基本信息
宋永相  男  硕导  中国科学院南海海洋研究所
电子邮件: songx@scsio.ac.cn
通信地址: 广东省广州市海珠区新港西路164号
邮政编码: 510301

研究领域

主要从事海洋微生物活性次级代谢产物和新型功能酶的发掘

具体包括:

1)具有抗菌、抗肿瘤、杀虫、抗氧化等海洋微生物活性物质的发现。

2)微生物体内,合成新颖活性物质的酶的发现和利用。


招生信息

欢迎有志于海洋微生物活性物质的发现与利用的学生报考!

招生方向:海洋微生物活性物质的发掘与应用

招生专业:生物工程

教育背景

2008-09--2011-06   中山大学   博士
2005-09--2008-06   大连海洋大学   硕士
2001-09--2005-06   河南农业大学   学士

工作经历

2013.12-今,中国科学院南海海洋研究所,中科院热带海洋生物资源与生态重点实验室,副研究员,期间于2017.04-2018.04,在加大大学洛杉矶分校(University of California, Los Angeles/UCLA),化学与生物化学系(Department of Chemistry & Biochemistry),以CAS-UCLA联合培养公派项目在Prof. Yi Tang课题组做访问学者。

2011.07-2013.12,中国科学院南海海洋研究所,中科院热带海洋生物资源与生态重点实验室,助理研究员。


出版信息

   
发表论文
[1] 合成生物学. 2024, 第 1 作者
[2] Chem Sci. 2024, 第 1 作者
[3] Yang, Jiafan, Song, Yongxiang, Zhou, Zhenbin, Huang, Yun, Wang, Songtao, Yuan, Jie, Wong, NaiKei, Yan, Yan, Ju, Jianhua. Sulfoxanthicillin from the deep-sea derived Penicillium sp. SCSIO sof101: an antimicrobial compound against Gram-positive and -negative pathogens. JOURNAL OF ANTIBIOTICS[J]. 2023, 第 2 作者  通讯作者  76(3): 113-120, http://dx.doi.org/10.1038/s41429-022-00593-9.
[4] 宋永相, 李晓悦, 鞠建华. 深海放线菌Streptomyces koyangensis SCSIO 5802中次级代谢产物neoabyssomicin H的分离鉴定. 热带海洋学报[J]. 2023, 第 1 作者42(3): 169-173, http://lib.cqvip.com/Qikan/Article/Detail?id=7109703645.
[5] Jiafan Yang, Zhenbin Zhou, Yingying Chen, Yongxiang Song, Jianhua Ju. Characterization of the depsidone gene cluster reveals etherification, decarboxylation and multiple halogenations as tailoring steps in depsidone assembly. ACTA PHARMACEUTICA SINICA B[J]. 2023, 第 4 作者13(9): 3919-3929, http://dx.doi.org/10.1016/j.apsb.2023.05.036.
[6] Natural Product Research. 2023,   通讯作者  
[7] Acta Pharmaceutica Sinica B. 2023,   通讯作者  
[8] J. Fungi. 2022, 第 5 作者
[9] Yang, Jiafan, Zhou, Le, Zhou, Zhenbin, Song, Yongxiang, Ju, Jianhua. Anti-pathogenic depsidones and its derivatives from a coral-derived fungus Aspergillus sp. SCSIO SX7S7. BIOCHEMICAL SYSTEMATICS AND ECOLOGY[J]. 2022, 第 4 作者  通讯作者  102: http://dx.doi.org/10.1016/j.bse.2022.104415.
[10] Journal of Agriculture and Food Chemistry. 2021,   通讯作者  
[11] Yang, Jiafan, Song, Yongxiang, Tang, ManCheng, Li, Mingzhe, Deng, Junwei, Wong, NaiKei, Ju, Jianhua. Genome-Directed Discovery of Tetrahydroisoquinolines from Deep-Sea Derived Streptomyces niveus SCSIO 3406. JOURNAL OF ORGANIC CHEMISTRY[J]. 2021, 第 2 作者  通讯作者  86(16): 11107-11116, http://dx.doi.org/10.1021/acs.joc.1c00123.
[12] 周晓雪, 杨佳凡, 李明哲, 宋永相, 鞠建华, 李晓帆, 王立岩. 珊瑚来源真菌Parengyodontium album SCSIO SX7W11中聚酮化合物的发现及其生物合成途径分析. 微生物学报[J]. 2021, 第 4 作者61(11): 3631-3641, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20211122?st=article_issue.
[13] Song, Yongxiang, Yang, Jiafan, Yu, Jianchen, Li, Jie, Yuan, Jie, Wong, NaiKei, Ju, Jianhua. Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities. JOURNAL OF ANTIBIOTICS[J]. 2020, 第 1 作者73(8): 542-547, http://dx.doi.org/10.1038/s41429-020-0307-4.
[14] Sun, Jianbin, Shao, Junli, Sun, Changli, Song, Yongxiang, Li, Qinglian, Lu, Laichun, Hu, Yunfeng, Gui, Chun, Zhang, Hua, Ju, Jianhua. Borrelidins F-I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2018, 第 4 作者26(8): 1488-1494, http://dx.doi.org/10.1016/j.bmc.2018.01.010.
[15] Zhu, Qinghua, Chen, Qi, Song, Yongxiang, Huang, Hongbo, Li, Jun, Ma, Junying, Li, Qinglian, Ju, Jianhua. Deciphering the sugar biosynthetic pathway and tailoring steps of nucleoside antibiotic A201A unveils a GDP-L-galactose mutase. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 第 3 作者114(19): 4948-4953, http://ir.scsio.ac.cn/handle/344004/16284.
[16] Song, Yongxiang, Li, Qinglian, Qin, Fengxiang, Sun, Changli, Liang, Hao, Wei, Xiaoyi, Wong, NaiKei, Ye, Li, Zhang, Yun, Shao, Mingwei, Ju, Jianhua. Neoabyssomicins A-C, polycyclic macrolactones from the deep-sea derived Streptomyces koyangensis SCSIO 5802. TETRAHEDRON[J]. 2017, 第 1 作者73(36): 5366-5372, http://dx.doi.org/10.1016/j.tet.2017.07.034.
[17] Yongxiang Song, Guangfu Liu, Jie Li, Hongbo Huang, Xing Zhang, Hua Zhang, Jianhua Ju, Sergey A Dyshlovoy. Cytotoxic and Antibacterial Angucycline- and Prodigiosin- Analogues from the Deep-Sea Derived Streptomyces sp. SCSIO 11594. MDPI. 2015, 第 1 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA202003190015249ZK.
[18] Li, Qinglian, Song, Yongxiang, Qin, Xiangjing, Zhang, Xing, Sun, Aijun, Ju, Jianhua. Identification of the Biosynthetic Gene Cluster for the Anti-infective Desotamides and Production of a New Analogue in a Heterologous Host. JOURNAL OF NATURAL PRODUCTS[J]. 2015, 第 2 作者78(4): 944-948, http://ir.scsio.ac.cn/handle/344004/14841.
[19] Song, Yongxiang, Li, Qinglian, Liu, Xue, Chen, Yuchan, Zhang, Yun, Sun, Aijun, Zhang, Weimin, Zhang, Jingren, Ju, Jianhua. Cyclic Hexapeptides from the Deep South China Sea-Derived Streptomyces scopuliridis SCSIO ZJ46 Active Against Pathogenic Gram-Positive Bacteria. JOURNAL OF NATURAL PRODUCTS[J]. 2014, 第 1 作者77(8): 1937-1941, https://www.webofscience.com/wos/woscc/full-record/WOS:000340861800023.
[20] 唐桂岭, , 黄洪波, 王博, 田新朋, 鞠建华, 宋永相. 南海深海链霉菌Streptomyces sp.SCSIO 5604次级代谢产物lyngbyatoxin A的研究. 天然产物研究与开发[J]. 2014, 第 7 作者26(11): 1767-1770,1892, http://www.trcw.ac.cn/CN/Y2014/V26/I11/1767.
[21] Zhou, Xiao, Huang, Hongbo, Li, Jie, Song, Yongxiang, Jiang, Renwang, Liu, Jing, Zhang, Si, Hua, Yan, Ju, Jianhua. New anti-infective cycloheptadepsipeptide congeners and absolute stereochemistry from the deep sea-derived Streptomyces drozdowiczii SCSIO 10141. TETRAHEDRON[J]. 2014, 第 4 作者70(42): 7795-7801, http://dx.doi.org/10.1016/j.tet.2014.02.007.
[22] Changtao Ji, Qi Chen, Qinglian Li, Hongbo Huang, Yongxiang Song, Junying Ma, Jianhua Ju. Chemoenzymatic synthesis of β-carboline derivatives using McbA, a new ATP-dependent amide synthetase. TETRAHEDRON LETTERS. 2014, 第 5 作者55(35): 4901-4904, http://dx.doi.org/10.1016/j.tetlet.2014.07.004.
[23] Ji, Changtao, Chen, Qi, Li, Qinglian, Huang, Hongbo, Song, Yongxiang, Ma, Junying, Ju, Jianhua. Chemoenzymatic synthesis of beta-carboline derivatives using McbA, a new ATP-dependent amide synthetase. TETRAHEDRON LETTERS[J]. 2014, 第 5 作者55(35): 4901-4904, https://www.webofscience.com/wos/woscc/full-record/WOS:000340985800013.
[24] Xie, Yunchang, Li, Qinglian, Song, Yongxiang, Ma, Junying, Ju, Jianhua. Involvement of SgvP in Carbon-Sulfur Bond Formation during Griseoviridin Biosynthesis. CHEMBIOCHEM[J]. 2014, 第 3 作者15(8): 1183-1189, https://www.webofscience.com/wos/woscc/full-record/WOS:000337582200017.
[25] Zhang, Yun, Zhou, Xiao, Huang, Hongbo, Tian, Xinpeng, Song, Yongxiang, Zhang, Si, Ju, Jianhua. 03219A, a new Delta(8,9)-pregnene isolated from Streptomyces sp SCSIO 03219 obtained from a South China Sea sediment. JOURNAL OF ANTIBIOTICS[J]. 2013, 第 5 作者66(6): 327-331, https://www.webofscience.com/wos/woscc/full-record/WOS:000321003000004.
[26] Chen, Qi, Ji, Changtao, Song, Yongxiang, Huang, Hongbo, Ma, Junying, Tian, Xinpeng, Ju, Jianhua. Discovery of McbB, an Enzyme Catalyzing the beta-Carboline Skeleton Construction in the Marinacarboline Biosynthetic Pathway. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2013, 第 3 作者52(38): 9980-9984, 
[27] Wang, Bo, Song, Yongxiang, Luo, Minghe, Chen, Qi, Ma, Junying, Huang, Hongbo, Ju, Jianhua. Biosynthesis of 9-Methylstreptimidone Involves a New Decarboxylative Step for Polyketide Terminal Diene Formation. ORGANIC LETTERS[J]. 2013, 第 2 作者15(6): 1278-1281, https://www.webofscience.com/wos/woscc/full-record/WOS:000316520300032.
[28] Song, Yongxiang, Huang, Hongbo, Chen, Yuchan, Ding, Jie, Zhang, Yun, Sun, Aijun, Zhang, Weimin, Ju, Jianhua. Cytotoxic and Antibacterial Marfuraquinocins from the Deep South China Sea-Derived Streptomyces niveus SCSIO 3406. JOURNAL OF NATURAL PRODUCTS[J]. 2013, 第 1 作者76(12): 2263-2268, https://www.webofscience.com/wos/woscc/full-record/WOS:000329331200012.
[29] Zhang, Yun, Huang, Hongbo, Chen, Qi, Luo, Minghe, Sun, Aijun, Song, Yongxiang, Ma, Junying, Ju, Jianhua. Identification of the Grincamycin Gene Cluster Unveils Divergent Roles for GcnQ in Different Hosts, Tailoring the L-Rhodinose Moiety. ORGANIC LETTERS[J]. 2013, 第 6 作者15(13): 3254-3257, https://www.webofscience.com/wos/woscc/full-record/WOS:000321605800016.
[30] Li, Z Y, Sun, R, Li, J, Song, Y X, Lin, Y C, Zeng, X, He, H J, Wei, J, Yang, F, Zheng, H Q, Lv, Z Y, Wu, Z D. Efficacy of albendazole combined with a marine fungal extract (m2-9) against Angiostrongylus cantonensis-induced meningitis in mice. JOURNAL OF HELMINTHOLOGY[J]. 2012, 86(4): 410-417, https://www.webofscience.com/wos/woscc/full-record/WOS:000310856200006.
[31] Huang, Hongbo, Yang, Tingting, Ren, Xiangmei, Liu, Jing, Song, Yongxiang, Sun, Aijun, Ma, Junying, Wang, Bo, Zhang, Yun, Huang, Caiguo, Zhang, Changsheng, Ju, Jianhua. Cytotoxic Angucycline Class Glycosides from the Deep Sea Actinomycete Streptomyces lusitanus SCSIO LR32. JOURNAL OF NATURAL PRODUCTS[J]. 2012, 第 5 作者75(2): 202-208, http://www.irgrid.ac.cn/handle/1471x/767859.
[32] Chen, Ziming, Song, Yongxiang, Chen, Yuchan, Huang, Hongbo, Zhang, Weimin, Ju, Jianhua. Cyclic Heptapeptides, Cordyheptapeptides C-E, from the Marine-Derived Fungus Acremonium persicinum SCSIO 115 and Their Cytotoxic Activities. JOURNAL OF NATURAL PRODUCTS[J]. 2012, 第 2 作者75(6): 1215-1219, http://www.irgrid.ac.cn/handle/1471x/767813.
[33] Ma Junying. Characterization of a single gene cluster that is responsible for methylpendolmycin and pendolmycin biosynthesis in the deep sea bacterium Marinactinospora thermotolerans.. ChemBioChem. 2012, 
[34] Chen, Ziming, Zheng, Zhihui, Huang, Hongbo, Song, Yongxiang, Zhang, Xuelian, Ma, Junying, Wang, Bo, Zhang, Changsheng, Ju, Jianhua. Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp SOF07. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2012, 第 4 作者22(9): 3332-3335, http://dx.doi.org/10.1016/j.bmcl.2012.02.106.
[35] Huang, Hongbo, Wang, Fazuo, Luo, Minghe, Chen, Yuchan, Song, Yongxiang, Zhang, Weimin, Zhang, Si, Ju, Jianhua. Halogenated Anthraquinones from the Marine-Derived Fungus Aspergillus sp SCSIO F063. JOURNAL OF NATURAL PRODUCTS[J]. 2012, 第 5 作者75(7): 1346-1352, https://www.webofscience.com/wos/woscc/full-record/WOS:000306783500014.
[36] Mo, Xuhua, Ma, Junying, Huang, Hongbo, Wang, Bo, Song, Yongdang, Zhang, Si, Zhang, Changsheng, Ju, Jianhua. Delta(11,12) Double Bond Formation in Tirandamycin Biosynthesis is Atypically Catalyzed by TrdE, a Glycoside Hydrolase Family Enzyme. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2012, 134(6): 2844-2847, http://www.irgrid.ac.cn/handle/1471x/767857.
[37] 宋永相. Metabolites of mangrove fungus Xylaria sp. BL321 from the South China Sea. Planta Med.. 2012, 第 1 作者
[38] Yongxiang Song, Jiajian Wang, Hongbo Huang, Lin Ma, Jun Wang, Yucheng Gu, Lan Liu. Four Eremophilane Sesquiterpenes from the Mangrove Endophytic Fungus Xylaria sp. BL321. MDPI. 2012, 第 1 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA202003190046221ZK.
[39] Zhou, Xiao, Huang, Hongbo, Chen, Yuchan, Tan, Jiaheng, Song, Yongxiang, Zou, Jianhua, Tian, Xinpeng, Hua, Yan, Ju, Jianhua. Marthiapeptide A, an Anti-infective and Cytotoxic Polythiazole Cyclopeptide from a 60 L Scale Fermentation of the Deep Sea-Derived Marinactinospora thermotolerans SCSIO 00652. JOURNAL OF NATURAL PRODUCTS[J]. 2012, 第 5 作者75(12): 2251-2255, http://www.irgrid.ac.cn/handle/1471x/767738.
[40] Song, YongXiang, Cheng, Bin, Zhu, Xun, Qiao, LiTao, Wang, JiaJian, Gu, YuCheng, Li, MengFeng, Liu, Lan, Lin, YongCheng. Synthesis and Cytotoxic Evaluation of Eremophilane Sesquiterpene 07H239-A Derivatives. CHEMICAL & PHARMACEUTICAL BULLETIN[J]. 2011, 第 1 作者59(9): 1186-1189, https://www.webofscience.com/wos/woscc/full-record/WOS:000294387500022.
[41] Song, YongXiang, Qiao, LiTao, Wang, JiaJian, Zeng, HuaMing, She, ZhiGang, Miao, ChengDu, Hong, Kui, Gu, YuCheng, Liu, Lan, Lin, YongCheng. Two New Meroterpenes from the Mangrove Endophytic Fungus Aspergillus sp 085241B. HELVETICA CHIMICA ACTA[J]. 2011, 第 1 作者94(10): 1875-1880, https://www.webofscience.com/wos/woscc/full-record/WOS:000297245500017.