基本信息
司婧  女  硕导  中国科学院近代物理研究所
电子邮件: sijing@impcas.ac.cn
通信地址: 兰州市南昌路509号
邮政编码:

研究领域

辐射生物学;肿瘤分子生物学;遗传毒理学

招生信息

   
招生专业
071011-生物物理学
招生方向
辐射生物学,肿瘤分子生物学,遗传毒理学

教育背景

2004-09--2009-12   兰州大学   博士学位
2000-09--2004-06   兰州大学   学士学位
学历
理学博士

学位
理学博士

工作经历

   
工作简历
2016-02~2016-03,日本国立放射线研究中心, 访问学者
2013-11~现在, 中国科学院近代物理研究所, 副研究员
2013-03~2014-03,德国癌症研究中心, 访问学者
2010-03~2013-10,中国科学院近代物理研究所, 助理研究员

专利与奖励

   
奖励信息
(1) 水质污染物生物毒性分子机理研究及检测应用, 一等奖, 市地级, 2019
(2) P73变异体在恶性肿瘤放射治疗中的应用基础研究, 二等奖, 市地级, 2018
(3) 斑马鱼在环境污染检测中的应用基础研究, 一等奖, 市地级, 2018
(4) 天然抗氧化剂对辐射损伤和修复的双向调控作用, 二等奖, 市地级, 2018
(5) P73变异体在恶性肿瘤放射治疗中的应用基础研究, 三等奖, 省级, 2018
(6) 斑马鱼在环境污染检测中的应用基础研究, 二等奖, 省级, 2018
(7) 新型生物医学量子点材料的制备及应用, 二等奖, 省级, 2016
(8) 西部首个斑马鱼模式动物平台在兰州水质生物安全预警中的应用研究, 一等奖, 市地级, 2015
(9) 西部首个斑马鱼模式动物平台建设及在放射生物学研究中的应用, 二等奖, 省级, 2014
(10) 难治性肿瘤新辐射技术的应用基础研究, 三等奖, 省级, 2014
(11) 碳离子束治疗难治性肿瘤的基础与应用研究, 二等奖, 市地级, 2013

出版信息

   
发表论文
[1] li pingping, zhang jinhua, Liu, Xiaoyi, gan lu, xie yi, zhang hong, si jing. The Function and the Affecting Factors of the Zebrafish Gut Microbiota.. Front. Microbiol.[J]. 2022, [2] Zhang, Jinhua, Si, Jing, Gan, Lu, Zhou, Rong, Guo, Menghuan, Zhang, Hong. Harnessing the targeting potential of differential radiobiological effects of photon versus particle radiation for cancer treatment. JOURNAL OF CELLULAR PHYSIOLOGY[J]. 2021, 236(3): 1695-1711, https://www.webofscience.com/wos/woscc/full-record/WOS:000550508600001.
[3] Wang, Fang, Xiao, Yi, Yan, JunFang, Huang, GuoMin, Zhang, JinHua, Di, CuiXia, Si, Jing, Zhang, Hong, Mao, AiHong. Carbon ion irradiation-induced DNA damage evokes cell cycle arrest and apoptosis via the pRb/E2F1/c-Myc signaling pathway in p53-deficient prostate cancer PC-3 cells. NUCLEAR SCIENCE AND TECHNIQUES[J]. 2021, 32(3): 82-93, http://lib.cqvip.com/Qikan/Article/Detail?id=7104192801.
[4] Yan, Junfang, Xie, Yi, Si, Jing, Gan, Lu, Li, Hongyan, Sun, Chao, Di, Cuixia, Zhang, Jinhua, Huang, Guomin, Zhang, Xuetian, Zhang, Hong. Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESnull. 2021, 22(2): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830632/.
[5] Hu, Guodong, Jia, Huiyi, Hou, Yanan, Han, Xiao, Gan, Lu, Si, Jing, Cho, DongHyung, Zhang, Hong, Fang, Jianguo. Decrease of Protein Vicinal Dithiols in Parkinsonism Disclosed by a Monoarsenical Fluorescent Probe. ANALYTICAL CHEMISTRY[J]. 2020, 92(6): 4371-4378, https://www.webofscience.com/wos/woscc/full-record/WOS:000526563900028.
[6] Zhang, Jinhua, Si, Jing, Gan, Lu, Guo, Menghuan, Yan, Junfang, Chen, Yuhong, Wang, Fang, Xie, Yi, Wang, Yupei, Zhang, Hong. Inhibition of Wnt signalling pathway by XAV939 enhances radiosensitivity in human cervical cancer HeLa cells. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY[J]. 2020, 48(1): 479-487, https://www.webofscience.com/wos/woscc/full-record/WOS:000509033500001.
[7] Guo, Menghuan, Gan, Lu, Si, Jing, Zhang, Jinhua, Liu, Zhiyuan, Zhao, Jin, Gou, Zhong, Zhang, Hong. Role of miR-302/367 cluster in human physiology and pathophysiology. ACTA BIOCHIMICA ET BIOPHYSICA SINICAnull. 2020, 52(8): 791-800, http://lib.cqvip.com/Qikan/Article/Detail?id=7103057016.
[8] Jing Si, zhang jinhua, gan lu, guo menghuan, xie yi, di cuixia, SUN Chao, wang fang, yan junfang, zhang hong. The effects of the Wnt/β‑catenin signaling pathway on apoptosis in HeLa cells induced by carbon ion irradiation.. Oncology Reports[J]. 2020, [9] Liu, Yang, Bai, Jing, Yao, Huijun, Li, Guo, Zhang, Taofeng, Li, Sirui, Zhang, Luwei, Si, Jing, Zhou, Rong, Zhang, Hong. Embryotoxicity assessment and efficient removal of naphthalene from water by irradiated graphene aerogels. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2020, 189: http://dx.doi.org/10.1016/j.ecoenv.2019.110051.
[10] Li, Hongyan, Zhang, Hong, Huang, Guomin, Dou, Zhihui, Xie, Yi, Si, Jing, Di, Cuixia. Heavy ion radiation-induced DNA damage mediates apoptosis via the Rp127a-Rp15-MDM2-p53/E2F1 signaling pathway in mouse spermatogonia. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2020, 201: https://www.webofscience.com/wos/woscc/full-record/WOS:000546898000059.
[11] Yan, Junfang, Xie, Yi, Wang, Fang, Chen, Yuhong, Zhang, Jinhua, Dou, Zhihui, Gan, Lu, Li, Hongyan, Si, Jing, Sun, Chao, Di, Cuixia, Zhang, Hong. Carbon ion combined with tigecycline inhibits lung cancer cell proliferation by inducing mitochondrial dysfunction. LIFE SCIENCES[J]. 2020, 263: http://dx.doi.org/10.1016/j.lfs.2020.118586.
[12] Wang, Fang, Wang, Wendi, Lu, Lina, Xie, Yi, Yan, Junfang, Chen, Yuhong, Di, Cuixia, Gan, Lu, Si, Jing, Zhang, Hong, Mao, Aihong. MicroRNA-16-5p regulates cell survival, cell cycle and apoptosis by targeting AKT3 in prostate cancer cells. ONCOLOGY REPORTS[J]. 2020, 44(3): 1282-1292, https://www.webofscience.com/wos/woscc/full-record/WOS:000563563700041.
[13] Si, Jing, Zhang, Jinhua, Gan, Lu, Gu, Menghuan, Xie, Yi, Di, Cuixia, Sun, Chao, Wang, Fang, Yan, Junfang, Zhang, Hong. The effects of the Wnt/beta-catenin signaling pathway on apoptosis in HeLa cells induced by carbon ion irradiation. ONCOLOGY REPORTS[J]. 2020, 44(1): 303-312, https://www.webofscience.com/wos/woscc/full-record/WOS:000540620900026.
[14] 郭梦环, 甘露, 司婧, 张金花, 张红. 毛蕊花糖苷的药理作用及作用机制研究进展. 中成药[J]. 2020, 42(8): 2119-2125, http://lib.cqvip.com/Qikan/Article/Detail?id=7102691405.
[15] Sun, Chao, Liu, Xiongxiong, Wang, Bing, Wang, Zhenhua, Liu, Yang, Di, Cuixia, Si, Jing, Li, Hongyan, Wu, Qingfeng, Xu, Dan, Li, Ji, Li, Gang, Wang, Yupei, Wang, Fang, Zhang, Hong. Endocytosis-mediated mitochondrial transplantation: Transferring normal human astrocytic mitochondria into glioma cells rescues aerobic respiration and enhances radiosensitivity. THERANOSTICS[J]. 2019, 9(12): 3595-3607, https://www.webofscience.com/wos/woscc/full-record/WOS:000469953000015.
[16] Wang, Yupei, Zhou, Xin, Zhao, Baoquan, Ren, Xiaotang, Chen, Yuhong, Si, Jing, Zhou, Rong, Gan, Lu, Zhang, Hong. Early embryonic exposure of ionizing radiations disrupts zebrafish pigmentation. JOURNAL OF CELLULAR PHYSIOLOGY[J]. 2019, 234(1): 940-949, https://www.webofscience.com/wos/woscc/full-record/WOS:000451533300079.
[17] Li, Yongxin, Di, Cuixia, Wu, Jiang, Si, Jing, Zhang, Qianjing, Zhang, Hong, Ge, Yushu, Liu, Dan, Liu, Weisheng. Selective imaging of analytes in living cells and zebrafish using a novel peptide-based fluorescence chemosensor with different responses. MICROCHEMICAL JOURNAL[J]. 2019, 150: http://dx.doi.org/10.1016/j.microc.2019.104182.
[18] Gan, Lu, Guo, Menghuan, Si, Jing, Zhang, Jinhua, Liu, Zhiyuan, Zhao, Jin, Wang, Fang, Yan, Junfang, Li, Hongyan, Zhang, Hong. Protective effects of phenformin on zebrafish embryonic neurodevelopmental toxicity induced by X-ray radiation. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY[J]. 2019, 47(1): 4202-4210, [19] Li, Hongyan, Zhang, Weihong, Zhang, Hong, Xie, Yi, Sun, Chao, Di, Cuixia, Si, Jing, Gan, Lu, Yan, Junfang. Mitochondrial proteomics reveals the mechanism of spermatogenic cells apoptosis induced by carbon ion radiation in zebrafish. JOURNAL OF CELLULAR PHYSIOLOGY[J]. 2019, 234(12): 22439-22449, [20] 张金花, 杨碎胜, 司婧. 乳腺癌放疗增敏与机制研究进展. 中华肿瘤防治杂志. 2019, 26(4): 277-284, http://lib.cqvip.com/Qikan/Article/Detail?id=7001684413.
[21] Zhang, Jinhua, Si, Jing, Gan, Lu, Di, Cuixia, Xie, Yi, Sun, Chao, Li, Hongyan, Guo, Menghuan, Zhang, Hong. Research progress on therapeutic targeting of quiescent cancer cells. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY[J]. 2019, 47(1): 2810-2819, https://www.webofscience.com/wos/woscc/full-record/WOS:000474568400005.
[22] Si, Jing, Zhou, Rong, Zhao, Baoquan, Xie, Yi, Gan, Lu, Zhang, Jinhua, Wang, Yupei, Zhou, Xin, Ren, Xiaotang, Zhang, Hong. Effects of ionizing radiation and HLY78 on the zebrafish embryonic developmental toxicity. TOXICOLOGY[J]. 2019, 411: 143-153, http://dx.doi.org/10.1016/j.tox.2018.10.004.
[23] Yan, Junfang, Xie, Yi, Zhang, Qianjing, Gan, Lu, Wang, Fang, Li, Hongyan, Si, Jing, Zhang, Hong. Dynamic recognition and repair of DNA complex damage. JOURNAL OF CELLULAR PHYSIOLOGY[J]. 2019, 234(8): 13014-13020, [24] Lu Gan, Zhenhua Wang, Jing Si, Rong Zhou, Chao Sun, Yang Liu, Yancheng Ye, Yanshan Zhang, Zhiyuan Liu, Hong Zhang. Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion 56Fe radiation induced brain injury in mice. Toxicology and Applied Pharmacology. 2018, 341: 1-7, http://dx.doi.org/10.1016/j.taap.2018.01.003.
[25] Xie, Yi, Si, Jing, Wang, YuPei, Li, HongYan, Di, CuiXia, Yan, JunFang, Ye, YanCheng, Zhang, YanShan, Zhang, Hong. E2F is involved in radioresistance of carbon ion induced apoptosis via Bax/caspase 3 signal pathway in human hepatoma cell. JOURNAL OF CELLULAR PHYSIOLOGY[J]. 2018, 233(2): 1312-1320, https://www.webofscience.com/wos/woscc/full-record/WOS:000414593500052.
[26] Liu, Yang, Yan, Jiawei, Sun, Cao, Li, Guo, Li, Sirui, Zhang, Luwei, Di, Cuixia, Gan, Lu, Wang, Yupei, Zhou, Rong, Si, Jing, Zhang, Hong. Ameliorating mitochondrial dysfunction restores carbon ion-induced cognitive deficits via co-activation of NRF2 and PINK1 signaling pathway. REDOX BIOLOGY[J]. 2018, 17: 143-157, http://dx.doi.org/10.1016/j.redox.2018.04.012.
[27] Zhao, Libo, Si, Jing, Wei, Yuan, Li, Sirui, Jiang, Yanjiao, Zhou, Rong, Liu, Bin, Zhang, Hong. Toxicity of porcelain-fused-to-metal substrate to zebrafish (Danio rerio) embryos and larvae. LIFE SCIENCES[J]. 2018, 203: 66-71, http://dx.doi.org/10.1016/j.lfs.2018.04.019.
[28] Zhang, Haijuan, Zhang, Baoxin, Di, Cuixia, Ali, Mohammad Chand, Chen, Jia, Li, Zhan, Si, Jing, Zhang, Hong, Qiu, Hongdeng. Label-free fluorescence imaging of cytochrome c in living systems and anti-cancer drug screening with nitrogen doped carbon quantum dots. NANOSCALE[J]. 2018, 10(11): 5342-5349, http://210.77.64.217/handle/362003/24519.
[29] Gan, Lu, Wang, Zhenhua, Si, Jing, Zhou, Rong, Sun, Chao, Liu, Yang, Ye, Yancheng, Zhang, Yanshan, Liu, Zhiyuan, Zhang, Hong. Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion Fe-56 radiation induced brain injury in mice. TOXICOLOGY AND APPLIED PHARMACOLOGY[J]. 2018, 341: 1-7, [30] Wang, Yupei, Hou, Qinzheng, Xiao, Guoqing, Yang, Shifeng, Di, Cuixia, Si, Jing, Zhou, Rong, Ye, Yancheng, Zhang, Yanshan, Zhang, Hong. Selective ATP hydrolysis inhibition in F1Fo ATP synthase enhances radiosensitivity in non-small-cell lung cancer cells (A549). ONCOTARGET[J]. 2017, 8(32): 53602-53612, https://www.webofscience.com/wos/woscc/full-record/WOS:000407124100127.
[31] Jing Si, Rong Zhou, Jinge Song, Lu Gan, Xin Zhou, Cuixia Di, Yang Liu, Aihong Mao, Qiuyue Zhao, Yupei Wang, Hong Zhang. Toxic effects of 56Fe ion radiation on the zebrafish (Danio rerio) embryonic development. Aquatic Toxicology. 2017, 186: 87-95, http://dx.doi.org/10.1016/j.aquatox.2017.02.028.
[32] 张金花, 桂芳, 司婧, 张红, 周蓉, 甘露. 斑马鱼肠道微生物的研究进展. 中国实验动物学报[J]. 2017, 25(6): 637-642, http://lib.cqvip.com/Qikan/Article/Detail?id=7000409391.
[33] Song Jing E, Si Jing, Zhou Rong, Liu Hua Peng, Wang Zhen Guo, Gan Lu, Gui Fang, Liu Bin, Zhang Hong. Effects of Exogenous Carbon Monoxide Releasing Molecules on the Development of Zebrafish Embryos and Larvae. BIOMEDICAL AND ENVIRONMENTAL SCIENCES[J]. 2016, 29(6): 453-456, http://lib.cqvip.com/Qikan/Article/Detail?id=669467482.
[34] Zhou, Rong, Song, Jinge, Si, Jing, Zhang, Hong, Liu, Bin, Gan, Lu, Zhou, Xin, Wang, Yupei, Yan, Junfang, Zhang, Qianjing. Effects of Ru(CO)3Cl-glycinate on the developmental toxicities induced by X-ray and carbon-ion irradiation in zebrafish embryos. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS[J]. 2016, 793: 41-50, http://dx.doi.org/10.1016/j.mrfmmm.2016.11.001.
[35] Zhao, Qiuyue, Mao, Aihong, Yan, Jiawei, Si, Jing, Zhou, Rong, Gan, Lu, Liu, Yang, Zhang, Hong. Fe-56 ion irradiation induced apoptosis through Nrf2 pathway in mouse testis. LIFE SCIENCES[J]. 2016, 157: 32-37, http://www.corc.org.cn/handle/1471x/2376002.
[36] Chen, Yong, Li, XiangKai, Si, Jing, Wu, GuangJian, Tian, LiDe, Xiang, ShuRong. Changes of the Bacterial Abundance and Communities in Shallow Ice Cores from Dunde and Muztagata Glaciers, Western China. FRONTIERS IN MICROBIOLOGY[J]. 2016, 7: http://ir.itpcas.ac.cn/handle/131C11/7506.
[37] Mao, Aihong, Liu, Yang, Wang, Yali, Zhao, Qiuyue, Zhou, Xin, Sun, Chao, Di, Cuixia, Si, Jing, Gan, Lu, Zhang, Hong. miR-449a enhances radiosensitivity through modulating pRb/E2F1 in prostate cancer cells. TUMOR BIOLOGY[J]. 2016, 37(4): 4831-4840, https://www.webofscience.com/wos/woscc/full-record/WOS:000374904500064.
[38] Mao, Aihong, Zhao, Qiuyue, Zhou, Xin, Sun, Chao, Si, Jing, Zhou, Rong, Gan, Lu, Zhang, Hong. MicroRNA-449a enhances radiosensitivity by downregulation of c-Myc in prostate cancer cells. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000376862000001.
[39] Di, Cuixia, Sun, Chao, Li, Hongyan, Si, Jing, Zhang, Hong, Han, Lu, Zhao, Qiuyue, Liu, Yang, Liu, Bin, Miao, Guoying, Gan, Lu, Liu, Yuanyuan. Diallyl disulfide enhances carbon ion beams-induced apoptotic cell death in cervical cancer cells through regulating Tap73/Delta Np73. CELL CYCLE[J]. 2015, 14(23): 3725-3733, https://www.webofscience.com/wos/woscc/full-record/WOS:000366450600013.
[40] Zhou, Xin, Wang, Yupei, Si, Jing, Zhou, Rong, Gan, Lu, Di, Cuixia, Xie, Yi, Zhang, Hong. Laser controlled singlet oxygen generation in mitochondria to promote mitochondrial DNA replication in vitro. SCIENTIFIC REPORTS[J]. 2015, 5: http://dx.doi.org/10.1038/srep16925.
[41] Zhou, R, Si, J, Zhang, H, Wang, Z, Li, J, Zhou, X, Can, L, Liu, Y. The effects of x-ray radiation on the eye development of zebrafish. HUMAN & EXPERIMENTAL TOXICOLOGY[J]. 2014, 33(10): 1040-1050, https://www.webofscience.com/wos/woscc/full-record/WOS:000343382400005.
[42] 鲁疆, 贺靖, 孙培环, 姚雯, 司婧, 甘露, 周鑫, 张红, 王振华. 迷迭香酸对氯化镉致斑马鱼胚胎发育毒性的保护作用. 生物物理学报[J]. 2013, 29(5): 338-350, [43] Jing Si, zhang hong, wang zhen hua, wu zhenhua, lu jiang, di cuixia, wang xiaowei. Effects of 12C6+ ion radiation and ferulic acid on zebrafish (Danio rerio) embryonic oxidative stress response and gene expression.. Mutat Res.[J]. 2013, [44] 司婧, 张红, 武振华. 离子注入技术在植物育种中的应用与研究进展. 辐射研究与辐射工艺学报[J]. 2012, 30(6): 321-327, 

科研活动

   
科研项目
( 1 ) 重离子辐射诱导斑马鱼心血管损伤分子机理的研究, 主持, 国家级, 2014-01--2016-12
( 2 ) 利用单核苷酸多态性标志物预测乳腺癌放疗敏感性的基础研究及应用, 主持, 部委级, 2014-01--2016-12
( 3 ) 利用斑马鱼监测黄河兰州段水质——分子标志物筛选的研究及应用, 主持, 省级, 2016-01--2017-12
( 4 ) 重离子克服静止期癌细胞辐射抗拒性的分子机理研究, 主持, 国家级, 2019-08--2024-07
( 5 ) 肠道微生物对重离子放疗的调控作用研究, 主持, 省级, 2019-01--2021-12