基本信息

陈庆安  研究员  博士生导师  中国科学院大连化学物理研究所

电子邮件: qachen@dicp.ac.cn
通信地址: 辽宁省大连市中山路 457 号催化楼209
邮编: 116023
电话: 0411-82463702

研究组主页http://www.lbcs.dicp.ac.cn/

研究领域

陈庆安福建泉州人。 2007年本科毕业于中国科学技术大学化学系,导师尤田耙教授。2012年在中国科学院大连化学物理研究所获得博士学位,导师周永贵研究员。2012年至2015年在美国加州大学欧文分校进行博士后研究,合作导师Vy M.Dong教授。2015年至2017年作为德国洪堡学者在德国柏林工业大学Martin Oestreich教授课题组工作。20174月加入大连化物所开展独立研究工作,被聘为课题组组长、张大煜青年学者。

  自开展研究工作以来,先后在Chem. Rev., Chem. Soc. Rev., Nature Catal., Nature Chem., Nature Commun., J.  Am. Chem. Soc., Angew.  Chem. Int. Ed. 等国际权威期刊上发表文章59篇,总引用次数为3000余次,平均引用50余次(截止2022年6月)。此外还受邀担任J.  Am. Chem. Soc.,Chem.  Sci. 等国际知名学术期刊的独立审稿人。2017年获得辽宁省自然科学一等奖(排名第二),2020年获得“Thieme  Chemistry Journal Award”国际学术奖。目前主要研究领域为仿生催化合成和金属有机化学。


课题组研究方向为过渡金属催化和有机合成,目前研究兴趣包括:
1)基于生物代谢的基本原理,发展仿生催化合成
2)过渡金属催化烯烃和炔烃的高效不对称转化
3)发展新的有机合成方法学

招生信息

   在国家,研究所的大力支持下,陈老师将为课题组成员提供一流的学习和研究条件,营造民主、自由的学术环境。同时,陈老师会和大家一起战斗在科研的第一线,互相切磋,共同进步。本课题组表现优秀的成员将被推荐到国外优秀实验室进一步交流和深造。

   热忱欢迎有志于有机合成研究的青年才俊加盟,大家一起努力,早日建成具有国际影响力的一流研究小组。


招生要求
1. 化学相关专业本科或硕士,有扎实的化学实验基础;
2. 工作勤奋踏实,有事业心,良好的学术道德和团队协作精神; 
3. 有较强的英文阅读和写作能力


招生专业:有机化学(070303)

招生方向:不对称催化,仿生催化,绿色化学

出版信息

代表性文章:

31. Xiang-Ting Min,  Yong-Kang Mei,  Bing-Zhi Chen, Li-Bowen He, Ting-Ting Song, Ding-Wei Ji,Yan-Cheng Hu, Boshun Wan, Qing-An Chen.*  Rhodium-Catalyzed Deuterated Tsuji-Wilkinson Decarbonylation of Aldehydes with Deuterium Oxide. J. Am. Chem. Soc. 2022, Accepted.(Impact Factor 16.4).


30. Chao-Yang Zhao,  Ying-Ying Liu,  Xiang-Xin Zhang, Gu-Cheng He, Heng Liu, Ding-Wei Ji,Yan-Cheng Hu, Qing-An Chen.*  Bioinspired and Ligand-Regulated Unnatural Prenylation and Geranylation of Oxindoles with Isoprene under Pd Catalysis. Angew. Chem. Int. Ed. 2022, Accepted.(Impact Factor 16.8).



29. Xin Huang,†  Bing-Zhi Chen,  Pengbin Li, Ding-Wei Ji, Jinxian Liu, Hao Zheng, Sa-Na Yang, Yan-Cheng Hu, Boshun Wan, Xiang-Ping Hu, Chunling Fu, Yankai Huang, Jian Zheng,* Qing-An Chen,* Shengming Ma.*  Palladium-catalyzed construction of butafulvenes. Nature Chemistry 2022, Accepted.(Impact Factor 24.3).


28. Hao Zheng,  Chang-Hui Liu, Shi-Yu Guo, Gu-Cheng He, Xiang-Ting Min, Bo-Chao Zhou, Ding-Wei Ji, Yan-Cheng Hu, Qing-An Chen.*  Regioselective C−H Phosphorylation of Group 8 Metallocenes under Electrochemical Autocatalysis. Nature Communications 2022, 13, 3496.(Impact Factor 17.7).


27. Lei-Lei Qian, Yan-Cheng Hu,*  Xiang-Ting Min, Sa-Na Yang, Bing-Xue Shen, Boshun Wan, Qing-An Chen.*  CPA-Catalyzed Multicomponent Reaction of Anilines, Aldehydes, and Azetidinones: Rapid Access to Enantiopure Fused Azetidines. Chem Catalysis 2022, Accepted.


26. Yan-Cheng Hu,  Xiang-Ting Min, Ding-Wei Ji, Qing-An Chen.*  Catalytic Prenylation and Reverse-Prenylation of Aromatics. Trends in Chemistry 2022, 4, 658-675.(Impact Factor 22.4).


25. Gu-Cheng He,  Shi-Yu Guo, Hao Zheng, Chang-Hui Liu, Ying Li, Xiang-Ting Min, Ding-Wei Ji and Qing-An Chen.*  Photo-Induced Catalytic C−H Heteroarylation of Group 8 Metallocenes. Cell Rep. Phys. Sci. 2022, 3, 100768.


24. Wei-Song Zhang,  Ding-Wei Ji, Ying Li, Xiang-Xin Zhang, Chao-Yang Zhao, Yan-Cheng Hu and Qing-An Chen.*  Regio- and Stereoselective Diarylation of 1,3-Dienes via Ni/Cr Co-catalysis. ACS Cat. 2022, 12, 2158-2165.(Impact Factor 13.7).


23. Shi-Yu Guo, Fan Yang, Ting-Ting Song, Yu-Qing Guan, Xiang-Ting Min, Ding-Wei Ji, Yan-Cheng Hu and Qing-An Chen.*  Photo-Induced Catalytic Halopyridylation of Alkenes. Nature Communications 2021, 12, 6538.(Impact Factor 17.7).


22. Heng Liu, Gu-Cheng He, Chao-Yang Zhao, Xiang-Xin Zhang, Ding-Wei Ji, Yan-Cheng Hu and Qing-An Chen.*  Redoxdivergent Construction of (Dihydro)thiophenes with DMSO. Angew. Chem. Int. Ed. 2021, 60, 24284-24291.(Impact Factor 16.8).


21. Chao-Yang Zhao, Ding-Wei Ji, Hao Zheng, Gu-Cheng He, Heng Liu, Yan-Cheng Hu, and Qing-An Chen.*  Pd-Catalyzed Redox Divergent Coupling of Ketones with Terpenols. ACS Cat. 2021,11, 6825-6834.(Impact Factor 13.7).

20. Wen-Shuang Jiang+, Ding-Wei Ji+, Wei-Song Zhang, Gong Zhang, Xiang-Ting Min, Yan-Cheng Hu, Xu-Liang Jiang*, and Qing-An Chen.*  Orthogonal Regulation of Nucleophilic and Electrophilic Sites in Pd-Catalyzed Regiodivergent Couplings between Indazoles and Isoprene. Angew. Chem. Int. Ed. 2021, 60, 8321-8328.(Impact Factor 16.8).

19. Yan-Cheng Hu+, Yingying Zhao+, Boshun Wan*, Qing-An Chen.*  Reactivity of Ynamides in Catalytic Intermolecular Annulations. Chem. Soc. Rev. 2021, 50, 2582-2625.(Impact Factor 60.6).

18. Xiang-Ting Min, Ding-Wei Ji, Yu-Qing Guan, Shi-Yu Guo, Yan-Cheng Hu, Boshun Wan, Qing-An Chen.*  Visible Light-Induced Bifunctional Rhodium Catalysis for Decarbonylative Coupling of Imides with Alkynes. Angew. Chem. Int. Ed. 2021, 60, 1583-1587.(Impact Factor 16.8).


17. Chang-Sheng Kuai+, Ding-Wei Ji+, Chao-Yang Zhao, Heng Liu, Yan-Cheng Hu, Qing-An Chen.*  Ligand Regulated Regiodivergent Hydrosilylation of Isoprene under Iron Catalysis. Angew. Chem. Int. Ed. 2020DOI: 10.1002/anie.202007930.(Impact Factor 16.8).


16. Chao-Yang Zhao, Hao Zheng, Ding-Wei Ji, Xiang-Ting Min, Yan-Cheng Hu, and Qing-An Chen.*  Copper-Catalyzed Asymmetric Carboboronation of Allenes to Access α-Quaternary Amino Esters with Adjacent Stereocenters. Cell Reports Physical Science 2020, 1, 100067.


15. Yan-Cheng Hu, Ding-Wei Ji, Chao-Yang Zhao, Hao Zheng, Qing-An Chen.* Catalytic Prenylation and Reverse-Prenylation of Indoles with Isoprene: Regioselectivity Manipulation by Metal-Hydride. Angew. Chem. Int. Ed. 2019, 58, 5438-5442. (Impact Factor 16.8).



14. Jun Yang, Ding-Wei Ji, Yan-Cheng Hu, Xiang-Ting Min, Xiang-Ge Zhou,* Qing-An Chen.* Cobalt-Catalyzed Hydroxymethylarylation of Terpenes with Formaldehyde and Arenes. Chem. Sci. 2019, 10, 9560-9564.(Impact Factor 9.9).


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13. Ding-Wei Ji, Yan-Cheng Hu, Hao Zheng,Chao-Yang Zhao, Qing-An Chen* and Vy M. Dong. Catalytic Regioselectivity Switch in Pd-Catalyzed Hydroallylation of Alkynes. Chem. Sci. 2019, 10, 6311-6315. (Impact Factor 9.9).



12.  Qing-An Chen, Hendrik F. T. Klare, and Martin Oestreich.* Brønsted Acid-Promoted Formation of Stabilized Silylium Ions for Catalytic Friedel–Crafts C–H Silylation. J. Am. Chem. Soc. 2016, 138, 7868-7871. (Impact Factor 16.4).


11.  Qing-An Chen, Zhiwei Chen, Vy M. Dong.* Rhodium-Catalyzed Enantioselective Hydroamination of Alkynes with Indolines. J. Am. Chem. Soc. 2015137, 8392-8395. (Impact Factor 16.4).


10. Qing-An Chen, Faben A. Cruz, Vy M. Dong.* Alkyne Hydroacylation: Switching Regio- selectivity by Tandem Ruthenium Catalysis. J. Am. Chem. Soc. 2015, 137, 3157-3160. (Impact Factor 16.4).


9. Qing-An Chen, Daniel K. Kim, Vy M. Dong.* Regioselective Hydroacylation of 1,3-Dienes by Cobalt-Catalysis. J. Am. Chem. Soc. 2014, 136, 3772-3775.(Impact Factor 16.4).


8. Qing-An Chen, Zhi-Shi Ye, Ying Duan and Yong-Gui Zhou.* Homogeneous Palladium Catalyzed Asymmetric Hydrogenation. Chem. Soc. Rev. 2013, 42, 497-511. (Impact Factor 60.6).


7. Qing-An Chen, Kai Gao, Ying Duan, Zhi-Shi Ye, Lei Shi, Yan Yang and Yong-Gui Zhou.* Dihydrophenanthridine: A New and Easily Regenerable NAD(P)H Model for Biomimetic Asymmetric Hydrogenation. J. Am. Chem. Soc. 2012, 134, 2442-2448. (Impact Factor 16.4).


6. Qing-An Chen, Mu-Wang Chen, Chang-Bin Yu, Lei Shi, Duo-Sheng Wang, Yan Yang and Yong-Gui Zhou.* Biomimetic Asymmetric Hydrogenation: In Situ Regenerable Hantzsch Esters for Asymmetric Hydrogenation of Benzoxazinones. J. Am. Chem. Soc. 2011, 133, 16432-16435. (Impact Factor 16.4).



5. Qing-An Chen, Duo-Sheng Wang, Yong-Gui Zhou,* Ying Duan, Hong-Jun Fan,* Yan Yang, Zhang Zhang. Convergent Asymmetric Disproportionation Reactions: Metal/Brønsted Acid Relay Catalysis for Enantioselective Reduction of Quinoxalines. J. Am. Chem. Soc. 2011, 133, 6126-6129. (Impact Factor 16.4).


4. Duo-Sheng Wang, Qing-An Chen, Sheng-Mei Lu and Yong-Gui Zhou.* Asymmetric Hydrogenation of Heteroarenes and Arenes. Chem. Rev. 2012, 112, 2557-2590. (Impact Factor 72.1).


3. Zhi-Shi Ye, Mu-Wang Chen, Qing-An Chen, Lei Shi, Ying Duan and Yong-Gui Zhou.* Ir-Catalyzed Asymmetric Hydrogenation of Pyridinium Salts. Angew. Chem. Int. Ed. 2012, 51, 10181-10184. (Impact Factor 16.8).


2. Duo-Sheng Wang, Zhi-Shi Ye, Qing-An Chen, Yong-Gui Zhou,* Chang-Bin Yu, Hong-Jun Fan,* Ying Duan. Highly Enantioselective Partial Hydrogenation of Simple Pyrroles: A Facile Access to Chiral 1-Pyrrolines. J. Am. Chem. Soc. 2011, 133, 8866-8869.  (Impact Factor 16.4).


1. Duo-Sheng Wang, Qing-An Chen, Wei Li, Chang-Bin Yu, Yong-Gui Zhou,* Xumu Zhang.* Pd-Catalyzed Asymmetric Hydrogenation of Unprotected Indoles Activated by Brønsted Acids. J. Am. Chem. Soc. 2010132, 8909-8911. (Impact Factor 16.4).


代表性专利:

 7、陈庆安、呼延成、季定纬,一种在吲哚C3位引入异戊烯基的方法,中国发明专利, 2019年,申请号:201910078673.1。
6、陈庆安、呼延成、季定纬,一种在吲哚C3位引入叔异戊烯基的方法,中国发明专利,2019年,申请号:201910078682.0。
5、陈庆安
、季定纬、呼延成,一种1,5-二烯衍生物的合成方法,中国发明专利,2019年,申请号:201910078655.3。
4、周永贵、段英、陈木旺、陈庆安,一种合成3-取代吲哚和2,3-二取代吲哚的方法,中国发明专利,2011年,申请号:201110376382.4。
3、周永贵、陈庆安、高凯、时磊、余长斌,一种合成二氢菲啶的方法,中国发明专利,2011年,申请号:201110236779.3。
2、
周永贵、陈庆安、时磊、陈木旺、余长斌、段英,一种合成Hantzsch酯的方法,中国发明专利, 2011年,申请号:201110153294.8
1、周永贵、陈庆安、陈木旺,一类具有轴手性双亚砜配体及其合成方法,中国发明专利,2009年,申请
     号:200910187742.9。