Investigating the mechanisms of mitochondria in development, aging, and disease

• 2012–09 – 2015–07: University of Chinese Academy of Sciences, Ph.D.
• 2008–09 – 2011–07: South China University of Technology, M.S.
• 2004–09 – 2008–07: Hunan Normal University, B.S.

   

First-author papers:

(1) Hu Z#, Yang L#, Zhang M#, Tang H, Huang Y, Su Y, Ding Y, Li C, Wang M, Zhou Y, Zhang Q, Guo L, Wu Y, Wang Q, Liu N, Kang H, Wu Y, Yao D, Li Y, Ruan Z, Wang H, Bao F, Liu G, Wang J, Wang Y, Wang W, Lu G, Qin D, Pei D, Chan W, Liu X*. A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development. [J] Cell Metabolism, 2024, 36(7):1586-1597.e7. (#co-first author)

(2) Yang L#, Ruan Z#, Lin X#, Wang H, Xin Y, Tang H, Hu Z, Zhou Y, Wu Y, Wang J, Qin D, Lu G, Loomes K, Chan W, Liu X*. NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations. [J] Nature Communications, 2024, 15(1):546.

(3) Yang L#, Hu Y#, Ding Y#, Hu Z#, Zhang X, Sun Y, Liu X. Impact of mtDNA-encoded proteins arising from cytosolic translation (mPACT). [J] Science Bulletin, 2024, 69(23):3648–3651.

(4) Yang L#, Lin X#, Tang H, Fan Y, Zeng S, Jia L, Li Y, Shi Y, He S, Wang H, Hu Z, Gong X, Liang X, Yang Y, Liu X*. Mitochondrial DNA mutation exacerbates female reproductive ageing via impairment of the NADH/NAD+ redox. [J] Aging Cell, 2020, 19(9):e13206.

(5) Yang L#, Long Q, Liu J, Tang H, Li Y, Bao F, Qin D, Pei D, Liu X*. Mitochondrial fusion provides an 'initial metabolic complementation' controlled by mtDNA. [J] Cell Mol Life Sci, 2015, 72(13):2585-98.

(6) Yang L#, Tang H#, Lin X, Wu Y, Zeng S, Pan Y, Li Y, Xiang G, Lin Y, Zhuang S, Song Z, Jiang Y, Liu X*. OPA1-Exon4b binds to mtDNA D-loop for transcriptional and metabolic modulation, independent of mitochondrial fusion. [J] Front Cell Dev Biol, 2020, 8:180.

(7) Yang L#, Mei T, Lin X, Tang H, Wu Y, Wang R, Liu J, Shah Z, Liu X*. Current approaches to reduce or eliminate mitochondrial DNA mutations. [J] Sci China Life Sci, 2016, 59(5):532-5.

(8) …Yang L#… …Liu X*… Biomarkers of Aging. [J] Sci China Life Sci, 2023, 66(5):893-1066. (co-first author, listed alphabetically by surname)

(9) Hong WX#, Yang L#, Chen M#, Yang X, Ren X, Fang S, Ye J, Huang H, Peng C, Zhou L, Huang X, Yang F, Wu D, Zhuang Z, Liu J*. Proteomic analysis of trichloroethylene-induced alterations in expression, distribution, and interactions of SET/TAF-Iα and two SET/TAF-Iα-binding proteins, eEF1A1 and eEF1A2, in hepatic L-02 cells. [J] Toxicol Appl Pharmacol, 2012, 263(2):259-72. (co-first author)

(10) Tang H#, Hu Z#, Yang L#, Ruan Z, Wang H, Zhou Y, Bao F, Liu X*. OPA1-Exon4b modulates the migration and invasion of hepatocellular carcinoma cells by ATP regulation. [J] Mitochondrial Communications, 2023, 1:16-22. (co-first author)

(11) Yang L#, Yang XF, Zhang Y, Liu JJ*, Li J. Validation of the interaction between SET and EEF1A1 in human hepatocytes using co-immunoprecipitation. [J] Journal of Anhui Agricultural Sciences, 2010, 35:19946-19948. (in Chinese)

Corresponding author papers:

(12) Chen X#, Pang L, Yang W, Tian H, Wang J, Yang L, Xia B. Synergistic role of deep eutectic solvents in improving engineered chitinase activity for insoluble chitin hydrolysis. [J] Food Biosci, 2025, 65:106009. (*co-corresponding author)

(13) Yang W#, Chen X#, Pang L, Tian H, Yang L, Xia B. Deciphering the catalytic proficiency and mechanism of the N-2 acetylglucosamine deacetylase from Pantoea dispersa. [J] Biotechnol Bioeng, 2025, 122(3):495-508. (*co-corresponding author)

(14) Liu Q#, Sun J#, Shao P, Shi R, Li L, Zeng W, Chen F, Li W, Li L, Yang L. Assessment of Carcinogenic Risk and Non-Carcinogenic Hazard Index Associated with Trihalomethanes Exposure in Indoor Swimming Pools in Shenzhen, China. [J] Hum Ecol Risk Assess, 2026, 32(1-2):16-35. (*co-corresponding author)

1. Liu Xingguo, Yang Liang, Lin Xiaobing, Tang Haite. Method and system for detecting mtDNA mutations. 2022-05-06, China, ZL201910509687.4.
2. Liu Xingguo, Yang Liang, Tang Haite. Use of Opa1 isoform protein in regulating proliferation ability of hepatocellular carcinoma cells. 2022-07-26, China, ZL201910105768.8.
3. Liu Xingguo, Ruan Zifeng, Yang Liang. Isolated circular RNA and use thereof. 2026-03-27, China, ZL 202211657706.6.
4. Liu Xingguo, Yang Liang, Lin Xiaobing, Tang Haite. Method and system for detecting mtDNA mutations. US12584166B2 (PCT, USA), 2026-03-24.

1. 2021: Silver Award (Project Leader) in the First National Postdoctoral Innovation and Entrepreneurship Competition
2. 2024: Excellence Award (Project Leader) in the “UCAS Cup” Innovation and Entrepreneurship Competition
3. 2015: Tied First Place Award (shared by two recipients) at the Cold Spring Harbor Asia Conference on Mitochondria
4. 2015: Poster Award at the 12th International Conference of the Asian Society of Mitochondrial Biomedicine and Research & the 6th Academic Conference of the Chinese Mitochondrial Society
5. 2020: First Prize of Natural Science Award, Guangdong Provincial Science and Technology Award (6/15)
6. 2023: First Prize of Natural Science Award, Guangdong Provincial Precision Medicine Science and Technology Award (11/15)