Proteostasis and healthspan

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1999-2003 B.Sc., Wuhan University

2003-2008 Ph.D, Institute of Biophysics, Chinese Academy of Sciences

2008-2011 Research Associate, Institute of Biophysics, Chinese Academy of Sciences

2012-2023 Associate Professor, Institute of Biophysics, Chinese Academy of Sciences

2015-2016 Visiting Scholar, The Scripps Research Institute, La Jolla, CA, USA

2024-       Professor, Institute of Biophysics, Chinese Academy of Sciences

1. Sun Y, Wang X*. (2024) Reticulophagy mediated by the V-ATPase-ATG16L1-LC3C axis. Autophagy, 20(6):1457-1458.

2. Sun Y, Wang X, Yang X, Wang L, Ding J, Wang CC, Zhang H, Wang X*. (2023) V-ATPase recruitment to ER exit sites switches COPII-mediated transport to lysosomal degradation. Dev Cell, 58(23):2761-2775.

3. Liu P, Wang X*, Sun Y, Zhao H, Cheng F, Wang J, Yang F, Hu J, Zhang H, Wang CC, Wang L*. (2022) SARS-CoV-2 ORF8 reshapes the ER through forming mixed disulfides with ER oxidoreductases. Redox Biol, 54:102388.

4. Yang K, Li DF, Wang X, Liang J, Sitia R, Wang CC*, Wang X*. (2016) Crystal structure of the ERp44-Peroxiredoxin 4 complex reveals the molecular mechanisms of thiol-mediated protein retention. Structure, 4;24(10):1755-1765.

5. Sun S, Wang C, Hu J, Zhao P, Wang X, Balch WE. (2025) Spatial covariance reveals isothiocyanate natural products adjust redox stress to restore function in alpha-1-antitrypsin deficiency, Cell Rep Med, 6(1):101917.

6. Zhao P, Wang C, Sun S, Wang X, Balch WE. (2024) Tracing genetic diversity captures the molecular basis of misfolding disease. Nat Commun, 15(1):3333.

7. Wang L, Wang X, Lv X, Jin Q, Shang H, Wang CC, Wang L. (2022) The extracellular Ero1α/PDI electron transport system regulates platelet function by increasing glutathione reduction potential. Redox Biol, 50:102244.

8. Yu J, Li T, Liu Y, Wang X, Zhang J, Wang X, Shi G, Lou J, Wang L, Wang CC, Wang L. (2020) Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress. EMBO J, 39(10):e103841.