General
周旭宇 男 汉族 博导 微生物研究所
Email: xuyu.zh@gmail.com
Telephone:
Address: 北京市海淀区北四环西路10号
Postcode: 100190

Research Areas

Treg are a specialized CD4+ T cell lineage that plays a central role in the preservation of self-tolerance and whose dysfunction has been implicated in autoimmune. Research in our laboratory is aimed at decipher the mechanism of Treg suppression. More recently, we found that the essential role for microRNA-dependent regulation of gene expression in the maintenance of Treg-cell-specific deletion of dicer developed a spontaneous, aggressive autoimmune disease that was indistinguishable from that observed in mice that lack Foxp3 or Treg cells. The major research goals of our laboratory are extending our previous work and determining the individual microRNAs and microRNA targets that are important in maintaining Treg identity.

Education

Ph.D., Osaka University Graduate School, 2001(Medical Science)
M.S., Shandong Agricultural University, 1996
B. S., Shandong University, 1993

Experience

Postdoctoral, University of California at San Francisco, San Francisco, CA

Publications

1.      Hu, T., Phiwpan, K., Guo, J., Zhang, W., Guo, J., Zhang, Z., Zou, M., Zhang, X., Zhan, J., Zhou, X. (2016) MicroRNA-142-3p Negatively Regulates Canonical Wnt Signaling Pathway. PLoS One 11, e0158432.

2.      Phiwpan, K., Guo, J., Zhang, W., Hu, T., Boruah, B.M., Zhang, J., and Zhou, X. (2015). A Novel Transgenic Mouse Line for Tracing MicroRNA-155-5p Activity In Vivo. PLoS One 10, e0128198.

3.      Guo, J., and Zhou, X. (2015). Regulatory T cells turn pathogenic. Cell Mol Immunol 12, 525-532.

4.      Stumpf, M., Zhou, X., Chikuma, S., and Bluestone, J.A. (2014). Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function. Eur J Immunol 44, 1737-1746.

5.      Pan, X., Ding, H., Zhou, X., and Tien, P. (2014). Identification of hepatitis B virus-specific CTL epitopes presented by HLA-A*33:03 in peripheral blood mononuclear cells from patients and transgenic mice. Biochem Biophys Res Commun 449, 135-140.

6.      Lv, Q., Hao, H., Bi, L., Zheng, Y., Zhou, X., and Jiang, Y. (2014). Suilysin remodels the cytoskeletons of human brain microvascular endothelial cells by activating RhoA and Rac1 GTPase. Protein Cell 5, 261-264.

7.      Liu, P., Liu, D., Yang, X., Gao, J., Chen, Y., Xiao, X., Liu, F., Zou, J., Wu, J., Ma, J., Zhao, F., Zhou, X., Gao, G. F., Zhu, B. (2014). Characterization of human alphabetaTCR repertoire and discovery of D-D fusion in TCRbeta chains. Protein Cell 5, 603-615.

8.      Guo, J., Zhang, J., Zhang, X., Zhang, Z., Wei, X., and Zhou, X. (2014). Constitutive activation of MEK1 promotes Treg cell instability in vivo. J Biol Chem 289, 35139-35148.

9.      Stumpf, M., Zhou, X., and Bluestone, J.A. (2013). The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes. J Immunol 190, 961-969.

10.   Li, X., Liu, Z., Yan, X., Zhang, X., Li, Y., Zhao, B., Wang, S., Zhou, X., Gao, G.F., and Meng, S. (2013). Induction of regulatory T cells by high-dose gp96 suppresses murine liver immune hyperactivation. PLoS One 8, e68997.

11.   Jeker, L.T., Zhou, X., Blelloch, R., and Bluestone, J.A. (2013). DGCR8-mediated production of canonical microRNAs is critical for regulatory T cell function and stability. PLoS One 8, e66282.

12.   Hao, H., Hui, W., Liu, P., Lv, Q., Zeng, X., Jiang, H., Wang, Y., Zheng, X., Zheng, Y., Li, J., Zhou, X., Jiang, Y. (2013). Effect of licochalcone A on growth and properties of Streptococcus suis. PLoS One 8, e67728.

13.   Bailey-Bucktrout, S.L., Martinez-Llordella, M., Zhou, X., Anthony, B., Rosenthal, W., Luche, H., Fehling, H.J., and Bluestone, J.A. (2013). Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response. Immunity 39, 949-962.

14.   Zhang, J., Chen, Y., Qi, J., Gao, F., Liu, Y., Liu, J., Zhou, X., Kaufman, J., Xia, C., and Gao, G.F. (2012). Narrow groove and restricted anchors of MHC class I molecule BF2*0401 plus peptide transporter restriction can explain disease susceptibility of B4 chickens. J Immunol 189, 4478-4487.

15.   Jeker, L.T., Zhou, X., Gershberg, K., de Kouchkovsky, D., Morar, M.M., Stadthagen, G., Lund, A.H., and Bluestone, J.A. (2012). MicroRNA 10a marks regulatory T cells. PLoS One 7, e36684.

16.   Beyer, M., Thabet, Y., Muller, R.U., Sadlon, T., Classen, S., Lahl, K., Basu, S., Zhou, X., Bailey-Bucktrout, S.L., Krebs, W., et al. (2011). Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol 12, 898-907.

17.   Zhou, X., Bailey-Bucktrout, S.L., Jeker, L.T., Penaranda, C., Martinez-Llordella, M., Ashby, M., Nakayama, M., Rosenthal, W., and Bluestone, J.A. (2009). Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol 10, 1000-1007.

18.   Zhou, X., Bailey-Bucktrout, S., Jeker, L.T., and Bluestone, J.A. (2009). Plasticity of CD4(+) FoxP3(+) T cells. Curr Opin Immunol 21, 281-285.

19.   Zhou, X., Jeker, L.T., Fife, B.T., Zhu, S., Anderson, M.S., McManus, M.T., and Bluestone, J.A. (2008). Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med 205, 1983-1991.

20.   Liu, W., Putnam, A.L., Zhou, X., Szot, G.L., Lee, M.R., Zhu, S., Gottlieb, P.A., Kapranov, P., Gingeras, T.R., Fazekas de St Groth, B., et al. (2006). CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 203, 1701-1711.

21.   Morimoto, Y., Bian, Y., Gao, P., Yashiro-Ohtani, Y., Zhou, X., Ono, S., Nakahara, H., Kogo, M., Hamaoka, T., and Fujiwara, H. (2005). Induction of surface CCR4 and its functionality in mouse Th2 cells is regulated differently during Th2 development. J Leukoc Biol 78, 753-761.

22.   Earle, K.E., Tang, Q., Zhou, X., Liu, W., Zhu, S., Bonyhadi, M.L., and Bluestone, J.A. (2005). In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation. Clin Immunol 115, 3-9.

23.   Bian, Y., Hiraoka, S., Tomura, M., Zhou, X., Yashiro-Ohtani, Y., Mori, Y., Shimizu, J., Ono, S., Dunussi-Joannopoulos, K., Wolf, S., and Fujiwara, H. (2005). The capacity of the natural ligands for CD28 to drive IL-4 expression in naive and antigen-primed CD4+ and CD8+ T cells. Int Immunol 17, 73-83.

24.   Yamaguchi, N., Hiraoka, S., Mukai, T., Takeuchi, N., Zhou, X., Ono, S., Kogo, M., Dunussi-Joannopoulos, K., Ling, V., Wolf, S., and Fujiwara, H. (2004). Induction of tumor regression by administration of B7-Ig fusion proteins: mediation by type 2 CD8+ T cells and dependence on IL-4 production. J Immunol 172, 1347-1354.

25.   Takeuchi, N., Hiraoka, S., Zhou, X., Nagafuku, M., Ono, S., Tsujimura, T., Nakazawa, M., Yura, Y., Hamaoka, T., and Fujiwara, H. (2004). Anti-HER-2/neu immune responses are induced before the development of clinical tumors but declined following tumorigenesis in HER-2/neu transgenic mice. Cancer Res 64, 7588-7595.

26.   Park, W.R., Nakahira, M., Sugimoto, N., Bian, Y., Yashiro-Ohtani, Y., Zhou, X., Yang, Y.F., Hamaoka, T., and Fujiwara, H. (2004). A mechanism underlying STAT4-mediated up-regulation of IFN-gamma induction inTCR-triggered T cells. Int Immunol 16, 295-302.

27.   Gao, P., Zhou, X., Yashiro-Ohtani, Y., Yang, Y.F., Sugimoto, N., Ono, S., Nakanishi, T., Obika, S., Imanishi, T., Egawa, T., et al. (2003). The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3. J Leukoc Biol 73, 273-280.

28.   Zhou, X., Yashiro-Ohtani, Y., Nakahira, M., Park, W.R., Abe, R., Hamaoka, T., Naramura, M., Gu, H., and Fujiwara, H. (2002). Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 costimulatory molecules to IL-2 promoter activation. J Immunol 168, 3847-3854.

29.   Park, C.S., Yang, Y.F., Zhou, X., Toyooka, K., Yashiro-Ohtani, Y., Park, W.R., Tomura, M., Tai, X.G., Hamaoka, T., and Fujiwara, H. (2002). Reversible CD8 expression induced by common cytokine receptor gamma chain-dependent cytokines in a cloned CD4(+) T(h)1 cell line. Int Immunol 14, 259-266.

30.   Zhou, X., Yashiro-Ohtani, Y., Toyo-Oka, K., Park, C.S., Tai, X.G., Hamaoka, T., and Fujiwara, H. (2000). CD5 costimulation up-regulates the signaling to extracellular signal-regulated kinase activation in CD4+CD8+ thymocytes and supports their differentiation to the CD4 lineage. J Immunol 164, 1260-1268.

31.   Yashiro-Ohtani, Y., Zhou, X., Toyo-Oka, K., Tai, X.G., Park, C.S., Hamaoka, T., Abe, R., Miyake, K., and Fujiwara, H. (2000). Non-CD28 costimulatory molecules present in T cell rafts induce T cell costimulation by enhancing the association of TCR with rafts. J Immunol 164, 1251-1259.

32.   Tomura, M., Zhou, X., Maruo, S., Ahn, H.J., Hamaoka, T., Okamura, H., Nakanishi, K., Tanimoto, T., Kurimoto, M., and Fujiwara, H. (1998). A critical role for IL-18 in the proliferation and activation of NK1.1+ CD3- cells. J Immunol 160, 4738-4746.

33.   Tomura, M., Maruo, S., Mu, J., Zhou, X., Ahn, H.J., Hamaoka, T., Okamura, H., Nakanishi, K., Clark, S., Kurimoto, M., and Fujiwara, H. (1998). Differential capacities of CD4+, CD8+, and CD4-CD8- T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18. J Immunol 160, 3759-3765.

 


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Students

已指导学生

胡探宇  博士研究生  071010-生物化学与分子生物学  

魏训东  博士研究生  071010-生物化学与分子生物学  

张忠美  博士研究生  071010-生物化学与分子生物学  

邹芒阁  硕士研究生  071010-生物化学与分子生物学  

黄满  博士研究生  071010-生物化学与分子生物学  

朱雪平  博士研究生  100102-免疫学  

张雪洁  博士研究生  100102-免疫学  

赵修峰  硕士研究生  100102-免疫学  

张会玲  硕士研究生  100102-免疫学  

徐威  硕士研究生  085238-生物工程  

现指导学生

谷千冲  博士研究生  100102-免疫学  

王婷  博士研究生  100102-免疫学  

李丽萍  博士研究生  100102-免疫学  

曹雪  博士研究生  100102-免疫学  

柴馨  硕士研究生  077802-免疫学  

张秦  硕士研究生  085238-生物工程  

陈高影  硕士研究生  086000-生物与医药  

金秋珠  硕士研究生  077802-免疫学  

张鑫朝  硕士研究生  077802-免疫学  

徐威  博士研究生  100102-免疫学