蛋白质稳态与人类健康

2024-现在, 中国科学院生物物理研究所, 项目研究员

2015-2016,The Scripps Research Institute, 访问学者

2012-2023,中国科学院生物物理研究所, 副研究员

2008-2011,中国科学院生物物理研究所, 助理研究员

1. Sun Y, Wang X*. (2024) Reticulophagy mediated by the V-ATPase-ATG16L1-LC3C axis. Autophagy, 20(6):1457-1458.

2. Sun Y, Wang X, Yang X, Wang L, Ding J, Wang CC, Zhang H, Wang X*. (2023) V-ATPase recruitment to ER exit sites switches COPII-mediated transport to lysosomal degradation. Dev Cell, 58(23):2761-2775.

3. Liu P, Wang X*, Sun Y, Zhao H, Cheng F, Wang J, Yang F, Hu J, Zhang H, Wang CC, Wang L*. (2022) SARS-CoV-2 ORF8 reshapes the ER through forming mixed disulfides with ER oxidoreductases. Redox Biol, 54:102388.

4. Yang K, Li DF, Wang X, Liang J, Sitia R, Wang CC*, Wang X*. (2016) Crystal structure of the ERp44-Peroxiredoxin 4 complex reveals the molecular mechanisms of thiol-mediated protein retention. Structure, 4;24(10):1755-1765.

5. Sun S, Wang C, Hu J, Zhao P, Wang X, Balch WE. (2025) Spatial covariance reveals isothiocyanate natural products adjust redox stress to restore function in alpha-1-antitrypsin deficiency, Cell Rep Med, 6(1):101917.

6. Zhao P, Wang C, Sun S, Wang X, Balch WE. (2024) Tracing genetic diversity captures the molecular basis of misfolding disease. Nat Commun, 15(1):3333.

7. Wang L, Wang X, Lv X, Jin Q, Shang H, Wang CC, Wang L. (2022) The extracellular Ero1α/PDI electron transport system regulates platelet function by increasing glutathione reduction potential. Redox Biol, 50:102244.

8. Yu J, Li T, Liu Y, Wang X, Zhang J, Wang X, Shi G, Lou J, Wang L, Wang CC, Wang L. (2020) Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress. EMBO J, 39(10):e103841.