Radiation biology， tumor molecular biology， genetic toxicology

2004.9 – 2009.12  Studies at the School of Life Sciences, Lanzhou University, Ph.D.

2000.9 – 2004.7  Studies at the School of Life Sciences, Lanzhou University, Bachelor degree

Since 2013.11.   Institute of Modern Physics, Chinese Academy of Sciences, China; Associate Researcher

2013.3 – 2014.3.  German Cancer Research Center (DKFZ), Germany; Visiting Scholar

2010.3 - 2013.10.  Institute of Modern Physics, Chinese Academy of Sciences, China; Assistant Researcher

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1.      Zhang JH, Si J*, Gan L, et al. Inhibition of wnt signalling pathway by XAV939 enhances radiosensitivity in human cervical cancer Hela cells.Artificial Cells, Nanomedicine, and Biotechnology. 2020 Dec;48(1):479-487.

2.      Zhang JH, Si J*, Gan L, et al.  Research progress on therapeutic targeting of quiescent cancer cells.Artificial Cells, Nanomedicine, and Biotechnology.47:1, 2810-2820

3.      Si J#, Zhou R#, Zhao B, et al. Effects of ionizing radiation and HLY78 on the zebrafish embryonic developmental toxicity.Toxicology. 2019, 411: 143-153.

4.      Si J#, Zhou R#, Song JE, et al. Toxic effects of56Fe ion radiation on the zebrafish (Danio rerio) embryonic development,Aquatic Toxicology, 2017, 186: 87-95.

5.      Si J, Zhang H, Wang ZH, et al. Effects of 12C6+ ion radiation and ferulic acid on the zebrafish (Danio rerio) embryonic oxidative stress response and gene expression.2013.Mutation Research.745-746:26-33.

6.      Zhao L#, Si J#, Wei Y, et al. Toxicity of porcelain-fused-to-metal substrate to zebrafish (Danio rerio) embryos and larvae.Life Sciences.2018, 203: 66–71.

7.      Song JE#, Si J#, Zhou R, et al. Effects of Exogenous Carbon Monoxide Releasing Molecules on the Development of Zebrafish Embryos and Larvae.Biomedical and environmental sciences : BES2016;29(6):453-6.

8.      Gan L,Guo M, Si J, et al. Protective effects of phenformin on zebrafish embryonic neurodevelopmental toxicity induced by X-ray radiation.Artif Cells Nanomed Biotechnol.2019 Dec;47(1):4202-4210.

9.      Li Y,Di C,Wu J, Si J, et al. A peptide-based fluorescent sensor for selective imaging of glutathione in living cells and zebrafish.Anal Bioanal Chem.2019 Nov 14. doi: 10.1007/s00216-019-02257-4.

10.  Sun C, Liu X, Wang B, Wang Z, Liu Y, Di C, Si J, et al.  Endocytosis-mediated mitochondrial transplantation: Transferring normal human astrocytic mitochondria into glioma cells rescues aerobic respiration and enhances radiosensitivity.Theranostics.2019 May 26;9(12):3595-3607.

11.  Zhang H, Zhang B, Di C, Ali MC, Chen J, Li Z, Si J, Zhang H, Qiu H. Label-free fluorescence imaging of cytochrome c in living systems and anti-cancer drug screening with nitrogen doped carbon quantum dots.Nanoscale. 2018, 10(11):5342-5349.

12.  Gan L, Wang Z, Si J, et al. Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion 56Fe radiation induced brain injury in mice.Toxicol Appl Pharmacol.2018 ,341:1-7.

13.  Xie Y, Si J, Wang YP, et al. E2F is involved in radioresistance of carbon ion induced apoptosis via Bax/caspase 3 signal pathway in human hepatoma cell.J Cell Physiol. 2018, 233(2):1312-1320.

14.  Zhou R^#, Song JE^#, Si J, et al. Effects of Ru(CO)3Cl-glycinate on the developmental toxicitiesinduced by X-ray and carbon-ion irradiation in zebrafish embryos. 2016.Mutation Research, 793: 41-50.

15.  Chen Y, Li XK, Si J, et al. Changes of the bacterial abundance and communities in shallow ice cores from dunde and Muztagata glaciers, western China. 2016.Frontiers in microbiology. 7: 1716.

16.  Zhao QY, Mao AH, Yan JW, Si J, et al. (56)Fe ion irradiation induced apoptosis through Nrf2 pathway in mouse testis.Life sciences2016;157:32-7.

17.  Zhou X, Wang Y, Si J, et al. Laser controlled singlet oxygen generation in mitochondria to promote mitochondrial DNA replication in vitro. 2015.Scientific reports. 5:16925.

18.  Zhou R, Zhang H*, Wang ZG, Zhou X, Si J, et al. The developmental toxicity and apoptosis in zebrafish eyes induced by carbon-ion irradiation. 2015.Life Sci.139:114-122.

19.  Di CX, Sun C, Li HY, Si J, et al. Diallyl disulfide enhances carbon ion beams-induced apoptotic cell death in cervical cancer cells through regulating Tap73 /DeltaNp73. 2015.Cell Cycle. 14(23): 3725-3733.

20.  Zhou R, Si J, Zhang H*, et al. The effects of x-ray radiation on the eye development of zebrafish. 2014.Hum Exp Toxicol.,59:207–214.

21.  Ying S, Dünnebier T, Si J, Hamann U*. Estrogen receptor alpha and nuclear factor Y coordinately regulate the transcription of the SUMO-conjugating UBC9 gene in MCF-7 breast cancer cells. 2013.PLoS One.27;8(9):e75695.

       Awards

2016, Japan-Asia Youth Exchange Program in Science

Funds and projects

2019-2024, National Key R&D Program of China (2018YFE0205102)

2019-2021, Science and Technology Plan Project of Chengguan district, Lanzhou (2019RCCX0071)

2014-2017, West Light Foundation of the Chinese Academy of Sciences (2013-165)

2014-2016, National Natural Science Foundation of China (No. 11305226)