基本信息
魏亮 男 硕导 中国科学院天津工业生物技术研究所
电子邮件： weil@tib.cas.cn
通信地址： 天津市空港经济区西七道32号
邮政编码：300308
研究领域
合成生物学，代谢工程，酶工程
招生信息
招生专业
071005-微生物学
071010-生物化学与分子生物学
0710J5-食品安全与健康
071010-生物化学与分子生物学
0710J5-食品安全与健康
招生方向
代谢工程、合成生物学、酶工程
教育背景
2015-09--2019-06 中国科学院天津工业生物技术研究所 博士研究生
工作经历
工作简历
2022-07~现在, 中国科学院天津工业生物技术研究所, 副研究员
2019-07~2022-06,中国科学院天津工业生物技术研究所, 博士后
2019-07~2022-06,中国科学院天津工业生物技术研究所, 博士后
专利与奖励
奖励信息
（1） 中国科学院院长奖, , 部委级, 2019
专利成果
（ 1 ） 基于动态调控硫回收利用的L-半胱氨酸工程菌的构建方法与应用, 发明专利, 2023, 第 3 作者, 专利号: CN115651882B
（ 2 ） 一种L-半胱氨酸生物传感器及其应用, 发明专利, 2022, 第 3 作者, 专利号: CN113980992A
（ 3 ） 高丝氨酸乙酰转移酶突变体及其在生产O-乙酰高丝氨酸中的应用, 专利授权, 2021, 第 2 作者, 专利号: CN112501144A
（ 4 ） 一种高丝氨酸生物传感器及其构建方法和应用, 专利授权, 2021, 第 2 作者, 专利号: CN112375771A
（ 5 ） 一种代谢工程改造谷氨酸棒杆菌高产L-半胱氨酸的方法, 发明专利, 2020, 第 2 作者, 专利号: CN111040979A
（ 6 ） 一种谷氨酸棒杆菌人工启动子文库, 发明专利, 2019, 第 2 作者, 专利号: CN110317807A
（ 2 ） 一种L-半胱氨酸生物传感器及其应用, 发明专利, 2022, 第 3 作者, 专利号: CN113980992A
（ 3 ） 高丝氨酸乙酰转移酶突变体及其在生产O-乙酰高丝氨酸中的应用, 专利授权, 2021, 第 2 作者, 专利号: CN112501144A
（ 4 ） 一种高丝氨酸生物传感器及其构建方法和应用, 专利授权, 2021, 第 2 作者, 专利号: CN112375771A
（ 5 ） 一种代谢工程改造谷氨酸棒杆菌高产L-半胱氨酸的方法, 发明专利, 2020, 第 2 作者, 专利号: CN111040979A
（ 6 ） 一种谷氨酸棒杆菌人工启动子文库, 发明专利, 2019, 第 2 作者, 专利号: CN110317807A
出版信息
发表论文
[1] Huanmin Du, Qiao, Jinfang, Yuting Qi, Lingcong Li, Ning Xu, Li Shao, Liang Wei, Jun Liu. Reprogramming the sulfur recycling network to improve L-cysteine production in Corynebacterium glutamicum. Green Chemistry[J]. 2023, 25: 3152-3165,
[2] Wang, Tailin, Zhang, Jiwei, Wei, Liang, Zhao, Dongdong, Bi, Changhao, Xu, Ning, Liu, Jun. Developing a PAM-Flexible CRISPR-Mediated Dual-Deaminase Base Editor to Regulate Extracellular Electron Transport in Shewanella oneidensis. ACS SYNTHETIC BIOLOGY[J]. 2023, https://pubs.acs.org/doi/10.1021/acssynbio.3c00045.
[3] Huanmin Du, Yuting Qi, Jinfang Qiao, Lingcong Li, Liang Wei, Ning Xu, Li Shao, Jun Liu, Haruyuki Atomi. Transcription factor OxyR regulates sulfane sulfur removal and L-cysteine biosynthesis in Corynebacterium glutamicum. APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2023, 89(9): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537588/.
[4] Huanmin Du, Yuting Qi, Qiao, Jinfang, Lingcong Li, Ning Xu, Li Shao, Liang Wei, Jun Liu. Balancing Redox Homeostasis to Improve l-Cysteine Production in Corynebacterium glutamicum. Journal Of Agricultural And Food Chemistry[J]. 2023, 71(37): 13848-13856,
[5] Ju, Yun, Zhang, Hongyu, Du, Xiaocong, Wei, Jingxuan, Liu, Jun, Wei, Liang, Liu, Qingdai, Xu, Ning. DRAGON: Harnessing the power of DNA repair for accelerating genome evolution in Corynebacterium glutamicum. METABOLIC ENGINEERING[J]. 2023, 79: 182-191, http://dx.doi.org/10.1016/j.ymben.2023.08.002.
[6] 张悦, 张继伟, 徐宁, 刘君, 魏亮, 吴硕. 谷氨酸棒杆菌人工核糖体结合位点（RBS）文库的建立与应用. 食品与发酵工业[J]. 2023, 第 5 作者49(23): 25-32, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7618380&detailType=1.
[7] 赵金花, 魏亮, 徐宁, 马振平, 刘君. 双酶偶联法测定发酵液中L-高丝氨酸的含量. 食品与发酵工业[J]. 2023, 第 2 作者49(2): 239-245, http://lib.cqvip.com/Qikan/Article/Detail?id=7108775635.
[8] Liang Wei, Jinhua Zhao, Yiran Wang, Jinshan Gao, Muhua Du, Yue Zhang, Ning Xu, Huanmin Du, Jiansong Ju, Qingdai Liu, Jun Liu. Engineering of Corynebacterium glutamicum for high-level γ-aminobutyric acid production from glycerol by dynamic metabolic control. Metabolic Engineering[J]. 2022, 69: 134-146,
[9] Gao, Jinshan, Du, Muhua, Zhao, Jinhua, Zhao, Jinhua, Xu, Ning, Du, Huanmin, Ju, Jiansong, Wei, Liang, Liu, Jun. Design of a genetically encoded biosensor to establish a high-throughput screening platform for L-cysteine overproduction. METABOLIC ENGINEERING[J]. 2022, 73: 144-157, http://dx.doi.org/10.1016/j.ymben.2022.07.007.
[10] Xue Zhang, Ning Xu, Jialong Li, Zhenping Ma, Liang Wei, Qingdai Liu, Jun Liu. Engineering of L-glutamate oxidase as the whole-cell biocatalyst for the improvement of α-ketoglutarate production. ENZYME AND MICROBIAL TECHNOLOGY. 2020, 136: http://dx.doi.org/10.1016/j.enzmictec.2020.109530.
[11] 魏亮, 刘君, 江会锋. 天津工业生物所在代谢工程改造大肠杆菌生产甲硫氨酸前体O-乙酰高丝氨酸方面取得新进展. 高科技与产业化[J]. 2019, 第 1 作者79-79, http://lib.cqvip.com/Qikan/Article/Detail?id=7002532700.
[12] Wei, Liang, Wang, Qian, Xu, Ning, Cheng, Jian, Zhou, Wei, Han, Guoqiang, Jiang, Huifeng, Liu, Jun, Ma, Yanhe. Combining Protein and Metabolic Engineering Strategies for High-Level Production of O-Acetylhomoserine in Escherichia coli. ACS SYNTHETIC BIOLOGY[J]. 2019, 8(5): 1153-1167,
[13] Xu, Ning, Wei, Liang, Liu, Jun. Recent advances in the applications of promoter engineering for the optimization of metabolite biosynthesis. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY. 2019, 35(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000457399800002.
[14] Wei, Liang, Wang, Hao, Xu, Ning, Zhou, Wei, Ju, Jiansong, Liu, Jun, Ma, Yanhe. Metabolic engineering of Corynebacterium glutamicum for l-cysteine production. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2019, 103(3): 1325-1338, http://dx.doi.org/10.1007/s00253-018-9547-7.
[15] Wei, Liang, Xu, Ning, Wang, Yiran, Zhou, Wei, Han, Guoqiang, Ma, Yanhe, Liu, Jun. Promoter library-based module combination (PLMC) technology for optimization of threonine biosynthesis in Corynebacterium glutamicum. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2018, 102(9): 4117-4130, https://www.webofscience.com/wos/woscc/full-record/WOS:000429800600021.
[16] Xu, Ning, Wei, Liang, Liu, Jun. Biotechnological advances and perspectives of gamma-aminobutyric acid production. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY. 2017, 33(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000398100300023.
[17] Wei, Liang, Liu, Jiao, Qi, Haishan, Wen, Jianping. Engineering Scheffersomyces stipitis for fumaric acid production from xylose. BIORESOURCE TECHNOLOGY[J]. 2015, 187: 246-254, http://dx.doi.org/10.1016/j.biortech.2015.03.122.
[2] Wang, Tailin, Zhang, Jiwei, Wei, Liang, Zhao, Dongdong, Bi, Changhao, Xu, Ning, Liu, Jun. Developing a PAM-Flexible CRISPR-Mediated Dual-Deaminase Base Editor to Regulate Extracellular Electron Transport in Shewanella oneidensis. ACS SYNTHETIC BIOLOGY[J]. 2023, https://pubs.acs.org/doi/10.1021/acssynbio.3c00045.
[3] Huanmin Du, Yuting Qi, Jinfang Qiao, Lingcong Li, Liang Wei, Ning Xu, Li Shao, Jun Liu, Haruyuki Atomi. Transcription factor OxyR regulates sulfane sulfur removal and L-cysteine biosynthesis in Corynebacterium glutamicum. APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2023, 89(9): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10537588/.
[4] Huanmin Du, Yuting Qi, Qiao, Jinfang, Lingcong Li, Ning Xu, Li Shao, Liang Wei, Jun Liu. Balancing Redox Homeostasis to Improve l-Cysteine Production in Corynebacterium glutamicum. Journal Of Agricultural And Food Chemistry[J]. 2023, 71(37): 13848-13856,
[5] Ju, Yun, Zhang, Hongyu, Du, Xiaocong, Wei, Jingxuan, Liu, Jun, Wei, Liang, Liu, Qingdai, Xu, Ning. DRAGON: Harnessing the power of DNA repair for accelerating genome evolution in Corynebacterium glutamicum. METABOLIC ENGINEERING[J]. 2023, 79: 182-191, http://dx.doi.org/10.1016/j.ymben.2023.08.002.
[6] 张悦, 张继伟, 徐宁, 刘君, 魏亮, 吴硕. 谷氨酸棒杆菌人工核糖体结合位点（RBS）文库的建立与应用. 食品与发酵工业[J]. 2023, 第 5 作者49(23): 25-32, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7618380&detailType=1.
[7] 赵金花, 魏亮, 徐宁, 马振平, 刘君. 双酶偶联法测定发酵液中L-高丝氨酸的含量. 食品与发酵工业[J]. 2023, 第 2 作者49(2): 239-245, http://lib.cqvip.com/Qikan/Article/Detail?id=7108775635.
[8] Liang Wei, Jinhua Zhao, Yiran Wang, Jinshan Gao, Muhua Du, Yue Zhang, Ning Xu, Huanmin Du, Jiansong Ju, Qingdai Liu, Jun Liu. Engineering of Corynebacterium glutamicum for high-level γ-aminobutyric acid production from glycerol by dynamic metabolic control. Metabolic Engineering[J]. 2022, 69: 134-146,
[9] Gao, Jinshan, Du, Muhua, Zhao, Jinhua, Zhao, Jinhua, Xu, Ning, Du, Huanmin, Ju, Jiansong, Wei, Liang, Liu, Jun. Design of a genetically encoded biosensor to establish a high-throughput screening platform for L-cysteine overproduction. METABOLIC ENGINEERING[J]. 2022, 73: 144-157, http://dx.doi.org/10.1016/j.ymben.2022.07.007.
[10] Xue Zhang, Ning Xu, Jialong Li, Zhenping Ma, Liang Wei, Qingdai Liu, Jun Liu. Engineering of L-glutamate oxidase as the whole-cell biocatalyst for the improvement of α-ketoglutarate production. ENZYME AND MICROBIAL TECHNOLOGY. 2020, 136: http://dx.doi.org/10.1016/j.enzmictec.2020.109530.
[11] 魏亮, 刘君, 江会锋. 天津工业生物所在代谢工程改造大肠杆菌生产甲硫氨酸前体O-乙酰高丝氨酸方面取得新进展. 高科技与产业化[J]. 2019, 第 1 作者79-79, http://lib.cqvip.com/Qikan/Article/Detail?id=7002532700.
[12] Wei, Liang, Wang, Qian, Xu, Ning, Cheng, Jian, Zhou, Wei, Han, Guoqiang, Jiang, Huifeng, Liu, Jun, Ma, Yanhe. Combining Protein and Metabolic Engineering Strategies for High-Level Production of O-Acetylhomoserine in Escherichia coli. ACS SYNTHETIC BIOLOGY[J]. 2019, 8(5): 1153-1167,
[13] Xu, Ning, Wei, Liang, Liu, Jun. Recent advances in the applications of promoter engineering for the optimization of metabolite biosynthesis. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY. 2019, 35(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000457399800002.
[14] Wei, Liang, Wang, Hao, Xu, Ning, Zhou, Wei, Ju, Jiansong, Liu, Jun, Ma, Yanhe. Metabolic engineering of Corynebacterium glutamicum for l-cysteine production. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2019, 103(3): 1325-1338, http://dx.doi.org/10.1007/s00253-018-9547-7.
[15] Wei, Liang, Xu, Ning, Wang, Yiran, Zhou, Wei, Han, Guoqiang, Ma, Yanhe, Liu, Jun. Promoter library-based module combination (PLMC) technology for optimization of threonine biosynthesis in Corynebacterium glutamicum. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2018, 102(9): 4117-4130, https://www.webofscience.com/wos/woscc/full-record/WOS:000429800600021.
[16] Xu, Ning, Wei, Liang, Liu, Jun. Biotechnological advances and perspectives of gamma-aminobutyric acid production. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY. 2017, 33(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000398100300023.
[17] Wei, Liang, Liu, Jiao, Qi, Haishan, Wen, Jianping. Engineering Scheffersomyces stipitis for fumaric acid production from xylose. BIORESOURCE TECHNOLOGY[J]. 2015, 187: 246-254, http://dx.doi.org/10.1016/j.biortech.2015.03.122.
科研活动
科研项目
（ 1 ） 谷氨酸棒杆菌高产L-甲硫氨酸的机制解析与动态调控研究, 负责人, 国家任务, 2021-01--2023-12