研究线粒体在发育、衰老、疾病中的作用机制

   

线粒体与衰老

2012-09--2015-07   中国科学院大学   博士
2008-09--2011-07   华南理工大学   硕士
2004-09--2008-07   湖南师范大学   学士

   

（ 1 ） Method and system for detecting mtDNA mutations, 专利授权, 2026, 第 2 作者, 专利号: US12584166B2

（ 2 ） 分离的环状RNA及其用途, 专利授权, 2022, 第 3 作者, 专利号: ZL 202211657706.6

（ 3 ） Opa1异形体蛋白在调控肝癌细胞增殖能力中的用途, 专利授权, 2022, 第 2 作者, 专利号: ZL201910105768.8

（ 4 ） 检测mtDNA突变的方法和系统, 专利授权, 2022, 第 2 作者, 专利号: ZL201910509687.4

   

（1） Autologous bone marrow mesenchymal stem cell mitochondrial transplantation in recurrent assisted reproductive technology failure: a randomized controlled trial, Stem Cell Res Ther, 2026, 第 8 作者
（2） Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkison's disease models, Cell, 2026, 第 6 作者
（3） Glucose restriction induces degeneration of neurons with mitochondrial DNA depletion by altering ER-mitochondria calcium transfer, MOLECULAR PSYCHIATRY, 2025, 第 8 作者
（4） Synergistic role of deep eutectic solvents in improving engineered chitinase activity for insoluble chitin hydrolysis, FOOD BIOSCIENCE, 2025, 第 6 作者  通讯作者
（5） Perinuclear mitochondrial clustering for mesenchymal-to-epithelial transition in pluripotency induction, STEM CELL REPORTS, 2025, 第 16 作者
（6） Deciphering the catalytic proficiency and mechanism of the N-2 acetylglucosamine deacetylase from Pantoea dispersa, Biotechnol Bioeng, 2025, 第 5 作者  通讯作者
（7） Assessment of Carcinogenic Risk and Non-Carcinogenic Hazard Index Associated with Trihalomethanes Exposure in Indoor Swimming Pools in Shenzhen, China, HUM ECOL RISK ASSESS, 2025, 第 10 作者  通讯作者
（8） NAD + dependent UPR mt activation underlies intestinal aging caused by mitochondrial DNA mutations, NATURE COMMUNICATIONS, 2024, 第 1 作者
（9） Impact of mtDNA-encoded proteins arising from cytosolic translation(mPACT), 线粒体DNA编码胞质翻译蛋白的重要性, SCIENCE BULLETIN, 2024, 第 1 作者
（10） A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development, CELL METABOLISM, 2024, 第 2 作者
（11） Biomarkers of aging, Biomarkers of aging, SCIENCE CHINA-LIFE SCIENCES, 2023, 第 48 作者
（12） OPA1-Exon4b modulates the migration and invasion of hepatocellular carcinoma cells by ATP regulation, MITOCHONDRIAL COMMUNICATIONS, 2023, 第 3 作者
（13） Mitochondrial DNA mutation affects the pluripotency of embryonic stem cells with metabolism modulation, Genome Instability & Disease, 2022, 第 7 作者
（14） Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space, Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space, SCIENCE CHINA-LIFE SCIENCES, 2022, 第 9 作者
（15） Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms, Science Advances, 2022, 第 8 作者
（16） Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021, 第 10 作者
（17） A Combined Model of Human iPSC-Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome, ADVANCED SCIENCE, 2021, 第 8 作者
（18） Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD(+)redox, AGING CELL, 2020, 第 1 作者
（19） Topology-dependent, bifurcated mitochondrial quality control under starvation, AUTOPHAGY, 2020, 第 9 作者
（20） OPA1-Exon4b Binds to mtDNA D-Loop for Transcriptional and Metabolic Modulation, Independent of Mitochondrial Fusion, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 第 1 作者
（21） A novel mitochondrial micropeptide MPM enhances mitochondrial respiratory activity and promotes myogenic differentiation, CELL DEATH AND DISEASE, 2019, 第 6 作者
（22） Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming, CELL METABOLISM, 2018, 第 13 作者
（23） Polybrene induces neural degeneration by bidirectional Ca2+ influx-dependent mitochondrial and ER-mitochondrial dynamics, CELL DEATH & DISEASE, 2018, 第 4 作者
（24） Choosing proper fluorescent dyes, imaging techniques to study mitochondrial dynamics in mammalian cells, Biophys Rep, 2017, 第 2 作者
（25） BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming, AUTOPHAGY, 2017, 第 2 作者
（26） Mitochondrial Membrane Potential‐dependent Endoplasmic Reticulum Fragmentation is an Important Step in Neuritic Degeneration, CNS NEUROSCIENCE & THERAPEUTICS, 2016, 第 4 作者
（27） Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming, CELL METABOLISM, 2016, 第 8 作者
（28） Current approaches to reduce or eliminate mitochondrial DNA mutations, SCIENCE CHINA Life Sciences, 2016, 第 1 作者
（29） Mitochondrial fusion provides an 'initial metabolic complementation' controlled by mtDNA, CELLULAR AND MOLECULAR LIFE SCIENCES, 2015, 第 1 作者
（30） Modeling of Mitochondrial Donut Formation, BIOPHYSICAL JOURNAL, 2015, 第 4 作者
（31） Valproic Acid-Induced Hepatotoxicity in Alpers Syndrome Is Associated With Mitochondrial Permeability Transition Pore Opening-Dependent Apoptotic Sensitivity in an Induced Pluripotent Stem Cell Model, HEPATOLOGY, 2015, 第 5 作者
（32） Trichloroethylene Induces Biphasic Concentration-dependent Changes in Cell Proliferation and the Expression of SET-Associated Proteins in Human Hepatic L-02 Cells, BIOMEDICAL AND ENVIRONMENTAL SCIENCES, 2013, 第 7 作者
（33） Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 第 9 作者
（34） 三氯乙烯对L-02肝细胞活力及SET蛋白表达的影响, 毒理学杂志, 2012, 第 5 作者
（35） Proteomic analysis of trichloroethylene-induced alterations in expression, distribution, and interactions of SET/TAF-Iα and two SET/TAF-Iα-binding proteins, eEF1A1 and eEF1A2, in hepatic L-02 cells, TOXICOLOGY AND APPLIED PHARMACOLOGY, 2012, 第 2 作者
（36） 人SET基因RNA干扰重组质粒载体的构建及其在肝细胞中的表达, Construction of human SET gene RNA interference recombinant plasmid vector and its expression in L-02 liver cells, 热带医学杂志, 2011, 第 5 作者
（37） 利用免疫共沉淀技术验证SET与eEF1A1在人肝细胞内的相互作用, Verification of the Interaction between SET and eEF1A1 in Human Liver Cells by Co-immunoprecipitation, 安徽农业科学, 2010, 第 1 作者

   

（ 1 ） 衰老积累的线粒体DNA突变通过肠道微生物调控免疫稳态失衡的机制研究, 负责人, 国家任务, 2026-01--2029-12
（ 2 ） 人工真核生物线粒体的合成组装及调控, 参与, 国家任务, 2024-12--2029-11