Synthetic biology, Metabolic engineering, Enzyme engineering

2015-09--2019-06, PhD, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

   

2022-07 to present, Associate Researcher, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

 

2019-07~2022-06, Postdoctoral Fellow, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

   

（1） Reprogramming the sulfur recycling network to improve L-cysteine production in Corynebacterium glutamicum, Green Chemistry, 2023, 
（2） Developing a PAM-Flexible CRISPR-Mediated Dual-Deaminase Base Editor to Regulate Extracellular Electron Transport in Shewanella oneidensis, ACS SYNTHETIC BIOLOGY, 2023, 
（3） Transcription factor OxyR regulates sulfane sulfur removal and L-cysteine biosynthesis in Corynebacterium glutamicum, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2023, 
（4） Balancing Redox Homeostasis to Improve l-Cysteine Production in Corynebacterium glutamicum, Journal Of Agricultural And Food Chemistry, 2023, 
（5） DRAGON: Harnessing the power of DNA repair for accelerating genome evolution in Corynebacterium glutamicum, METABOLIC ENGINEERING, 2023, 
（6） 谷氨酸棒杆菌人工核糖体结合位点（RBS）文库的建立与应用, 食品与发酵工业, 2023, 第 5 作者
（7） 双酶偶联法测定发酵液中L-高丝氨酸的含量, Determination of L-homoserine concentration in fermentation broth using double-enzyme coupling method, 食品与发酵工业, 2023, 第 2 作者
（8） Engineering of Corynebacterium glutamicum for high-level γ-aminobutyric acid production from glycerol by dynamic metabolic control, Metabolic Engineering, 2022, 
（9） Design of a genetically encoded biosensor to establish a high-throughput screening platform for L-cysteine overproduction, METABOLIC ENGINEERING, 2022, 
（10） Engineering of L-glutamate oxidase as the whole-cell biocatalyst for the improvement of α-ketoglutarate production, ENZYME AND MICROBIAL TECHNOLOGY, 2020, 
（11） 天津工业生物所在代谢工程改造大肠杆菌生产甲硫氨酸前体O-乙酰高丝氨酸方面取得新进展, 高科技与产业化, 2019, 第 1 作者
（12） Combining Protein and Metabolic Engineering Strategies for High-Level Production of O-Acetylhomoserine in Escherichia coli, ACS SYNTHETIC BIOLOGY, 2019, 
（13） Recent advances in the applications of promoter engineering for the optimization of metabolite biosynthesis, WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2019, 
（14） Metabolic engineering of Corynebacterium glutamicum for l-cysteine production, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2019, 
（15） Promoter library-based module combination (PLMC) technology for optimization of threonine biosynthesis in Corynebacterium glutamicum, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2018, 
（16） Biotechnological advances and perspectives of gamma-aminobutyric acid production, WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2017, 
（17） Engineering Scheffersomyces stipitis for fumaric acid production from xylose, BIORESOURCE TECHNOLOGY, 2015, 

（ 1 ） 基于动态调控硫回收利用的L-半胱氨酸工程菌的构建方法与应用, 发明专利, 2023, 第 3 作者, 专利号: CN115651882B

（ 2 ） 一种L-半胱氨酸生物传感器及其应用, 发明专利, 2022, 第 3 作者, 专利号: CN113980992A

（ 3 ） 高丝氨酸乙酰转移酶突变体及其在生产O-乙酰高丝氨酸中的应用, 专利授权, 2021, 第 2 作者, 专利号: CN112501144A

（ 4 ） 一种高丝氨酸生物传感器及其构建方法和应用, 专利授权, 2021, 第 2 作者, 专利号: CN112375771A

（ 5 ） 一种代谢工程改造谷氨酸棒杆菌高产L-半胱氨酸的方法, 发明专利, 2020, 第 2 作者, 专利号: CN111040979A

（ 6 ） 一种谷氨酸棒杆菌人工启动子文库, 发明专利, 2019, 第 2 作者, 专利号: CN110317807A