Prof. Dr. Qing-An Chen
Dalian Institute of Chemical Physics,
Chinese Academy of Sciences
Address: 457 Zhongshan Road, Dalian 116023, China
Tel: 86-411-82463702
Email: qachen@dicp.ac.cn
Web: http://www.lbcs.dicp.ac.cn/
Research Areas
Asymmetric catalysis, Biomimetic Chemistry, Green Chemistry
Education
Ph.D. Organic Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
Supervisor: Prof. Yong-Gui Zhou
September 2007 to July 2012
Research Topic: Biomimetic Asymmetric Hydrogenations Promoted by NAD(P)H Models
B.S. Chemistry, University of Science and Technology of China
Supervisor: Prof. Tian-Pa You
September 2003 to July 2007
Research Topic: Nickel-Catalyzed Cascade Ullmann-Pinacol Couplings
Experience
Postdoctoral Scholar, Technical University of Berlin
Supervisor: Prof. Martin Oestreich
June 2015 to March 2017
Research Topic: Brønsted Acid-Promoted Catalytic Friedel–Crafts C–H Silylation
Postdoctoral Scholar, University of California, Irvine
Supervisor: Prof. Vy M. Dong.
August 2012 to May 2015
Research Topic: Transition Metal-Catalyzed Hydroacylations
Publications
Representative Publications:
16. Chao-Yang Zhao, Hao Zheng, Ding-Wei Ji, Xiang-Ting Min, Yan-Cheng Hu, and Qing-An Chen.* Copper-Catalyzed Asymmetric Carboboronation of Allenes to Access α-Quaternary Amino Esters with Adjacent Stereocenters. Cell Reports Physical Science 2020, 1, 100067.
15. Yan-Cheng Hu, Ding-Wei Ji, Chao-Yang Zhao, Hao Zheng, Qing-An Chen.* Catalytic Prenylation and Reverse-Prenylation of Indoles with Isoprene: Regioselectivity Manipulation by Metal-Hydride. Angew. Chem. Int. Ed. 2019, 58, 5438-5442. (Impact Factor 12.102).
14. Jun Yang, Ding-Wei Ji, Yan-Cheng Hu, Xiang-Ting Min, Xiang-Ge Zhou,* Qing-An Chen.* Cobalt-Catalyzed Hydroxymethylarylation of Terpenes with Formaldehyde and Arenes. Chem. Sci. 2019, 10, 9560-9564.
13. Ding-Wei Ji, Yan-Cheng Hu, Hao Zheng,Chao-Yang Zhao, Qing-An Chen* and Vy M. Dong. Catalytic Regioselectivity Switch in Pd-Catalyzed Hydroallylation of Alkynes. Chem. Sci. 2019, 10, 6311-6315.
12. Qing-An Chen, Hendrik F. T. Klare, and Martin Oestreich.* Brønsted Acid-Promoted Formation of Stabilized Silylium Ions for Catalytic Friedel–Crafts C–H Silylation. J. Am. Chem. Soc. 2016, 138, 7868-7871. (Impact Factor 13.038).
11. Qing-An Chen, Zhiwei Chen, Vy M. Dong.* Rhodium-Catalyzed Enantioselective Hydroamination of Alkynes with Indolines. J. Am. Chem. Soc. 2015, 137, 8392-8395. (Impact Factor 14.357).
10. Qing-An Chen, Faben A. Cruz, Vy M. Dong.* Alkyne Hydroacylation: Switching Regio- selectivity by Tandem Ruthenium Catalysis. J. Am. Chem. Soc. 2015, 137, 3157-3160. (Impact Factor 14.357).
9. Qing-An Chen, Daniel K. Kim, Vy M. Dong.* Regioselective Hydroacylation of 1,3-Dienes by Cobalt-Catalysis. J. Am. Chem. Soc. 2014, 136, 3772-3775. (Impact Factor 14.357).
8. Qing-An Chen, Zhi-Shi Ye, Ying Duan and Yong-Gui Zhou.* Homogeneous Palladium Catalyzed Asymmetric Hydrogenation. Chem. Soc. Rev. 2013, 42, 497-511. (Impact Factor 34.090).
7. Qing-An Chen, Kai Gao, Ying Duan, Zhi-Shi Ye, Lei Shi, Yan Yang and Yong-Gui Zhou.* Dihydrophenanthridine: A New and Easily Regenerable NAD(P)H Model for Biomimetic Asymmetric Hydrogenation. J. Am. Chem. Soc. 2012, 134, 2442-2448. (Impact Factor 14.357).
6. Qing-An Chen, Mu-Wang Chen, Chang-Bin Yu, Lei Shi, Duo-Sheng Wang, Yan Yang and Yong-Gui Zhou.* Biomimetic Asymmetric Hydrogenation: In Situ Regenerable Hantzsch Esters for Asymmetric Hydrogenation of Benzoxazinones. J. Am. Chem. Soc. 2011, 133, 16432-16435. (Impact Factor 14.357).
5. Qing-An Chen, Duo-Sheng Wang, Yong-Gui Zhou,* Ying Duan, Hong-Jun Fan,* Yan Yang, Zhang Zhang. Convergent Asymmetric Disproportionation Reactions: Metal/Brønsted Acid Relay Catalysis for Enantioselective Reduction of Quinoxalines. J. Am. Chem. Soc. 2011, 133, 6126-6129. (Impact Factor 14.357).
4. Duo-Sheng Wang, Qing-An Chen, Sheng-Mei Lu and Yong-Gui Zhou.* Asymmetric Hydrogenation of Heteroarenes and Arenes. Chem. Rev. 2012, 112, 2557-2590. (Impact Factor 37.369).
3. Zhi-Shi Ye, Mu-Wang Chen, Qing-An Chen, Lei Shi, Ying Duan and Yong-Gui Zhou.* Ir-Catalyzed Asymmetric Hydrogenation of Pyridinium Salts. Angew. Chem. Int. Ed. 2012, 51, 10181-10184. (Impact Factor 12.102).
2. Duo-Sheng Wang, Zhi-Shi Ye, Qing-An Chen, Yong-Gui Zhou,* Chang-Bin Yu, Hong-Jun Fan,* Ying Duan. Highly Enantioselective Partial Hydrogenation of Simple Pyrroles: A Facile Access to Chiral 1-Pyrrolines. J. Am. Chem. Soc. 2011, 133, 8866-8869. (Impact Factor 14.357).
1. Duo-Sheng Wang, Qing-An Chen, Wei Li, Chang-Bin Yu, Yong-Gui Zhou,* Xumu Zhang.* Pd-Catalyzed Asymmetric Hydrogenation of Unprotected Indoles Activated by Brønsted Acids. J. Am. Chem. Soc. 2010, 132, 8909-8911. (Impact Factor 14.357).
Honors & Distinctions
• National " Thousand Plan" Youth program (2017)
• Alexander von Humboldt Foundation Research Fellowship (Germany, 2015)
• President’s Award in Excellence, Chinese Academy of Science for Graduates (2012)
• The First Prize Scholarship of Yan Chang Petroleum (2011)
• The Zhuliyuehua Scholarship for Doctoral Students of the Chinese Academy of Sciences (2011)
• Merit Student of the Chinese Academy of Sciences (2010)
• The Second Prize Scholarship for Undergraduates, University of Science and Technology of China (2006)