General

Current Research: 

Biomedical Materials: Ceramics, glasses, glass-ceramics and composites for medical and dental applications; bioactive materials; scaffolds for musculoskeletal tissue engineering; ceramics and glasses for drug delivery and wound healing

Advanced Ceramics: Processing, sintering, and microstructure control of ceramics


Research Areas

Bone Tissue Engineering

Bioactive Glass

Osteoimmunology

Wound dressing

Marine biomaterials


Education

02/2018-now Shenzhen Institutes of Advanced Technology, CAS Associate professor

07/2015-01/2018 Shenzhen Institutes of Advanced Technology, CAS Research associate

09/2010-03/2015 Tongji University Materials Science Ph. D

09/2007-07/2010 Huaqiao University Materials processing engineering M.S

09/2003 - 07/2007 Huaqiao University Materials Science and Engineering B.S

Experience

   
Work Experience

Associate research fellow in Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

Senior engineer of Medical Devices
Teaching Experience
Biomaterials

Tissue Engineering

Sintering and Microstructure Control

Organic Additives in Ceramic Processing

Thermal Processes in Ceramics

Publications


Papers

  1. Mengke Fan#, Youliang Ren#, Yanbin Zhu#, Hao Zhang, Shuaijie Li, Chunyu Liu, Hongzhi Lv, Lei Chu, Zhiyong Hou, Yingze Zhang, Haobo Pan*, Xu Cui*, Wei Chen*. Borosilicate bioactive glass synergizing low-dose antibiotic loaded implants to combat bacteria through ATP disruption and oxidative stress to sequentially achieve osseointegration. Bioactive Materials, 2025, 44, 184–204. (JCR Q1, IF 18)
  2. Liyan Zhang#, Jing Huang#, Li Li#, Hao Zhang, Shuaijie Li, Wenwen Chai, Xiaochen Chen, Chunyu Liu, John Robert Honiball, Bing Li, Youliang Ren, Lei Chu, Xuegang Luo*, Haobo Pan*, Xu Cui*. Exploratory Investigation of Zinc-Modified Borosilicate Bioactive Glass: A New Methodology for Its Biocompatibility, Immunoregulation, and Pro-Angiogenic Property Evaluation. ACS Applied Materials & Interfaces, 2024, 16, 46016−46034. (JCR Q1, IF 8.5)
  3. Ying Jin#, Hang Liu#, Lei Chu#, Jin Yang, Xiuyang Li, Hang Zhou, Haitao Jiang, Lei Shi, Jason Weeks, Joshua Rainbolt, Changjiang Yang, Thomas Xue, Haobo Pan, Zhongliang Deng*, Chao Xie, Xu Cui*, Youliang Ren*. Initial therapeutic evidence of a borosilicate bioactive glass (BSG) and Fe3O4 magnetic nanoparticle scaffold on implant-associated Staphylococcal aureus bone infection. Bioactive Materials, 2024, 40, 148-167. (JCR Q1, IF 18)
  4. Wenwen Chai, Xiaochen Chen, Jing Liu, Liyan Zhang, Chunyu Liu, Li Li, John Robert Honiball, Haobo Pan*, Xu Cui*, Deping Wang*. Recent progress in functional metal–organic frameworks for bio-medical application. Regenerative Biomaterials, 2024, 11, rbad115. (JCR Q1, IF 5.7)
  5. Xiaochen Chen#, Liyan Zhang#, Wenwen Chai, Pengfei Tian, Jua Kim, Jingxin Ding, Hao Zhang, Chunyu Liu, Deping Wang*, Xu Cui*, Haobo Pan*. Hypoxic Microenvironment Reconstruction with Synergistic Biofunctional Ions Promotes Diabetic Wound. Advanced Healthcare Materials, 2023, 2301984. (JCR Q1, IF 10.0)
  6. Chunyu Liu#, Xu Cui#, Yunbo Du#, Xue Wang, Jua Kim, Shuaijie Li, Liyan Zhang, Xiaoli Zhao, Limin Zhao, Pengfei Tian, Hao Zhang, Kun Su, Xian Li, Haobo Pan*. Unusual Surface Coagulation Activation Patterns of Crystalline and Amorphous Silicate-Based Biominerals. Advanced Healthcare Materials, 2023, 2300039. (JCR Q1, IF 10.0)
  7. Hao Zhang#, Li Li#, Lei Chu#, Jing Huang, Xiaochen Chen, Xianglong Zhuo, Yulin Wang, John Robert Honiball, Bin Wang, Wei Chen, William W. Lu, Deping Wang, Bing Li*, Xu Cui*, Haobo Pan*. Dual-functional borosilicate glass (BSG) delivery implant for osteomyelitis treatment and bone regeneration. Composites Part B: Engineering, 2023, 259, 110749. (JCR Q1, IF 12.7)
  8. Pengfei Tian#, Limin Zhao#, Jua Kim, Xian Li, Chunyu Liu, Xu Cui, Tao Liang, Yunbo Du, Xiehui Chen, Haobo Pan*. Dual stimulus responsive borosilicate glass (BSG) scaffolds promote diabetic alveolar bone defects repair by modulating macrophage phenotype. Bioactive Materials, 2023, 26, 231-248. (JCR Q1, IF 18)
  9. Shuaijie Li, Liyan Zhang, Chunyu Liu, Jua Kim, Kun Su, Tingli Chen, Limin Zhao, Xiaomei Lu, Hao Zhang, Yinglin Cui, Xu Cui*, Feng Yuan*, Haobo Pan*. Spontaneous immunomodulation and regulation of angiogenesis and osteogenesis by Sr/Cu-borosilicate glass (BSG) bone cement to repair critical bone defects. Bioactive Materials, 2023, 23, 101-117. (JCR Q1, IF 18)
  10. Hao Zhang#, Yinglin Cui#, Xianglong Zhuo#, Jua Kim, Honglong Li, Shuaijie Li, Hongsheng Yang, Kun Su, Chunyu Liu, Pengfei Tian, Xian Li, Li Li, Deping Wang, Limin Zhao, Jianyun Wang, Xu Cui*, Bing Li*, Haobo Pan*. Biological fixation of bioactive bone cement in vertebroplasty: The first clinical investigation of borosilicate glass (BSG) reinforced PMMA bone cement. ACS Applied Materials & Interfaces, 2022, 14, 51711-51727. (JCR Q1, IF 8.5)
  11. Li Li#, Yonghua Huang#, Jianguo Qin#, John Robert Honiball, Dingfu Wen, Xiangtao Xie, Zhanying Shi*, Xu Cui*, Bing Li*. Development of a borosilicate bioactive glass scaffold incorporating calcitonin gene-related peptide for tissue engineering. Biomaterials Advances, 2022,138, 212949. (JCR Q1, IF 5.5)
  12. Libin Pang#, Renliang Zhao#, Jing Chen#, Jingxin Ding, Xiaochen Chen, Wenwen Chai, Xu Cui, Xiaolin Li*, Deping Wang*, Haobo Pan*. Osteogenic and anti-tumor Cu and Mn-doped borosilicate nanoparticles for syncretic bone repair and chemodynamic therapy in bone tumor treatment. Bioactive Materials, 2022, 12, 1-15. (JCR Q1, IF 18)
  13. Libin Pang#, Pengfei Tian#, Xu Cui#, Xiuping Wu*, Xiaoli Zhao, Hui Wang, Deping Wang*, Haobo Pan*. In Situ Photo-Cross-Linking Hydrogel Accelerates Diabetic Wound Healing through Restored Hypoxia-Inducible Factor 1-Alpha Pathway and Regulated Inflammation. ACS Applied Materials & Interfaces, 2021, 13, 25, 29363-29379. (JCR Q1, IF 8.5)
  14. Xu Cui#, Chengcheng Huang#, Zhizhen Chen#, Meng Zhang, Chunyu Liu, Kun Su, Jianyun Wang, Li Li, Renxian Wang, Bing Li, Dafu Chen, Changshun Ruan, Deping Wang, William W. Lu, Haobo Pan*. Hyaluronic acid facilitates bone repair effects of calcium phosphate cement by accelerating osteogenic expression. Bioactive Materials, 2021, 6, 3801-3811. (JCR Q1, IF 18)
  15. Zhangfan Wu, Ziyang Lin, Aihua Yao, Song Ye, Haobo Pan, Xu Cui*, Deping Wang*. Influence of particle size distribution on the rheological properties and mathematical model fitting of injectable borosilicate bioactive glass bone cement. Ceramics International, 2020, 46 (15): 24395-22406. (JCR Q1, IF 5.1)
  16. Yucheng Yang, Ziyang Lin, Xin Xie, Zhangfan Wu, Aihua Yao, Song Ye, Jian Lin, Deping Wang*, Xu Cui*. An injectable composite bone cement based on mesoporous borosilicate bioactive glass spheres. Journal of Inorganic Materials, 2020, 35 (12), 1398-1406. (JCR Q3, IF 1.7)
  17. Xu Cui#, Yadong Zhang#, Jianyun Wang#, Chengcheng Huang, Yudong Wang, Hongsheng Yang, Wenlong Liu, Ting Wang, Deping Wang, Guocheng Wang, Changshun Ruan, Dafu Chen*, William W. Lu, Wenhai Huang, Mohamed N. Rahaman*, Haobo Pan*. Strontium Modulates Osteogenic Activity of Bone Cement Composed of Bioactive Borosilicate Glass Particles by Activating Wnt/β-catenin signaling pathway. Bioactive Materials, 2020, 5, 334-347. (JCR Q1, IF 18)
  18. Meng Zhang, Jukka P. Matinlinna, James K. H. Tsoi, Wenlong Liu, Xu Cui, William W. Lu, Haobo Pan. Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview. Journal of Orthopaedic Translation, 2020, 22, 26-33. (JCR Q1, IF 5.9)
  19. Fei Gao, Ziyang Xu, Qingfei Liang, Haofei Li, Liuqi Peng, Mingming Wu, Xiaoli Zhao, Xu Cui, Changshun Ruan*, Wenguang Liu*. Osteochondral Regeneration with 3DPrinted Biodegradable HighStrength Supramolecular Polymer Reinforced-Gelatin Hydrogel Scaffolds. Advanced Science, 2019, 6 (15), 1900867. (JCR Q1, IF 14.3)
  20. Wenlong Liu, Xiuli Dan, William W. Lu, Xiaoli Zhao, Changshun Ruan, Ting Wang, Xu Cui, Xinyun Zhai, Yufei Ma, Deping Wang, Wenhai Huang, Haobo Pan*. Spatial Distribution of Biomaterial Microenvironment pH and Its Modulatory Effect on Osteoclasts at the Early Stage of Bone Defect Regeneration. ACS Applied Materials & Interfaces, 2019, 11(9), 9557-9572. (JCR Q1, IF 8.5)
  21. Tiancheng Lv, Wei Liang, Li Li, Xu Cui, Xiaomou Wei, Haobo Pan, Bing Li*. Novel calcitonin generelated peptide/chitosanstrontiumcalcium phosphate cement: Enhanced proliferation of human umbilical vein endothelial cells in vitro. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2019, 107(1), 19-28. (JCR Q3, IF 3.2)
  22. Xu Cui, Chengcheng Huang, Meng Zhang, Changshun Ruan*, Songlin Peng, Li Li, Wenlong Liu, Ting Wang, Bing Li, Wenhai Huang, Mohamed N. Rahaman, William W Lu, Haobo Pan*. Enhanced osteointegration of poly(methylmethacrylate) bone cements by incorporating strontium-containing borate bioactive glass. Journal of the Royal Society Interface, 2017, 14(131), 20161057. (JCR Q2, IF 3.7)
  23. Xu Cui, Wenhai Huang, Yadong Zhang*, Chengcheng Huang, Zunxiong Yu, Lei Wang, Wenlong Liu, Ting Wang, Jie Zhou, Hui Wang, Nai Zhou, Deping Wang, Haobo Pan*, Mohamed N. Rahaman*. Evaluation of an injectable bioactive borate glass cement to heal bone defects in a rabbit femoral condyle model. Materials Science and Engineering: C, 2017, 73, 585–595. (JCR Q1, IF 8.1)
  24. Li Li, Xiaozhong Peng, Yongbao Qin, Renchong Wang, Jingli Tang, Xu Cui, Ting Wang, Wenlong Liu, Haobo Pan*, Bing Li*. Acceleration of bone regeneration by activating Wnt/β-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis. Scientific Reports, 2017, 7, 45204. (JCR Q2, IF 3.8)
  25. Guilin Luo, Yufei Ma, Xu Cui, Lixin Jiang, Mingming Wu, Yang Hu, Yanfeng Luo, Haobo Pan, Changshun Ruan*. 13-93 bioactive glass/alginate composite scaffolds 3D printed under mild conditions for bone regeneration. RSC Advances, 2017, 7, 11880-11889. (JCR Q2, IF 3.9)
  26. Li Li, Renchong Wang, Baichuan Li, Wei Liang, Haobo Pan, Xu Cui, Jingli Tang, Bing Li*. Lithium doped calcium phosphate cement maintains physical mechanical properties and promotes osteoblast proliferation and differentiation. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2016, 105(5), 944-952. (JCR Q3, IF 3.2)
  27. Wei Liang, Zhongfei Tang, Xiaomou Wei, Bing Li*, Li Li, Xu Cui, Haobo Pan. Enhanced proliferation and differentiation effects of a CGRP- and Sr-enriched calcium phosphate cement on bone mesenchymal stem cells. Journal of Applied Biomaterials & Functional Materials, 2016, 14(4), 431-440. (JCR Q4, IF 3.1)
  28. Xu Cui#, Yadong Zhang#, Shichang Zhao, Hui Wang, Haobo Pan*, Mohamed N. Rahaman*, Wenhai Huang*, Changqing Zhang. An injectable borate bioactive glass cement for bone repair: Preparation, bioactivity and setting mechanism. Journal of Non-Crystalline Solids, 2016, 432, 150-157. (JCR Q1, IF 3.2)
  29. Hui WangShichang Zhao,  Jie Zhou, Kaiping Zhu, Xu Cui,   Wenhai Huang,   Mohamed N. Rahaman*,  Changqing Zhang*, Deping Wang*. Biocompatibility and osteogenic capacity of borosilicate bioactive glass scaffolds loaded with Fe3O4 magnetic nanoparticles. Journal of Materials Chemistry B, 2015, 21, 4377-4387. (JCR Q1, IF 6.1)
  30. Hui WangShichang Zhao, Wei Xiao, Xu CuiWenhai HuangMohamed N. Rahaman*, Changqing Zhang*, Deping Wang*. Three-dimensional zinc incorporated borosilicate bioactive glass scaffolds for rodent critical-sized calvarial defects repair and regeneration. Colloids and Surfaces B: Biointerfaces, 130, 149-156, 2015. (JCR Q2, IF 5.4)
  31. Hui Wang, Shichang Zhao, Xu Cui, Yangyi Pan, Wenhai Huang, Song Ye, Shihua Luo, Mohamed N. Rahaman, Changqing Zhang, Deping Wang. Evaluation of three-dimensional silver-doped borate bioactive glass scaffolds for bone repair: Biodegradability, biocompatibility, and antibacterial activity. Journal of Materials Research, 2015, 30(18), 2722-2735. (JCR Q3, IF 2.7)
  32. Yadong Zhang#, Xu Cui#, Shichang Zhao, Hui Wang, Mohamed N. Rahaman, Wenhai Huang, Changqing Zhang. Evaluation of Injectable Strontium-Containing Borate Bioactive Glass Cement with Enhanced Osteogenic Capacity in a Critical-Sized Rabbit Femoral Condyle Defect Model. ACS Applied Materials & Interfaces, 2015, 7(4), 2393-2403. (JCR Q1, IF 8.5)
  33. Xu Cui, Cunju Zhao, Yifei GuLe LiHui WangWenhai Huang*, Nai Zhou, Deping Wang, Yi Zhu, Jun Xu, Shihua LuoChangqing Zhang, Mohamed N. Rahaman*. A novel injectable borate bioactive glass cement for local delivery of vancomycin to cure osteomyelitis and regenerate bone. Journal of Materials Science: Materials in Medicine, 2014, 25(3), 733-745. (JCR Q2, IF 4.2)
  34. Hao Ding, Cun-Ju Zhao, Xu Cui, Yi-Fei Gu,Wei-Tao Jia, Mohamed N. Rahaman, Yang Wang, Wen-Hai Huang*,Chang-Qing Zhang*. A Novel Injectable Borate Bioactive Glass Cement as an Antibiotic Delivery Vehicle for Treating Osteomyelitis. Plos one, 2014, 9(10), 1-9. (JCR Q2, IF 2.9)
  35. Xu CuiYifei GuLe LiHui WangZhongping XieShihua LuoNai ZhouWenhai Huang*, Mohamed N. Rahaman. In vitro bioactivity, cytocompatibility, and antibiotic release profile of gentamicin sulfate-loaded borate bioactive glass/chitosan composites. Journal of Materials Science: Materials in Medicine, 2013, 24(10), 2391-2403. (JCR Q2, IF 4.2)
  36. Zongping XieXu CuiCunju ZhaoWenhai HuangJianqiang Wang,  Changqing Zhang*. Gentamicin-Loaded Borate Bioactive Glass Eradicates Osteomyelitis Due to Escherichia coli in a Rabbit Model. Antimicrobial agents and chemotherapy, 2013, 57(7), 3293-3298. (JCR Q2, IF 4.1)

Students

已指导学生

卢丹萍  硕士研究生  085204-材料工程  

叶丰明  硕士研究生  085204-材料工程  

胡成深  硕士研究生  085204-材料工程  

张倩  硕士研究生  085600-材料与化工  

纪佳雯  硕士研究生  085600-材料与化工  

张旭  硕士研究生  086000-生物与医药  

唐澜  硕士研究生  085204-材料工程  

钟继锐  硕士研究生  086000-生物与医药  

现指导学生

秦瑞晴  硕士研究生  086000-生物与医药  

方心怡  硕士研究生  086000-生物与医药