Virology

virus replication

virus-host interactions

pathogenesis

antiviral drugs/vaccines

Cell biology

JAK-STAT signaling

inflammation

2008-09--2015-06   Wuhan Institute of Virology, CAS   PhD

   

2021-09~    ，Wuhan Institute of Virology，CAS，Professor

2017-08~2021-08, Wuhan Institute of Virology, CAS, Associate Professor
2015-07~2017-07, Wuhan Institute of Virology, CAS, Assistant Professor

   

（1） Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1, Journal of Biological Chemistry, 2019, Corresponding Author
（2） Interferon-gamma-Directed Inhibition of a Novel High-Pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1, Frontiers in Immunology, 2019, 1st Author
（3） The major hurdle for effective baculovirus transduction into mammalian cells is passing early endosomes, Journal of Virology, 2019, 3rd Author
（4） Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo, Protein & Cell, 2018, 1st Author
（5） The roles of ebolavirus glycoproteins in viral pathogenesis, Virologica Sinica, 2017, 1st Author
（6） Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction, Journal of Biological Chemistry, 2017, 1st Author
（7） A novel glycoprotein D-specific monoclonal antibody neutralizes herpes simplex virus, Antiviral Research, 2017, 7th Author
（8） Disruption of type I interferon signaling by the nonstructural protein of severe fever with thrombocytopenia syndrome virus via the hijacking of STAT2 and STAT1 into inclusion bodies, Journal of Virology, 2015, 1st Author

（9） Viral suppression of innate immunity via spatial isolation of TBK1/IKKepsilon from mitochondrial antiviral platform, Journal of Molecular Cell Biology, 2014, 1st Author

‍‍（10） Guertu virus NSs protein disrupts host defense by blocking antiviral interferon induction and action, ACS infectious diseases, 2020, Corresponding Author‍‍

（11） Combinatorial Minigenome Systems for Emerging Banyangviruses Reveal Viral Reassortment Potential and Importance of a Protruding Nucleotide in Genome “Panhandle” for Promoter Activity and Reassortment, Frontiers in Microbiology, 2020, Corresponding Author
（12） A RIG-I-like Receptor Directs Antiviral Responses to a Bunyavirus and Is Antagonized by Virus-Induced Blockade of TRIM25-mediated Ubiquitination, Journal of Biological Chemistry, 2020, Corresponding Author

（13） Host restriction of emerging high-pathogenic bunyaviruses via MOV10 by targeting viral nucleoprotein and blocking ribonucleoprotein assembly, PLoS Pathogens, 2020, Corresponding Author
（14） SARS-CoV-2 nsp1: Bioinformatics, Potential Structural and Functional Features, and Implications for Drug/Vaccine Designs, Frontiers in Microbiology, 2020, Corresponding Author

（15）Jiawen Sun, YuanQin Min, Yunjie Li, Xiulian Sun, Fei Deng, Hualin Wang, Ning, Yun-Jia. Animal Model of Severe Fever With Thrombocytopenia Syndrome Virus Infection. Frontiers in Microbiology[J]. 2022, 12: Corresponding Author

（16）Min, YuanQin, Huang, Mengzhuo, Sun, Xiulian, Deng, Fei, Wang, Hualin, Ning, YunJia. Immune evasion of SARS-CoV-2 from interferon antiviral system. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNALnull. 2021, 19: 4217-4225, http://dx.doi.org/10.1016/j.csbj.2021.07.023. Corresponding Author

（17）Kuan Feng, YuanQin Min, Xiulian Sun, Fei Deng, Peiqing Li, Hualin Wang, YunJia Ning. Interactome profiling reveals interaction of SARS-CoV-2 NSP13 with host factor STAT1 to suppress interferon signaling. Journal of Molecular Cell Biology[J]. 2021, Corresponding Author

（18）Dai, Shiyu, Deng, Fei, Wang, Hualin, Ning, Yunjia. Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral Strategies. VIRUSES-BASEL[J]. 2021, 13(7): http://dx.doi.org/10.3390/v13071195. Corresponding Author

（19）Ren, Fuli, Shen, Shu, Ning, YunJia, Wang, Qiongya, Dai, Shiyu, Shi, Junming, Zhou, Min, Wang, Hualin, Huang, Chaolin, Zhang, DingYu, Deng, Fei. Non-structural Proteins of Severe Fever With Thrombocytopenia Syndrome Virus Suppress RNA Synthesis in a Transcriptionally Active cDNA-Derived Viral RNA Synthesis System. FRONTIERS IN MICROBIOLOGY[J]. 2021, 12: http://dx.doi.org/10.3389/fmicb.2021.709517. 

（20）Fuli Ren, Shu Shen, Qiongya Wang, Gang Wei, Chaolin Huang, Hualin Wang, YunJia Ning, DingYu Zhang, Fei Deng. Recent Advances in Bunyavirus Reverse Genetics Research: Systems Development, Applications, and Future Perspectives. Frontiers in Microbiology[J]. 2021, 12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689132/. Corresponding Author

（21）Haijun Wang, Zili Zhang, Junfen Zhou, Shuqing Han, Zhenyu Kang, Haoyu Chuang, Heng Fan, Hongyang Zhao, Lin Wang, Yunjia Ning, Alexey Sarapultsev, Willis X Li, Jinghong Li, Zhicheng Lin, Shanshan Luo, Nian Xiong, Desheng Hu. Next-Generation Sequencing and Proteomics of Cerebrospinal Fluid From COVID-19 Patients With Neurological Manifestations. Frontiers in Immunology[J]. 2021, 12: 

（22） Sun J, Min YQ, Li Y, Sun X, Deng F, Wang H, Ning YJ. Animal Model of SevereFever With Thrombocytopenia Syndrome Virus Infection. Front Microbiol. 2022 Jan11;12:797189. doi: 10.3389/fmicb.2021.797189. PMID: 35087498; PMCID: PMC8787146.

（23) Ni L, Li Y, Wu K, Deng F, Wang H, Ning YJ. Antitumor efficacy of CRISPR/Cas9-engineered ICP6 mutant herpes simplex viruses in a mouse xenograft model for lung adenocarcinoma. J Med Virol. 2022 Dec;94(12):6000-6015. doi: 10.1002/jmv.28069. Epub 2022 Sep 1. PMID: 35965331.

(24) Mo Q, Feng K, Dai S, Wu Q, Zhang Z, Ali A, Deng F, Wang H, Ning YJ. Transcriptome profiling highlights regulated biological processes and type III interferon antiviral responses upon Crimean-Congo hemorrhagic fever virus infection. Virol Sin. 2023 Feb;38(1):34-46. doi: 10.1016/j.virs.2022.09.002. Epub 2022 Sep 6. PMID: 36075566; PMCID: PMC10006212.

(25) Feng K, Zhang H, Jiang Z, Zhou M, Min YQ, Deng F, Li P, Wang H, Ning YJ. SFTS bunyavirus NSs protein sequestrates mTOR into inclusion bodies and deregulates mTOR-ULK1 signaling, provoking pro-viral autophagy. J Med Virol. 2023 Jan; 95(1):e28371. doi: 10.1002/jmv.28371. PMID: 36458534.

(26) Min YQ, Huang M, Feng K, Jia Y, Sun X, Ning YJ. A new cellular interactome of SARS-CoV-2 nucleocapsid protein and its biological implications. Mol Cell Proteomics. 2023 May 19:100579. doi: 10.1016/j.mcpro.2023.100579. Epub ahead of print. PMID: 37211047; PMCID: PMC10198743.

Yun-Jia Ning, You Zhang, Hualin Wang, Fei Deng; New application of Ammonium pyrrolidinedithiocarbamate; 202210051206.1

现指导学生

黄梦卓  硕士研究生  086000-生物与医药  

邓薇  硕士研究生  086000-生物与医药