General

Prof. Dr. Qing-An Chen

Dalian Institute of Chemical Physics,
Chinese Academy of Sciences

Address: 457 Zhongshan Road, Dalian 116023, China

Tel: 86-411-82463702

Email: qachen@dicp.ac.cn                       

Web: http://www.lbcs.dicp.ac.cn/


Research Areas

Asymmetric catalysis, Biomimetic Chemistry, Green Chemistry

Education

Ph.D. Organic Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences 

Supervisor: Prof. Yong-Gui Zhou

September 2007 to July 2012

       Research Topic: Biomimetic Asymmetric Hydrogenations Promoted by NAD(P)H Models

 

B.S. Chemistry, University of Science and Technology of China

Supervisor: Prof. Tian-Pa You

September 2003 to July 2007

       Research Topic: Nickel-Catalyzed Cascade Ullmann-Pinacol Couplings


Experience

Postdoctoral Scholar, Technical University of Berlin

Supervisor: Prof. Martin Oestreich

June 2015 to March 2017

       Research Topic: Brønsted Acid-Promoted Catalytic Friedel–Crafts C–H Silylation

 

Postdoctoral Scholar, University of California, Irvine

Supervisor: Prof. Vy M. Dong.

August 2012 to May 2015

       Research Topic: Transition Metal-Catalyzed Hydroacylations


Publications

Representative Publications:

16. Chao-Yang Zhao, Hao Zheng, Ding-Wei Ji, Xiang-Ting Min, Yan-Cheng Hu, and Qing-An Chen.*  Copper-Catalyzed Asymmetric Carboboronation of Allenes to Access α-Quaternary Amino Esters with Adjacent Stereocenters. Cell Reports Physical Science 2020, 1, 100067.


15. Yan-Cheng Hu, Ding-Wei Ji, Chao-Yang Zhao, Hao Zheng, Qing-An Chen.* Catalytic Prenylation and Reverse-Prenylation of Indoles with Isoprene: Regioselectivity Manipulation by Metal-Hydride. Angew. Chem. Int. Ed. 2019, 58, 5438-5442. (Impact Factor 12.102).



14. Jun Yang, Ding-Wei Ji, Yan-Cheng Hu, Xiang-Ting Min, Xiang-Ge Zhou,* Qing-An Chen.* Cobalt-Catalyzed Hydroxymethylarylation of Terpenes with Formaldehyde and Arenes. Chem. Sci. 2019, 10, 9560-9564.


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13. Ding-Wei Ji, Yan-Cheng Hu, Hao Zheng,Chao-Yang Zhao, Qing-An Chen* and Vy M. Dong. Catalytic Regioselectivity Switch in Pd-Catalyzed Hydroallylation of Alkynes. Chem. Sci. 2019, 10, 6311-6315.



12.  Qing-An Chen, Hendrik F. T. Klare, and Martin Oestreich.* Brønsted Acid-Promoted Formation of Stabilized Silylium Ions for Catalytic Friedel–Crafts C–H Silylation. J. Am. Chem. Soc. 2016, 138, 7868-7871.  (Impact Factor 13.038).


11.  Qing-An Chen, Zhiwei Chen, Vy M. Dong.* Rhodium-Catalyzed Enantioselective Hydroamination of Alkynes with Indolines. J. Am. Chem. Soc. 2015137, 8392-8395.  (Impact Factor 14.357).


10. Qing-An Chen, Faben A. Cruz, Vy M. Dong.* Alkyne Hydroacylation: Switching Regio- selectivity by Tandem Ruthenium Catalysis. J. Am. Chem. Soc. 2015, 137, 3157-3160. (Impact Factor 14.357).


9. Qing-An Chen, Daniel K. Kim, Vy M. Dong.* Regioselective Hydroacylation of 1,3-Dienes by Cobalt-Catalysis. J. Am. Chem. Soc. 2014, 136, 3772-3775. (Impact Factor 14.357).


8. Qing-An Chen, Zhi-Shi Ye, Ying Duan and Yong-Gui Zhou.* Homogeneous Palladium Catalyzed Asymmetric Hydrogenation. Chem. Soc. Rev. 2013, 42, 497-511. (Impact Factor 34.090).


7. Qing-An Chen, Kai Gao, Ying Duan, Zhi-Shi Ye, Lei Shi, Yan Yang and Yong-Gui Zhou.* Dihydrophenanthridine: A New and Easily Regenerable NAD(P)H Model for Biomimetic Asymmetric Hydrogenation. J. Am. Chem. Soc. 2012, 134, 2442-2448. (Impact Factor 14.357).


6. Qing-An Chen, Mu-Wang Chen, Chang-Bin Yu, Lei Shi, Duo-Sheng Wang, Yan Yang and Yong-Gui Zhou.* Biomimetic Asymmetric Hydrogenation: In Situ Regenerable Hantzsch Esters for Asymmetric Hydrogenation of Benzoxazinones. J. Am. Chem. Soc. 2011, 133, 16432-16435. (Impact Factor 14.357).



5. Qing-An Chen, Duo-Sheng Wang, Yong-Gui Zhou,* Ying Duan, Hong-Jun Fan,* Yan Yang, Zhang Zhang. Convergent Asymmetric Disproportionation Reactions: Metal/Brønsted Acid Relay Catalysis for Enantioselective Reduction of Quinoxalines. J. Am. Chem. Soc. 2011, 133, 6126-6129.  (Impact Factor 14.357).


4. Duo-Sheng Wang, Qing-An Chen, Sheng-Mei Lu and Yong-Gui Zhou.* Asymmetric Hydrogenation of Heteroarenes and Arenes. Chem. Rev. 2012, 112, 2557-2590. (Impact Factor 37.369).


3. Zhi-Shi Ye, Mu-Wang Chen, Qing-An Chen, Lei Shi, Ying Duan and Yong-Gui Zhou.* Ir-Catalyzed Asymmetric Hydrogenation of Pyridinium Salts. Angew. Chem. Int. Ed. 2012, 51, 10181-10184. (Impact Factor 12.102).


2. Duo-Sheng Wang, Zhi-Shi Ye, Qing-An Chen, Yong-Gui Zhou,* Chang-Bin Yu, Hong-Jun Fan,* Ying Duan. Highly Enantioselective Partial Hydrogenation of Simple Pyrroles: A Facile Access to Chiral 1-Pyrrolines. J. Am. Chem. Soc. 2011, 133, 8866-8869.  (Impact Factor 14.357).


1. Duo-Sheng Wang, Qing-An Chen, Wei Li, Chang-Bin Yu, Yong-Gui Zhou,* Xumu Zhang.* Pd-Catalyzed Asymmetric Hydrogenation of Unprotected Indoles Activated by Brønsted Acids. J. Am. Chem. Soc. 2010132, 8909-8911. (Impact Factor 14.357).




Honors & Distinctions

National " Thousand Plan" Youth program (2017)

• Alexander von Humboldt Foundation Research Fellowship (Germany, 2015)

• President’s Award in Excellence, Chinese Academy of Science for Graduates (2012)

The First Prize Scholarship of Yan Chang Petroleum (2011)

The Zhuliyuehua Scholarship for Doctoral Students of the Chinese Academy of Sciences (2011)

Merit Student of the Chinese Academy of Sciences (2010)

The Second Prize Scholarship for Undergraduates, University of Science and Technology of China (2006)