Diseases of the nervous system, ranging from epilepsy, stroke, and Alzheimer's disease, which affect millions, to rare ones such as Rett's Syndrome and Rasmussen's Encephalitis, have devastating consequences for individuals of all ages and represent increasing medical and socioeconomic problems. Although symptomatic treatments are available in some diseases, mechanism-based therapies to prevent or cure these diseases are lacking. The long-term Research Interests of our laboratory are to understand the molecular and cellular mechanisms of neurological diseases, especially those relating to mental retardation and epilepsy.

August, 1995-Feb., 2000           Ph.D. 

                                                  Baylor College of Medicine, Department of Pharmacology

Sept., 1992-July, 1995               M.S.   

                                                  Shanghai Institute of Materia Medica, Chinese Acadymy of Science, Department of Pharmacology

Sept., 1987-June, 1992              Pharm.B. 

                                                   West China University of Medical Sciences  (Sichuan University Huaxi Medical Center) School of Pharmacy

2015-04~now          Professor

                                 University of Chinese Academy of Sciences

2014-09~now          Director of Department of Brain Diseases

                                 CAS Center for Excellence in Brain Science and Intelligence Technology
2014-03~now          Distinguished Professor

                                 Shanghaitech University
2012-05~now          Senior Investigator

                                 Institute of Neuroscience, Chinese Academy of Sciences, Laboratory of Neurobiology of Disease

2003-08~2012-04    Investigator

                                 Institute of Neuroscience, Chinese Academy of Sciences, Laboratory of Neurobiology of Disease

2000-03~2003-07    Research Associate & Postdoctoral training

                                 Duke University Medical Center, Department of Neurobiology  

（1） Interactions between N-Ethylmaleimide-Sensitive Factor and GluA2 contribute to effects of glucocorticoid hormones on AMPA receptor function in the rodent hippocampus., Hippocampus, 2016
（2） Rcan1 deficiency impairs neuronal migration and causes periventricular heterotopia., J. Neurosci., 2015, correspondence author
（3） PRRT2 c.649dupC mutation derived from de novo in paroxysmal kinesigenic dyskinesia, CNS Neurosci. Ther., 2013
（4） The Angelman Syndrome protein Ube3a is required for polarized dendrite morphogenesis in pyramidal neurons, J. Neurosci., 2013, correspondence author

（5） Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development, Proc. Natl. Acad. Sci. USA., 2013, correspondence author

（6） X-linked microtubule-associated protein, Mid1, regulates axon development., Proc. Natl. Acad. Sci. USA., 2013, correspondence author

（7） Serum inducible kinase is a positive regulator of cortical dendrite development and is required for BDNF-promoted dendritic arborization, Cell Research, 2012, correspondence author

（8） Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons, Nature Neuroscience, 2012, correspondence author

（9） Pulse labeling and long-term tracing of newborn neurons in the adult subgranular zone, Cell Research, 2011, correspondence author

（10） Conditional deletion of NRSF in forebrain neurons accelerates epileptogenesis in the kindling model, Cerebral Cortex, 2011, correspondence author

（11） Neuron-restrictive silencer factor is not required for the antiepileptic effect of the ketogenic diet, Epilepsia, 2011, correspondence author

（12） Exome sequencing identifies truncating mutations in PRRT2 that casue paroxysmal kinesigenic dyskinesia, Nature Genetics, 2011
（13） CDKL5,  a  protein  associated  with  Rett syndrome, regulates neuronal morphogenesis via Rac1 signaling, J Neurosci., 2010, correspondence author

（14） NGF-dependent retrograde signaling: survival versus death., Cell Research, 2009, correspondence author（15） Zn2+ mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus., J. Neurochem., 2009, correspondence author

（16） TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons., J. Neurosci., 2009, correspondence author

（17） Limbic epileptogenesis in a mouse model of fragile X syndrome., Cerebral Cortex, 2009, correspondence author

（18） Fragile X syndrome and epilepsy., Neurosci. Bull., 2008, correspondence author

（19） Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse., Neuron, 2008
（20） Clathrin-dependent endocytosis is required for TrkB-dependent Akt-mediated neuronal protection and dendritic growth., J. Biol. Chem., 2008, correspondence author

（21） Brain-derived neurotrophic factor-tropomyosin-related kinase B signaling contributes to activity-dependent changes in synaptic proteins., J. Biol. Chem., 2008, correspondence author

（22） Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance, Stroke, 2008, correspondence author

（23） Differential roles of NR2A- and NR2B-containing NMDA receptors in activity-dependent brain-derived neurotrophic factor gene regulation and limbic epileptogenesis., J. Neurosci., 2007, correspondence author（24） Transducer of regulated CREB and late phase long-term synaptic potentiation, FEBS J., 2007, correspondence author

（25） Requirement of TORC1 for late-phase long-term potentiation in the hippocampus., PLoS ONE, 2006, correspondence author

（26） Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration., J. Neurosci., 2003, first author
（27） Fas(t) balls and Lou Gehrig disease. A clue to selective vulnerability of motor neurons?, Neuron, 2002, first author

（28） Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack., Neuron, 2002, first author

（29） Effects of postsynaptic GABAB receptor activation on epileptiform activity in hippocampal slices., Neuropharmacology, 2001, first author

（30） Prolonged bursts occur in normal calcium in hippocampal slices after raising excitability and blocking synaptic transmission., J. Neurophysiol., 2001, first author

（31） Regulation of extracellular pH in the developing hippocampus, Dev. Brain Res., 2000, first author（32） Sodium pump activity, not glial spatial buffering, clears potassium after epileptiform activity induced in the dentate gyrus, J. Neurophysiol., 2000, first author

（33） pH sensitivity of non-synaptic field bursts in the dentate gyrus., J. Neurophysiol., 2000
（34） Extracellular pH responses in CA1 and the dentate gyrus during electrical stimulation, seizure discharges, and spreading depression., J. Neurophysiol., 2000, first author

（35） Activity-dependent intracellular acidification correlates with the duration of seizure activity., J. Neurosci., 2000, first author

（36） Cesium induces spontaneous epileptiform activity without changing extracellular potassium regulation in rat hippocampus, J. Neurophysiol, 1999, first author

（37） Astrocytic regulation of the recovery of extracellular potassium after seizures in vivo, Eur. J. Neurosci., 1999, first author

（38） Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit, Zhongguo Yao Li Xue Bao, 1998, first author

（39） Effects of felbamate, gabapentin and lamotrigine on seizure parameters and excitability in the rat hippocampus, Epilepsy Res, 1997, first author

（40） Effect of –N omega-nitro-L-arginie on working memory of rats in eight-arm maze task, Acta Pharmacologica Sinica, 1995, first author

（41） Effects of isovanihuperzine A on cholinesterase and scopolamine-induced memory impairment, Acta Pharmacologica Sinica, 1995, first author

（42） Effect of huperzine A, a novel acetyl-cholinesterase inhibitor, on radial maze performance in rats, Pharmacol. Biochem. Behav., 1995, first author

（43） Huperzine A ameliorates the spatial working memory impairments induced by AF64A, NeuroReport, 1995, first author

（1）Molecular mechanism of intellectual disability   2015-11-07
（2）Synaptic and circuit basis of PKD   2015-09-21
（3）Palmitoylation-dependent CDKL5–PSD95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development   2014-11-15
（4）Synaptic function of CDKL5   2014-06-23
（5）Reelin regulates intramembrane proteolysis signaling to control radial migration of cortical neuron.   2014-05-12
（6）Prrt2-deficiency Impairs Presynaptic Plasticity and Voluntary Movements   2014-04-25

已指导学生

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周杨  01  19179  

胡晓玲  01  19179  

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