基本信息

崔旭  男  博导  中国科学院深圳先进技术研究院
电子邮件: xu.cui@siat.ac.cn
通信地址: 广东省深圳市南山区西丽大学城学苑大道1068号
邮政编码: 518055

研究领域

骨组织工程

碱性微环境

骨免疫学

生物活性玻璃

创伤敷料

海洋生物材料


招生信息

   
招生专业
080501-材料物理与化学
071010-生物化学与分子生物学
070304-物理化学
招生方向
生物医用材料,生物活性玻璃
组织工程,骨修复
骨免疫学

教育背景

2014-03--2015-03   中国科学院深圳先进技术研究院   客座博士研究生
2010-09--2015-03   同济大学   博士研究生
2007-09--2010-06   国立华侨大学   硕士研究生
2003-09--2007-06   国立华侨大学   本科
学历

博士研究生

学位
博士

工作经历

   
工作简历
2018-01~2018-06,中国科学院深圳先进技术研究院, 高级工程师
2015-07~2017-12,中国科学院深圳先进技术研究院, 助理研究员
社会兼职
2014-05-30-2020-06-30,深圳市中科海世御生物科技有限公司, 研发总监

专利与奖励

   
专利成果
[1] 潘浩波, 王聿栋, 崔旭. 掺硼生物活性玻璃微球及其制备方法与应用. CN: CN110272209A, 2019-09-24.
[2] 潘浩波, 张朦, 崔旭, 杨鸿生. 生物活性骨水泥固相剂及制备方法、生物活性骨水泥浆体、固化体和试剂盒及应用. CN: CN109602948A, 2019-04-12.
[3] 崔旭, 崔旭, 程德林, 杨鸿生, 黄程程, 张朦, 吴桐. 聚氨酯海绵材料及其制备方法、应用和聚氨酯海绵制品. CN: CN109550071A, 2019-04-02.
[4] 潘浩波, 崔旭, 崔旭, 黄程程. 骨水泥成型模具. 中国: CN204673985U, 2015-09-30.
[5] 余遵雄, 崔旭, 黄程程, 潘浩波. 骨水泥成型模具及成型方法. 中国: CN104908288A, 2015-09-16.
[6] 潘浩波, 崔旭, 崔旭, 高楠莎, 岳建辉, 李红龙, 窦庶华. 一种金枪鱼鱼骨粉材料及其制备方法和应用. 中国: CN104841016A, 2015-08-19.

出版信息

发表论文
[1] Pang, Libin, Zhao, Renliang, Chen, Jing, Ding, Jingxin, Chen, Xiaochen, Chai, Wenwen, Cui, Xu, Li, Xiaolin, Wang, Deping, Pan, Haobo. Osteogenic and anti-tumor Cu and Mn-doped borosilicate nanoparticles for syncretic bone repair and chemodynamic therapy in bone tumor treatment. BIOACTIVE MATERIALS[J]. 2022, 12: 1-15, [2] Cui, Xu, Huang, Chengcheng, Chen, Zhizhen, Zhang, Meng, Liu, Chunyu, Su, Kun, Wang, Jianyun, Li, Li, Wang, Renxian, Li, Bing, Chen, Dafu, Ruan, Changshun, Wang, Deping, Lu, William W, Pan, Haobo. Hyaluronic acid facilitates bone repair effects of calcium phosphate cement by accelerating osteogenic expression. BIOACTIVE MATERIALS[J]. 2021, 6(11): 3801-3811, http://dx.doi.org/10.1016/j.bioactmat.2021.03.028.
[3] Pang, Libin, Tian, Pengfei, Cui, Xu, Wu, Xiuping, Zhao, Xiaoli, Wang, Hui, Wang, Deping, Pan, Haobo. In Situ Photo-Cross-Linking Hydrogel Accelerates Diabetic Wound Healing through Restored Hypoxia-Inducible Factor 1-Alpha Pathway and Regulated Inflammation. ACS APPLIED MATERIALS & INTERFACES[J]. 2021, 13(25): 29363-29379, http://dx.doi.org/10.1021/acsami.1c07103.
[4] Xu Cui, Yadong Zhang, Jianyun Wang, Chengcheng Huang, Yudong Wang, Hongsheng Yang, Wenlong Liu, Ting Wang, Deping Wang, Guocheng Wang, Changshun Ruan, Dafu Chen, William W Lu, Wenhai Huang, Mohamed N Rahaman, Haobo Pan. Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating Wnt/β-catenin signaling pathway. Bioactive Materials[J]. 2020, 5(2): 334-347, http://lib.cqvip.com/Qikan/Article/Detail?id=7103847721.
[5] Zhang, Meng, Matinlinna, Jukka P, Tsoi, James K H, Liu, Wenlong, Cui, Xu, Lu, William W, Pan, Haobo. Recent developments in biomaterials for long-bone segmental defect reconstruction: A narrative overview. JOURNAL OF ORTHOPAEDIC TRANSLATIONnull. 2020, 22: 26-33, http://dx.doi.org/10.1016/j.jot.2019.09.005.
[6] Wu, Zhangfan, Lin, Ziyang, Yao, Aihua, Ye, Song, Pan, Haobo, Cui, Xu, Wang, Deping. Influence of particle size distribution on the rheological properties and mathematical model fitting of injectable borosilicate bioactive glass bone cement. CERAMICS INTERNATIONAL[J]. 2020, 46(15): 24395-24406, http://dx.doi.org/10.1016/j.ceramint.2020.06.222.
[7] 黄勇华, 李理, 石展英, 崔旭, 潘浩波, 李兵. 生物活性玻璃在骨修复中的应用和研究现状. 中国修复重建外科杂志[J]. 2020, 34(5): 660-666, http://lib.cqvip.com/Qikan/Article/Detail?id=7101769737.
[8] 常宇辰, 林子扬, 谢昕, 吴章凡, 姚爱华, 叶松, 林健, 王德平, 崔旭. 基于介孔硼硅酸盐生物活性玻璃微球的可注射复合骨水泥. 无机材料学报. 2020, 35(12): 1398-1406, http://lib.cqvip.com/Qikan/Article/Detail?id=7103609270.
[9] Chang Yuchen, Lin Ziyang, Xie Xin, Wu Zhangfan, Yao Aihua, Ye Song, Lin Jian, Wang Deping, Cui Xu. An Injectable Composite Bone Cement Based on Mesoporous Borosilicate Bioactive Glass Spheres. JOURNAL OF INORGANIC MATERIALS[J]. 2020, 35(12): 1398-1406, https://www.webofscience.com/wos/woscc/full-record/WOS:000592928500014.
[10] Cui, Xu, Zhang, Yadong, Wang, Jianyun, Huang, Chengcheng, Wang, Yudong, Yang, Hongsheng, Liu, Wenlong, Wang, Ting, Wang, Deping, Wang, Guocheng, Ruan, Changshun, Chen, Dafu, Lu, William W, Huang, Wenhai, Rahaman, Mohamed N, Pan, Haobo. Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating Wnt/beta-catenin signaling pathway. BIOACTIVE MATERIALS[J]. 2020, 5(2): 334-347, https://www.webofscience.com/wos/woscc/full-record/WOS:000533604500014.
[11] Gao, Fei, Xu, Ziyang, Liang, Qingfei, Li, Haofei, Peng, Liuqi, Wu, Mingming, Zhao, Xiaoli, Cui, Xu, Ruan, Changshun, Liu, Wenguang. Osteochondral Regeneration with 3D-Printed Biodegradable High-Strength Supramolecular Polymer Reinforced-Gelatin Hydrogel Scaffolds. ADVANCED SCIENCE[J]. 2019, 6(15): https://doaj.org/article/7a8457ed56f346eaa5c7c99fe39f48ca.
[12] Lv, Tiancheng, Liang, Wei, Li, Li, Cui, Xu, Wei, Xiaomou, Pan, Haobo, Li, Bing. Novel calcitonin gene-related peptide/chitosan-strontium-calcium phosphate cement: Enhanced proliferation of human umbilical vein endothelial cells in vitro. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS[J]. 2019, 107(1): 19-28, [13] Liu, Wenlong, Dan, Xiuli, Lu, William W, Zhao, Xiaoli, Ruan, Changshun, Wang, Ting, Cui, Xu, Zhai, Xinyun, Ma, Yufei, Wang, Deping, Huang, Wenhai, Pan, Haobo. Spatial Distribution of Biomaterial Microenvironment pH and Its Modulatory Effect on Osteoclasts at the Early Stage of Bone Defect Regeneration. ACS APPLIED MATERIALS & INTERFACES[J]. 2019, 11(9): 9557-9572, [14] 崔旭. patial Distribution of Biomaterial Microenvironment pH and Its Modulatory Effect on Osteoclasts at the Early Stage of Bone Defect Regeneration. ACS Applied Materials & Interfaces. 2018, [15] Cui, Xu, Huang, Chengcheng, Zhang, Meng, Ruan, Changshun, Peng, Songlin, Li, Li, Liu, Wenlong, Wang, Ting, Li, Bing, Huang, Wenhai, Rahaman, Mohamed N, Lu, William W, Pan, Haobo. Enhanced osteointegration of poly(methylmethacrylate) bone cements by incorporating strontium-containing borate bioactive glass. JOURNAL OF THE ROYAL SOCIETY INTERFACE[J]. 2017, 14(131): http://www.chinair.org.cn/handle/1471x/1748091.
[16] Li, Li, Peng, Xiaozhong, Qin, Yongbao, Wang, Renchong, Tang, Jingli, Cui, Xu, Wang, Ting, Liu, Wenlong, Pan, Haobo, Li, Bing. Acceleration of bone regeneration by activating Wnt/beta-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis. SCIENTIFIC REPORTS[J]. 2017, 7: https://www.webofscience.com/wos/woscc/full-record/WOS:000397305700001.
[17] Luo, Guilin, Ma, Yufei, Cui, Xu, Jiang, Lixin, Wu, Mingming, Hu, Yang, Luo, Yanfeng, Pan, Haobo, Ruan, Changshun. 13-93 bioactive glass/alginate composite scaffolds 3D printed under mild conditions for bone regeneration. RSC ADVANCES[J]. 2017, 7(20): 11880-11889, https://www.webofscience.com/wos/woscc/full-record/WOS:000395873500009.
[18] Cui Xu, Huang Wenhai, Zhang Yadong, Huang Chengcheng, Yu Zunxiong, Wang Lei, Liu Wenlong, Wang Ting, Zhou Jie, Wang Hui, Zhou Nai, Wang Deping, Pan Haobo, Rahaman Mohamed N. Evaluation of an injectable bioactive borate glass cement to heal bone defects in a rabbit femoral condyle model. Materials Science & Engineering C[J]. 2017, 73: 585-595, http://dx.doi.org/10.1016/j.msec.2016.12.101.
[19] Li, Li, Wang, Renchong, Li, Baichuan, Liang, Wei, Pan, Haobo, Cui, Xu, Tang, Jingli, Li, Bing. Lithium doped calcium phosphate cement maintains physical mechanical properties and promotes osteoblast proliferation and differentiation. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS[J]. 2017, 105(5): 944-952, http://www.chinair.org.cn/handle/1471x/1748084.
[20] 邓育红, 崔旭, 彭松林. SrHA/PMMA复合骨水泥的制备、理化性能及细胞相容性研究. 生物骨科材料与临床研究. 2016, 13(4): 1-7, http://lib.cqvip.com/Qikan/Article/Detail?id=669976056.
[21] Liang, Wei, Li, Li, Cui, Xu, Tang, Zhongfei, Wei, Xiaomou, Pan, Haobo, Li, Bing. Enhanced proliferation and differentiation effects of a CGRP- and Sr-enriched calcium phosphate cement on bone mesenchymal stem cells. JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS[J]. 2016, 14(4): E431-E440, https://www.webofscience.com/wos/woscc/full-record/WOS:000392835100005.
[22] Cui, Xu, Zhang, Yadong, Wang, Hui, Gu, Yifei, Li, Le, Zhou, Jie, Zhao, Shichang, Huang, Wenhai, Zhou, Nai, Wang, Deping, Pan, Haobo, Rahaman, Mohamed N. An injectable borate bioactive glass cement for bone repair: Preparation, bioactivity and setting mechanism. JOURNAL OF NON-CRYSTALLINE SOLIDS[J]. 2016, 432: 150-157, http://dx.doi.org/10.1016/j.jnoncrysol.2015.06.001.
[23] Wang, Hui, Zhao, Shichang, Zhou, Jie, Zhu, Kaiping, Cui, Xu, Huang, Wenhai, Rahaman, Mohamed N, Zhang, Changqing, Wang, Deping. Biocompatibility and osteogenic capacity of borosilicate bioactive glass scaffolds loaded with Fe3O4 magnetic nanoparticles. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2015, 3(21): 4377-4387, https://www.webofscience.com/wos/woscc/full-record/WOS:000354964300009.
[24] Wang, Hui, Zhao, Shichang, Xiao, Wei, Cui, Xu, Huang, Wenhai, Rahaman, Mohamed N, Zhang, Changqing, Wang, Deping. Three-dimensional zinc incorporated borosilicate bioactive glass scaffolds for rodent critical-sized calvarial defects repair and regeneration. COLLOIDS AND SURFACES B-BIOINTERFACES[J]. 2015, 130: 149-156, http://dx.doi.org/10.1016/j.colsurfb.2015.03.053.
[25] Wang, Hui, Zhao, Shichang, Cui, Xu, Pan, Yangyi, Huang, Wenhai, Ye, Song, Luo, Shihua, Rahaman, Mohamed N, Zhang, Changqing, Wang, Deping. Evaluation of three-dimensional silver-doped borate bioactive glass scaffolds for bone repair: Biodegradability, biocompatibility, and antibacterial activity. JOURNAL OF MATERIALS RESEARCH[J]. 2015, 30(18): 2722-2735, https://www.webofscience.com/wos/woscc/full-record/WOS:000362976100005.
[26] Zhang, Yadong, Cui, Xu, Zhao, Shichang, Wang, Hui, Rahaman, Mohamed N, Liu, Zhongtang, Huang, Wenhai, Zhang, Changqing. Evaluation of Injectable Strontium-Containing Borate Bioactive Glass Cement with Enhanced Osteogenic Capacity in a Critical-Sized Rabbit Femoral Condyle Defect Model. ACS APPLIED MATERIALS & INTERFACES[J]. 2015, 7(4): 2393-2403, https://www.webofscience.com/wos/woscc/full-record/WOS:000349137300032.
[27] Ding, Hao, Zhao, CunJu, Cui, Xu, Gu, YiFei, Jia, WeiTao, Rahaman, Mohamed N, Wang, Yang, Huang, WenHai, Zhang, ChangQing. A Novel Injectable Borate Bioactive Glass Cement as an Antibiotic Delivery Vehicle for Treating Osteomyelitis. PLOS ONE[J]. 2014, 9(1): https://doaj.org/article/4fc945e916794c51affaa94f1c85dc35.
[28] Cui, Xu, Zhao, Cunju, Gu, Yifei, Li, Le, Wang, Hui, Huang, Wenhai, Zhou, Nai, Wang, Deping, Zhu, Yi, Xu, Jun, Luo, Shihua, Zhang, Changqing, Rahaman, Mohamed N. A novel injectable borate bioactive glass cement for local delivery of vancomycin to cure osteomyelitis and regenerate bone. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE[J]. 2014, 25(3): 733-745, https://www.webofscience.com/wos/woscc/full-record/WOS:000332667700013.
[29] Xie, Zongping, Cui, Xu, Zhao, Cunju, Huang, Wenhai, Wang, Jianqiang, Zhang, Changqing. Gentamicin-Loaded Borate Bioactive Glass Eradicates Osteomyelitis Due to Escherichia coli in a Rabbit Model. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY[J]. 2013, 57(7): 3293-3298, https://www.webofscience.com/wos/woscc/full-record/WOS:000320229600048.
[30] Cui, Xu, Gu, Yifei, Li, Le, Wang, Hui, Xie, Zhongping, Luo, Shihua, Zhou, Nai, Huang, Wenhai, Rahaman, Mohamed N. In vitro bioactivity, cytocompatibility, and antibiotic release profile of gentamicin sulfate-loaded borate bioactive glass/chitosan composites. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE[J]. 2013, 24(10): 2391-2403, https://www.webofscience.com/wos/woscc/full-record/WOS:000324672900009.

科研活动

   
科研项目
( 1 ) 锶硼协同的可降解生物活性玻璃骨水泥用于骨质疏松性椎体压缩骨折的治疗及其成骨促进机制, 主持, 省级, 2017-05--2020-04
( 2 ) 中科稳健联合实验室项目子项目-硼酸盐生物活性敷料的开发, 主持, 院级, 2017-11--2020-10
( 3 ) 体内微环境pH在骨质疏松性骨折修复过程中对干细胞及破骨细胞的影响-基于硅硼体系材料表面可控pH研究, 参与, 国家级, 2017-01--2020-12
( 4 ) 新型仿生骨材料的关键技术研发, 参与, 省级, 2016-01--2018-01
( 5 ) 骨质疏松性椎体骨折修复新技术研发, 参与, 省级, 2015-08--2017-08
( 6 ) 海洋源生物活性骨水泥在脊柱压缩性骨折中应用的临床前研究, 参与, 省级, 2015-08--2017-07
( 7 ) 生物材料微碱性环境对骨质疏松骨折修复再生机制的研究, 参与, 省级, 2017-07--2020-08
( 8 ) 纳米生物活性玻璃新型骨重建材料及产品研发, 参与, 国家级, 2018-09--2021-06
( 9 ) 含锂硼硅酸盐生物活性纤维调控Wnt/β-catenin信号通路促进糖尿病溃疡创面修复重建的机理研究, 主持, 国家级, 2019-01--2021-12
( 10 ) 生物活性植入材料在大段骨缺损和韧带损伤修复重建中的机制研究, 参与, 部委级, 2018-08--2019-12
( 11 ) 生物活性玻璃基于miR-155介导单核巨噬细胞功能表达关联调控骨免疫和骨稳态的机制研究, 主持, 国家级, 2021-01--2024-12
参与会议
(1)锶硼生物活性玻璃/聚甲基丙烯酸甲酯复合骨水泥的理化性能、生物相容性和骨整合性能   2017中国生物材料大会   2017-10-27
(2)生物活性可注射型骨植入
材料的成果转化   2017 年全国骨材料与器械产学研医管交流会   2017-08-10
(3)Enhanced Osteointegration of Poly (methylmethacrylate) Bone Cements by Incorporating Strontium-containing Borate Bioactive Glass   2017-05-20
(4)可注射的硼酸盐骨再生水泥的制备,体外活性,固化机理及作为局部药物载体用于骨髓炎的治疗及骨修复研究   2016首届健康与纳米纳米生物与医药技术专业委员会 2016 学术年会   2016-12-09
(5)其他   2016年7月苏州国际植入介入医疗器械新兴技术应用峰会   2016-07-20
(6)Handling properties, bioactivity and setting mechanism of an injectable borate bioactive glass cement   2016-04-17
(7)硼酸盐生物玻璃 在生物医学中的应用   2015年中国生物材料大会   2015-11-19
(8)硼酸盐生物玻璃在生物医学中的应用   中国材料大会2015   2015-07-10

指导学生

已指导学生

卢丹萍  硕士研究生  085204-材料工程  

叶丰明  硕士研究生  085204-材料工程  

现指导学生

胡成深  硕士研究生  085204-材料工程  

纪佳雯  硕士研究生  085600-材料与化工  

张旭  硕士研究生  086000-生物与医药