![](/self/img/13aa473a-8468-4e5c-b8c4-d4bf6f2f8eb8.jpeg)
电子邮件: haoyajing@big.ac.cn
通信地址: 朝阳区北辰西路1号院104号楼
邮政编码:
研究领域
郝亚静研究员2018年毕业于中国科学院生物物理研究所,师从陈润生院士,获生物信息学博士学位。2018年于加州大学圣地亚哥校区细胞分子医学系付向东课题组从事RNA生物学博士后研究,于2023年8月起担任中国科学院基因组研究所(国家生物信息中心)研究员、研究组长、博士生导师。郝亚静博士曾发表第一/共第一作者研究论文13篇及其他共同作者论文共22篇,总引用>2000, H-index 20。相关研究成果发表于Nature , Cell, Molecular Cell, Genome Biology, Genome Research, Journal of Clinical Investigation等国际著名期刊。
本研究组主要通过干/湿实验相结合的手段,致力于通过RNA视角深化对基因至表型复杂调控机制的理解。近年来,团队开发了多维高通量数据处理算法,建立了多重比对序列回收流程,搭建了ncRNAs互作组、突变组和翻译组数据库。干湿相结合解析了RNA结合蛋白在神经再生中的机理;发现了与基因组稳定性相关的ncRNAs并阐明了其功能机制; 揭示了RNA调控在病理过程中的重要作用。团队未来将继续探索生命普遍存在的基因调控机制,并重点阐明RNA加工调控机理。拟通过开发技术平台并结合AI大模型,系统鉴定RNA加工调控因子,揭示RNA加工调控的因果规律,并探究其在疾病中的转化潜力。
已有成果见: https://www.ncbi.nlm.nih.gov/myncbi/1LoJccRRI2PAM/bibliography/public/ 。
欢迎有志人士加入,我们一起“Work hard, play harder”,共同探究“RNA”这个无比有意思的分子。
招生信息
欢迎具有生物学、计算机科学、数学/统计、生物信息学及其他生物相关背景的考生报考!
招生专业
0710Z2-计算生物学
0710Z1-基因组学
招生方向
人工智能算法
异染色质
教育背景
2008-09--2013-06 哈尔滨医科大学 理学学士学位
工作经历
工作简历
2018-09~2023-07,加州大学圣地亚哥分校, 博士后研究员
专利与奖励
奖励信息
(2) 2018年全国“遗传·发育”研究生论坛报告一等奖, 一等奖, 研究所(学校), 2018
(3) 地奥奖学金一等奖, 一等奖, 院级, 2017
(4) 国家奖学金, 一等奖, 国家级, 2014
出版信息
发表论文
[2] Nature. 2023, 第 1 作者
[3] Hao, Yajing, Cai, Ting, Liu, Chang, Zhang, Xuan, Fu, XiangDong. Sequential Polyadenylation to Enable Alternative mRNA3' End Formation. MOLECULES AND CELLS. 2023, 第 1 作者46(1): 57-64, http://dx.doi.org/10.14348/molcells.2023.2176.
[4] CNCB-NGDC Memebers & Partners. Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2023. NUCLEIC ACIDS RESEARCH[J]. 2023, 51(D1): D18-D28, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9825504/.
[5] Li Jiang, Yajing Hao, Changwei Shao, Qiulian Wu, Briana C Prager, Ryan C Gimple, Gabriele Sulli, Leo JY Kim, Guoxin Zhang, Zhixin Qiu, Zhe Zhu, XiangDong Fu, Jeremy N Rich. ADAR1-mediated RNA editing links ganglioside catabolism to glioblastoma stem cell maintenance. THE JOURNAL OF CLINICAL INVESTIGATION[J]. 2022, 第 2 作者132(6): https://doaj.org/article/9e343997925d42dba86e8ff866779674.
[6] Hao, Yajing, Zhang, Shuyang, Shao, Changwei, Li, Junhui, Zhao, Guofeng, Zhang, DongEr, Fu, XiangDong. ZetaSuite: computational analysis of two-dimensional high-throughput data from multi-target screens and single-cell transcriptomics. GENOME BIOLOGY[J]. 2022, 第 1 作者23(1): http://dx.doi.org/10.1186/s13059-022-02729-4.
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[8] YiJou Huang, JiaYu Chen, Ming Yan, Amanda G Davis, Sayuri Miyauchi, Liang Chen, Yajing Hao, Sigrid Katz, Rafael Bejar, Omar AbdelWahab, XiangDong Fu, DongEr Zhang. RUNX1 deficiency cooperates with SRSF2 mutation to induce multilineage hematopoietic defects characteristic of MDS. BLOOD ADVANCES. 2022, 第 7 作者6(23): 6078-6092, http://dx.doi.org/10.1182/bloodadvances.2022007804.
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发表著作
(2) R-Loops: 方法与指南, R-Loops: Methods and Protocols, Springer US, 2022-06, 第 其他 作者
科研活动
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Reviewers for Briefings in Bioinformatics, Bioinformatics, IEEE/ACM Transactions on Computational Biology and Bioinformatics, ncRNAs, Cancers, Cells, the International Journal of Molecular Sciences, Computers in Biology and Medicine and Plos one.
Guest editor for the special issue "Exploring the Possibility of RNA in Diverse Biological Processes" in the International Journal of Molecular Sciences.
科研项目
( 2 ) 生物多维认知智能大模型MultiFormer解析基因调控 核心机制(联合申请A), 负责人, 国家任务, 2024-01--2026-12
参与会议
(2)Exploring the Extensive RNA-based regulatory network 第十二届核糖核酸 (RNA)学术会议-青年会议 2023-12-06
(3)ZetaSuite: Computational Analysis of Two-dimensional High-Throughput Data from Multi-target Screens and Single-cell Transcriptomics 第十二届全国生物信息学与系统生物学学术大会 2023-10-27
(4)ZetaSuite:screen和单细胞转录组的二维高通量数据的计算分析 华人基因组学在线沙龙 2022-09-24