Bioactive secondary metabolites investigation from marine derived micoorganisms

2008. 9-2011.6, Ph.D., Chemical Biology, Sun Yat-sen University, Guangzhou, China.

2005. 9-2008. 6, M.S., Aquatic Products Processing and Storage Engineering

2005.9-2006.6, Dalian Ocean University, Dalian, China

2006.6-2008.5, yellow sea fisheries research institute, Chinese academy of fishery sciences (YSFRI), Qingdao, China

2001. 9-2005.6, B.S., Food Science and Engineering, Henan Agriculture University, Zhengzhou, China

2013.12- Associate Professor

South China Sea Institute of Oceanology (SCSIO), Chinese Academy of Sciences

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology

2017.04-2018.04, Visiting scholar

University of California Los Angeles, Department of Chemical and Biochemistry

2011. 7-2013. 12, Assistant researcher

South China Sea Institute of Oceanology (SCSIO), Chinese Academy of Sciences

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology

   

2024

1.        Y. Song, W. Wang, J. Yang, D. Gao, J. Billingsley, S Wang, Y. Zhu, J. Wang, J. Ju, Y. Yan*, J. Ju and Y. Tang, β-Terrecyclene Synthase Constructs the Quadrane Backbone in Terrecyclic Acid Biosynthesis, Chemical Science 2024, doi.org/10.1039/D4SC01208A.

2.        宋永相, 张秀凤, 李艳芹, 肖华, 闫岩。自抗性基因导向的活性天然产物挖掘。合成生物学，2024，DOI: 10.12211/2096-8280.2023-099

3.        Y. Li, M. Cong, W. Wang, X. Zhang, Y. Zhu, Y. Song, W. Zhang, H. Xiao, Y. Liu, C. Zhang, Wang, Y. Yan. An Enzymatic Carbon-Carbon Bond Cleavage and Aldol Reaction Cascade Converts an Angular Scaffold into the Linear Tetracyclic Core of Ochraceopones. Angewandte Chemie International Edition 2024， doi.org/10.1002/anie.202403365.

4.        X. Zhang, X. Pang, L. Zhang, Y. Li, Y. Song, H. Xiao, Y. Liu, J. Wang* and Y. Yan*. Genome Mining Uncovers a Flavoenzyme-Catalyzed Isomerization Process during the Maturation of Pyrenophorol Dilactones. Organic Letters 2024, 26, 8, 1612-1617.

5.        H. Huang, Y. Zhang, Y. Song, C. Ling, S. Peng, B. Ding, Y. Tao* and J. Ju*. Deciphering the Glycosylation Steps in the Biosynthesis of P-1894B and Grincamycin Isolated from Marine-Derived Streptomyces lusitanus SCSIO LR32. Marine Drugs 2024, 22(1), 32-44.

2023

6.        X. Li, W. Shen, G. Li, Y. Song^*, X. Lu, N. Wong, Y. Yan, Alternaphenol B2, a new IDH1 inhibitor from the coral-derived fungus Parengyodontium album SCSIO SX7W11. Natural Product Research 2023 18:1-7.

7.       J. Yang, Y. Song, * Z. Zhou, Y. Huang, S. Wang, J. Yuan, N. Wong, Y. Yan, J. Ju*, Sulfoxanthicillin from the deep-sea derived Penicillium sp. SCSIO sof101: an antimicrobial compound against Gram-positive and -negative pathogens. Journal of Antibiotics (Tokyo) 2023, 76, (3), 113-120.

8.        J. Yang, Z. Zhou, Y. Chen, Y. Song,* J. Ju*. Characterization of the depsidone gene cluster reveals etherification, decarboxylation and multiple halogenations as tailoring steps in depsidone assembly. Acta Pharmaceutica Sinica B 2023, 13, (9), 3919-3929.

9.        宋永相*，李晓悦，鞠建华。深海放线菌Streptomyces koyangensis SCSIO 5802中次级代谢产物neoabyssomicin H的分离鉴定。热带海洋学报 2023，42 (3): 169-173.

2022

10.    J. Yang, L. Zhou, Z. Zhou, Y. Song* and J. Ju*. Anti-Pathogenic Depsidones and its Derivatives from a Coral-Derived Fungus Aspergillus Sp. SCSIO SX7S7. Biochemical Systematic and Ecology. 2022, 102, 104415

11.    Y. Chen, C. Cai, J. Yang, J. Shi, Y. Song, D. Hu, J. Ma *, J. Ju *. Development of CRISPR-Cas9 system for the marine-derived fungi Spiromastix sp. SCSIO F190 and Aspergillus sp. SCSIO SX7S7. J. Fungi 2022, 8(7), 715.

12.    H. Zhang, Y. Chen, Y. Li, Y. Song, J. Ma and J. Ju*. Secondary Metabolites and Biosynthetic Gene Clusters Analysis of Deep-Sea Hydrothermal Vent-Derived Streptomyces sp. SCSIO ZS0520. Mar. Drugs 2022, 20(6), 393.

2021

13.    Q. Lu, L. Xu, L.Liu, Y. Zhou, T. Liu,* Y. Song,* Jianhua Ju, Qing Yang. Lynamicin B is a Potential Pesticide by Acting as a Lepidoptera-Exclusive Chitinase Inhibitor. Journal of Agriculture and Food Chemistry 2021, 69(47),14086-14091.

14.              J. Yang,# Y. Song,#* M. Tang, M. Li, J. Deng, N. Wong and J. Ju*. Genome-Directed Discovery of Tetrahydroisoquinolines from Deep-Sea Derived Streptomyces niveus SCSIO 3406. Journal of Organic Chemistry 2021. 86, (16), 11107-11116.

15.              R. Xu^#, Y. Song^#, J. Li, J. Ju, Q. Li*. Chemical Synthesis and Structure-Activity Relationship Study Yield Desotamide a Analogues with Improved Antibacterial Activity. Marine Drugs 2021, 19, 303-313. https://doi.org/10.3390/md19060303

16.    Q. Zhu, W. Cheng, Y. Song, Q. He, J. Ju, Q. Li*. Complete genome sequence of the deep South China Sea-derived Streptomyces niveus SCSIO 3406, the producer of cytotoxic and antibacterial marfuraquinocins. PLoS One 2021, 16, (3), e0248404.

17.    周晓雪; 杨佳凡; 李明哲; 宋永相; 鞠建华; 李晓帆; 王立岩。珊瑚来源真菌Parengyodontium album SCSIO SX7W11中聚酮化合物的发现及其生物合成途径分析. 微生物学报 2021, 61, (11), 3631-3641.

2020

18.              Y. Song, J. Yang, J. Yu, J. Li, J. Yuan, N. Wong and J. Ju *. Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities. Journal of Antibiotics (Tokyo) 2020, 73, 542-547.

19.    X. Ji, J. Tu, Y. Song, C. Zhang, L. Wang, Q. Li, * J. Ju*. A Luciferase-Like Monooxygenase and Flavin Reductase Pair AbmE2/AbmZ Catalyzes Baeyer-Villiger Oxidation in Neoabyssomicin Biosynthesis. Acs Catal. 2020, 10, (4), 2591-2595.

20.    D. Yee, T. Kakule, W. Cheng, M. Chen, C. Chong, Y. Hai, L. Hang, Y. Hung, N. Liu, M. Ohashi, I. Okorafor, Y. Song, M. Tang, Z. Zhang, Y. Tang. Genome Mining of Alkaloidal Terpenoids from a Hybrid Terpene and Nonribosomal Peptide Biosynthetic Pathway. J. Am. Chem. Soc. 2020, 142, 710-714.

21 P. Kumar, C. Ling, Z. Zhou, Y. Dong, C. Sun, Y. Song, N. Wong, J. Ju. Chemical Diversity of Metabolites and Antibacterial Potential of Actinomycetes Associated with Marine Invertebrates from Intertidal Regions of Daya Bay and Nansha Islands. Microbiology 2020, 89, (4), 483-492.

1.         宋永相，李晓悦，陈夏雨，邓音乐，闫岩，鞠建华。一类吡咯烷醇酸类化合物在制备抑制白色念珠菌致病性药物中的应用（申请日2023.12.08，申请号2023116805419）。

2.   宋永相，杨佳凡，周镇槟，李晓悦，马俊英，闫岩，鞠建华。一类异腈基化合物及其制备方法和在制备抗菌药物中的应用。（授权专利号：202211386568.2，）

3.   鞠建华，周镇槟，杨佳凡，宋永相，田新朋。两个大环内酯化合物及其在制备抗菌、抗癌药物中的应用。（2022.09.20授权专利号：202210128899.X，申请日2022.02.11.）

4.   宋永相，鞠建华，刘田，李洁，杨佳凡，李晓悦，卢琼，杨青。深海放线菌11791在制备防治农牧业鳞翅目害虫药物中的应用（授权专利号：202111348237.5,已转化）。

5.   李青连，徐润，宋永相，李骏，鞠建华。一种环六肽化合物desotamide A4及其在制备抗菌药物中的应用（2023.06.06授权专利号：202110555444.1）

6.   杨青，刘田，宋永相，卢琼，鞠建华。双吲哚吡咯类化合物的应用（2022.04.15授权专利号：202110493094.0,已转化）。

7.   鞠建华，宋永相，杨佳凡。一类骨架新颖的6/6/6/6/5/5环生物碱类化合物及其在制备抗菌药物中的应用（2023.01.03授权专利号：202011087495.8）。

8.   宋永相，杨佳凡，赖添财，鞠建华。深海放线菌生物制剂在制备预防柑橘溃疡疾病药物中的应用（2020.11.10授权专利号：202010048059.3）