以NMR技术和计算机分子模拟技术为主要手段研究蛋白质与蛋白质之间、药物靶标蛋白质与小分子之间的相互作用；与疾病相关的NMR代谢组学研究。

招收攻读硕士学位研究生（含推免生），应试学生应具备生物或化学专业知识背景，有志于从事NMR结构生物学研究。欢迎有兴趣的同学与我直接联系。

   

1994.9 - 1998.7 北京医科大学 药物化学 理学学士
1998.9 - 2003.7 中国科学院上海有机化学研究所 结构生物学 理学博士
2004.5 - 2008.6 美国明尼苏达大学 结构生物学 博士后

张乃霞研究员于1998年毕业于北京医科大学，获得药物化学专业学士学位。同年进入上海有机化学研究所攻读博士学位，并于2003年获得结构生物学专业博士学位。在2004年5月加入了明尼苏达大学Kylie Walters博士的研究小组，开始博士后研究工作，并于2008年升职为研究助理教授。2010 年作为中国科学院“****”入选者加入上海药物研究所分析化学研究室。

2010-10--今 中国科学院上海药物研究所 “****”研究员
2008-05--2010-02 美国明尼苏达大学 研究助理教授
2004-05--2008-05 美国明尼苏达大学 博士后
2003-08--2004-05 中国科学院上海有机化学研究所 科研人员

   

[1] Zhou, Chen, Zhang, Jingjing, Luo, Xinwen, Lian, Fulin, Zeng, Yangyang, Zhang, Zhenqing, Zhang, Haiyan, Zhang, Naixia. Sodium Oligomannate Electrostatically Binds to Aβ and Blocks Its Aggregation. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2023, http://dx.doi.org/10.1021/acs.jpcb.3c00280.
[2] Gao, Jing, Zhou, Chen, Zhong, Yan, Shi, Li, Luo, Xuanyang, Su, Haixia, Li, Minjun, Xu, Yechun, Zhang, Naixia, Zhou, Hu. Dipyridamole interacts with the N-terminal domain of HSP90 and antagonizes the function of the chaperone in multiple cancer cell lines. BIOCHEMICAL PHARMACOLOGY[J]. 2023, 207: http://dx.doi.org/10.1016/j.bcp.2022.115376.
[3] Qing Wang, Sheng Yao, Ze-xian Yang, Chen Zhou, Yu Zhang, Ye Zhang, Lei Zhang, Jin-Tian Li, Zhi-Jian Xu, Wei-Liang Zhu, Nai-Xia Zhang, Yang Ye, Lin-Yin Feng. Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson's disease treatment. Acta Pharmacologica Sinica[J]. 2023, 44(6): 1122-1134, https://www.nature.com/articles/s41401-022-01039-6.
[4] Di Zhou, Zhuo Xu, Yaodong Huang, Hui Wang, Xiaoli Zhu, Wentao Zhang, Weiwei Song, Tong Gao, Tongchao Liu, Meng Wang, Li Shi, Naixia Zhang, Bing Xiong. Structure-based discovery of potent USP28 inhibitors derived from Vismodegib. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2023, 254: http://dx.doi.org/10.1016/j.ejmech.2023.115369.
[5] Zhu, Mengying, Wang, Hui, Ding, Yiluan, Yang, Yuanyuan, Xu, Zhuo, Shi, Li, Zhang, Naixia. Ribonucleotide reductase holoenzyme inhibitor COH29 interacts with deubiquitinase ubiquitin-specific protease 2 and downregulates its substrate protein cyclin D1. FASEB JOURNAL[J]. 2022, 36(5): http://dx.doi.org/10.1096/fj.202101914RR.
[6] Xiao, Senhao, Guo, Siqi, Han, Jie, Sun, Yanli, Wang, Mingchen, Chen, Yantao, Fang, Xueyu, Yang, Feng, Mu, Yajuan, Zhang, Liang, Ding, Yiluan, Zhang, Naixia, Jiang, Hualiang, Chen, Kaixian, Zhao, Kehao, Luo, Cheng, Chen, Shijie. High-Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases and demethylases. NUCLEIC ACIDS RESEARCH[J]. 2022, 50(2): http://dx.doi.org/10.1093/nar/gkab989.
[7] Mao, Jianhua, Zhu, Kongkai, Long, Zhangbiao, Zhang, Huimin, Xiao, Bing, Xi, Wenda, Wang, Yun, Huang, Jiansong, Liu, Jingqiu, Shi, Xiaofeng, Jiang, Hao, Lu, Tian, Wen, Yi, Zhang, Naixia, Meng, Qian, Zhou, Hu, Ruan, Zheng, Wang, Jin, Luo, Cheng, Xi, Xiaodong. Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis. ADVANCED SCIENCE[J]. 2022, 9(7): http://dx.doi.org/10.1002/advs.202103228.
[8] Lan, Xiaofang, Olaleye, Olajide E, Lu, Junlan, Yang, Wei, Du, Feifei, Yang, Junling, Cheng, Chen, Shi, Yanhong, Wang, Fengqing, Zeng, Xueshan, Tian, Nannan, Liao, Peiwei, Yu, Xuan, Xu, Fang, Li, Yingfei, Wang, Hongtao, Zhang, Naixia, Jia, Weiwei, Li, Chuan. Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule. ACTA PHARMACOLOGICA SINICA[J]. 2021, 42(12): 2155-2172, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086230/.
[9] Wang, Shuni, Yang, Hong, Su, Mingbo, Lian, Fulin, Cong, Zhanqing, Wei, Rongrui, Zhou, Yubo, Li, Xingjun, Zheng, Xingling, Li, Chunpu, Fu, Xuhong, Han, Xu, Shi, Qiongyu, Li, Cong, Zhang, Naixia, Geng, Meiyu, Liu, Hong, Li, Jia, Huang, Xun, Wang, Jiang. 5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 222: http://dx.doi.org/10.1016/j.ejmech.2021.113592.
[10] Liu, Xia, Ruan, Zhi, Shao, Xingcheng, Feng, Hongxuan, Wu, Lei, Wang, Wei, Wang, Hongmin, Mu, Hongyan, Zhang, Rujun, Zhao, Weimin, Zhang, Haiyan, Zhang, Naixia. Protective Effects of 28-O-Cafeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis (vol 89, pg 631, 2020). NEUROCHEMICAL RESEARCH. 2021, 46(3): 699-700, https://www.webofscience.com/wos/woscc/full-record/WOS:000608105100001.
[11] Hu, Shuwei, Chen, Xiaoyu, Zhu, Mengying, Hu, Huifang, Zhou, Chen, Shi, Li, Zhang, Naixia. Expression, purification and characterization of the second DUSP domain of deubiquitinase USP20/VDU2. PROTEIN EXPRESSION AND PURIFICATION[J]. 2021, 181: http://dx.doi.org/10.1016/j.pep.2021.105836.
[12] Shi, Li, Zhang, Naixia. Applications of Solution NMR in Drug Discovery. MOLECULES[J]. 2021, 26(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865596/.
[13] Wang, Hui, Meng, Qian, Ding, Yiluan, Xiong, Muya, Zhu, Mengying, Yang, Yuanyuan, Su, Haixia, Gu, Lei, Xu, Yechun, Shi, Li, Zhou, Hu, Zhang, Naixia. USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines. FEBS JOURNAL[J]. 2021, 288(4): 1325-1342, https://www.webofscience.com/wos/woscc/full-record/WOS:000550433200001.
[14] Hu, Huifang, Wang, Qing, Du, Jingwen, Liu, Zhijun, Ding, Yiluan, Xue, Hongjuan, Zhou, Chen, Feng, Linyin, Zhang, Naixia. Aha1 Exhibits Distinctive Dynamics Behavior and Chaperone-Like Activity. MOLECULES[J]. 2021, 26(7): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8037086/.
[15] Li, Wen, Liao, Liping, Song, Ning, Liu, Yanjun, Ding, Yiluan, Zhang, Yuanyuan, Zhou, Xiaoru, Sun, Zhongya, Xiao, Senhao, Wang, Hongbo, Lu, Jing, Zhang, Naixia, Jiang, Hualiang, Chen, Kaixian, Liu, Chuanpeng, Zheng, Jie, Zhao, Kehao, Luo, Cheng. Natural product 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase. ACTA PHARMACOLOGICA SINICA[J]. 2021, https://www.webofscience.com/wos/woscc/full-record/WOS:000639768200002.
[16] Liu, Xia, Ruan, Zhi, Shao, Xingcheng, Feng, Hongxuan, Wu, Lei, Wang, Wei, Wang, Hongmin, Mu, Hongyan, Zhang, Rujun, Zhao, Weimin, Zhang, Haiyan, Zhang, Naixia. Protective Effects of 28-O-Caffeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis. NEUROCHEMICAL RESEARCH[J]. 2021, 46(3): 686-698, https://www.webofscience.com/wos/woscc/full-record/WOS:000604515400001.
[17] Xiao, Ruoxuan, Ding, Chunyong, Zhu, Hongwen, Liu, Xia, Gao, Jing, Liu, Qian, Lu, Dayun, Zhang, Naixia, Zhang, Ao, Zhou, Hu. Suppression of asparagine synthetase enhances the antitumor potency of ART and artemalogue SOMCL-14-221 in non-small cell lung cancer. CANCER LETTERS[J]. 2020, 475: 22-33, http://dx.doi.org/10.1016/j.canlet.2020.01.035.
[18] Sun, Zhongya, Zhang, Hao, Zhang, Yuanyuan, Liao, Liping, Zhou, Wen, Zhang, Fengcai, Lian, Fulin, Huang, Jing, Xu, Pan, Zhang, Rukang, Lu, Wenchao, Zhu, Mingrui, Tao, Hongru, Yang, Feng, Ding, Hong, Chen, Shijie, Yue, Liyan, Zhou, Bing, Zhang, Naixia, Tan, Minjia, Jiang, Hualiang, Chen, Kaixian, Liu, Bo, Liu, Chuanpeng, Dang, Yongjun, Luo, Cheng. Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion. ADVANCED SCIENCE[J]. 2020, 7(14): https://doaj.org/article/2e4dbc3d2ae14c49977b0ef0da5f68ca.
[19] Zhou, Chen, Zhang, Chi, Zhu, Hongwen, Liu, Zhijun, Su, Haixia, Zhang, Xianglei, Chen, Tingting, Zhong, Yan, Hu, Huifang, Xiong, Muya, Zhou, Hu, Xu, Yechun, Zhang, Ao, Zhang, Naixia. Allosteric Regulation of Hsp90 alpha's Activity by Small Molecules Targeting the Middle Domain of the Chaperone. ISCIENCE[J]. 2020, 23(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000518637100004.
[20] Chen Zhou, Chi Zhang, Hongwen Zhu, Zhijun Liu, Haixia Su, Xianglei Zhang, Tingting Chen, Yan Zhong, Huifang Hu, Muya Xiong, Hu Zhou, Yechun Xu, Ao Zhang, Naixia Zhang. Allosteric Regulation of Hsp90α’s Activity by Small Molecules Targeting the Middle Domain of the Chaperone. ISCIENCE[J]. 2020, 23(2): http://dx.doi.org/10.1016/j.isci.2020.100857.
[21] Wang, Yingcong, Huang, Jing, Li, Bo, Xue, Han, Tricot, Guido, Hu, Liangning, Xu, Zhijian, Sun, Xiaoxiang, Chang, Shuaikang, Gao, Lu, Tao, Yi, Xu, Hongwei, Xie, Yongsheng, Xiao, Wenqin, Yu, Dandan, Kong, Yuanyuan, Chen, Gege, Sun, Xi, Lian, Fulin, Zhang, Naixia, Wu, Xiaosong, Mao, Zhiyong, Khan, Fenghuang, Zhu, Weiliang, Shi, Jumei. A Small-Molecule Inhibitor Targeting TRIP13 Suppresses Multiple Myeloma Progression. CANCERRESEARCH[J]. 2020, 80(3): 536-548, https://www.webofscience.com/wos/woscc/full-record/WOS:000514161100017.
[22] Su, Haixia, Zou, Yi, Chen, Guofeng, Dou, Huixia, Xie, Hang, Yuan, Xiaojing, Zhang, Xianglei, Zhang, Naixia, Li, Minjun, Xu, Yechun. Exploration of Fragment Binding Poses Leading to Efficient Discovery of Highly Potent and Orally Effective Inhibitors of FABP4 for Anti-inflammation. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2020, 63(8): 4090-4106, https://www.webofscience.com/wos/woscc/full-record/WOS:000529170200018.
[23] Chen, Yu, Bi, Xiaoyang, Zhang, Fengcai, Sun, Zhongya, Xu, Pan, Jiang, Hao, Lu, Wenchao, Lu, Tian, Ding, Hong, Zhang, Naixia, Jiang, Hualiang, Chen, Kaixian, Zhou, Bing, Luo, Cheng. Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain. BIOORGANIC CHEMISTRY[J]. 2020, 101: http://dx.doi.org/10.1016/j.bioorg.2020.103991.
[24] Wang, Hui, Meng, Qian, Ding, Yiluan, Xiong, Muya, Zhu, Mengying, Yang, Yuanyuan, Su, Haixia, Gu, Lei, Xu, Yechun, Shi, Li, Zhou, Hu, Zhang, Naixia. USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines. FEBS JOURNAL[J]. 2020, 18-, [25] Yang, Yuanyuan, Ding, Yiluan, Zhou, Chen, Wen, Yi, Zhang, Naixia. Structural and functional studies of USP20 ZnF-UBP domain by NMR. PROTEIN SCIENCE[J]. 2019, 28(9): 1606-1619, https://www.webofscience.com/wos/woscc/full-record/WOS:000481129000001.
[26] Huang, Yue, Su, Rui, Sheng, Yue, Dong, Lei, Dong, Ze, Xu, Hongjiao, Ni, Tengfeng, Zhang, Zijie Scott, Zhang, Tao, Li, Chenying, Han, Li, Zhu, Zhenyun, Lian, Fulin, Wei, Jiangbo, Deng, Qiangqiang, Wang, Yungui, Wunderlich, Mark, Gao, Zhiwei, Pan, Guoyu, Zhong, Dafang, Zhou, Hu, Zhang, Naixia, Gan, Jianhua, Jiang, Hualiang, Mulloy, James C, Qian, Zhijian, Chen, Jianjun, Yang, CaiGuang. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. CANCER CELL[J]. 2019, 35(4): 677-+, http://dx.doi.org/10.1016/j.ccell.2019.03.006.
[27] Ye, Xiaoqing, Zhang, Rukang, Lian, Fulin, Zhang, Weiyao, Lu, Wenchao, Han, Jie, Zhang, Naixia, Jin, Jia, Luo, Cheng, Chen, Kaixian, Ye, Fei, Ding, Hong. The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2019, 29(4): 638-645, http://dx.doi.org/10.1016/j.bmcl.2018.12.035.
[28] Danqi Chen, Yuehong Chen, Fulin Lian, Liu Chen, Yanlian Li, Danyan Cao, Xin Wang, Lin Chen, Jian Li, Tao Meng, Min Huang, Meiyu Geng, Jingkang Shen, Naixia Zhang, Bing Xiong. Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2019, 163: 597-609, http://dx.doi.org/10.1016/j.ejmech.2018.12.018.
[29] Zhang, Dan, Han, Jie, Lu, Wenchao, Lian, Fulin, Wang, Jun, Lu, Tian, Tao, Hongru, Xiao, Senhao, Zhang, Fengcai, Liu, YuChih, Liu, Rongfeng, Zhang, Naixia, Jiang, Hualiang, Chen, Kaixian, Zhao, Chunshen, Luo, Cheng. Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening. BIOORGANIC CHEMISTRY[J]. 2019, 86: 494-500, http://dx.doi.org/10.1016/j.bioorg.2019.01.035.
[30] Lu, Wenchao, Wang, Jun, Li, Yong, Tao, Hongru, Xiong, Huan, Lian, Fulin, Gao, Jing, Ma, Hongna, Lu, Tian, Zhang, Dan, Ye, Xiaoqing, Ding, Hong, Yue, Liyan, Zhang, Yuanyuan, Tang, Huanyu, Zhang, Naixia, Yang, Yaxi, Jiang, Hualiang, Chen, Kaixian, Zhou, Bing, Luo, Cheng. Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2019, 184: http://dx.doi.org/10.1016/j.ejmech.2019.111767.
[31] Chen, Danqi, Chen, Yuehong, Lian, Fulin, Chen, Liu, Li, Yanlian, Cao, Danyan, Wang, Xin, Chen, Lin, Li, Jian, Meng, Tao, Huang, Min, Geng, Meiyu, Shen, Jingkang, Zhang, Naixia, Xiong, Bing. Fragment-based drug discovery of triazole inhibitors to block PDE delta-RAS protein-protein interaction. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2019, 163: 597-609, https://www.webofscience.com/wos/woscc/full-record/WOS:000458597300045.
[32] Liu Xia, Wang Wei, Chen Huali, Zhang Haiyan, Zhang Naixia. Interplay between Alzheimer's disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice. ACTA PHARMACOLOGICA SINICA[J]. 2019, 40(10): 1259-1268, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6584269&detailType=1.
[33] Zhang, Rui, Tang, Chunping, Liu, HongChun, Ren, Yongmei, Ke, ChangQiang, Yao, Sheng, Cai, Yaoyao, Zhang, Naixia, Ye, Yang. Tetramerized Sesquiterpenoid Ainsliatetramers A and B from Ainsliaea fragrans and Their Cytotoxic Activities. ORGANIC LETTERS[J]. 2019, 21(20): 8211-8214, [34] Guan, Dongliang, Chen, Feifei, Xiong, Lun, Tang, Feng, Faridoon, Qu, Yunguang, Zhang, Naixia, Gong, Likun, Li, Jian, Lan, Lefu, Huang, Wei. Extra Sugar on Vancomycin: New Analogues for Combating Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci. JOURNALOFMEDICINALCHEMISTRY[J]. 2018, 61(1): 286-304, https://www.webofscience.com/wos/woscc/full-record/WOS:000422810800016.
[35] Ding, Hong, Lu, Wen Chao, Hu, Jun Chi, Liu, YuChih, Zhang, Chen Hua, Lian, Fu Lin, Zhang, Nai Xia, Meng, Fan Wang, Luo, Cheng, Chen, Kai Xian. Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search. MOLECULES[J]. 2018, 23(3): https://doaj.org/article/c75d4259fffc4c9b92baa2eae4a9a0cd.
[36] Zhang, Nating, Cheng, Chen, Olaleye, Olajide E, Sun, Yan, Li, Li, Huang, Yuhong, Du, Feifei, Yang, Junling, Wang, Fengqing, Shi, Yanhong, Xu, Fang, Li, Yanfen, Wen, Qi, Zhang, Naixia, Li, Chuan. Pharmacokinetics-Based Identification of Potential Therapeutic Phthalides from XueBiJing, a Chinese Herbal Injection Used in Sepsis Management. DRUG METABOLISM AND DISPOSITION[J]. 2018, 46(6): 823-834, https://www.webofscience.com/wos/woscc/full-record/WOS:000439228300007.
[37] Hou, Xiaochen, Wang, Meining, Wen, Yi, Ni, Tengfeng, Guan, Xiangna, Lan, Lefu, Zhang, Naixia, Zhang, Ao, Yang, CaiGuang. Quinone skeleton as a new class of irreversible inhibitors against Staphylococcus aureus sortase A. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2018, 28(10): 1864-1869, http://dx.doi.org/10.1016/j.bmcl.2018.04.005.
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[39] Wu, Dang, Wang, Wanyan, Chen, Wuyan, Lian, Fulin, Lang, Li, Huang, Ying, Xu, Yechun, Zhang, Naixia, Chen, Yinbin, Liu, Mingyao, Nussinov, Ruth, Cheng, Feixiong, Lu, Weiqiang, Huang, Jin. Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells. HAEMATOLOGICA[J]. 2018, 103(9): 1472-1483, https://www.webofscience.com/wos/woscc/full-record/WOS:000443259100022.
[40] Song, Yakai, Li, Linjuan, Chen, Yantao, Liu, Jingqiu, Xiao, Senhao, Lian, Fulin, Zhang, Naixia, Ding, Hong, Zhang, Yuanyuan, Chen, Kaixian, Jiang, Hualiang, Zhang, Chenhua, Liu, YuChih, Chen, Shijie, Luo, Cheng. Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2018, 26(8): 1751-1758, http://dx.doi.org/10.1016/j.bmc.2018.02.020.
[41] Yang, Yuanyuan, Wen, Yi, Zhang, Naixia. H-1, C-13 and N-15 backbone and side-chain resonance assignments of the ZnF-UBP domain of USP20/VDU2. BIOMOLECULAR NMR ASSIGNMENTS[J]. 2017, 11(1): 91-93, https://www.webofscience.com/wos/woscc/full-record/WOS:000396133800018.
[42] Yao, Changliang, Yang, Wenzhi, Si, Wei, Shen, Yao, Zhang, Naixia, Chen, Huali, Pan, Huiqin, Yang, Min, Wu, Wanying, Guo, Dean. An enhanced targeted identification strategy for the selective identification of flavonoid O-glycosides from Carthamus tinctorius by integrating offline two-dimensional liquid chromatography/linear ion-trap-Orbitrap mass spectrometry, high-resolution diagnostic product ions/neutral loss filtering and liquid chromatography-solid phase extraction-nuclear magnetic resonance. JOURNAL OF CHROMATOGRAPHY A[J]. 2017, 1491: 87-97, http://dx.doi.org/10.1016/j.chroma.2017.02.041.
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[45] Yang, Yuanyuan, Shi, Li, Ding, Yiluan, Shi, Yanhong, Hu, HongYu, Wen, Yi, Zhang, Naixia. Structural and Functional Investigations of the N-Terminal Ubiquitin Binding Region of Usp25. BIOPHYSICAL JOURNAL[J]. 2017, 112(10): 2099-2108, http://dx.doi.org/10.1016/j.bpj.2017.04.022.
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