Environmental pollution and human health

Interactions between environmental contaminants and gut microbiota

Oral bioavailability of heavy metals in soil/food and human health risk assessment

09/2012-06/2018, Chinese Academy of Sciences (UCAS), Doctor

02/2017-02/2018, Commonwealth Scientific and Industrial Research Organisation, UCAS Joint PhD Training Program

09/2008-07/2012, Hebei University, Bachelor

08/2020- Present, University of Chinese Academy of Sciences, Associate Professor/Doctoral supervisor

07/2018-08/2020, University of Chinese Academy of Sciences, Postdoctoral Fellow

2025

[54] Hassan SA, Yin NY*, Xiao P, Arshad M, Cai XL, Aadil RM, Khalid MS, Shahzadi Z, Khaneghah AM*, Cui, YS*. 2025. Emerging strategies to boost mineral bioaccessibility in foods: Current trends and innovations. Food Reviews International <https://doi.org/10.1080/87559129.2025.2589372>

[53] Xiao P, Zhou Y, Wang PF, Li R, Xiong SM, Jiang XY, Li YP, Wu Y, Yang YT, Cai XL, Yin NY*, Cui YS*. 2025. Integrated assessment of chromium exposure risk from agricultural soils using chemical extraction, in vitro simulation, and mouse bioassay. Journal of Hazardous Materials 499, 140093. <https://doi.org/10.1016/j.jhazmat.2025.140093>

[52] Xiao P, Li Y, Xiong SM, Zhou Y, Yin NY*, Li YP, Jiang XY, Chang XH, Wang PF, Cai XL, Chen XC, Guo GL, Cui YS*. 2025. Arsenic bioavailability and transformation from As(V)-sorbed aluminum oxides: The influence of Fe(III) and human gut microbiota. Journal of Hazardous Materials 496, 139288.<https://doi.org/10.1016/j.jhazmat.2025.139288>

[51] Xiong SM, Xie B, Yin NY*, Zhu HM, Gao HM, Xu X., Xiao K., Cai XL, Sun GX, Sun XL*, Cui YS, Van de Wiele T, Zhu YG*. 2025. Prenatal exposure to trace elements impacts mother-infant gut microbiome, metabolome and resistome during the first year of life. Nature Communications 16, 5186. <https://doi.org/10.1038/s41467-025-60508-8> <UCAS NEWShttps://news.ucas.ac.cn//kydt/4b33039b114a4d4099f247b265dd7c6f.htm>

[50] Ma JN, Yin NY*, Wang PF, Cai XL, Jiang XY, Geng ZQ, Tian W, Xu ZL, Sun GX, Huang YZ, Li P, Cui YS*. 2025. Bioaccessibility of essential elements and arsenic in brown rice, milled rice, and bran: Implications for consumer choices. Food Research International 214, 116651. <https://doi.org/10.1016/j.foodres.2025.116651>

[49] Chen XC, Zhang ZD, Hsueh YS, Zhang CP, Yu JY, Zhu JY, Niu J, Yin NY*, Zhang JY, Cui XY, Liu XH, Xu KQ, Yuan C*. 2025. Interactions between environmental pollutants and gut microbiota: A review connecting the conventional heavy metals and the emerging microplastics. Environmental Research 269, 120928. <https://doi.org/10.1016/j.envres.2025.120928>

[48] Yan XM, Ma Q, Li YP, Chang XH, Liu XT, Yin NY, Cai XL, Cui YS. 2025. Soil fertilizer enhancement and Chinese Cabbage quality improvement: a comparative study of three organic fertilizer strategies. International Journal of Vegetable Science. < https://doi.org/10.1080/19315260.2025.2577824 >

[47] Zhou Y, Fan CF, Xiao P, Wang YT, Chang XH, Li H, Huang XH, Geng ZQ, Yin NY, Cai XL*, Cui YS*. 2025. Stabilization of arsenic-contaminated soils with iron-lanthanide-loaded zeolite materials and its mechanisms. Geoderma 459, 117379. < https://doi.org/10.1016/j.geoderma.2025.117379 >

2020-2024

[46] Ma JN, Yin NY*, Wang PF, Cai XL, Geng ZQ, Fan CF, Cui YS*, Sjödin A.2024. Bioaccessibility assessment of arsenic and cadmium in polished and unpolished rice: Comparison of three in vitro methods. Food Research International 177, 113853. <https://doi.org/10.1016/j.foodres.2023.113853>

[45] Zhou Y, Zhao YL, Xiao P, Wang PF, Li YP, Xiong SM, Li XT, Wang YT, Cai XL, Yin NY*, Cui YS*. 2024. Different effects of vitamin supplementation on arsenic bioaccessibility in contaminated soils using multiple in vitro methods and their relevant mechanisms. Ecotoxicology and Environmental Safety 283, 116808. <https://doi.org/10.1016/j.ecoenv.2024.116808>

[44] Liu XT, Cai XL*, Yin NY, Huang XH, Wang PF, Basheer MZ, Fan CF, Chang XH, Hu ZY, Sun GX, Cui YS*. 2024. The pH-dependent role of different manganese oxides in the fate of arsenic during microbial reduction of arsenate-bearing goethite. Water Research 261, 121988. <https://doi.org/10.1016/j.watres.2024.121988>

[43] Geng ZQ, Wang PF, Yin NY, Cai XL, Fu YQ, Fan CF, Chang XH, Li YP, Ma JN, Cui YS*, Holm PE. 2024. Assessment of the stabilization effect of ferrous sulfate for arsenic-contaminated soils based on chemical extraction methods and in vitro methods: Methodological differences and linkages. Science of the Total Environment 925, 171729. <https://doi.org/10.1016/j.scitotenv.2024.171729>

[42] Chen XC, Huang ZJ, Wang A, Yu JY, Zhang JY, Xiao ZJ, Cui XY, Liu XH, Yin NY, Cui YS. 2024. Immobilisation remediation of arsenic-contaminated soils with promising CaAl-layered double hydroxide and bioavailability, bioaccessibility, and speciation-based health risk assessment. Journal of Hazardous Materials 469, 134096. <https://doi.org/10.1016/j.jhazmat.2024.134096>

[41] Yin NY, Chang XH, Xiao P, Zhou Y, Liu XT, Xiong SM, Wang PF, Cai XL, Sun GX*, Cui YS*, Hu ZY. 2023. Role of microbial iron reduction in arsenic metabolism from soil particle size fractions in simulated human gastrointestinal tract. Environment International 174, 107911. <https://doi.org/10.1016/j.envint.2023.107911>

[40] Li YP, Yin NY*, Cai XL, Wang PF, Fan CF, Chang XH, Liu XT, Geng ZQ, Cui LW, Du X, Cui YS*. 2023. Effects of calcium supplements on oral bioavailability of fluoride in soil based on in vivo and in vitro methods. Journal of Hazardous Materials 456, 131663. <https://doi.org/10.1016/j.jhazmat.2023.131663>

[39] Fan CF, Cui YS, Zhang QR, Yin NY, Cai XL, Yuan XZ, Senadheera S, Cho Y, Ok YS. 2023. A critical review of the interactions between rhizosphere and biochar during the remediation of metal(loid) contaminated soils. Biochar 5, 87. <https://doi.org/10.1007/s42773-023-00278-y>

[38] Fu YQ, Du HL, Wang PF, Yin NY, Cai XL, Geng ZQ, Li YP, Cui YS. 2023. Effects of foods and food components on the in vitro bioaccessibility of total arsenic and arsenic species from Hizikia fusiforme seaweed. Science of the Total Environment 900, 165775. <https://doi.org/10.1016/j.scitotenv.2023.165775>

[37] Chang XH, Cai XL, Yin NY, Wang PF, Fan CF, Liu XT, Li YP, Wang SP, Cui LW, Cui YS*. 2023. Arsenic and iron bioavailability in Caco-2 cells: The influence of their co-existence and concentration. Food and Chemical Toxicology 175, 113727. <https://doi.org/10.1016/j.fct.2023.113727>

[36] Liu XT, Cai XL*, Wang PF, Yin NY, Fan CF, Chang XH, Huang XH, Du X, Wang SP*, Cui YS. 2023. Effect of manganese oxides on arsenic speciation and mobilization in different arsenic-adsorbed iron-minerals under microbially-reducing conditions. Journal of Hazardous Materials 445, 130602. <https://doi.org/10.1016/j.jhazmat.2022.130602>

[35] Yin NY, Han ZL, Jia WB*, Fu YQ, Ma JN, Liu XT, Cai XL, Chen XC, Cui YS*. 2022. Effect of vitamin C supplement on lead bioaccessibility in contaminated soils using multiple in vitro gastrointestinal assays: mechanisms and health risks. Ecotoxicology and Environmental Safety 243, 113968. <https://doi.org/10.1016/j.ecoenv.2022.113968>

[34] Yin NY, Cai XL, Wang PF, Feng R, Du HL, Fu YQ, Sun GX, Cui YS*. 2022. Predictive capabilities of in vitro colon bioaccessibility for estimating in vivo relative bioavailability of arsenic from contaminated soils: arsenic speciation and gut microbiota considerations. Science of the Total Environment 818, 151804. <https://doi.org/10.1016/j.scitotenv.2021.151804>

[33] Li HB*, Xue RY, Chen XQ, Lin XY, Shi XX, Du HY, Yin NY, Cui YS, Li LN, Scheckel KG, Juhasz AL, Xue XM, Zhu YG*, Ma, LQ*. 2022. Ca Minerals and oral bioavailability of Pb, Cd, and As from indoor dust in mice: Mechanisms and health implications. Environmental Health Perspectives 130 (12), 127004. <https://doi.org/10.1289/EHP11730>

[32] Wang PF, Du HL, Fu YQ, Cai XL, Yin NY, Cui YS*. 2022. Role of human gut bacteria in arsenic biosorption and biotransformation. Environment International 165, 107314. <https://doi.org/10.1016/j.envint.2022.107314>

[31] Cai XL, Yin NY, Liu XT, Wang PF, Du HL, Cui YS*, Hu ZY. 2022. Biogeochemical processes of arsenic transformation and redistribution in contaminated soils: combined effects of iron, sulfur, and organic matter. Geoderma 422, 115948. <https://doi.org/10.1016/j.geoderma.2022.115948>

[30] Cai XL, Zhang ZN, Yin NY, Lu WY, Du HL, Yang M, Cui LW, Chen SB, Cui YS*. 2022. Controlling microbial arsenite oxidation and mobilization in arsenite-adsorbed iron minerals: the influence of pH conditions and mineralogical composition. Journal of Hazardous Materials 433, 128778. <https://doi.org/10.1016/j.jhazmat.2022.128778>

[29] Fan CF, Yin NY, Cai XL, Du X, Wang PF, Liu XT, Li YP, Chang XH, Du HL, Ma JN, Cui YS*. 2022. Stabilization of fluorine-contaminated soil in aluminum smelting site with biochar loaded iron-lanthanide and aluminum-lanthanide bimetallic materials. Journal of Hazardous Materials 426, 128072. <https://doi.org/10.1016/j.jhazmat.2021.128072>

[28] Yin NY, Li YP, Cai XL, Du HL, Wang PF, Han ZL, Sun GX, Cui YS*. 2021. The role of soil arsenic fractionation in the bioaccessibility, transformation, and fate of arsenic in the presence of human gut microbiota. Journal of Hazardous Materials 401, 123366. <https://doi.org/10.1016/j.jhazmat.2020.123366>

[27] Yin NY, Li YP, Yang YT, Fan CF, Li Y, Du X, Sun GX, Cui YS*. 2021. Human health risk assessment in aluminium smelting site: soil fluoride bioaccessibility and relevant mechanism in simulated gastrointestinal tract. Journal of Hazardous Materials 416, 125899. <https://doi.org/10.1016/j.jhazmat.2021.125899>

[26] Yin NY, Zhao YL, Wang PF, Du HL, Yang M, Han ZL, Chen XC, Sun GX, Cui YS*. 2021. Effect of gut microbiota on in vitro bioaccessibility of heavy metals and human health risk assessment from ingestion of contaminated soils. Environmental Pollution 279, 116943. <https://doi.org/10.1016/j.envpol.2021.116943>

[25] Wang PF, Yin NY, Cai XL, Du HL, Fu YQ, Geng ZQ, Sultana MS, Sun GX, Cui YS*. 2021. Assessment of arsenic distribution, bioaccessibility and speciation in rice utilizing continuous extraction and in vitro digestion. Food Chemistry 346, 128969. <https://doi.org/10.1016/j.foodchem.2020.128969>

[24] Yue CS, Du HL, Li Y, Yin NY, Peng B, Cui YS*. 2021. Stabilization of soil arsenic with iron and nano-iron materials: a review. Journal of Nanoscience and Nanotechnology 21, 10-21. <https://doi.org/10.1166/jnn.2021.18476>

[23] Fu YQ, Yin NY, Cai XL, Du HL, Wang PF, Sultana MS, Sun GX, Cui YS*. 2021. Arsenic speciation and bioaccessibility in raw and cooked seafood: influence of seafood species and gut microbiota. Environmental Pollution 280, 116958. <https://doi.org/10.1016/j.envpol.2021.116958>

[22] Yin NY, Cai XL, Zheng LR, Du HL, Wang PF, Sun GX, Cui YS*. 2020. In vitro assessment of arsenic release and transformation from As(V)-sorbed goethite and jarosite: the influence of human gut microbiota. Environmental Science and Technology 54, 4432-4442. <https://doi.org/10.1021/acs.est.9b07235>

[21] Yin NY, Han ZL, Du HL, Wang PF, Li YP, Chen XC, Sun GX, Cui YS*, Hu ZY. 2020. Effect of dietary vitamins in oral bioaccessibility of lead in contaminated soils based on the physiologically based extraction test. Science of the Total Environment 747, 141299. <https://doi.org/10.1016/j.scitotenv.2020.141299>

[20] Sultana MS, Wang PF, Yin NY, Rahman MH, Du HL, Cai XL, Fu YQ, Cui YS*. 2020. Assessment of nutrients effect on the bioaccessibility of Cd and Cu in contaminated soil. Ecotoxicology and Environmental Safety 202, 110913. <https://doi.org/10.1016/j.ecoenv.2020.110913>

[19] Wang PF, Yin NY, Cai XL, Du HL, Li Y, Sun GX, Cui YS*. 2020. Comparison of bioaccessibility and relative bioavailability of arsenic in rice bran: the in vitro with PBET/SHIME and in vivo with mice model. Chemosphere 259, 127443. <https://doi.org/10.1016/j.chemosphere.2020.127443>

[18] Cai XL, Yin NY, Wang PF, Du HL, Liu XT, Cui YS*. 2020. Arsenate-reducing bacteria-mediated arsenic speciation changes and redistribution during mineral transformations in arsenate-associated goethite. Journal of Hazardous Materials 398, 122886. <https://doi.org/10.1016/j.jhazmat.2020.122886>

[17] Cai XL, Wang PF, Li ZJ, Li Y, Yin NY, Du HL, Cui YS*. 2020. Mobilization and transformation of arsenic from ternary complex OM-Fe(III)-As(V) in the presence of As(V)-reducing bacteria. Journal of Hazardous Materials 381, 120975. <https://doi.org/10.1016/j.jhazmat.2019.120975>

[16] Du HL, Yin NY, Cai XL, Wang PF, Li Y, Fu YQ, Sultana MS, Sun GX, Cui YS*. 2020. Lead bioaccessibility in farming and mining soils: the influence of soil properties, types and human gut microbiota. Science of the Total Environment 708, 135227. <https://doi.org/10.1016/j.scitotenv.2019.135227>

2020年以前

[15] Yin NY, Wang PF, Li Y, Du HL, Chen XC, Sun GX, Cui YS*. 2019. Arsenic in rice bran products: in vitro oral bioaccessibility, arsenic transformation by human gut microbiota, and human health risk assessment. Journal of Agricultural and Food Chemistry 67, 4987-4994. <https://doi.org/10.1021/acs.jafc.9b02008>

[14] Yin NY, Gao R, Knowles B, Wang JS, Wang PF, Sun GX, Cui YS*. 2019. Formation of silver nanoparticles by human gut microbiota. Science of the Total Environment 651, 1489-1494. <https://doi.org/10.1016/j.scitotenv.2018.09.312>

[13] Wang PF, Yin NY, Cai XL, Du HL, Li ZJ, Sun GX, Cui YS*. 2019. Variability of chromium bioaccessibility and speciation in vegetables: the influence of in vitro methods, gut microbiota and vegetable species. Food Chemistry 277, 347-352. <https://doi.org/10.1016/j.foodchem.2018.10.120>

[12] Wang PF, Yin NY, Cai XL, Du HL, Li ZJ, Sun GX, Cui YS*. 2018. Nutritional status affects the bioaccessibility and speciation of arsenic from soils in a simulator of the human intestinal microbial ecosystem. Science of the Total Environment 644, 815-821. <https://doi.org/10.1016/j.scitotenv.2018.07.003>

[11] Remaili TM, Yin NY, Bennett WW, Simpson SL, Jolley DF, Welsh DT. 2018. Contrasting effects of bioturbation on metal toxicity of contaminated sediments results in misleading interpretation of the AVS-SEM metal-sulfide paradigm. Environmental Science-Processes & Impacts 20, 1285-1296. <https://doi.org/10.1039/C8EM00266E>

[10] Yin NY, Du HL, Wang PF, Cai XL, Chen P, Sun GX, Cui YS*. 2017. Interindividual variability of soil arsenic metabolism by human gut microbiota using SHIME model. Chemosphere 184, 460-466. <https://doi.org/10.1016/j.chemosphere.2017.06.018>

[9] Yin NY, Cai XL, Du HL, Zhang ZN, Li ZJ, Chen XC, Sun GX, Cui YS*. 2017. In vitro study of soil arsenic release by human gut microbiota and its intestinal absorption by Caco-2 cells. Chemosphere 168, 358-364. <https://doi.org/10.1016/j.chemosphere.2016.10.091>

[8] Yin NY, Chen XC*, Du HL, Wang PF, Cai XL, Sun GX, Cui YS*. 2017. Investigation of bioaccessibility of Cu, Fe, Mn, and Zn in market vegetables in the colon using PBET combined with SHIME. Scientific Reports 7, 17578. <https://doi.org/10.1038/s41598-017-17901-1>

[7] Cai XL, Chen XC*, Yin NY, Du HL, Sun GX, Wang LH, Xu YD, Chen YQ, Cui YS*. 2017. Estimation of the bioaccessibility and bioavailability of Fe, Mn, Cu, and Zn in Chinese vegetables using the in vitro digestion/Caco-2 cell model: the influence of gut microbiota. Food & Function 8, 4592-4600. <https://doi.org/10.1039/C7FO01348E>

[6] Yin NY, Du HL, Zhang ZN, Cai XL, Li ZJ, Sun GX, Cui YS*. 2016. Variability of arsenic bioaccessibility and metabolism in soils by human gut microbiota using different in vitro methods combined with SHIME. Science of the Total Environment 566-567, 1670-1677. <https://doi.org/10.1016/j.scitotenv.2016.06.071>

[5] Cai XL, Zhang ZN, Yin NY, Du HL, Li ZJ, Cui YS*. 2016. Comparison of arsenate reduction and release by three As(V)-reducing bacterium isolated from arsenic contaminated soil of Inner Mongolia, China. Chemosphere 161, 200-207. <https://doi.org/10.1016/j.chemosphere.2016.06.102>

[4] Zhang ZN, Yin NY, Du HL, Cai XL, Cui YS*. 2016. The fate of arsenic adsorbed on iron oxides in the presence of arsenite-oxidizing bacteria. Chemosphere 151, 108-115. <https://doi.org/10.1016/j.chemosphere.2016.02.065>

[3] Zhang ZN, Yin NY, Cai XL, Wang ZZ, Cui YS*. 2016. Arsenic redox transformation by Pseudomonas sp. HN-2 isolated from arsenic-contaminated soil in Hunan, China. Journal of Environmental Sciences 47, 165-173. <https://doi.org/10.1016/j.jes.2015.11.036>

[2] Yin NY, Zhang ZN, Cai XL, Du HL, Sun GX, Cui YS*. 2015. In vitro method to assess soil arsenic metabolism by human gut microbiota: arsenic speciation and distribution. Environmental Science and Technology 49, 10675-10681. <https://doi.org/10.1021/acs.est.5b03046>

[1] Yin NY, Cui YS*, Zhang ZN, Wang ZZ, Cai XL, Wang JJ. 2015. Bioaccessibility and dynamic dissolution of arsenic in contaminated soils from Hunan, China. Journal of Soils and Sediments 15, 584-593. <https://doi.org/10.1007/s11368-014-1022-1>

1. Naiyi Yin*, Yanshan Cui. Effect of Human Gut Microbiota on Arsenic Bioavailability in Soil and Its Health Risk Assessment. The 1st Joint ICOBTE & ICHMET Conference, Wuppertal, Germany, 6-10 September 2023.

2. Naiyi Yin, Yanshan Cui*, Stuart Simpson. In vitro assessment of soil arsenic metabolism by human gut microbiota. Society of Environmental Toxicology and Chemistry (SETAC) Australasia, Gold Coast, Australia, 4-6 September 2017.

3. Naiyi Yin, Yanshan Cui*. Assessment of soil arsenic bioaccessibility and metabolism using two in vitro methods combined with SHIME model. The 8th International Workshop on Contaminant Bioavailability in the Terrestrial Environment (IWCB), Nanjing, China, 18-21 October 2015.

4. Naiyi Yin, Yanshan Cui*. Impact of human gut microorganisms on arsenic speciation from contaminated soils upon in vitro method. Conference on Environmental Pollution and Public Health (EPPH), Beijing, China, 10-12 April 2015.