yajing Hao, Shuheng Wu, Jianjun Luo, Yuanchao Xue, Di Wang, Guohong Li, Lihui Liu, Changwei Shao, Huiyan Li, Jinfeng Yuan, Maoxiang Zhu, XiangDong Fu, Xiao Yang, Runsheng Chen, Yan Teng. LncRNA CCTT-mediated RNA-DNA and RNA-protein interactions facilitate the recruitment of CENP-C to centromeric DNA during kinetochore assembly. MOLECULAR CELL[J]. 2022, 82(21): 4018-4032.e9, http://dx.doi.org/10.1016/j.molcel.2022.09.022.(Co-First author)
      [6] Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2023. NUCLEIC ACIDS RESEARCH. 2022, 51(D1): D18-D28, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825504/.
      [7] YiJou Huang, JiaYu Chen, Ming Yan, Amanda G Davis, Sayuri Miyauchi, Liang Chen, Yajing Hao, Sigrid Katz, Rafael Bejar, Omar AbdelWahab, XiangDong Fu, DongEr Zhang. RUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS. BLOOD ADVANCES. 2022, 6(23): 6078-6092, http://dx.doi.org/10.1182/bloodadvances.2022007804.
      [8] Li, Yanyan, Zhou, Honghong, Chen, Xiaomin, Zheng, Yu, Kang, Quan, Hao, Di, Zhang, Lili, Song, Tingrui, Luo, Huaxia, Hao, Yajing, Chen, Runsheng, Zhang, Peng, He, Shunmin. SmProt: A Reliable Repository with Comprehensive Annotation of Small Proteins Identified from Ribosome Profiling. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2021, 19(4): 602-610, http://dx.doi.org/10.1016/j.gpb.2021.09.002.
      [9] Du, Zhonghua, Wen, Xue, Wang, Yichen, Jia, Lin, Zhang, Shilin, Liu, Yudi, Zhou, Lei, Li, Hui, Yang, Wang, Wang, Cong, Chen, Jingcheng, Hao, Yajing, Chen, Huiling, Li, Dan, Chen, Naifei, Celik, Ilkay, Zhu, Yanbo, Yan, Zi, Fu, Changhao, Liu, Shanshan, Jiao, Benzheng, Wang, Zhuo, Zhang, Hui, Gulsoy, Gunhan, Luo, Jianjun, Qin, Baoming, Gao, Sujun, Kapranov, Philipp, Esteban, Miguel A, Zhang, Songling, Li, Wei, Ay, Ferhat, Chen, Runsheng, Hoffman, Andrew R, Cui, Jiuwei, Hu, JiFan. Chromatin lncRNA Platr10 controls stem cell pluripotency by coordinating an intrachromosomal regulatory network. GENOME BIOLOGY[J]. 2021, 22(1): http://dx.doi.org/10.1186/s13059-021-02444-6.
      [10] Xue, HuaiJun, Niu, YiWei, Segraves, Kari A, Nie, RuiE, Hao, YaJing, Zhang, LiLi, Cheng, XinChao, Zhang, XueWen, Li, WenZhu, Chen, RunSheng, Yang, XingKe. The draft genome of the specialist flea beetle Altica viridicyanea (Coleoptera: Chrysomelidae). BMC GENOMICS[J]. 2021, 22(1): https://doaj.org/article/f0f02f9876224996a5adf161ca213375.
      [11] Zhang, Qing, Wu, Erzhong, Tang, Yiheng, Cai, Tanxi, Zhang, Lili, Wang, Jifeng, Hao, Yajing, Zhang, Bao, Zhou, Yue, Guo, Xiaojing, Luo, Jianjun, Chen, Runsheng, Yang, Fuquan. Deeply Mining a Universe of Peptides Encoded by Long Noncoding RNAs. MOLECULAR & CELLULAR PROTEOMICS[J]. 2021, 20: http://dx.doi.org/10.1016/j.mcpro.2021.100109.
      [12] Xue, Yongbiao, Bao, Yiming, Zhang, Zhang, Zhao, Wenming, Xiao, Jingfa, He, Shunmin, Zhang, Guoqing, Li, Yixue, Zhao, Guoping, Chen, Runsheng, Song, Shuhui, Ma, Lina, Zou, Dong, Tian, Dongmei, Li, Cuiping, Zhu, Junwei, Gong, Zheng, Chen, Meili, Wang, Anke, Ma, Yingke, Li, Mengwei, Teng, Xufei, Cui, Ying, Duan, Guangya, Zhang, Mochen, Jin, Tong, Shi, Chengmin, Du, Zhenglin, Zhang, Yadong, Liu, Chuandong, Li, Rujiao, Zeng, Jingyao, Hao, Lili, Jiang, Shuai, Chen, Hua, Han, Dali, Yongbiao, Xue, Zhang, Tao, Kang, Wang, Qu, Jing, Zhang, Weiqi, Liu, GuangHui, Liu, Lin, Zhang, Yang, Niu, Guangyi, Zhu, Tongtong, Feng, Changrui, Liu, Xiaonan, Zhang, Yuansheng, Li, Zhao, Chen, Ruru, Li, Qianpeng, Hua, Zhongyi, Jiang, Chao, Chen, Ziyuan, He, Fangshu, Zhao, Yuyang, Jin, Yan, Huang, Luqi, Yuan, Yuan, Zhou, Chenfen, Xu, Qingwei, He, Sheng, Ye, Wei, Cao, Ruifang, Wang, Pengyu, Ling, Yunchao, Yan, Xing, Wang, Qingzhong, Du, Qiang, Zong, Wenting, Kang, Hongen, Xiong, Zhuang, Huan, Wendi, Zhang, Sirui, Xia, Qiguang, Fan, Xiaojuan, Wang, Zefeng, Chen, Xu, Chen, Tingting, Zhang, Sisi, Tang, Bixia, Dong, Lili, Zhang, Zhewen, Wang, Zhonghuang, Kang, Hailong, Wang, Yanqing, Wu, Song, Wang, Honggen, Chen, Ming, Liu, Chang, Xiong, Yujia, Shao, Xueying, Li, Yanyan, Zhou, Honghong, Chen, Xiaomin, Zheng, Yu, Kang, Quan, Hao, Di, Zhang, Lili, Luo, Huaxia, Hao, Yajing, Zhang, Peng, Nie, Zhi, Yu, Shuhuan, Yang, Fei, Sang, Jian, Li, Zhaohua, Zhang, Xiangquan, Zhou, Qing, Zhai, Shuang, Zhang, Yaping, Wang, Guodong, Zhu, Qianghui, Li, Xin, Li, Menghua, Yan, Jun, Li, Chen, Wang, Zhennan, Wang, Xiangfeng, Liu, Yuanming, Luo, Hong, Wu, Xiaoyuan, Jing, HaiChun, Song, Tinrui, Zhao, Yi, Mehmood, Furrukh, Ali, Shahid, Ali, Amjad, Saleem, Shoaib, Hussain, Irfan, Abbasi, Amir A, Zuo, Zhixiang, Ren, Jian, Zhang, Xinxin, Xiao, Yun, Li, Xia, Tu, Yiran, Xue, Yu, Wu, Wanying, Ji, Peifeng, Zhao, Fangqing, Meng, Xianwen, Peng, Di, Luo, Hao, Gao, Feng, Ning, Wanshan, Lin, Shaofeng, Liu, Teng, Guo, AnYuan, Yuan, Hao, Zhang, Yong E, Tan, Xiaodan, Zhang, Weizhi, Xie, Yubin, Wang, Chenwei, Liu, ChunJie, Yang, DeChang, Tian, Feng, Gao, Ge, Tang, Dachao, Yao, Lan, Cui, Qinghua, An, Ni A, Li, ChuanYun, Luo, XiaoTong. Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2021. NUCLEIC ACIDS RESEARCH[J]. 2021, 49(D1): D18-D28, http://dx.doi.org/10.1093/nar/gkaa1022.
      [13] Teng, Xueyi, Chen, Xiaomin, Xue, Hua, Tang, Yiheng, Zhang, Peng, Kang, Quan, Hao, Yajing, Chen, Runsheng, Zhao, Yi, He, Shunmin. NPInter v4.0: an integrated database of ncRNA interactions. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(D1): D160-D165, http://dx.doi.org/10.1093/nar/gkz969.
      [14] Zhang, Zhang, Zhao, Wenming, Xiao, Jingfa, Bao, Yiming, He, Shunmin, Zhang, Guoqing, Li, Yixue, Zhao, Guoping, Chen, Runsheng, Gao, Yang, Zhang, Chao, Yuan, Liyun, Xu, Shuhua, Ning, Zhilin, Lu, Yan, Zeng, Jingyao, Yuan, Na, Zhu, Junwei, Pan, Mengyu, Zhang, Hao, Wang, Qi, Shi, Shuo, Jiang, Meiye, Lu, Mingming, Qian, Qiheng, Gao, Qianwen, Shang, Yunfei, Wang, Jinyue, Du, Zhenglin, Tian, Dongmei, Wang, Pei, Tang, Bixia, Li, Cuiping, Teng, Xufei, Liu, Xiaonan, Zou, Dong, Song, Shuhui, Xiong, Zhuang, Li, Mengwei, Yang, Fei, Ma, Yingke, Sang, Jian, Li, Zhaohua, Li, Rujiao, Wang, Zhonghuang, Zhu, Qianghui, Li, Xin, Zhang, Sisi, Kang, Hailong, Dong, Lili, Ying, Cui, Duan, Guangya, Li, Menghua, Zhi, Xiaoyang, Ling, Yunchao, Cao, Ruifang, Jiang, Zhao, Zhou, Haokui, Lv, Daqing, Liu, Wan, Klenk, HansPeter, Zhang, Yadong, Zhang, Zhewen, Chen, Tingting, Chen, Xu, Wang, Yanqing, Wu, Song, Gong, Zheng, Chen, Meili, Fang, Shuangsang, Zhang, Lili, Guo, Jincheng, Niu, Yiwei, Wu, Yang, Li, Hui, Zhao, Lianhe, Li, Xiyuan, Teng, Xueyi, Sun, Xianhui, Sun, Liang, Zhao, Yi, Wang, Jiajia, Zhang, Peng, Li, Yanyan, Zheng, Yu, Chen, Xiaomin, Xue, Hua, Teng, Yiheng, Kang, Quan, Hao, Yajing, Cao, Jiabao, Liu, Lin, Li, Zhao, Li, Qianpeng, Du, Qiang, Abbasi, Amir A, Shireen, Huma, Pervaiz, Nashaiman, Batool, Fatima, Raza, Rabail Z, Ma, Lina, Niu, Guangyi, Zhang, Yuansheng, Zhu, Tongtong, Hao, Lili, Wang, Guoliang, Yan, Jun, Li, Chen, Wang, Zhennan, Wang, Xiangfeng, Li, Zhonghai, Zhang, Yang, Wang, Houling, Zhang, Yi, Xia, Xinli, Guo, Hongwei, Zhu, Junwen, Zhou, Qing, Kang, Hongen, Lan, Li, Zhang, Xin, Xue, Yongbiao, Sun, Yubin, Zhai, Shuang, Yu, Lei, Sun, Mingyuan, Chen, Huanxin, Hu, Hui, Guo, AnYuan, Lin, Shaofeng, Xue, Yu, Wang, Chenwei, Ning, Wanshan, Zhang, Xinxin, Xiao, Yun, Li, Xia, Tu, Yiran, Wu, Wanying, Ji, Peifeng, Zhao, Fangqing, Luo, Hao, Gao, Feng, Guo, Yaping, Yuan, Hao, Zhang, Yong E, Zhang, Qiong, Zhou, Jiaqi, Huang, Zhou, Cui, Qinghua, Miao, YaRu, Ruan, Chen, Yuan, Chunhui, Chen, Ming, Jin, JinPu, Tian, Feng, Gao, Ge, Shi, Ying, Yao, Lan, Li, Xiangshang, Li, ChuanYun, Tang, Qing, Peng, Di. Database Resources of the National Genomics Data Center in 2020. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(D1): D24-D33, https://www.webofscience.com/wos/woscc/full-record/WOS:000525956700004.
      [15] Gou, LanTao, Lim, DoHwan, Ma, Wubin, Aubol, Brandon E, Hao, Yajing, Wang, Xin, Zhao, Jun, Liang, Zhengyu, Shao, Changwei, Zhang, Xuan, Meng, Fan, Li, Hairi, Zhang, Xiaorong, Xu, Ruiming, Li, Dangsheng, Rosenfeld, Michael G, Mellon, Pamela L, Adams, Joseph A, Liu, MoFang, Fu, XiangDong. Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation. CELL[J]. 2020, 180(6): 1212-+, http://dx.doi.org/10.1016/j.cell.2020.02.020.
      [16] Fan, Zhen, Chen, Xiaowei, Liu, Lu, Zhu, Caihong, Xu, Jinhua, Yin, Xianyong, Sheng, Yujun, Zhu, Zhengwei, Wen, Leilei, Zuo, Xianbo, Zheng, Xiaodong, Zhang, Yaohua, Xu, Jingkai, Huang, He, Zhou, Fusheng, Sun, Liangdan, Luo, Jianjun, Zhang, Dongdong, Chen, Xiaomin, Cui, Ya, Hao, Yajing, Cui, Yong, Zhang, Xuejun, Chen, Runsheng. Association of the Polymorphism rs13259960 in SLEAR With Predisposition to Systemic Lupus Erythematosus. ARTHRITIS & RHEUMATOLOGY[J]. 2020, 72(6): 985-996, https://www.webofscience.com/wos/woscc/full-record/WOS:000528476200001.
      [17] Zhang, Min, Yang, Hui, Wan, Lingfei, Wang, Zhaohai, Wang, Haiyang, Ge, Chen, Liu, Yunhui, Hao, Yajing, Zhang, Dongdong, Shi, Gaona, Gong, Yandong, Ni, Yanli, Wang, Chaojie, Zhang, Yuan, Xi, Jiafei, Wang, Sen, Shi, Lei, Zhang, Lina, YUe, Wen, Pei, Xuetao, Liu, Bing, Yan, Xinlong. Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma. JOURNAL OF HEPATOLOGY[J]. 2020, 73(5): 1118-1130, http://dx.doi.org/10.1016/j.jhep.2020.05.039.
      [18] Hao, Yajing, Wang, Dongpeng, Wu, Shuheng, Li, Xiao, Shao, Changwei, Zhang, Peng, Chen, JiaYu, Lim, DoHwan, Fu, XiangDong, Chen, Runsheng, He, Shunmin. Active retrotransposons help maintain pericentromeric heterochromatin required for faithful cell division. GENOME RESEARCH[J].  2020, 30(11):  1570-1582,  https://www.webofscience.com/wos/woscc/full-record/WOS:000586893200003.(First author)
      [19] Hu, Jing, Gao, Chen, Wei, Chaoliang, Xue, Yuanchao, Shao, Changwei, Hao, Yajing, Gou, LanTao, Zhou, Yu, Zhang, Jianlin, Ren, Shuxun, Chen, Ju, Wang, Yibin, Fu, XiangDong. RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 116(13): 6172-6180, 
    • [20] Zhang, Shilin, Wang, Yichen, Jia, Lin, Wen, Xue, Du, Zhonghua, Wang, Cong, Hao, Yajing, Yu, Dehai, Zhou, Lei, Chen, Naifei, Chen, Jingchen, Chen, Huiling, Zhang, Hui, Celik, Ilkay, Gulsoy, Gunhan, Luo, Jianjun, Qin, Baoming, Cui, Xueling, Liu, Zhonghui, Zhang, Songling, Esteban, Miguel A, Ay, Ferhat, Xu, Wei, Chen, Runsheng, Li, Wei, Hoffman, Andrew R, Hu, Jifan, Cui, Jiuwei. Profiling the long noncoding RNA interaction network in the regulatory elements of target genes by chromatin in situ reverse transcription sequencing. GENOME RESEARCH[J]. 2019, 29(9): 1521-1532, http://dx.doi.org/10.1101/gr.244996.118.
      [21] Jing Li, Yajing Hao, Wenzhe Mao, Xiaowei Xue, Pengchao Xu, Lihui Liu, Jiao Yuan, Dongdong Zhang, Na Li, Hua Chen, Lin Zhao, Zhao Sun, Jianjun Luo, Runsheng Chen, Robert Chunhua Zhao. LincK contributes to breast tumorigenesis by promoting proliferation and epithelial-to-mesenchymal transition. JOURNAL OF HEMATOLOGY & ONCOLOGY[J]. 2019, 12(1): 1-17, https://doaj.org/article/12ae3bc9c3cb4b46a368bdada1711521.(Co-First author)
      [22] Yuan Tian, Bin Yang, Weinan Qiu, Yajing Hao, Zhenxing Zhang, Bo Yang, Nan Li, Shuqun Cheng, Zhangjun Lin, Yaocheng Rui, Otto K W Cheung, Weiqin Yang, William K K Wu, YueSun Cheung, Paul B S Lai, Jianjun Luo, Joseph J Y Sung, Runsheng Chen, HongYang Wang, Alfred S L Cheng, Pengyuan Yang. ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy. NATURE COMMUNICATIONS[J]. 2019, 10(1): 1-16, https://doaj.org/article/a8d1c1e18c374e28bc9f4c1c7dd4b98d.
      [23] Wu, Jiayi, Zhu, Pingping, Lu, Tiankun, Du, Ying, Wang, Yanying, He, Luyun, Ye, Buqing, Liu, Benyu, Yang, Liuliu, Wang, Jing, Gu, Yang, Lan, Jie, Hao, Yajing, He, Lei, Fan, Zusen. The long non-coding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog signaling. JOURNAL OF HEPATOLOGY[J]. 2019, 70(5): 918-929, http://dx.doi.org/10.1016/j.jhep.2018.12.015.
      [24] Hao, Yajing, Zhang, Lili, Niu, Yiwei, Cai, Tanxi, Luo, Jianjun, He, Shunmin, Zhang, Bao, Zhang, Dejiu, Qin, Yan, Yang, Fuquan, Chen, Runsheng. SmProt: a database of small proteins encoded by annotated coding and non-coding RNA loci. BRIEFINGS IN BIOINFORMATICS[J]. 2018, 19(4): 636-643, https://www.webofscience.com/wos/woscc/full-record/WOS:000441243300010. (First author)
      [25] Dang, Yujie, Wang, Xiaoyan, Hao, Yajing, Zhang, Xinyue, Zhao, Shidou, Ma, Jinlong, Qin, Yingying, Chen, ZiJiang. MicroRNA-379-5p is associate with biochemical premature ovarian insufficiency through PARP1 and XRCC6. CELL DEATH & DISEASE[J]. 2018, 9:  https://www.webofscience.com/wos/woscc/full-record/WOS:000427385100009.
      [26] Zhang, Chong, Hao, Yajing, Wang, Yanxiao, Xu, Jiaqian, Teng, Yan, Yang, Xiao. TGF-beta/SMAD4-Regulated LncRNA-LINP1 Inhibits Epithelial-Mesenchymal Transition in Lung Cancer. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2018, 14(12): 1715-1723, http://dx.doi.org/10.7150/ijbs.27197.
      [27] Li, Hao, Yue, Haiyan, Hao, Yajing, Li, Haowen, Wang, Shuo, Yu, Lanbing, Zhang, Dong, Cao, Yong, Zhao, Jizong. Expression profile of long noncoding RNAs in human cerebral aneurysms: a microarray analysis. JOURNAL OF NEUROSURGERY[J]. 2017, 127(5): 1055-1062, http://dx.doi.org/10.3171/2016.9.JNS16839.
      [28] Chen, Xiaowei, Hao, Yajing, Cui, Ya, Fan, Zhen, He, Shunmin, Luo, Jianjun, Chen, Runsheng. LncVar: a database of genetic variation associated with long non-coding genes. BIOINFORMATICS[J]. 2017, 33(1): 112-118, https://www.webofscience.com/wos/woscc/full-record/WOS:000397091600015.(Co-First author)
      [29] Wang, Zheng, Hao, Yajing, Zhang, Chuanbao, Wang, Zhiliang, Liu, Xing, Li, Guanzhang, Sun, Lihua, Liang, Jingshan, Luo, Jianjun, Zhou, Dabiao, Chen, Runsheng, Jiang, Tao. The Landscape of Viral Expression Reveals Clinically Relevant Viruses with Potential Capability of Promoting Malignancy in Lower-Grade Glioma. CLINICAL CANCER RESEARCH[J]. 2017, 23(9): 2177-2185, https://www.webofscience.com/wos/woscc/full-record/WOS:000400270900007. (Co-First author)
      [30] Yan, Xinlong, Zhang, Dongdong, Wu, Wei, Wu, Shuheng, Qian, Jingfeng, Hao, Yajing, Yan, Fang, Zhu, Pingping, Wu, Jiayi, Huang, Guanling, Huang, Yinghui, Luo, Jianjun, Liu, Xinhui, Liu, Benyu, Chen, Xiaomin, Du, Ying, Chen, Runsheng, Fan, Zusen. Mesenchymal Stem Cells Promote Hepatocarcinogenesis via lncRNA-MUF Interaction with ANXA2 and miR-34a. CANCER RESEARCH[J]. 2017, 77(23): 6704-6716, http://dx.doi.org/10.1158/0008-5472.CAN-17-1915.
      [31] Hao, Yajing, Yang, Xinling, Zhang, Dongdong, Luo, Jianjun, Chen, Runsheng. Long noncoding RNA LINC01186, regulated by TGF-beta/SMAD3, inhibits migration and invasion through Epithelial-Mesenchymal-Transition in lung cancer. GENE[J]. 2017, 608: 1-12, https://www.webofscience.com/wos/woscc/full-record/WOS:000395213100001. (First author)
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    Honors & Distinctions

    2013 Outstanding Graduates.
    2014, 2015 Merit Student.
    2014 National Scholarship.
    2016 Excellent Student Cadre.
    2017 The Di’ao First Prize Scholarship.
    2018 First Prize Oral Presentation Award,     2018 “Genetics & Development” academic meeting