Dr. Naixia Zhang graduated from Beijing Medical University in 1998, and got a Bachelor degree with the major in medicinal chemistry. In the same year Dr. Zhang got admitted into the PhD training program at Shanghai Institute of Organic Chemistry, and got the PhD degree in 2003. In May of 2004, Dr. Zhang joined Dr. Kylie Walters’ lab in the Department of Biochemistry, Molecular Biology, and Biophysics at the University of Minnesota as a postdoctoral fellow, and was then promoted to research assistant professor in 2008. In October of 2010, Dr. Naixia Zhang joined Shanghai Institute of Materia Medica, Chinese Academy of Sciences as a principal investigator. Dr. Zhang’s major research interests focus on NMR studies of protein-ligand (protein, DNA, small molecule etc.) interactions, and have got excellent achievements in quite a few of research projects. Up to date, Dr. Naixia Zhang has published more than 100 research articles.

1. Zhou, C.^#, Zhang, J.^#, Luo, X.^#, Lian, F., Zeng, Y., Zhang, Z., Zhang, H.*, Zhang, N.*, Sodium oligomannate electrostatically binds to Aβ and blocks its aggregation, Journal of Physical Chemistry B, 127(9), 1983-1994, 2023.
2. Xu, Z.^#, Wang, H.^#, Meng, Q., Ding, Y., Zhu, M., Zhou, H., Zhang, N.*, Shi, L.*, Otilonium Bromide acts as a selective USP28 inhibitor and exhibits cytotoxic activity against multiple human cancer cell lines, Biochemical Pharmacology, 215, 115746, 2023.
3. Tang, J., Hu, H., Zhou, C.*, Zhang, N.*, Human Aha1's N-terminal extension confers it holdase activity in vitro, Protein Science, 32(9), e4735, 2023.
4. Gao, J.^#, Zhou, C.^#, Zhong, Y.^#, Shi, L., Luo, X., Su, H., Li, M., Xu, Y., Zhang, N.*, Zhou, H.*, Dipyridamole interacts with the N-terminal domain of HSP90 and antagonizes the function of the chaperone in multiple cancer cell lines, Biochemical Pharmacology, 207, 115376, 2023.
5. Zhu, M., Wang, H., Ding, Y., Yang, Y., Xu, Z., Shi, L.*, Zhang, N.*, Ribonucleotide reductase holoenzyme inhibitor COH29 interacts with deubiquitinase ubiquitin-specific protease 2 and downregulates its substrate protein cyclin D1, FASEB Journal, 36(5), e22329, 2022.
6. Wang, H., Meng, Q., Ding, Y., Xiong, M., Zhu, M., Yang, Y., Su, H., Gu, L., Xu, Y., Shi, L.*, Zhou, H.*, Zhang, N.*, USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines, FEBS Journal, 288(4), 1325-1342, 2021.
7. Zhou, C.^#, Zhang, C.^#, Zhu, H.^#, Liu, Z., Su, H., Zhang, X., Chen, T., Zhong, Y., Hu, H., Xiong, M., Zhou, H., Xu, Y.*, Zhang, A.*, Zhang, N.*, Allosteric Regulation of Hsp90α's Activity by Small Molecules Targeting the Middle Domain of the Chaperone, iScience, 23(2), 100857, 2020.
8. Yang, Y., Ding, Y., Zhou, C., Wen, Y., Zhang, N.*, Structural and Functional Studies of USP20 ZnF-UBP Domain by NMR, Protein Science, 28(9), 1606-1619, 2019.
9. Yang, Y.^#, Shi, L.^#, Ding, Y., Shi, Y., Hu, H., Wen, Y.*, Zhang, N.*, Structural and Functional Investigations of the N-Terminal Ubiquitin Binding Region of Usp25, Biophysical Journal, 112(10), 2099-2108, 2017.
10. Yu, J.^#, Chen, T.^#, Zhou, C.^#, Lian, F., Tang, X., Wen, Y., Shen, J., Xu, Y., Xiong, B.*, Zhang, N.*, NMR-based Platform for Fragment-Based Lead Discovery Used in Screening BRD4-targeted Compounds, Acta Pharmacologica Sinica, 37(7), 984-93, 2016.
11. Wen, Y.^#, Shi, L.^#, Ding, Y., Cui, R., He, W.T., Hu, H.*, Zhang, N.*, The N-terminal ubiquitin-binding region of ubiquitin-specific protease 28 modulates its deubiquitination function: NMR structural and mechanistic insights, Biochemical Journal, 471(2), 155-65, 2015.
12. Zhang, N.^#, Wang, Q.^#, Ehlinger, A.^#, Randles, L.^#, Lary, J.W., Kang, Y., Haririnia, A., Storaska, A.J., Cole, J.L., Fushman, D., Walters, K.J.*, Structure of the S5a:K48-linked diubiquitin complex and its interactions with Rpn13, Molecular Cell, 35(3), 280-290, 2009.
13. Husnjak, K.^#, Elsasser, S.^#, Zhang, N.^#, Chen, X., Randles, L., Shi, Y., Hofmann, K., Walters, K.J.*, Finley, D.*, Dikic, I.*, Proteasome subunit Rpn13 is a novel ubiquitin receptor, Nature, 453(7194), 481-488, 2008.

已指导学生

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现指导学生

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