Dr. Tan’s  research interest is mainly focused on developing mass spectrometry-based chemical proteomics technologies to characterize protein post-translational modifications (PTMs), investigate the roles of PTMs in diseases, and identify new therapeutic opportunities and biomarkers.  

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09/1999-06/2003,  B.Sc. degree in Pharmacy, Fudan University
09/2003-07/2008,  Ph.D. degree in Medicinal Chemistry, Shanghai Institute of MateriaMedica, Chinese Academy of Sciences

1.  Du W, Xu J,* Li Y, Zhang M, Huang Y, Zhao S, Zhou Y, hao L, Xu K, Zhai L, Zhao W, Liu J, Ni J, Dai J, Liu T, Hong J, Jiang H, Zhao S, Zhang J, Zhou L, Wang J, Yin B, Liu R, Li J,* Ye B,* Tan M.* (2026) Gut microbiota-derived lysine phenylacetylation impairs mitochondrial function and is alleviated by SIRT3 Cell Metab in press

2.  Fan R, Ni J, Zhou T, Jiang H, Zhao W*, Tan M.* (2026) Proteomics-Driven Strategies for Proximity-Inducing Drug Discovery. Angew Chem Int Ed DOI: 10.1002/anie.3307512

3.  Wang Z, Jin M, Zhai L, Huang B, Jin X, Wang X, Boudemia AE, Yang X, Wei Z, He Y, Yang J, Li Y, Ding X, Li R, Zhou X, Zheng W, Ouyang Y, Wang Q, Song Y, Zeng Z, Li Y, Lu L, Liu J, Li Y, Li L, Li K, Chen CL, Lou Z, Tan M*, Wu J*, Chen Y*, Yuan J*. (2026) RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer. Mol Cell 86:585-603.

4.  Zhao W, Zhao L, Lian Y, Liu Z, Li Y, Wang X, Zhang M, Li N, Guo J, Shen D, Mo S, Li J, Zhai L, Ni J, Lee S, Liu B, Li J, Wang F, Peng J*, Qin J*, Tan M*. Proteogenomic Characterization Reveals Metabolic Vulnerabilities and Aberrant Phosphorylation in Colorectal Metastasis to Liver. Adv Sci 2026; 13(4):e11744.

5.  Xu Y, Zhao W, Fu J, Liu Z, Nie HJ, Zhang J, Guo J, Tan M*, Chen XH*. (2026) Multiplexed Photo-Cross-Linking Reveals Comprehensive Midnolin Interactome: Insights into Ubiquitin-Independent Degradation and Functional Diversity. J Am Chem Soc 148:11962-11973.

6. Zhang Y, Lan Y, Fan R, Feng L, Wang G, Wu X, Wen L, Duan Z, Xia Y, Wang X, Zhang L, Zhou L*, Tan M*, Liao C*, Lu X*. (2025) Biocatalytic- and Chemoproteomic-Guided Discovery of a PHGDH Inhibitor from Chemoenzymatic-Promoted DNA-Encoded Libraries Selection Platform. J Am Chem Soc 147:44396-44405.

7. Wu X, Pan J, Fan R, Zhang Y, Wang C, Wang G, Liu J, Cui M, Yue J, Jin R, Duan Z, Zheng M, Mei L, Zhou L, Tan M*, Ai J*, Lu X*. (2025) Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads. J Am Chem Soc 147:15469-15481.

8. Xu Y, Hu H, Ran Y, Zhao W, Guo AD, Nie HJ, Zhai L, Yin GL, Cheng J, Tao S, Yang B*, Tan M*, Chen XH*. (2025) Visible-Light-Controlled Lysine-Selective Crosslinking Decodes Protein Complexes and Dynamic Interactomes in Live Cells. Angew Chem Int Ed 64,2025:e202507254.

9. Xu Y, Zhao W, Nie HJ, Wang J, Fu J, Hu H, Liu Z, Tao S, Zhang M, Zhou Y, Li J*, Tan M*, Chen XH*. (2025) Cross-Linking Profiling of Molecular Glue Degrader-Induced E3 Ligase Interactome to Expand Target Space. Angew Chem Int Ed 64:e202505053.

10. Dong B, Xu JY*, Huang Y, Guo J, Dong Q, Wang Y, Li N, Liu Q, Zhang M, Pan Q, Wang H, Jiang J, Chen B, Shen D, Ma Y, Zhai L, Zhang J, Li J*, Xue W*, Tan M*, Qin J*. (2024) Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers. Nat Cancer 5:1427-1447

11. Lu Y, Xu J, Li Y, Wang R, Dai C, Zhang B, Zhang X, Xu L, Tao Y, Han M, Guo R,Wu Q, Wu L*, Meng Z*, Tan M*, Li J*. (2024) DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser56 to diminish pancreatic β cell function upon overnutrition. Sci Transl Med 16:eade8647

12. Hu H, Hu W, Guo AD, Zhai L, Ma S, Nie HJ, Zhou BS, Liu T, Jia X, Liu X, Yao X, Tan M*, Chen XH*. (2024) Spatiotemporal and direct capturing global substrates of lysine-modifying enzymes in living cells. Nat Commun 15:1465.

13. Guo A, Yan K, Hu, H, Zhai L, Hu T, Su,H, Chi Y, Zha,J, Xu Y, Zhao,Y Lu X, Xu Y, Zhang J, Tan M*, Chen X*. (2023) Spatiotemporal and global profiling of DNA-protein interactions enables discovery of low-affinity transcription factors. Nat Chem 15:803-814.

14. Jiang L, Liu S, Jia X, Gong Q, Wen X, Lu W, Yang J, Wu X, Wang X, Suo Y, Li Y, Uesugi M, Qu ZB, Tan M,* Lu X,* Zhou L*. (2023) ABPP-CoDEL: Activity-Based Proteome Profiling-Guided Discovery of Tyrosine-Targeting Covalent Inhibitors from DNA- Encoded Libraries. J Am Chem Soc 145, 46, 25283–25292.

15. Zhou Q, Hao B, Cao X, Gao L, Yu Z, Zhao Y, Zhu M, Zhong G, Chi F, Dai X, Mao J, Zhu Y, Rong P, Chen L, Bai X, Ye C, Chen S, Liang T, Li L, Feng XH*, Tan M*, Zhao B*. (2022) Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha. Mol Cell 82:4700-4711.

16. Li Y, Xu J, Lu Y, Bian H, Yang L, Wu H, Zhang X, Zhang B, Xiong M, Chang Y, Tang J, Yang F, Zhao L, Li J, Gao X, Xia M*, Tan M*, Li J*. (2021) DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing. Cell Metab 33: 2004-2020.

17. Liu Z, Liu Y, Qian L, Jiang S, Gai X, Ye S, Chen Y, Wang X, Zhai L, Xu J, Pu C, Li J, He F, Huang M*, and Tan M*.  (2021) A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies. Mol Cell 81: 4076-4090.

18. Xu J, Zhang C, Wang X, Zhai L, Ma Y, Mao Y, Qian K, Sun CQ Liu ZW Jiang SW, Wang M, Feng L, Zhao L, Liu P, Wang B, Zhao X, Xie H, Yang XY Zhao L, Chang Y, Jia J, Wang X, Zhang Y, Wang Y, Yang Y, Wu Z, Yang L, Liu B, Zhao T, Ren S, Sun A, Zhao Y, Ying W, Wang F, Wang G, Zhang Y, Cheng S, Qin J, Qian X, Wang Y*, Li J*, He F*, Xiao T*, Tan M*. (2020) Integrative proteomic characterization of human lung adenocarcinoma. Cell 182:245-261.

19. Huang X, Yan J, Zhang M, Wang Y, Chen Y, Fu X, Wei R, Zheng XL, Liu Z, Zhang X, Yang H, Hao B, Shen YY, Su Y, Cong X, Huang M, Tan M*, Ding J*, Geng M*. (2018) Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors. Cell 175(1):186-199.

20. Liu B, Jiang S, Li M, Xiong X, Zhu M, Li D, Zhao L, Qian L, Zhai L, Li J, Lu H, Sun S, Lin J, Lu Y *, Li X*, Tan M*. (2018) Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN. Nat Commun 9: 4770.