神经系统疾病是一类发病率较高的疾病，中风、癫痫、早老性痴呆等常见的神经系统疾病影响全球数千万人的健康，加上一些较为罕见的疾病如雷特综合征、Rasmussen脑炎等，已经成为日益严重的医疗负担和社会问题。虽然目前已有一些手段及方法应用于某些神经系统疾病的临床诊断和治疗，但基于发病机制研究的、用于预防或治愈这类神经系统疾病的方案依旧匮乏。本研究组的长期研究方向是了解这些神经系统疾病在细胞和分子水平的发病机理，其中特别关注儿童智力发育障碍疾病和癫痫病的研究。

   

071006-神经生物学

疾病神经生物学

1995-08--2000-01   美国贝勒医学院   药理学和神经科学专业，博士
1992-09--1995-07   中国科学院上海药物所   神经药理学专业，硕士
1987-09--1992-06   华西医科大学   药学专业，学士

   

2015-04~现在, 中国科学院大学, 岗位教授
2014-09~现在, 中国科学院脑科学与智能技术卓越创新中心, 脑疾病部主任
2014-03~现在, 上海科技大学, 特聘教授
2012-05~现在, 中国科学院神经科学研究所, 高级研究员，博士生导师
2003-08~2012-04,中国科学院神经科学研究所, 研究员、博士生导师
2000-03~2003-07,美国杜克大学医学中心James McNamara实验室, 博士后

2016-06-01-今,中国神经科学学会青年组会主任,
2016-06-01-今,中国神经科学学会神经病学基础与临床分会 副主任委员,
2015-10-01-今,中国神经科学学会常务理事,
2015-02-01-今,《Neurogenesis》编委,
2013-07-01-今,《Developmental Neurobiology》编委,
2012-03-01-今,《中国细胞生物学学报》编委,

神经生物学

   

（1） 赛诺菲中国神经科学优秀学者奖, 特等奖, 其他, 2014
（2） 国家百千万人才工程， “有突出贡献中青年专家”, 特等奖, 国家级, 2013
（3） 张香桐基金会青年神经科学家奖, 特等奖, 其他, 2013
（4） 中科院优秀博士论文奖导师奖, 特等奖, 院级, 2013
（5） 国务院特殊津贴, 特等奖, 国家级, 2012
（6） 上海市优秀学术带头人, 特等奖, 市地级, 2012
（7） 国家杰出青年科学基金, 特等奖, 国家级, 2009
（8） 中科院上海分院杰出青年科技创新人才奖, 特等奖, 院级, 2008
（9） 上海市“浦江人才计划”, 特等奖, 市地级, 2006
（10） 中科院“****”, 特等奖, 院级, 2003

[1] 熊志奇, 封雪, 李明倢. 激活异染色质基因的方法及应用. CN: CN116376975A, 2023-07-04.
[2] 熊志奇, 翟荣伟, 赵敏. 一种非人灵长类动物物质成瘾模型的构建方法与应用. CN: CN114903006A, 2022-08-16.
[3] 熊志奇, 翟荣伟. 一种灵长类动物药物成瘾性评估的装置. CN: CN114667963A, 2022-06-28.
[4] 熊志奇, 翟荣伟, 赵敏. 一种灵长类药物成瘾性评估的方法与应用. CN: CN114667964A, 2022-06-28.
[5] 熊志奇, 王红涛, 程学文, 朱姊艾. 癫痫动物模型的制备及其应用. CN: CN114304068A, 2022-04-12.
[6] 孙强, 刘真, 熊志奇, 李奎. 一种性早熟动物模型的构建方法及其应用. CN: CN113615638A, 2021-11-09.
[7] 孙强, 陆宗阳, 刘真, 熊志奇, 姜建. STXBP1突变动物模型的构建及其应用. CN: CN113528584B, 2023-07-21.
[8] 孙强, 陆宗阳, 刘真, 熊志奇, 姜建. STXBP1突变动物模型的构建及其应用. CN: CN113528584A, 2021-10-22.
[9] 熊志奇, 孙强, 翟荣伟, 王振. 制备具有强迫仪式样行为的非人灵长类动物模型的方法. CN: CN110810323B, 2021-09-14.
[10] 熊志奇, 王杰. Ube3a泛素化PP2A激活因子PTPA在治疗天使综合症和孤独症中的应用. CN: CN110237257B, 2023-01-03.
[11] 陈万金, 王柠, 熊志奇, 姚香平, 程学文, 王冲, 赵淼. 原发性家族性脑钙化症致病基因MYORG及其应用. CN: CN108715838A, 2018-10-30.
[12] 王柠, 陈万金, 程学文, 熊志奇, 姚香平. 第103位点发生突变的人类PFBC致病基因MYORG及其应用. CN: CN112342206A, 2021-02-09.
[13] 熊志奇, 朱志川, 李奎. KPNB1抑制剂和Bcl-xL抑制剂在制备抗肿瘤药物中的应用. CN: CN109718377A, 2019-05-07.
[14] 熊志奇, 朱志川, 李奎. KPNB1抑制剂和蛋白降解途径抑制剂在制备抗肿瘤药物中的应用. CN: CN109718378A, 2019-05-07.
[15] 熊志奇, 李奎, 吴明月, 谭国鹤, 陈任超, 陈蕾. 一种运动障碍动物的建立方法及其用途. CN: CN109112125B, 2022-02-15.
[16] 熊志奇, 朱志川, 李奎. 一种治疗肿瘤的联合用药方法. CN: CN108619488A, 2018-10-09.
[17] 熊志奇, 陆斌, 吴雪妹, 何俊彦, 张静. 作用于前脑兴奋性神经元的PRRT2及其上调剂的应用. CN: CN117122688B, 2024-06-04.
[18] 熊志奇, 陆斌, 吴雪妹, 何俊彦, 张静. 作用于前脑兴奋性神经元的PRRT2及其上调剂的应用. CN: CN117122688A, 2023-11-28.
[19] 熊志奇, 封雪, 李明倢. 激活异染色质基因的方法及应用. CN: CN116376975B, 2024-05-14.
[20] 熊志奇, 陈万金, 程学文, 赵淼, 苏惠珍, 曾一恒. 线粒体障碍和脑钙化模型的制备方法. CN: CN117887766A, 2024-04-16.
[21] 熊志奇, 翟荣伟, 赵敏. 一种非人灵长类药物成瘾性评估的方法与应用. CN: CN114667964B, 2023-11-14.
[22] 熊志奇, 翟荣伟. 一种非人灵长类动物药物成瘾性评估的装置. CN: CN114667963B, 2024-04-26.

   

[1] Jiang, Mengying, Xu, Qiwu, Yang, Can, Li, Dan, Liu, JiWei, Zhang, Yuxian, Zhu, YongChuan, Xiong, ZhiQi. Activity-Dependent Phosphorylation of CDKL5 at Serine 407 Regulates Synaptogenesis and Plasticity. NEUROSCIENCE BULLETIN[J]. 2023, 第 8 作者  通讯作者  39(9): 1454-1458, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7546608&detailType=1.
[2] Xu, RuoShui, Wu, XueMei, Xiong, ZhiQi. Low-intensity ultrasound directly modulates neural activity of the cerebellar cortex. BRAIN STIMULATION[J]. 2023, 第 3 作者  通讯作者  16(3): 918-926, http://dx.doi.org/10.1016/j.brs.2023.05.012.
[3] Zhu, ZiAi, Li, YiYan, Xu, Juan, Xue, Hui, Feng, Xue, Zhu, YongChuan, Xiong, ZhiQi. CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling. CELL REPORTS[J]. 2023, 第 7 作者  通讯作者  42(10): http://dx.doi.org/10.1016/j.celrep.2023.113202.
[4] Zhai RW, Tong GY, Xiong ZQ, Wang Z. Rhesus monkeys exhibiting spontaneous ritualistic behaviors resembling obsessive-compulsive disorder.. National Science Review[J]. 2023, 10(11): 
[5] Min Zhao, Zijing Wang, Hang Su, Haifeng Jiang, ZhiQi Xiong, Wenlei Zhang, Jiahui Zhou, Xiaocheng Zhang, Weichen Song, Chengjie Tang, Kadir Uluda, Rongwei Zhai. Repeated methamphetamine exposure decreases plasma brain-derived neurotrophic factor levels in rhesus monkeys. GENERAL PSYCHIATRY[J]. 2023, 第 5 作者36(5): 410-416, https://doaj.org/article/fef95218a9f24d84909b6df9254b3963.
[6] Zhao, M., Su, H., Zeng, Y, Sun, Y., Guo, X., Li, Y., Wang, C, Zhao, Z., Huang, X., Lin, K., Ye, Z., Lin, B., Hong, S., Zheng, J., Liu, Y., Yao, X., Yang, D., Lu, Y., Chen, H., Zuo, E., Yang, G., Wang, H., Huang, C., Lin, X., Cen, Z., Lai, L., Zhang, Y., Li, X., Lai, T., Lin, L., Zuo, D., Lin, M., Liou, C., Kong, Q., Yan, C., xiong zhiqi, Wang, N., Luo, W., Zhao, C., Cheng, X., Chen, W.. Loss of function of CMPK2 causes mitochondria deficiency and brain calcification.. Cell Discovery[J]. 2022, 第 36 作者8: 128, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9705363/pdf/41421_2022_Article_475.pdf.
[7] Lu, Bin, Lou, SenSen, Xu, RuoShui, Kong, DeLun, Wu, RongJie, Zhang, Jing, Zhuang, Ling, Wu, XueMei, He, JunYan, Wu, ZhiYing, Xiong, ZhiQi. Cerebellar spreading depolarization mediates paroxysmal movement disorder. CELL REPORTS[J]. 2021, 第 11 作者  通讯作者  36(12): http://dx.doi.org/10.1016/j.celrep.2021.109743.
[8] Wang, HongTao, Zhu, ZiAi, Li, YiYan, Lou, SenSen, Yang, Guang, Feng, Xue, Xu, Wei, Huang, ZhiLi, Cheng, Xuewen, Xiong, ZhiQi. CDKL5 deficiency in forebrain glutamatergic neurons results in recurrent spontaneous seizures. EPILEPSIA[J]. 2021, 第 10 作者  通讯作者  62(2): 517-528, http://dx.doi.org/10.1111/epi.16805.
[9] Wang, Fei, Wang, Qianqian, Liu, Baowei, Mei, Lisheng, Ma, Sisi, Wang, Shujuan, Wang, Ruoyu, Zhang, Yan, Niu, Chaoshi, Xiong, Zhiqi, Zheng, Yong, Zhang, Zhi, Shi, Juan, Song, Xiaoyuan. The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum. CELL DEATH AND DIFFERENTIATION[J]. 2021, 第 10 作者28(9): 2634-2650, http://dx.doi.org/10.1038/s41418-021-00774-3.
[10] Liu, Zhen, Li, Kui, Cai, Yijun, Liu, Qiming, Zhang, Tikui, Lu, Yong, Nie, Yanhong, Wang, Yan, Yan, Zhiguang, Qu, Yinwei, Li, Yuzhuo, Wang, Zhanyang, Xiong, ZhiQi, Sun, Qiang. Accelerated passage of gene-modified monkeys by hormone-induced precocious puberty. NATIONAL SCIENCE REVIEW[J]. 2021, 第 13 作者  通讯作者  8(7): 63-66, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7059495&detailType=1.
[11] Xiong Zhiqi. TMEM151A variants cause paroxysmal kinesigenic dyskinesias. Cell Discovery. 2021, 第 1 作者  通讯作者  
[12] Qin, XinYa, Shan, QingHong, Fang, Hui, Wang, Yu, Chen, Peng, Xiong, ZhiQi, Swaab, Dick F, Zhou, JiangNing. PSD-93 up-regulates the synaptic activity of corticotropin-releasing hormone neurons in the paraventricular nucleus in depression. ACTA NEUROPATHOLOGICA[J]. 2021, 第 6 作者142(6): 1045-1064, http://dx.doi.org/10.1007/s00401-021-02371-7.
[13] WanJin Chen, Xuewen Cheng, Ying Fu, Miao Zhao, Jennifer McGinley, Ana Westenberger, ZhiQi Xiong. Rethinking monogenic neurological diseases. THE BMJ. 2020, 第 7 作者371: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542538/.
[14] Chen, WanJin, Cheng, Xuewen, Fu, Ying, Zhao, Miao, McGinley, Jennifer, Westenberger, Ana, Xiong, ZhiQi. Rethinking monogenic neurological diseases. BMJ-BRITISH MEDICAL JOURNAL[J]. 2020, 第 7 作者  通讯作者  371: http://dx.doi.org/10.1136/bmj.m3752.
[15] Liu, Jianan, Pan, Limin, Shang, Chunfeng, Lu, Bin, Wu, Rongjie, Feng, Yun, Chen, Weiyu, Zhang, Rongwei, Bu, Jiwen, Xiong, Zhiqi, Bu, Wenbo, Du, Jiulin, Shi, Jianlin. A highly sensitive and selective nanosensor for near-infrared potassium imaging. SCIENCEADVANCES[J]. 2020, 第 10 作者  通讯作者  6(16): https://www.webofscience.com/wos/woscc/full-record/WOS:000528276800006.
[16] Wang, Tingting, Wang, Jingyu, Wang, Jie, Mao, Lin, Tang, Bin, Vanderklish, Peter W, Liao, Xun, Xiong, ZhiQi, Liao, Lujian. HAP1 is an in vivo UBE3A target that augments autophagy in a mouse model of Angelman syndrome. NEUROBIOLOGY OF DISEASE[J]. 2019, 第 8 作者132: http://dx.doi.org/10.1016/j.nbd.2019.104585.
[17] Lin, Xiang, Su, HuiZhen, Dong, EnLin, Lin, XiaoHong, Zhao, Miao, Yang, Can, Wang, Chong, Wang, Jie, Chen, YiJun, Yu, Hongjie, Xu, Jianfeng, Ma, LiXiang, Xiong, ZhiQi, Wang, Ning, Chen, WanJin. Stop-gain mutations in UBAP1 cause pure autosomal-dominant spastic paraplegia. BRAIN[J]. 2019, 第 13 作者142: 2238-2252, http://dx.doi.org/10.1093/brain/awz158.
[18] Zhu, ZhiChuan, Liu, JiWei, Yang, Can, Li, MingJie, Wu, RongJie, Xiong, ZhiQi. Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells. CELL DEATH & DISEASE[J]. 2019, 第 6 作者  通讯作者  10(2): https://doaj.org/article/b3f1ac402efa455b8edd389c4f5c56d8.
[19] Zhu, ZhiChuan, Liu, JiWei, Yang, Can, Zhao, Miao, Xiong, ZhiQi. XPO1 inhibitor KPT-330 synergizes with Bcl-xL inhibitor to induce cancer cell apoptosis by perturbing rRNA processing and Mcl-1 protein synthesis. CELL DEATH & DISEASE[J]. 2019, 第 5 作者  通讯作者  10(6): http://dx.doi.org/10.1038/s41419-019-1627-9.
[20] Wang, Jie, Lou, SenSen, Wang, Tingting, Wu, RongJie, Li, Guangying, Zhao, Miao, Lu, Bin, Li, YiYan, Zhang, Jing, Cheng, Xuewen, Shen, Ya, Wang, Xing, Zhu, ZhiChuan, Li, MingJie, Takumi, Toru, Yang, Hui, Yu, Xiang, Liao, Lujian, Xiong, ZhiQi. UBE3A-mediated PTPA ubiquitination and degradation regulate PP2A activity and dendritic spine morphology. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 第 19 作者  通讯作者  116(25): 12500-12505, http://dx.doi.org/10.1073/pnas.1820131116.
[21] Zhu, ZhiChuan, Liu, JiWei, Li, Kui, Zheng, Jing, Xiong, ZhiQi. KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells. ONCOGENE[J]. 2018, 第 5 作者  通讯作者  37(22): 2936-2952, http://dx.doi.org/10.1038/s41388-018-0180-9.
[22] Xu, Qiong, Liu, Yuanyuan, Wang, Xiaoming, Tan, Guohe, Li, Huiping, Hulbert, Samuel W, Li, Chunyang, Hu, Chunchun, Xiong, Zhiqi, Xu, Xiu, Jiang, Yonghui. Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons. MOLECULAR AUTISM[J]. 2018, 第 9 作者9(1): https://doaj.org/article/f5e82f90f69d4bb7af33c882d69be995.
[23] Xu, Xingxing, Li, Chuanyin, Gao, Xiaobo, Xia, Kun, Guo, Hui, Li, Yali, Hao, Zijian, Zhang, Lei, Gao, Daming, Xu, Chenfan, Xu, Huatai, Xiong, ZhiQi, Qiu, Zilong, Mei, Ling, Xie, Xiaoduo, Ruan, Kangcheng, Hu, Ronggui. Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders. CELL RESEARCH[J]. 2018, 第 12 作者28(1): 48-68, http://202.127.25.143/handle/331003/3402.
[24] Tan, GuoHe, Liu, YuanYuan, Wang, Lu, Li, Kui, Zhang, ZeQiang, Li, HongFu, Yang, ZhongFei, Li, Yang, Li, Dan, Wu, MingYue, Yu, ChunLei, Long, JuanJuan, Chen, RenChao, Li, LiXi, Yin, LuPing, Liu, JiWei, Cheng, XueWen, Shen, Qi, Shu, YouSheng, Sakimura, Kenji, Liao, LuJian, Wu, ZhiYing, Xiong, ZhiQi. PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum. CELL RESEARCH[J]. 2018, 第 23 作者  通讯作者  28(1): 90-110, http://dx.doi.org/10.1038/cr.2017.128.
[25] Yao, XiangPing, Cheng, Xuewen, Wang, Chong, Zhao, Miao, Guo, XinXin, Su, HuiZhen, Lai, LuLu, Zou, XiaoHuan, Chen, XueJiao, Zhao, Yuying, Dong, EnLin, Lu, YingQian, Wu, Shuang, Li, Xiaojuan, Fan, Gaofeng, Yu, Hongjie, Xu, Jianfeng, Wang, Ning, Xiong, ZhiQi, Chen, WanJin. Biallelic Mutations in MYORG Cause Autosomal Recessive Primary Familial Brain Calcification. NEURON[J]. 2018, 第 19 作者  通讯作者  98(6): 1116-+, http://dx.doi.org/10.1016/j.neuron.2018.05.037.
[26] Yang, Zhi, Li, PengFei, Chen, RenChao, Wang, Jie, Wang, Shaoran, Shen, Ya, Wu, Xiaohui, Fang, Bing, Cheng, Xuewen, Xiong, ZhiQi. ADAM10-Initiated Release of Notch Intracellular Domain Regulates Microtubule Stability and Radial Migration of Cortical Neurons. CEREBRAL CORTEX[J]. 2017, 第 10 作者  通讯作者  27(2): 919-932, http://dx.doi.org/10.1093/cercor/bhx006.
[27] Zuo, Erwei, Cai, YiJun, Li, Kui, Wei, Yu, Wang, BangAn, Sun, Yidi, Liu, Zhen, Liu, Jiwei, Hu, Xinde, Wei, Wei, Huo, Xiaona, Shi, Linyu, Tang, Cheng, Liang, Dan, Wang, Yan, Nie, YanHong, Zhang, ChenChen, Yao, Xuan, Wang, Xing, Zhou, Changyang, Ying, Wenqin, Wang, Qifang, Chen, RenChao, Shen, Qi, Xu, GuoLiang, Li, Jinsong, Sun, Qiang, Xiong, ZhiQi, Yang, Hui. One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs. CELL RESEARCH[J]. 2017, 第 28 作者  通讯作者  27(7): 933-945, http://www.corc.org.cn/handle/1471x/2188612.
[28] Poo, Muming, Du, Jiulin, Ip, Nancy Y, Xiong, ZhiQi, Xu, Bo, Tan, Tieniu. China Brain Project: Basic Neuroscience, Brain Diseases, and Brain-Inspired Computing. NEURON. 2016, 第 4 作者92(3): 591-596, http://dx.doi.org/10.1016/j.neuron.2016.10.050.
[29] Liu, Zhen, Li, Xiao, Zhang, JunTao, Cai, YiJun, Cheng, TianLin, Cheng, Cheng, Wang, Yan, Zhang, ChenChen, Nie, YanHong, Chen, ZhiFang, Bian, WenJie, Zhang, Ling, Xiao, Jianqiu, Lu, Bin, Zhang, YueFang, Zhang, XiaoDi, Sang, Xiao, Wu, JiaJia, Xu, Xiu, Xiong, ZhiQi, Zhang, Feng, Yu, Xiang, Gong, Neng, Zhou, WenHao, Sun, Qiang, Qiu, Zilong. Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2. NATURE[J]. 2016, 第 20 作者530(7588): 98-+, http://dx.doi.org/10.1038/nature16533.
[30] Xiong, Hui, Casse, Frederic, Zhou, Ming, Xiong, ZhiQi, Joels, Marian, Martin, Stephane, Krugers, Harm J. Interactions Between N-Ethylmaleimide- Sensitive Factor and GluA2 Contribute to Effects of Glucocorticoid Hormones on AMPA Receptor Function in the Rodent Hippocampus. HIPPOCAMPUS[J]. 2016, 第 4 作者26(7): 848-856, https://www.webofscience.com/wos/woscc/full-record/WOS:000383272600003.
[31] Li, Yang, Wang, Jie, Zhou, Yang, Li, Dan, Xiong, ZhiQi. Rcan1 Deficiency Impairs Neuronal Migration and Causes Periventricular Heterotopia. JOURNAL OF NEUROSCIENCE[J]. 2015, 第 5 作者  通讯作者  35(2): 610-620, http://ir.sibs.ac.cn/handle/331001/2668.
[32] Miao, Sheng, Chen, Renchao, Ye, Jiahao, Tan, GuoHe, Li, Shuai, Zhang, Jing, Jiang, Yonghui, Xiong, ZhiQi. The Angelman Syndrome Protein Ube3a Is Required for Polarized Dendrite Morphogenesis in Pyramidal Neurons. JOURNAL OF NEUROSCIENCE[J]. 2013, 第 8 作者  通讯作者  33(1): 327-333, http://www.irgrid.ac.cn/handle/1471x/647571.
[33] Li, HongFu, Ni, Wang, Xiong, ZhiQi, Xu, Jianfeng, Wu, ZhiYing. PRRT2 c.649dupC Mutation Derived from De Novo in Paroxysmal Kinesigenic Dyskinesia. CNS NEUROSCIENCE & THERAPEUTICS[J]. 2013, 第 3 作者19(1): 61-65, http://www.irgrid.ac.cn/handle/1471x/647567.
[34] Lu, Tingjia, Chen, Renchao, Cox, Timothy C, Moldrich, Randal X, Kurniawan, Nyoman, Tan, Guohe, Perry, Jo K, Ashworth, Alan, Bartlett, Perry F, Xu, Li, Zhang, Jing, Lu, Bin, Wu, Mingyue, Shen, Qi, Liu, Yuanyuan, Richards, Linda J, Xiong, Zhiqi. X-linked microtubule-associated protein, Mid1, regulates axon development. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2013, 第 17 作者110(47): 19131-19136, http://dx.doi.org/10.1073/pnas.1303687110.
[35] Zhu, YongChuan, Li, Dan, Wang, Lu, Lu, Bin, Zheng, Jing, Zhao, ShiLin, Zeng, Rong, Xiong, ZhiQi. Palmitoylation-dependent CDKL5-PSD-95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2013, 第 8 作者  通讯作者  110(22): 9118-9123, http://www.irgrid.ac.cn/handle/1471x/735010.
[36] Guo, ShunLing, Tan, GuoHe, Li, Shuai, Cheng, XueWen, Zhou, Ya, Jia, YunFang, Xiong, Hui, Tao, Jiong, Xiong, ZhiQi. Serum inducible kinase is a positive regulator of cortical dendrite development and is required for BDNF-promoted dendritic arborization. CELL RESEARCH[J]. 2012, 第 9 作者  通讯作者  22(2): 387-398, http://lib.cqvip.com/Qikan/Article/Detail?id=42510480.
[37] Tan, GuoHe, Liu, YuanYuan, Hu, XiaoLing, Yin, DongMin, Mei, Lin, Xiong, ZhiQi. Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons. NATURE NEUROSCIENCE[J]. 2012, 第 6 作者15(2): 258-266, http://www.irgrid.ac.cn/handle/1471x/502192.
[38] Hu, XiaoLing, Cheng, Xuewen, Fei, Jian, Xiong, ZhiQi. Neuron-restrictive silencer factor is not required for the antiepileptic effect of the ketogenic diet. EPILEPSIA[J]. 2011, 第 4 作者52(9): 1609-1616, http://www.irgrid.ac.cn/handle/1471x/502194.
[39] Xiong Zhiqi. Exome sequencing identifies truncating mutations in PRRT2 that casue paroxysmal kinesigenic dyskinesia. Nature Genetics. 2011, 第 1 作者
[40] Cheng, Xuewen, Li, Yang, Huang, Ying, Feng, Xiaoyan, Feng, Guoping, Xiong, ZhiQi. Pulse labeling and long-term tracing of newborn neurons in the adult subgranular zone. CELL RESEARCH[J]. 2011, 第 6 作者  通讯作者  21(2): 338-349, http://www.irgrid.ac.cn/handle/1471x/502196.
[41] Hu, XiaoLing, Cheng, Xuewen, Cai, Lei, Tan, GuoHe, Xu, Li, Feng, XiaoYan, Lu, TingJia, Xiong, Hui, Fei, Jian, Xiong, ZhiQi. Conditional Deletion of NRSF in Forebrain Neurons Accelerates Epileptogenesis in the Kindling Model. CEREBRAL CORTEX[J]. 2011, 第 10 作者  通讯作者  21(9): 2158-2165, http://www.irgrid.ac.cn/handle/1471x/502195.
[42] Chen, Qian, Zhu, YongChuan, Yu, Jing, Miao, Sheng, Zheng, Jing, Xu, Li, Zhou, Yang, Li, Dan, Zhang, Chi, Tao, Jiong, Xiong, ZhiQi. CDKL5, a Protein Associated with Rett Syndrome, Regulates Neuronal Morphogenesis via Rac1 Signaling. JOURNAL OF NEUROSCIENCE[J]. 2010, 第 11 作者  通讯作者  30(38): 12777-12786, http://www.irgrid.ac.cn/handle/1471x/502197.
[43] Qiu, LiFeng, Lu, TingJia, Hu, XiaoLing, Yi, YongHong, Liao, WeiPing, Xiong, ZhiQi. Limbic Epileptogenesis in a Mouse Model of Fragile X Syndrome. CEREBRAL CORTEX[J]. 2009, 第 6 作者  通讯作者  19(7): 1504-1514, http://dx.doi.org/10.1093/cercor/bhn163.
[44] Zhou, Yang, Lu, TingJia, Xiong, ZhiQi. NGF-dependent retrograde signaling: survival versus death. CELL RESEARCH[J]. 2009, 第 3 作者  通讯作者  19(5): 525-526, http://lib.cqvip.com/Qikan/Article/Detail?id=30274310.
[45] Chen, Min, Chen, Qian, Cheng, XueWen, Lu, TingJia, Liu, HanXing, Jia, JieMin, Zhang, Chi, Xu, Li, Xiong, ZhiQi. Zn2+mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus. JOURNAL OF NEUROCHEMISTRY[J]. 2009, 第 9 作者  通讯作者  111(5): 1094-1103, http://www.irgrid.ac.cn/handle/1471x/502198.
[46] Huang, Yang Z, Pan, Enhui, Xiong, ZhiQi, McNamara, James O. Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy Fiber-CA3 pyramid synapse. NEURON[J]. 2008, 第 3 作者57(4): 546-558, http://dx.doi.org/10.1016/j.neuron.2007.11.026.
[47] Chen, Min, Lu, TingJia, Chen, XiaoJing, Zhou, Yang, Chen, Qian, Feng, XiaoYan, Xu, Li, Duan, WenHu, Xiong, ZhiQi. Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance. STROKE[J]. 2008, 第 9 作者  通讯作者  39(11): 3042-3048, http://ir.simm.ac.cn/handle/153631/1347.
[48] Zheng, Jing, Shen, WanHua, Lu, TingJia, Zhou, Yang, Chen, Qian, Wang, Zi, Xiang, Ting, Zhu, YongChuan, Zhang, Chi, Duan, Shumin, Xiong, ZhiQi. Clathrin-dependent endocytosis is required for TrkB-dependent Akt-mediated neuronal protection and dendritic growth. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2008, 第 11 作者  通讯作者  283(19): 13280-13288, http://dx.doi.org/10.1074/jbc.M709930200.
[49] LiFeng Qiu, YanHong Hao, QingZhang Li, ZhiQi Xiong. Fragile X syndrome and epilepsy. NEUROSCIENCE BULLETIN. 2008, 第 4 作者24(5): 338-344, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552528/.
[50] Chen, Qian, He, Songtao, Hu, XiaoLing, Yu, Jing, Zhou, Yang, Zheng, Jing, Zhang, Shilei, Zhang, Chi, Duan, WenHu, Xiong, ZhiQi. Differential roles of NR2A- and NR2B-containing NMDA receptors in activity-dependent brain-derived neurotrophic factor gene regulation and limbic epileptogenesis. JOURNAL OF NEUROSCIENCE[J]. 2007, 第 10 作者  通讯作者  27(3): 542-552, http://www.irgrid.ac.cn/handle/1471x/502209.
[51] Wu, Hao, Zhou, Yang, Xiong, ZhiQi. Transducer of regulated CREB and late phase long-term synaptic potentiation. FEBS JOURNAL[J]. 2007, 第 3 作者  通讯作者  274(13): 3218-3223, http://www.irgrid.ac.cn/handle/1471x/502208.
[52] Zhou, Yang, Wu, Hao, Li, Shuai, Chen, Qian, Cheng, XueWen, Zheng, Jing, Takemori, Hiroshi, Xiong, ZhiQi. Requirement of TORC1 for Late-Phase Long-Term Potentiation in the Hippocampus. PLOS ONE[J]. 2006, 第 8 作者  通讯作者  1(1): http://www.irgrid.ac.cn/handle/1471x/502210.
[53] Xiong, ZQ, Qian, WH, Suzuki, K, McNamara, JO. Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration. JOURNAL OF NEUROSCIENCE[J]. 2003, 23(3): 955-960, https://www.webofscience.com/wos/woscc/full-record/WOS:000180865400026.
[54] Xiong, ZQ, McNamara, JO. Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack. NEURON[J]. 2002, 36(3): 363-374, http://dx.doi.org/10.1016/S0896-6273(02)00977-7.
[55] Xiong, ZQ, McNamara, JO. Fas(t) balls and Lou Gehrig disease: A clue to selective vulnerability of motor neurons?. NEURON. 2002, 35(6): 1011-1013, http://dx.doi.org/10.1016/S0896-6273(02)00910-8.
[56] Zhi-Qi Xiong, Janet L Stringer. Effects of postsynaptic GABA B receptor activation on epileptiform activity in hippocampal slices. NEUROPHARMACOLOGY. 2001, 第 1 作者40(1): 131-138, http://dx.doi.org/10.1016/S0028-3908(00)00120-9.
[57] Xiong, ZQ, Stringer, JL. Prolonged bursts occur in normal calcium in hippocampal slices after raising excitability and blocking synaptic transmission. JOURNAL OF NEUROPHYSIOLOGY[J]. 2001, 86(5): 2625-2628, https://www.webofscience.com/wos/woscc/full-record/WOS:000172012800045.
[58] Schweitzer, JS, Wang, HW, Xiong, ZQ, Stringer, JL. pH sensitivity of non-synaptic field bursts in the dentate gyrus. JOURNAL OF NEUROPHYSIOLOGY[J]. 2000, 84(2): 927-933, https://www.webofscience.com/wos/woscc/full-record/WOS:000088684700029.
[59] Xiong, ZQ, Stringer, JL. Regulation of extracellular pH in the developing hippocampus. DEVELOPMENTAL BRAIN RESEARCH[J]. 2000, 122(2): 113-117, http://dx.doi.org/10.1016/S0165-3806(00)00057-2.
[60] Xiong, ZQ, Saggau, P, Stringer, JL. Activity-dependent intracellular acidification correlates with the duration of seizure activity. JOURNAL OF NEUROSCIENCE[J]. 2000, 20(4): 1290-1296, https://www.webofscience.com/wos/woscc/full-record/WOS:000085181200002.
[61] Xiong, ZQ, Stringer, FL. Sodium pump activity, not glial spatial buffering, clears potassium after epileptiform activity induced in the dentate gyrus. JOURNAL OF NEUROPHYSIOLOGY[J]. 2000, 83(3): 1443-1451, https://www.webofscience.com/wos/woscc/full-record/WOS:000085951200030.
[62] Xiong, ZQ, Stringer, JL. Extracellular pH responses in CA1 and the dentate gyrus during electrical stimulation, seizure discharges, and spreading depression. JOURNAL OF NEUROPHYSIOLOGY[J]. 2000, 83(6): 3519-3524, https://www.webofscience.com/wos/woscc/full-record/WOS:000087574000028.
[63] Xiong, ZQ, Stringer, JL. Cesium induces spontaneous epileptiform activity without changing extracellular potassium regulation in rat hippocampus. JOURNAL OF NEUROPHYSIOLOGY[J]. 1999, 82(6): 3339-3346, https://www.webofscience.com/wos/woscc/full-record/WOS:000084422100043.
[64] Xiong, ZQ, Stringer, JL. Astrocytic regulation of the recovery of extracellular potassium after seizures in vivo. EUROPEAN JOURNAL OF NEUROSCIENCE[J]. 1999, 11(5): 1677-1684, https://www.webofscience.com/wos/woscc/full-record/WOS:000080175500021.
[65] Xiong, ZQ, Cheng, DH, Tang, XC. Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit. ACTA PHARMACOLOGICA SINICA[J]. 1998, 19(2): 128-132, https://www.webofscience.com/wos/woscc/full-record/WOS:000072465400008.
[66] Xiong, ZQ, Stringer, JL. Effects of felbamate, gabapentin and lamotrigine on seizure parameters and excitability in the rat hippocampus. EPILEPSY RESEARCH[J]. 1997, 27(3): 187-194, http://dx.doi.org/10.1016/S0920-1211(97)00022-3.
[67] Xiong Zhiqi. Effect of –N omega-nitro-L-arginie on working memory of rats in eight-arm maze task. Acta Pharmacologica Sinica. 1995, 第 1 作者
[68] XIONG, ZQ, HAN, YF, TANG, XC. HUPERZINE-A AMELIORATES THE SPATIAL WORKING-MEMORY IMPAIRMENTS INDUCED BY AF64A. NEUROREPORT[J]. 1995, 6(16): 2221-2224, http://www.corc.org.cn/handle/1471x/2373277.
[69] XIONG, ZQ, TANG, XC. EFFECT OF HUPERZINE-A, A NOVEL ACETYLCHOLINESTERASE INHIBITOR, ON RADIAL MAZE PERFORMANCE IN RATS. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR[J]. 1995, 51(2-3): 415-419, http://www.corc.org.cn/handle/1471x/2373279.
[70] XIONG, ZQ, TANG, XC, LIN, JL, ZHU, DY. EFFECTS OF ISOVANIHUPERZINE-A ON CHOLINESTERASE AND SCOPOLAMINE-INDUCED MEMORY IMPAIRMENT. ACTA PHARMACOLOGICA SINICA[J]. 1995, 16(1): 21-25, https://www.webofscience.com/wos/woscc/full-record/WOS:A1995QB49300002.
[71] Yang Zhi, Li Peng-Fei, Chen Ren-Chao, Wang Jie, Wang Shaoran, Shen Ya, Wu Xiaohui, Fang Bing, Cheng Xuewen, Xiong Zhi-Qi. ADAM10-Initiated Release of Notch Intracellular Domain Regulates Microtubule Stability and Radial Migration of Cortical Neurons. CEREBRAL CORTEX (NEW YORK, NY). 第 10 作者27(2): 919-932, https://www.webofscience.com/wos/woscc/full-record/WOS:000397257600004.
[72] Jia Jie-Min, Chen Qian, Zhou Yang, Miao Sheng, Zheng Jing, Zhang Chi, Xiong Zhi-Qi. Brain-derived Neurotrophic Factor-Tropomyosin-related Kinase B Signaling Contributes to Activity-dependent Changes in Synaptic Proteins *. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 第 7 作者283(30): 21242-21250, http://dx.doi.org/10.1074/jbc.M800282200.

   

（ 1 ） 雷特综合症认知功能障碍的分子和神经环路基础, 主持, 国家级, 2014-01--2017-12
（ 2 ） 突触构造的发育与可塑性, 主持, 部委级, 2015-01--2017-07
（ 3 ） 神经元形态发生和功能成熟的分子细胞机制, 参与, 国家级, 2015-01--2019-12
（ 4 ） 大脑皮层和单胺类神经元发育的分子调控网络三期－熊志奇, 参与, 国家级, 2014-01--2016-12
（ 5 ） 囊泡蛋白质机器在神经发育中的作用, 参与, 国家级, 2016-07--2021-06
（ 6 ） 发作性运动障碍分子和环路机制研究, 主持, 部委级, 2016-09--2021-09

（1）Molecular mechanism of intellectual disability   2015-11-07
（2）Synaptic and circuit basis of PKD   2015-09-21
（3）Palmitoylation-dependent CDKL5–PSD95 interaction regulates synaptic targeting of CDKL5 and dendritic spine development   2014-11-15
（4）Synaptic function of CDKL5   2014-06-23
（5）Reelin regulates intramembrane proteolysis signaling to control radial migration of cortical neuron.   2014-05-12
（6）Prrt2-deficiency Impairs Presynaptic Plasticity and Voluntary Movements   2014-04-25

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