基于质谱技术的蛋白质组学和蛋白质翻译后修饰研究、生物标志物和个性化药物机理研究。

   

100706-药理学
070302-分析化学
071010-生物化学与分子生物学

蛋白质组学,蛋白翻译后修饰,生物质谱
生物标志物研究
组蛋白表观遗传学

2003-09--2008-07   中科院上海药物所   博士
1999-09--2003-07   复旦大学   学士

   

2012-09~现在, 中国科学院上海药物研究所, 研究员、课题组长、博士生导师
2008-10~2012-08,芝加哥大学, 博士后
2008-08~2008-09,德克萨斯大学达拉斯西南医学中心, 博士后

   

2020年，中国科学院上海分院第七届杰出青年科技创新人才 

2020年，药明康德生命化学研究奖 

2019年，第四届中源协和生命医学创新突破奖 

2018年，科技部中青年科技创新领军人才 

2013年，第八届中国人类蛋白组学大会优秀青年学者奖

* 通讯作者，#第一作者

1.       Liu Z, Liu Y, Qian L, Jiang S, Gai X, Ye S, Chen Y, Wang X, Zhai L, Xu J, Pu C, Li J, He F, Huang M*, and Tan M*. A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies. Mol Cell, 2021, 81: 4076-4090

2.       Li Y, Xu J, Lu Y, Bian H, Yang L, Wu H, Zhang X, Zhang B, Xiong M, Chang Y, Tang J, Yang F, Zhao L, Li J, Gao X, Xia M*, Tan M*, Li J*. DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing. Cell Metab. 2021 33: 2004–2020.

3.       Liu P, Cong X, Liao S, Jia X, Wang X, Dai W, Zhai L, Zhao L, Ji J, Ni D, Liu Z, Chen Y, Pan L, Liu W, Zhang J, Huang M, Liu B*, Tan M*. Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis. Cell Death Differ, 2021 DOI: 10.1038/s41418-021-00827-7

4.       Xu J, Zhang C, Wang X, Zhai L, Ma Y, Mao Y, Qian K, Sun C, Liu Z, Jiang S, Wang M, Feng L, Zhao L, Liu P, Wang B, Zhao X, Xie H, Yang X, Zhao L, Chang Y, Jia J, Wang X, Zhang Y, Wang Y, Yang Y, Wu Z, Yang L, Liu B, Zhao T, Ren S, Sun A, Zhao Y, Ying W, Wang F, Wang G, Zhang Y, Cheng S, Qin J, Qian X, Wang Y*, Li J*, He F*, Xiao T*, Tan M*. Integrative proteomic characterization of human lung adenocarcinoma. 2020 Cell 182: 245-261

5.       Huang X, Yan J, Zhang M, Wang Y, Chen Y, Fu X, Wei R, Zheng XL, Liu Z, Zhang X, Yang H, Hao B, Shen YY, Su Y, Cong X, Huang M, Tan M*, Ding J*, Geng M*. Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors. Cell 2018，175:186-199.

6.       Liu B, Jiang S, Li M, Xiong X, Zhu M, Li D, Zhao L, Qian L, Zhai L, Li J, Lu H, Sun S, Lin J, Lu Y *, Li X*, Tan M*. Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis. Nat Commun 2018, 9: 4770

7.       Hu H, Zhao W, Zhu M, Zhao L, Zhai L, Xu JY, Liu P, Tan M*. LysargiNase and Chemical Derivatization Based Strategy for Facilitating In-Depth Profiling of C-Terminome. Anal Chem. 2019 91: 14522-14529

8.       Tan, M.#, Peng, C.#, Anderson, K.A.#, Chhoy, P., Xie, Z., Dai, L., Park, J.S., Chen, Y., Huang, H., Zhang, Y., Ro, J., Wagner, G.R., Green, M.F., Madsen, A.S., Schmiesing, J., Peterson, B.S., Xu, G., Ilkayeva, O.R., Muehlbauer, M.J., Braulke, T., Mühlhausen, C., Backos, D.S., Olsen, C.A., McGuire, P.J., Pletcher, S.D., Lombard, D.B., Hirschey, M.D.*, Zhao, Y*. Lysine Glutarylation Is a Protein Post-Translational Modification Regulated by SIRT5. Cell Metab 2014,19: 605-617

9.       Tan M.#, Luo H.#, Lee S.#, Jin F., Yang J.S., Montellier E., Buchou T., Cheng Z., Rousseaux S., Rajagopal N., Lu Z., Ye Z., Zhu Q., Wysocka J., Ye Y., Khochbin S., Ren B., Zhao Y*. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 2011, 146, 1016-1028

10.    Zhang, Z.#, Tan, M.#, Xie, Z., Dai, L., Chen, Y., Zhao, Y.*. Identification of lysine succinylation as a new post-translational modification. Nat Chem Biol 2011, 7, 58-63