研究工作围绕基于蛋白组学技术的蛋白修饰调控和药物精准干预开展研究。发表SCI论文160余篇，包括以通讯作者发表在Cell、Cell Metab、 Mol Cell、Nat Chem、Nat Cancer、Sci Transl Med等期刊，总引用率2万余次，H因子58，入选爱思唯尔中国高被引学者和全球前2%顶尖科学家榜单。荣获国家杰出青年科学基金，国家特支计划科技创新领军人才，科技部中青年领军人才，国家海外高层次青年人才计划，中国青年科技奖，药明康德生命化学学者奖，中源协和生命医学创新突破奖等荣誉，研究工作入选《中国2020年度重要医学进展》。

   

100706-药理学
0703Z1-化学生物学
071010-生物化学与分子生物学

蛋白质组学,蛋白翻译后修饰，生物质谱，精准医学

2003-09--2008-07   中科院上海药物所   博士
1999-09--2003-07   复旦大学   学士

   

   

2025年，中国药学会科学技术奖一等奖

2025年，上海市浦东新区明珠计划菁英人才

2024年，上海药学科技奖一等奖

2023年，教育部高等学校科学研究优秀成果奖(科学技术)自然科学奖一等奖（2022）

2022年，国家杰出青年科学基金

2022年，第十七届中国青年科技奖

2022年，第十一届上海青年科技英才（基础研究类）

2022年，上海市优秀学术/技术带头人

2020年，中国科学院上海分院第七届杰出青年科技创新人才 

2020年，药明康德生命化学研究奖 

2019年，国家特支计划科技创新领军人才

2019年，中源协和生命医学创新突破奖 

2018年，科技部中青年科技创新领军人才 

2013年，第八届中国人类蛋白组学大会优秀青年学者奖

* 通讯作者：

1.  Du W, Xu J,* Li Y, Zhang M, Huang Y, Zhao S, Zhou Y, hao L, Xu K, Zhai L, Zhao W, Liu J, Ni J, Dai J, Liu T, Hong J, Jiang H, Zhao S, Zhang J, Zhou L, Wang J, Yin B, Liu R, Li J,* Ye B,* Tan M.* (2026) Gut microbiota-derived lysine phenylacetylation impairs mitochondrial function and is alleviated by SIRT3 Cell Metab 8(9):1864-1880.

2.  Fan R, Ni J, Zhou T, Jiang H, Zhao W*, Tan M.* (2026) Proteomics-Driven Strategies for Proximity-Inducing Drug Discovery. Angew Chem Int Ed 65(32):e3307512.

3.  Wang Z, Jin M, Zhai L, Huang B, Jin X, Wang X, Boudemia AE, Yang X, Wei Z, He Y, Yang J, Li Y, Ding X, Li R, Zhou X, Zheng W, Ouyang Y, Wang Q, Song Y, Zeng Z, Li Y, Lu L, Liu J, Li Y, Li L, Li K, Chen CL, Lou Z, Tan M*, Wu J*, Chen Y*, Yuan J*. (2026) RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer. Mol Cell 86:585-603.

4.  Zhao W, Zhao L, Lian Y, Liu Z, Li Y, Wang X, Zhang M, Li N, Guo J, Shen D, Mo S, Li J, Zhai L, Ni J, Lee S, Liu B, Li J, Wang F, Peng J*, Qin J*, Tan M*. Proteogenomic Characterization Reveals Metabolic Vulnerabilities and Aberrant Phosphorylation in Colorectal Metastasis to Liver. Adv Sci 2026; 13(4):e11744.

5.  Xu Y, Zhao W, Fu J, Liu Z, Nie HJ, Zhang J, Guo J, Tan M*, Chen XH*. (2026) Multiplexed Photo-Cross-Linking Reveals Comprehensive Midnolin Interactome: Insights into Ubiquitin-Independent Degradation and Functional Diversity. J Am Chem Soc 148:11962-11973.

6. Zhang Y, Lan Y, Fan R, Feng L, Wang G, Wu X, Wen L, Duan Z, Xia Y, Wang X, Zhang L, Zhou L*, Tan M*, Liao C*, Lu X*. (2025) Biocatalytic- and Chemoproteomic-Guided Discovery of a PHGDH Inhibitor from Chemoenzymatic-Promoted DNA-Encoded Libraries Selection Platform. J Am Chem Soc 147:44396-44405.

7. Wu X, Pan J, Fan R, Zhang Y, Wang C, Wang G, Liu J, Cui M, Yue J, Jin R, Duan Z, Zheng M, Mei L, Zhou L, Tan M*, Ai J*, Lu X*. (2025) Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads. J Am Chem Soc 147:15469-15481.

8. Xu Y, Hu H, Ran Y, Zhao W, Guo AD, Nie HJ, Zhai L, Yin GL, Cheng J, Tao S, Yang B*, Tan M*, Chen XH*. (2025) Visible-Light-Controlled Lysine-Selective Crosslinking Decodes Protein Complexes and Dynamic Interactomes in Live Cells. Angew Chem Int Ed 64,2025:e202507254.

9. Xu Y, Zhao W, Nie HJ, Wang J, Fu J, Hu H, Liu Z, Tao S, Zhang M, Zhou Y, Li J*, Tan M*, Chen XH*. (2025) Cross-Linking Profiling of Molecular Glue Degrader-Induced E3 Ligase Interactome to Expand Target Space. Angew Chem Int Ed 64:e202505053.

10. Dong B, Xu JY*, Huang Y, Guo J, Dong Q, Wang Y, Li N, Liu Q, Zhang M, Pan Q, Wang H, Jiang J, Chen B, Shen D, Ma Y, Zhai L, Zhang J, Li J*, Xue W*, Tan M*, Qin J*. (2024) Integrative proteogenomic profiling of high-risk prostate cancer samples from Chinese patients indicates metabolic vulnerabilities and diagnostic biomarkers. Nat Cancer 5:1427-1447

11. Lu Y, Xu J, Li Y, Wang R, Dai C, Zhang B, Zhang X, Xu L, Tao Y, Han M, Guo R,Wu Q, Wu L*, Meng Z*, Tan M*, Li J*. (2024) DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser56 to diminish pancreatic β cell function upon overnutrition. Sci Transl Med 16:eade8647

12. Hu H, Hu W, Guo AD, Zhai L, Ma S, Nie HJ, Zhou BS, Liu T, Jia X, Liu X, Yao X, Tan M*, Chen XH*. (2024) Spatiotemporal and direct capturing global substrates of lysine-modifying enzymes in living cells. Nat Commun 15:1465.

13. Guo A, Yan K, Hu, H, Zhai L, Hu T, Su,H, Chi Y, Zha,J, Xu Y, Zhao,Y Lu X, Xu Y, Zhang J, Tan M*, Chen X*. (2023) Spatiotemporal and global profiling of DNA-protein interactions enables discovery of low-affinity transcription factors. Nat Chem 15:803-814.

14. Jiang L, Liu S, Jia X, Gong Q, Wen X, Lu W, Yang J, Wu X, Wang X, Suo Y, Li Y, Uesugi M, Qu ZB, Tan M,* Lu X,* Zhou L*. (2023) ABPP-CoDEL: Activity-Based Proteome Profiling-Guided Discovery of Tyrosine-Targeting Covalent Inhibitors from DNA- Encoded Libraries. J Am Chem Soc 145, 46, 25283–25292.

15. Zhou Q, Hao B, Cao X, Gao L, Yu Z, Zhao Y, Zhu M, Zhong G, Chi F, Dai X, Mao J, Zhu Y, Rong P, Chen L, Bai X, Ye C, Chen S, Liang T, Li L, Feng XH*, Tan M*, Zhao B*. (2022) Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha. Mol Cell 82:4700-4711.

16. Li Y, Xu J, Lu Y, Bian H, Yang L, Wu H, Zhang X, Zhang B, Xiong M, Chang Y, Tang J, Yang F, Zhao L, Li J, Gao X, Xia M*, Tan M*, Li J*. (2021) DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing. Cell Metab 33: 2004-2020.

17. Liu Z, Liu Y, Qian L, Jiang S, Gai X, Ye S, Chen Y, Wang X, Zhai L, Xu J, Pu C, Li J, He F, Huang M*, and Tan M*.  (2021) A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies. Mol Cell 81: 4076-4090.

18. Xu J, Zhang C, Wang X, Zhai L, Ma Y, Mao Y, Qian K, Sun CQ Liu ZW Jiang SW, Wang M, Feng L, Zhao L, Liu P, Wang B, Zhao X, Xie H, Yang XY Zhao L, Chang Y, Jia J, Wang X, Zhang Y, Wang Y, Yang Y, Wu Z, Yang L, Liu B, Zhao T, Ren S, Sun A, Zhao Y, Ying W, Wang F, Wang G, Zhang Y, Cheng S, Qin J, Qian X, Wang Y*, Li J*, He F*, Xiao T*, Tan M*. (2020) Integrative proteomic characterization of human lung adenocarcinoma. Cell 182:245-261.

19. Huang X, Yan J, Zhang M, Wang Y, Chen Y, Fu X, Wei R, Zheng XL, Liu Z, Zhang X, Yang H, Hao B, Shen YY, Su Y, Cong X, Huang M, Tan M*, Ding J*, Geng M*. (2018) Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors. Cell 175(1):186-199.

20. Liu B, Jiang S, Li M, Xiong X, Zhu M, Li D, Zhao L, Qian L, Zhai L, Li J, Lu H, Sun S, Lin J, Lu Y *, Li X*, Tan M*. (2018) Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN. Nat Commun 9: 4770.

 

1.国家自然科学基金基础科学中心，T2488301，2025/01-2030/12，骨干

2.国家重点研发计划，2024YFC2815903，2025/01 - 2027/12，课题负责人

3.国家重点研发计划, 2023YFA1800400, 2023/12 -2028/11, 骨干

4.国家杰出青年科学基金，22225702，2023/01-2027/12，主持

5.上海市优秀学术带头人计划，22XD1420900， 2022/06-2025/05，主持

6.国家自然科学基金国际(地区)合作与交流项目，82111540276, 2022-2023，主持

7.国家自然科学基金重大研究计划集成项目，92153302，2022-2024，骨干

8.国家自然科学基金面上项目，32071432，2021-2024，主持

9.国家自然科学基金面上项目，81872888，2019-2022，主持

10.国家自然科学基金创新研究群体项目，81821005，2019-2024，骨干