General
Dr. Dong-Dong Wu, Principal Investigator.
Dong-Dong Wu obtained his B.S at the Fudan University in 2006, and received his Ph.D from Kunming institute of Zoology, CAS in 2011. He performed studies of artificial selection on domestic animals, particularly high altitude adaptation of domestic animals in Tibet. He has published more than 30 research papers in Nat Genet, Cell Res, Mol Biol Evol, PloS Genet, J Mol Cell Biol, Hum Mol Genet, etc, as first author or co-corresponding author.
Email: wudongdong@mail.kiz.ac.cn
Research Areas
Human and primate nervous system evolution, development and aging genetic mechanism
Animal evolution and medicine
Education
Molecular evolution, genome evolution
Genomic evolution
Computational comparative genomics
Genomic evolution
Computational comparative genomics
Publications
Papers
（1） Rapid Evolution of Genes Involved in Learning and Energy Metabolism for Domestication of the Laboratory Rat., Molecular Biology and Evolution, 2017, corresponding author
（2） Hypoxia potentially promotes Tibetan longevity., Cell Research., 2017, corresponding author
（3） An Evolutionary Genomic Perspective on the Breeding of Dwarf Chickens., Molecular Biology and Evolution, 2017, corresponding author
（4） Out of Southern East Asia of the Brown Rat Revealed by Large-Scale Genome Sequencing., Molecular Biology and Evolution, 2017, corresponding author
（5） Draft genome of the gayal,Bos frontalis., GIGAScience, 2017, corresponding author
（6） Origin of new genes after zygotic genome activation in vertebrate., Journal of Molecular Cell Biology, 2017, corresponding author
（7） The RNA editome of Macaca mulatta and functional characterization of RNA editing in mitochondria., Science Bulletin, 2017, corresponding author
（8） Annotating long intergenic non-coding RNAs under artificial selection during chicken domestication., BMC Evol Biol, 2017, corresponding author
（9） Population variation reveals independent selection towards small body size in Chinese Debao pony., Genome Biology and Evolution, 2016, corresponding author
（10） Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication., Cell Research, 2016, corresponding author
（11） Olfactory genes in Tibetan wild boar, Nature Genetics, 2016, corresponding author
（12） Transcriptome profiles using next generation sequencing reveal liver changes in the early stage of diabetes in tree shrew (Tupaia belangeri chinensis)., Journal of Diabetes Research, 2016, corresponding author
（13） Cellular responses to HSV-1 infection are linked to specific types of alterations in the host transcriptome., Scientific Reports, 2016, corresponding author
（14） Comparative population genomics reveal genetic basis underlying body size of domestic chickens, Journal of Molecular Cell Biology, 2016, corresponding author
（15） A molecular genome scan to identify DNA segments associated with live weight in Japanese quail., Mol Biol Rep, 2016, corresponding author
（16） Genomic Analyses Reveal Potential Independent Adaptation to High Altitude in Tibetan Chickens., Molecular Biology and Evolution, 2015, corresponding author
（17） Recent Positive Selection Drives the Expansion of a Schizophrenia Risk Nonsynonymous Variant at SLC39A8 in Europeans., Schizophrenia Bulletin, 2015, second author
（18） Integrative analysis of young genes, positively selected genes and lncRNAs in the development of Drosophila melanogaster., BMC Evol Biol, 2015, corresponding author
（19） Domestication of the dog from the wolf was promoted by enhanced excitatory synaptic plasticity: a hypothesis., Genome Biol Evol, 2014, corresponding author
（20） Out of pollen hypothesis for origin of new genes in flowering plants: study from Arabidopsis thaliana., Genome Biol Evol, 2014, first author
（21） Molecular evolution in the CREB1 signal pathway and a rare haplotype in CREB1 with genetic predisposition to schizophrenia., J Psychiatr Res., 2014, second author
（22） Population variation revealed high-altitude adaptation of tibetan mastiffs., Molecular Biology and Evolution, 2014, corresponding author
（23） Artificial Selection on Brain-Expressed Genes during the Domestication of Dog., Molecular Biology and Evolution, 2013, corresponding author
（24） Evidence of recent natural selection on the Southeast Asian deletion (--(SEA)) causing α-thalassemia in South China., BMC Evolutionary Biology , 2013, second author
（25） Evolution and function of de novo originated genes, Molecular Phylogenetics and Evolution, 2013, first author
（26） Rapid Evolution of the Mammalian HILS1 Gene and the Nuclear Condensation Process during Mammalian Spermiogenesis, Journal of Genetics and Genomics , 2013, corresponding author
（27） Positive selection on the osteoarthritis-risk and decreased-height associated variants at the GDF5 gene in East Asians, PLoS one, 2012, first author
（28） Positive selection on the gene RNASEL: correlation between patterns of evolution and function., Molecular Biology and Evolution , 2012, corresponding author
（29） The origin and evolution of variable number tandem repeat of CLEC4M gene in the global human population., PLoS one , 2012, third author
（30） De novo origin of human protein-coding genes, PLoS Genetics, 2011, first author
（31） Multi-locus analysis reveals a different pattern of genetic diversity for mitochondrial and nuclear DNA between wild and domestic pigs in East Asia, PLoS one , 2011, second author
（32） Eukaryotic origin of a metabolic pathway in virus by horizontal gene transfer, Genomics, 2011, first author
（33） Correlated evolution among six gene families in Drosophila revealed by parallel change of gene numbers., Genome Biology and Evolution, 2011, first author
（34） Different level of population differentiation among human genes, BMC Evolutionary Biology , 2011, first author
（35） Evidence for positive selection on the Osteogenin (BMP3) gene in human populations., PLoS one, 2010, first author
（36） Positive selection drives population differentiation in the skeletal genes in modern humans, Human Molecular Genetics, 2010, first author
（37） Association of disease-predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations., Journal of Pineal Research, 2010, third author
（38） A profound role for the expansion of trypsin-like serine protease family in the evolution of hematophagy in mosquito., Molecular Biology and Evolution, 2009, first author
（39） Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair. , BMC Evolutionary Biology , 2008, first author
（40） Intriguing balancing selection on the intron 5 region of LMBR1 in human population., PLoS one , 2008, second author
（41） Positive Darwinian selection in human population: a review, Chinese Science Bulletin, 2008, first author
（2） Hypoxia potentially promotes Tibetan longevity., Cell Research., 2017, corresponding author
（3） An Evolutionary Genomic Perspective on the Breeding of Dwarf Chickens., Molecular Biology and Evolution, 2017, corresponding author
（4） Out of Southern East Asia of the Brown Rat Revealed by Large-Scale Genome Sequencing., Molecular Biology and Evolution, 2017, corresponding author
（5） Draft genome of the gayal,Bos frontalis., GIGAScience, 2017, corresponding author
（6） Origin of new genes after zygotic genome activation in vertebrate., Journal of Molecular Cell Biology, 2017, corresponding author
（7） The RNA editome of Macaca mulatta and functional characterization of RNA editing in mitochondria., Science Bulletin, 2017, corresponding author
（8） Annotating long intergenic non-coding RNAs under artificial selection during chicken domestication., BMC Evol Biol, 2017, corresponding author
（9） Population variation reveals independent selection towards small body size in Chinese Debao pony., Genome Biology and Evolution, 2016, corresponding author
（10） Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication., Cell Research, 2016, corresponding author
（11） Olfactory genes in Tibetan wild boar, Nature Genetics, 2016, corresponding author
（12） Transcriptome profiles using next generation sequencing reveal liver changes in the early stage of diabetes in tree shrew (Tupaia belangeri chinensis)., Journal of Diabetes Research, 2016, corresponding author
（13） Cellular responses to HSV-1 infection are linked to specific types of alterations in the host transcriptome., Scientific Reports, 2016, corresponding author
（14） Comparative population genomics reveal genetic basis underlying body size of domestic chickens, Journal of Molecular Cell Biology, 2016, corresponding author
（15） A molecular genome scan to identify DNA segments associated with live weight in Japanese quail., Mol Biol Rep, 2016, corresponding author
（16） Genomic Analyses Reveal Potential Independent Adaptation to High Altitude in Tibetan Chickens., Molecular Biology and Evolution, 2015, corresponding author
（17） Recent Positive Selection Drives the Expansion of a Schizophrenia Risk Nonsynonymous Variant at SLC39A8 in Europeans., Schizophrenia Bulletin, 2015, second author
（18） Integrative analysis of young genes, positively selected genes and lncRNAs in the development of Drosophila melanogaster., BMC Evol Biol, 2015, corresponding author
（19） Domestication of the dog from the wolf was promoted by enhanced excitatory synaptic plasticity: a hypothesis., Genome Biol Evol, 2014, corresponding author
（20） Out of pollen hypothesis for origin of new genes in flowering plants: study from Arabidopsis thaliana., Genome Biol Evol, 2014, first author
（21） Molecular evolution in the CREB1 signal pathway and a rare haplotype in CREB1 with genetic predisposition to schizophrenia., J Psychiatr Res., 2014, second author
（22） Population variation revealed high-altitude adaptation of tibetan mastiffs., Molecular Biology and Evolution, 2014, corresponding author
（23） Artificial Selection on Brain-Expressed Genes during the Domestication of Dog., Molecular Biology and Evolution, 2013, corresponding author
（24） Evidence of recent natural selection on the Southeast Asian deletion (--(SEA)) causing α-thalassemia in South China., BMC Evolutionary Biology , 2013, second author
（25） Evolution and function of de novo originated genes, Molecular Phylogenetics and Evolution, 2013, first author
（26） Rapid Evolution of the Mammalian HILS1 Gene and the Nuclear Condensation Process during Mammalian Spermiogenesis, Journal of Genetics and Genomics , 2013, corresponding author
（27） Positive selection on the osteoarthritis-risk and decreased-height associated variants at the GDF5 gene in East Asians, PLoS one, 2012, first author
（28） Positive selection on the gene RNASEL: correlation between patterns of evolution and function., Molecular Biology and Evolution , 2012, corresponding author
（29） The origin and evolution of variable number tandem repeat of CLEC4M gene in the global human population., PLoS one , 2012, third author
（30） De novo origin of human protein-coding genes, PLoS Genetics, 2011, first author
（31） Multi-locus analysis reveals a different pattern of genetic diversity for mitochondrial and nuclear DNA between wild and domestic pigs in East Asia, PLoS one , 2011, second author
（32） Eukaryotic origin of a metabolic pathway in virus by horizontal gene transfer, Genomics, 2011, first author
（33） Correlated evolution among six gene families in Drosophila revealed by parallel change of gene numbers., Genome Biology and Evolution, 2011, first author
（34） Different level of population differentiation among human genes, BMC Evolutionary Biology , 2011, first author
（35） Evidence for positive selection on the Osteogenin (BMP3) gene in human populations., PLoS one, 2010, first author
（36） Positive selection drives population differentiation in the skeletal genes in modern humans, Human Molecular Genetics, 2010, first author
（37） Association of disease-predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations., Journal of Pineal Research, 2010, third author
（38） A profound role for the expansion of trypsin-like serine protease family in the evolution of hematophagy in mosquito., Molecular Biology and Evolution, 2009, first author
（39） Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair. , BMC Evolutionary Biology , 2008, first author
（40） Intriguing balancing selection on the intron 5 region of LMBR1 in human population., PLoS one , 2008, second author
（41） Positive Darwinian selection in human population: a review, Chinese Science Bulletin, 2008, first author
Students
已指导学生
王明山 博士研究生 071007-遗传学
现指导学生
任小蝶 硕士研究生 071007-遗传学
李明莉 博士研究生 071007-遗传学