基本信息
周旭宇  男  博导  中国科学院微生物研究所
电子邮件: zhouxy@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号
邮政编码: 100101

研究领域

  课题组目前的研究方向主要是聚焦在T细胞免疫调节,特别是致力于研究调节性T细胞(Treg)的抑制机理及其自身稳定性的调控机制,揭示Treg细胞功能转换的分子信号网络,跟踪分析Treg细胞在体内的动态变化规律,探讨Treg细胞和其他效应性T细胞与自身免疫性疾病、肿瘤、传染性疾病的关系及其应用。

  结合转基因小鼠的构建和细胞功能实验,本课题组主要研究工作包括:Treg的抑制机理和稳定性调控机制研究;效应性Treg的形成机制研究;探索免疫系统中CD4阳性T细胞的分化发展方向;肿瘤TCR-T治疗研发。

招生信息

   
招生专业-071010 生物化学与分子生物学
100102-免疫学
招生方向-调节性T细胞的抑制机理及其自身稳定性的调控机制
免疫调节与肿瘤
免疫调节与慢性感染
免疫调节与自身免疫性疾病

教育背景

1997-04--2001-03   日本大阪大学   医学博士
1993-09--1996-07   山东农业大学   理学硕士
1989-09--1993-07   山东大学   理学学士
学位
-- 博士
学历
-- 研究生

工作经历

   
工作简历
2003-10~2009-09,美国加州大学旧金山分校(UCSF), 博士后
2001-04~2003-09,日本大阪大学, 交流学者和研究助理

出版信息

   
发表论文
(1) A Split-Cre system designed to detect simultaneous expression of two genes based on SpyTag/SpyCatcher conjugation and Split-GFP dimerization, JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 通讯作者
(2) Editorial: Regulators of a Regulator: Post-Transcriptional Regulation in Tregs, FRONTIERS IN IMMUNOLOGY, 2021, 通讯作者
(3) Ex-TFRs: A Missing Piece of the SLE Puzzle?, FRONTIERS IN IMMUNOLOGY, 2021, 通讯作者
(4) A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity, NATURE, 2020, 第 10 作者
(5) A wave of Foxp3(+) regulatory T cell accumulation in the neonatal liver plays unique roles in maintaining self-tolerance, CELLULAR & MOLECULAR IMMUNOLOGY, 2020, 第 16 作者
(6) Down-regulated Treg cells in exacerbated periodontal disease during pregnancy, INTERNATIONAL IMMUNOPHARMACOLOGY, 2019, 第 10 作者
(7) Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells, CELL REPORTS, 2019, 通讯作者
(8) Foxp3 Instability Helps tTregs Distinguish Self and Non-self, FRONTIERS IN IMMUNOLOGY, 2019, 通讯作者
(9) B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen, IMMUNITY, 2018, 第 8 作者
(10) B Cell-Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle, JOURNAL OF IMMUNOLOGY, 2018, 第 9 作者
(11) Noc4L dictates Treg activation in vivo, JOURNAL OF IMMUNOLOGY, 2018, 第 1 作者
(12) MicroRNAs in regulatory T cells, CANCER LETTERS, 2018, 通讯作者
(13) Activation and Functional Specialization of Regulatory T Cells Lead to the Generation of Foxp3 Instability Article, The Journal of Immunology, 2017, 通讯作者
(14) Reciprocal Expression of IL-35 and IL-10 Defines Two Distinct Effector Treg Subsets that Are Required for Maintenance of Immune Tolerance, CELL REPORTS, 2017, 通讯作者
(15) Interaction of factor H-binding protein of Streptococcus suis with globotriaosylceramide promotes the development of meningitis, VIRULENCE, 2017, 通讯作者
(16) Activation and Functional Specialization of Regulatory T Cells Lead to the Generation of Foxp3 Instability, JOURNAL OF IMMUNOLOGY, 2017, 通讯作者
(17) MicroRNA-142-3p Negatively Regulates Canonical Wnt Signaling Pathway, PLOS ONE, 2016, 通讯作者
(18) Improved Transgenic Mouse Model for Studying HLA Class I Antigen Presentation, SCIENTIFIC REPORTS, 2016, 通讯作者
(19) Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters, SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2016, 第 14 作者
(20) Regulatory T cells turn pathogenic, Regulatory T cells turn pathogenic, 中国免疫学杂志:英文版, 2015, 
(21) Regulatory T cells turn pathogenic, CELLULAR & MOLECULAR IMMUNOLOGY, 2015, 通讯作者
(22) A Novel Transgenic Mouse Line for Tracing MicroRNA-155-5p Activity In Vivo, PLOS ONE, 2015, 通讯作者
(23) Identification of hepatitis B virus-specific CTL epitopes presented by HLA-A*33:03 in peripheral blood mononuclear cells from patients and transgenic mice, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 第 3 作者
(24) 小鼠T-bet逆转录病毒载体的构建与功能验证, 生物工程学报, 2014, 第 1 作者
(25) Sustained PI3K activation destabilized tTreg, JOURNAL OF IMMUNOLOGY, 2014, 第 1 作者
(26) Suilysin remodels the cytoskeletons of human brain microvascular endothelial cells by activation RhoA and Rac1 GTPase, Protein and Cell, 2014, 通讯作者
(27) Characterization of human αβTCR repertoire and discovery of D-D fusion in TCRβ chains, Protein & Cell, 2014, 其他(合作组作者)
(28) Constitutive Activation of MEK1 Promotes Treg Cell Instability in Vivo, JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 通讯作者
(29) Characterization of human alpha beta TCR repertoire and discovery of D-D fusion in TCR beta chains, PROTEIN & CELL, 2014, 其他(合作组作者)
(30) Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function, EUROPEAN JOURNAL OF IMMUNOLOGY, 2014, 第 2 作者
(31) Suilysin remodels the cytoskeletons of human brain microvascular endothelial cells by activating RhoA and Rac1 GTPase, PROTEIN & CELL, 2014, 通讯作者
(32) Effect of Licochalcone A on Growth and Properties of Streptococcus suis, PLOS ONE, 2013, 通讯作者
(33) Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response, IMMUNITY, 2013, 第 3 作者
(34) Induction of Regulatory T Cells by High-Dose gp96 Suppresses Murine Liver Immune Hyperactivation, PLOS ONE, 2013, 第 8 作者
(35) DGCR8-Mediated Production of Canonical Micrornas Is Critical for Regulatory T Cell Function and Stability, PLOS ONE, 2013, 第 2 作者
(36) MicroRNA 10a Marks Regulatory T Cells, PLOS ONE, 2012, 第 2 作者
(37) Narrow Groove and Restricted Anchors of MHC Class I Molecule BF2*0401 Plus Peptide Transporter Restriction Can Explain Disease Susceptibility of B4 Chickens, JOURNAL OF IMMUNOLOGY, 2012, 第 7 作者
(38) Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo, NATURE IMMUNOLOGY, 2009, 
(39) Plasticity of CD4 + FoxP3 + T cells, CURRENT OPINION IN IMMUNOLOGY, 2009, 
(40) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ Tregs, The Journal of Experimental Medicine, 2006, 第 1 作者
(41) Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 costimulatory molecules to IL-2 promoter activation, JOURNAL OF IMMUNOLOGY, 2002, 
(42) CD5 Costimulation Up-Regulates the Signaling to Extracellular Signal-Regulated Kinase Activation in CD4+CD8+ Thymocytes and Supports Their Differentiation to the CD4 Lineage, American Association of Immunologists, 2000, 
(43) The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes, Journal of immunology (Baltimore, Md. : 1950), 
(44) Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity, The Journal of Experimental Medicine, 

指导学生

已指导学生

胡探宇  博士研究生  071010-生物化学与分子生物学  

魏训东  博士研究生  071010-生物化学与分子生物学  

张忠美  博士研究生  071010-生物化学与分子生物学  

邹芒阁  硕士研究生  071010-生物化学与分子生物学  

黄满  博士研究生  071010-生物化学与分子生物学  

朱雪平  博士研究生  100102-免疫学  

张雪洁  博士研究生  100102-免疫学  

赵修峰  硕士研究生  100102-免疫学  

张会玲  硕士研究生  100102-免疫学  

徐威  硕士研究生  085238-生物工程  

现指导学生

谷千冲  博士研究生  100102-免疫学  

王婷  博士研究生  100102-免疫学  

李丽萍  博士研究生  100102-免疫学  

曹雪  博士研究生  100102-免疫学  

柴馨  硕士研究生  077802-免疫学  

张秦  硕士研究生  085238-生物工程  

陈高影  硕士研究生  086000-生物与医药  

金秋珠  硕士研究生  077802-免疫学  

张鑫朝  硕士研究生  077802-免疫学  

徐威  博士研究生  100102-免疫学