基本信息

宁云佳  男  硕导  中国科学院武汉病毒研究所
电子邮件: nyj@wh.iov.cn
通信地址: 武汉市武昌区小洪山中区44号
邮政编码: 430071

研究领域

病毒学

病毒复制机制

病毒-宿主互作

病毒致病机理

抗病毒药物、疫苗


细胞生物学

JAK-STAT信号转导

炎症反应



招生信息

   
招生专业
071005-微生物学
071010-生物化学与分子生物学
100102-免疫学
招生方向
病毒与宿主相互作用、免疫响应
新发病毒感染与致病机理
抗病毒药物、疫苗研究

教育背景

2008-09--2015-06   中国科学院武汉病毒研究所   理学博士学位
2004-09--2008-06   青岛科技大学   工学学士学位

工作经历

   
工作简历
2021-09~现在, 中国科学院武汉病毒研究所, 青年研究员
2017-08~2021-09,中国科学院武汉病毒研究所, 副研究员
2015-07~2017-07,中国科学院武汉病毒研究所, 助理研究员
社会兼职
2021-05-01-今,湖北省生物工程学会, 会员
2020-01-01-今,中国科学院青年创新促进会, 会员

教授课程

疫情期间研究生线上“科研达人论坛”
实验技术讲座-细胞培养
孙思邈论坛第二十九讲-讲评
东湖学术论坛暨第七届全国病毒学研究生论坛-讲评

专利与奖励

   
奖励信息
(1) 中国科学院武汉病毒研究所优秀青年科研骨干, 研究所(学校), 2020
(2) 中国科学院武汉病毒研究所优秀青年科研骨干, 研究所(学校), 2019
(3) 中国科学院青年创新促进会成员, 部委级, 2019
(4) 湖北省优秀博士学位论文奖, , 其他, 2017
(5) 病毒学国家重点实验室优秀青年骨干, 其他, 2017
(6) 湖北省优秀自然科学论文奖, , 其他, 2016
(7) 中国科学院院长奖, , 其他, 2015
(8) 中国科学院优秀毕业生, 其他, 2015
(9) 北京市高校优秀毕业生, 研究所(学校), 2015

出版信息

发表论文
[1] Jiawen Sun, YuanQin Min, Yunjie Li, Xiulian Sun, Fei Deng, Hualin Wang, Ning, Yun-Jia. Animal Model of Severe Fever With Thrombocytopenia Syndrome Virus Infection. Frontiers in Microbiology[J]. 2022, 12: 
[2] Min, YuanQin, Huang, Mengzhuo, Sun, Xiulian, Deng, Fei, Wang, Hualin, Ning, YunJia. Immune evasion of SARS-CoV-2 from interferon antiviral system. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL[J]. 2021, 19: 4217-4225, http://dx.doi.org/10.1016/j.csbj.2021.07.023.

[3] Kuan Feng, YuanQin Min, Xiulian Sun, Fei Deng, Peiqing Li, Hualin Wang, YunJia Ning. Interactome profiling reveals interaction of SARS-CoV-2 NSP13 with host factor STAT1 to suppress interferon signaling. Journal of Molecular Cell Biology[J]. 2021, 
[4] Dai, Shiyu, Deng, Fei, Wang, Hualin, Ning, Yunjia. Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral Strategies. VIRUSES-BASEL[J]. 2021, 13(7): http://dx.doi.org/10.3390/v13071195.

[5] Ren, Fuli, Shen, Shu, Ning, YunJia, Wang, Qiongya, Dai, Shiyu, Shi, Junming, Zhou, Min, Wang, Hualin, Huang, Chaolin, Zhang, DingYu, Deng, Fei. Non-structural Proteins of Severe Fever With Thrombocytopenia Syndrome Virus Suppress RNA Synthesis in a Transcriptionally Active cDNA-Derived Viral RNA Synthesis System. FRONTIERS IN MICROBIOLOGY[J]. 2021, 12: http://dx.doi.org/10.3389/fmicb.2021.709517.

[6] Fuli Ren, Shu Shen, Qiongya Wang, Gang Wei, Chaolin Huang, Hualin Wang, YunJia Ning, DingYu Zhang, Fei Deng. Recent Advances in Bunyavirus Reverse Genetics Research: Systems Development, Applications, and Future Perspectives. Frontiers in Microbiology[J]. 2021, 12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8689132/.

[7] Haijun Wang, Zili Zhang, Junfen Zhou, Shuqing Han, Zhenyu Kang, Haoyu Chuang, Heng Fan, Hongyang Zhao, Lin Wang, Yunjia Ning, Alexey Sarapultsev, Willis X Li, Jinghong Li, Zhicheng Lin, Shanshan Luo, Nian Xiong, Desheng Hu. Next-Generation Sequencing and Proteomics of Cerebrospinal Fluid From COVID-19 Patients With Neurological Manifestations. Frontiers in Immunology[J]. 2021, 12: 
[8] Shiyu Dai, Fei Deng, Hualin Wang, Yunjia Ning. Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral Strategies. Viruses[J]. 2021, 13: https://doaj.org/article/ca3d905a33a34de19d9d00e0aa306990.

[9] Min, YuanQin, Mo, Qiong, Wang, Jun, Deng, Fei, Wang, Hualin, Ning, YunJia. SARS-CoV-2 nsp1: Bioinformatics, Potential Structural and Functional Features, and Implications for Drug/Vaccine Designs. FRONTIERS IN MICROBIOLOGY[J]. 2020, 11: https://doaj.org/article/aeb6d47f471c4fcb8ec25d38057890c9.

[10] Min, YuanQin, Shi, Chen, Yao, Ting, Feng, Kuan, Mo, Qiong, Deng, Fei, Wang, Hualin, Ning, YunJia. The Nonstructural Protein of Guertu Virus Disrupts Host Defenses by Blocking Antiviral Interferon Induction and Action. ACS INFECTIOUS DISEASES[J]. 2020, 6(5): 857-870, https://www.webofscience.com/wos/woscc/full-record/WOS:000535176700010.

[11] Ren, Fuli, Zhou, Min, Deng, Fei, Wang, Hualin, Ning, YunJia. Combinatorial Minigenome Systems for Emerging Banyangviruses Reveal Viral Reassortment Potential and Importance of a Protruding Nucleotide in Genome "Panhandle" for Promoter Activity and Reassortment. FRONTIERS IN MICROBIOLOGY[J]. 2020, 11: https://doaj.org/article/ddaf545c2216480b95ea08d46db39143.

[12] Qiong Mo, Zhao Xu, Fei Deng, Hualin Wang, YunJia Ning. Host restriction of emerging high-pathogenic bunyaviruses via MOV10 by targeting viral nucleoprotein and blocking ribonucleoprotein assembly. PLOS PATHOGENS[J]. 2020, 16(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746268/.

[13] Min, YuanQin, Ning, YunJia, Wang, Hualin, Deng, Fei. A RIG-I?like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2020, 295(28): 9691-9711, http://dx.doi.org/10.1074/jbc.RA120.013973.

[14] Ning, YunJia, Mo, Qiong, Feng, Kuan, Min, YuanQin, Li, Mingyue, Hou, Dianhai, Peng, Cheng, Zheng, Xin, Deng, Fei, Hu, Zhihong, Wang, Hualin. Interferon-gamma-Directed Inhibition of a Novel High-Pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1. FRONTIERS IN IMMUNOLOGY[J]. 2019, 10: https://www.webofscience.com/wos/woscc/full-record/WOS:000469269400001.

[15] 梅琳达温纳莫耶, 宁云佳, 戴诗雨, 莫琼, 王华林. 疫苗具有“万能”效应?. 环球科学[J]. 2019, 54-61, http://lib.cqvip.com/Qikan/Article/Detail?id=7002346321.

[16] Feng, Kuan, Deng, Fei, Hu, Zhihong, Wang, Hualin, Ning, YunJia. Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2019, 294(24): 9503-9517, http://dx.doi.org/10.1074/jbc.RA118.006563.

[17] Kuan Feng, Fei Deng, Zhihong Hu, Hualin Wang, YunJia Ning. Heartland virus antagonizes type I and III interferon antiviral signaling by inhibiting phosphorylation and nuclear translocation of STAT2 and STAT1. The Journal of Biological Chemistry[J]. 2019, 294(24): 9503-9517, http://dx.doi.org/10.1074/jbc.RA118.006563.

[18] Hu, Liangbo, Li, Yimeng, Ning, YunJia, Deng, Fei, Vlak, Just M, Hu, Zhihong, Wang, Hualin, Wang, Manli. The Major Hurdle for Effective Baculovirus Transduction into Mammalian Cells Is Passing Early Endosomes. JOURNAL OF VIROLOGY[J]. 2019, 93(15): 
[19] YunJia Ning, Zhenyu Kang, Jingjun Xing, YuanQin Min, Dan Liu, Kuan Feng, Manli Wang, Fei Deng, Yiwu Zhou, Zhihong Hu, Hualin Wang. Ebola virus mucin-like glycoprotein (Emuc) induces remarkable acute inflammation and tissue injury: evidence for Emuc pathogenicity in vivo. Protein & Cell[J]. 2018, 9(4): 389-393, 
[20] Ning, YunJia, Deng, Fei, Hu, Zhihong, Wang, Hualin. The roles of ebolavirus glycoproteins in viral pathogenesis. VIROLOGICA SINICA[J]. 2017, 32(1): 3-15, http://www.corc.org.cn/handle/1471x/2373449.

[21] Ning, YunJia, Feng, Kuan, Min, YuanQin, Deng, Fei, Hu, Zhihong, Wang, Hualin. Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2017, 292(40): 16722-16733, http://dx.doi.org/10.1074/jbc.M117.805127.

[22] Du, Ruikun, Wang, Lili, Xu, Hao, Wang, Zhiying, Zhang, Tao, Wang, Manli, Ning, Yunjia, Deng, Fei, Hu, Zhihong, Wang, Hualin, Li, Yi. A novel glycoprotein D-specific monoclonal antibody neutralizes herpes simplex virus. ANTIVIRAL RESEARCH[J]. 2017, 147: 131-141, http://www.corc.org.cn/handle/1471x/2373306.

[23] Ning, YunJia, Feng, Kuan, Min, YuanQin, Cao, WuChun, Wang, Manli, Deng, Fei, Hu, Zhihong, Wang, Hualin. Disruption of Type I Interferon Signaling by the Nonstructural Protein of Severe Fever with Thrombocytopenia Syndrome Virus via the Hijacking of STAT2 and STAT1 into Inclusion Bodies. JOURNAL OF VIROLOGY[J]. 2015, 89(8): 4227-4236, https://www.webofscience.com/wos/woscc/full-record/WOS:000352218400018.

[24] 戴维·J·埃克, 宁云佳, 李淑芬, 王曼丽. 搭建流行病探测网络. 环球科学[J]. 2014, 42-47, http://lib.cqvip.com/Qikan/Article/Detail?id=50003225.

[25] Ning, YunJia, Wang, Manli, Deng, Maping, Shen, Shu, Liu, Wei, Cao, WuChun, Deng, Fei, Wang, YanYi, Hu, Zhihong, Wang, Hualin. Viral suppression of innate immunity via spatial isolation of TBK1/IKK epsilon from mitochondrial antiviral platform. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2014, 6(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000339916900006.

[26] Ning Yunjia, Wang Manli, Deng Maping, Shu Shen, Wei Liu, Cao Wuchun, Fei Deng, Wang Yanyi, Hu Zhihong, Wang Hualin. Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform. Journal of Molecular Cell Biology[J]. 2014, 6(4): 324-337, 
发表著作
(1) 搭建流行病探测网络, Germ Catcher, 环球科学杂志出版社, 2014-07, 第 1 作者
(2) 疫苗具有“万能效应”?, Vaccines Reimagined, 环球科学出版社, 2019-07, 第 1 作者

科研活动

   
科研项目
( 1 ) 宿主因子MOV10等调控新布尼亚病毒SFTSV复制的功能及机制研究, 主持, 国家级, 2019-01--2022-12
( 2 ) 发热伴血小板减少综合征病毒对IL-10等抗炎信号的调节机制, 主持, 国家级, 2017-01--2019-12
( 3 ) 高致病性病毒转录复制过程关键蛋白质机器的功能及调控机制, 参与, 国家级, 2018-05--2023-04
( 4 ) 发热伴血小板减少综合征病毒对炎症信号的调节机制研究, 主持, 省级, 2016-01--2017-12
( 5 ) 病毒与宿主相互作用的分子机理, 参与, 国家级, 2017-01--2019-12
( 6 ) 病毒的免疫逃逸及致病机制研究, 参与, 市地级, 2016-01--2020-12
( 7 ) 中科院青年创新促进会项目, 主持, 部委级, 2020-01--2023-12
( 8 ) 中俄合作_SARS-CoV-2感染的免疫介导机制:新途径和新挑战, 参与, 国家级, 2021-03--2023-02
( 9 ) 细胞因子与布尼亚病毒互作的功能与机制研究, 主持, 国家级, 2022-01--2025-12