PEI Gang

Ph.D., Professor

academician of the Chinese Academy of Sciences (1999), 

academicians of the Academy of Sciences for the Developing World (TWAS)(2001)

Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-yang Road, Shanghai 200031, China.

Tel: 54921371



Ph.D. in Biochemistry & Biophysics, Department of Biochemistry & Biophysics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, U. S. A. (19871991)

M.S. in Pharmaceutical Sciences, Department of Pharmaceutics, Shenyang College of Pharmacy, Shenyang,China(1982-1984) 

B.S. in Pharmacy, Shenyang College of Pharmacy, Shenyang, China (1977-1981).


Published more than 150 papers in international academic journals including Nature, Cell, Nature Immunology, Nature Medicine and Cell-Stem Cells, etc. These papers are cited more than a thousand times.

  1. Gao L, Guan W, Wang M, Wang H , Yu J, Liu Q, Qiu B, Yu Y, Ping Y, Bian X, Li S and Pei G. Direct Generation of Human Neuronal Cells from Adult Astrocytes by Small Molecules. Stem Cell Reports. 2017; 8:1 -10.
  2. Hu W, Qiu B, Guan W, Wang Q, Wang M, Li W, Gao L, Shen L, Huang Y, Xie G, Zhao H, Jin Y, Tang B, Yu Y, Zhao J, Pei G. Direct conversion of normal and Alzheimer's disease human fibroblasts into neuronal cells by small molecules. Cell Stem Cell. 2015; 17 (2) :204 -12.
  3. Cheng L, Hu W, Qiu B, Zhao J, Yu Y, Guan W, Yang W, Pei G. Generation of Neural Progenitor Cells by Chemical Cocktails and HypoxiaCell Res. 2014; 24(6):665-79.
  4. Liu X, Zhao X, Zeng X, Bossers K, Swaab D. F, Zhao J and Pei G. Beta-arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology. Cell Res. 2013; 23(3): 351-65.
  5. Yue R, Kang JH, Zhao C, Hu WX, Liu XS, Tang YW, Pei G. β-Arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Cell. 2009; 139(3):535-46.
  6. Du CS, Liu C, Kang JH, Zhao GX, Ye ZQ, Huang SC, Li ZX, Wu ZY, Pei G. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis.  Nat Immunol. 2009; 10(2):1252 –9.
  7. Luan B, Zhao J, Wu HY, Duan BY, Shu GW, Wang XY, Li DS, Jia WP, Kang JH and Pei G. Deficiency of a barrestin2 signal complex contributes to insulin resistance. Nature. 2009; 457(7233):1146-9.
  8. Shi YF, Feng Y, Kang J, Liu C, Li Z, Li D, Cao W, Qiu J, Guo Z, Bi E, Zang L,Lu C, Zang JZPei G. Critical regulation of CD4+ T cell survival and autoimmunity by β-arrestin 1. Nat Immunol. 2007; 8(8):817-24.
  9. Ni YX, Zhao X, Bao G, Zou L, Teng L, Wang Z, Song M, Xiong J, Bai Y, Pei G. Activation of β2-adrenergic receptor stimulates g-secretase activity and accelerates amyloid plaque formation. Nat Med. 2006; 12(12):1390-6.
  10. Kang JH, Shi YF, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Wang F, Zhang X, Yang R, Fan F, Chen X, Pei G and Ma L. A Nuclear Function of b-Arrestin1in GPCR Signaling: Regulation of Histone Acetylation and Gene Transcription. Cell. 2005; 123(5):833-47.

Research Interests

Our recent findings and reports from other groups demonstrate that βarrestin-mediated signalsomes and epigenetic regulation are of vital importance to GPCR-mediated signal transduction and consequent biological function of cells. Thus our future studies will focus on: 1. GPCR signaling and its cross-talk with other cellular signal pathways; 2. the epigenetic regulatory mechanisms of GPCR signaling and potential roles of GPCR signalsomes in important biological processes closely regulated by epigenetic events, including the development of embryonic stem cells, the reprogramming of somatic cells and etc.; 3. roles of GPCR signaling in the initiation, development, prevention and treatment of diseases, such as Alzheimer’s diseases, diabetes, and autoimmune disorders. 4. Underlying mechanisms of traditional Chinese medicine.

Professional society

Member, Chinese Academy of Sciences (CAS) (1999-)

Member, The World Academy of Sciences (TWAS) (2001-)

Vice-Chairman, Consortium for Globalization of Chinese Medicine (2007-)

Editor-in-Chief, Cell Research (2005-) 

Honorary President, Chinese Society for Cell Biology (CSCB) (2015-)

President, Chinese Society for Cell Biology (CSCB) (2003-2015)

President, Asian-Pacific Organization for Cell Biology (APOCB) (2003-2008)



施裕丰  博士研究生  071009-细胞生物学  

杜鹃  博士研究生  071010-生物化学与分子生物学  

倪燕翔  博士研究生  071009-细胞生物学  

岑博  博士研究生  071015-细胞生物学  

樊华萍  博士研究生  071009-细胞生物学  

俞国华  博士研究生  071009-细胞生物学  

凌堃  博士研究生  071015-细胞生物学  

余甬新  博士研究生  071009-细胞生物学  

濮璐  博士研究生  071009-细胞生物学  

王娅娅  博士研究生  071009-细胞生物学  

王平  博士研究生  071009-细胞生物学  

夏鹏  博士研究生  071009-细胞生物学  

赵晓晖  博士研究生  071009-细胞生物学  

张文波  博士研究生  071009-细胞生物学  

张喆  博士研究生  071015-细胞生物学  

程智洁  博士研究生  071015-细胞生物学  

屈彬  博士研究生  071009-细胞生物学  

周天华  博士研究生  071015-细胞生物学  

高华  博士研究生  071009-细胞生物学  

孙悦  博士研究生  071009-细胞生物学  

屈彬  硕士研究生  071009-细胞生物学  

张瑾  硕士研究生  071010-生物化学与分子生物学  

翟培彬  硕士研究生  071020-生物技术与医药  

栾冰  博士研究生  071009-细胞生物学  

唐亚威  博士研究生  071009-细胞生物学  

滕林  博士研究生  071009-细胞生物学  

李本  博士研究生  071020-生物技术与医药  

沈立  博士研究生  071009-细胞生物学  

薛博亮  硕士研究生  071020-生物技术与医药  

刘佳  硕士研究生  071020-生物技术与医药  

岳锐  博士研究生  071009-细胞生物学  

庄乐南  博士研究生  071009-细胞生物学  

刘畅  博士研究生  071009-细胞生物学  

李博  博士研究生  071009-细胞生物学  

陈涛涛  博士研究生  071009-细胞生物学  

李娟  博士研究生  071009-细胞生物学  

于洁  硕士研究生  071020-生物技术与医药  

袁得天  硕士研究生  071009-细胞生物学  

赵聪  硕士研究生  071009-细胞生物学  

刘小松  博士研究生  071009-细胞生物学  

万洪江  硕士研究生  071020-生物技术与医药  

黄世超  博士研究生  071009-细胞生物学  

侯羽君  博士研究生  071009-细胞生物学  

胡文祥  博士研究生  071009-细胞生物学  

崔进  博士研究生  071009-细胞生物学  

李媛媛  博士研究生  071009-细胞生物学  

李海森  博士研究生  071009-细胞生物学  

陈淑姣  硕士研究生  071020-生物技术与医药  

李晓行  博士研究生  071009-细胞生物学  

毛坚鑫  博士研究生  071009-细胞生物学  

李伟  硕士研究生  071009-细胞生物学  

赵存  硕士研究生  071009-细胞生物学  

裘斌龙  博士研究生  071009-细胞生物学  

杨文娟  硕士研究生  071009-细胞生物学  


王欣  博士研究生  071009-细胞生物学  

高龙飞  博士研究生  071009-细胞生物学  

周科言  硕士研究生  071009-细胞生物学  

张红  硕士研究生  071009-细胞生物学  

王勤英  博士研究生  071009-细胞生物学  

胡婷婷  硕士研究生  071009-细胞生物学  

安玉谦  硕士研究生  071009-细胞生物学  

Honors & Distinctions

1996   Distinguished Young Investigator Award from the National Natural Science Foundation of China

1997   Excellent Researcher Award in Biology and Medicine from Qui Shi Science Foundation of Hong Kong

1999   The Prize for Scientific and Technological Achievements of Ho Leung Ho Lee Foundation, Hong Kong

2001   The Science and Technology Progress Award, Shanghai (1st Prize)

2002   National Natural Science Award (2nd Prize)

2003   Distinguished Scholar Lecture, Garven Institute, Australia

2006   Natural Science Award, Shanghai (1st Prize)

2007   The Endeavour Executive Award, Australia 

2007   National Natural Science Award (2nd Prize)

2010   Tan Kah Kee Science Award

2011   The Science and Technology Progress Award, Shanghai (1st Prize)

2011   Tan Jiazhen Life Science Achievement Award

2012   Honorary Doctor of Science Degree, University of Nebraska Medical School

2012   Honorary Doctor of Engineering Degree, Feng Chia University, Taiwan

2015   Honorary Doctor of Science Degree, The Hong Kong Polytechnic University