基本信息
刘宁宁 女 中国科学院微生物研究所
电子邮件： liunn@im.ac.cn
通信地址： 北辰西路1号院3号
邮政编码： 100101
研究领域
l 炎癌转化及肝癌免疫微环境调控
l 代谢性肝脏疾病的糖脂代谢调控
l 移位感染的免疫调控-肠肝轴/肺肝轴
通过临床患者样本分析并结合小鼠肝脏疾病模型，利用单细胞转录组测序技术，基因编辑体内筛选系统，免疫细胞图谱分析以及代谢组学分析等前沿技术探究免疫微环境和糖脂代谢的调控机制，揭示肝脏慢性病及肝癌的潜在治疗靶点，探索治疗策略。
教育背景
2011-09--2014-06 中国科学院大学 博士学位
工作经历
工作简历
2022-11~现在, 中国科学院微生物研究所, 研究员
2021-09~2022-10,美国西南医学中心, 博士后
2017-11~2021-08,美国明尼苏达大学, 博士后
2014-07~2017-10,中国科学院微生物研究所, 助理研究员
2021-09~2022-10,美国西南医学中心, 博士后
2017-11~2021-08,美国明尼苏达大学, 博士后
2014-07~2017-10,中国科学院微生物研究所, 助理研究员
出版信息
发表论文
[1] WIREs Mechanisms of Disease. 2023, 通讯作者
[2] Oncogene. 2023, 第 1 作者
[3] Sun, Meiyu, Zhu, Li, Zhang, Yanan, Liu, Ningning, Zhang, Jinzheng, Li, Hui, Bai, Hongtong, Shi, Lei. Creation of new germplasm resources, development of SSR markers, and screening of monoterpene synthases in thyme. BMC PLANT BIOLOGY[J]. 2023, 第 4 作者23(1): http://dx.doi.org/10.1186/s12870-022-04029-2.
[4] Qi, Dandan, Lu, Min, Xu, Pengfei, Yao, Xinli, Chen, Yongchen, Gan, Lipeng, Li, Yong, Cui, Yahua, Tong, Xiaomei, Liu, Shuhong, Zhao, Jingmin, Liu, Ningning, Ye, Xin. Transcription factor ETV4 promotes the development of hepatocellular carcinoma by driving hepatic TNF-a signaling. CANCER COMMUNICATIONS. 2023, 第 12 作者 通讯作者 http://dx.doi.org/10.1002/cac2.12482.
[5] Liu, Ningning, Zhang, Tianpeng, Steer, Clifford J, Song, Guisheng. MicroRNA-378a-3p prevents initiation and growth of colorectal cancer by fine tuning polyamine synthesis. CELL AND BIOSCIENCE[J]. 2022, 第 1 作者12(1):
[6] Ningning Liu, Clifford J. Steer, and Guisheng Song. MicroRNA-15a/16-1 Prevent Hepatocellular Carcinoma by Disrupting the Communication between Kupffer Cells and Regulatory T Cells. Gastroenterology[J]. 2022,
[7] Ningning Liu, Clifford J Steer, Guisheng Song.. MicroRNA-206 Enhances Antitumor Immunity by Disrupting the Communication between Malignant Hepatocytes and Tregs in c-Myc Mice.. HEPTOLOGY[J]. 2022,
[8] 陈永臣, 温金燕, 祁丹丹, 童晓梅, 刘宁宁, 叶昕, , , , , , . 乙型肝炎病毒上调的lnc-HUR1抑制肝癌细胞凋亡. 生物工程学报[J]. 2022, 第 5 作者38(9): 3501-3514, https://cjb.ijournals.cn/cjbcn/article/abstract/gc22093501?st=article_issue.
[9] Ningning Liu, Xiaomei Wang, Clifford J. Steer, and Guisheng Song.. MicroRNA-206 Promotes the Recruitment of CD8+ T Cells by Driving M1 Phase Polarization of Kupffer Cells.. Gut[J]. 2022,
[10] Tianpeng Zhang*, Hongtao Shi*, Ningning Liu, Jing Tian, Clifford J. Steer, Qinghua Han* and Guisheng Song.. Activation of microRNA-378-3p biogenesis by E2F1 facilitates secretion of VLDL by modulating Sortilin-ApoB100 pathway.. Theranostics[J]. 2020,
[11] Qi Liu, Ningning Liu, Qilin Shangguan, Fang Zhang, Wenjia Chai, Xiaomei Tong, Xin Zhao, Zhiwei Li, Dandan Qi, Xin Ye. LncRNA SAMD12-AS1 promotes cell proliferation and inhibits apoptosis by interacting with NPM1. SCIENTIFIC REPORTS[J]. 2019, 第 2 作者9(1): http://dx.doi.org/10.1038/s41598-019-48116-1.
[12] Liu, Ningning, Liu, Qi, Yang, Xiaohai, Zhang, Fang, Li, Xinda, Ma, Yuanwu, Guan, Feifei, Zhao, Xin, Li, Zhiwei, Zhang, Lianfeng, Ye, Xin. Hepatitis B Virus-Upregulated LNC-HUR1 Promotes Cell Proliferation and Tumorigenesis by Blocking p53 Activity. HEPATOLOGY[J]. 2018, 第 1 作者68(6): 2130-2144, http://dx.doi.org/10.1002/hep.30098.
[13] Ma Yuanwu, Zhang Fang, Zhang Lianfeng, Liu Qi, Li Xinda, Li Zhiwei, Yang Xiaohai, Zhao Xin, Guan Feifei, Liu Ningning, Ye Xin. Hepatitis b virus-upregulated lnc-hur1 promotes cell proliferation and tumorigenesis by blocking p53 activity.. HEPATOLOGY (BALTIMORE, MD.)[J]. 2018, 第 10 作者http://www.corc.org.cn/handle/1471x/2157859.
[14] 焦童, 刘宁宁, 叶昕. HBx抑制IGFBP3转录的机制. 微生物学报[J]. 2017, 第 2 作者57(12): 1788-1796, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20171205?st=article_issue.
[15] Liu, Ningning, Zhang, Jinfang, Yang, Xiaohai, Jiao, Tong, Zhao, Xin, Li, Wenxia, Zhu, Jianhua, Yang, Pu, Jin, Jianping, Peng, Jirun, Li, Zhiwei, Ye, Xin. HDM2 Promotes NEDDylation of Hepatitis B Virus HBx To Enhance Its Stability and Function. JOURNAL OF VIROLOGY[J]. 2017, 第 1 作者91(16): http://www.corc.org.cn/handle/1471x/2159331.
[16] Gao, Jiming, Xiao, Shuqi, Xiao, Yihong, Wang, Xiangpeng, Zhang, Chong, Zhao, Qin, Nan, Yuchen, Huang, Baicheng, Liu, Hongliang, Liu, Ningning, Lv, Junhua, Du, Taofeng, Sun, Yani, Mu, Yang, Wang, Gang, Syed, Shahid Faraz, Zhang, Gaiping, Hiscox, Julian A, Goodfellow, Ian, Zhou, EnMin. MYH9 is an Essential Factor for Porcine Reproductive and Respiratory Syndrome Virus Infection. SCIENTIFIC REPORTS[J]. 2016, 第 10 作者6: http://dx.doi.org/10.1038/srep25120.
[17] 王寒, 齐建勋, 刘宁宁, 李燕, 高俊, 张廷虹, 柴彦, 高峰, 张浩. 埃博拉病毒入侵：人TIM分子的结构与结合PS的分子基础. 科学通报[J]. 2015, 第 3 作者60(35): 3438-3453, https://d.wanfangdata.com.cn/periodical/kxtb201535005.
[18] Liu, Ningning, Jiao, Tong, Huang, Yan, Liu, Wenjun, Li, Zhiwei, Ye, Xin. Hepatitis B Virus Regulates Apoptosis and Tumorigenesis through the MicroRNA-15a-Smad7-Transforming Growth Factor Beta Pathway. JOURNAL OF VIROLOGY[J]. 2015, 第 1 作者89(5): 2739-2749, http://dx.doi.org/10.1128/JVI.02784-14.
[19] Wu, Bo, Chu, Xiaoyu, Feng, Cong, Hou, Junwei, Fan, Hongxia, Liu, Ningning, Li, Changfei, Kong, Xianping, Ye, Xin, Meng, Songdong. Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer. CANCER LETTERS[J]. 2015, 第 6 作者359(2): 325-334, http://www.corc.org.cn/handle/1471x/2156254.
[20] Huang, Yan, Sun, Liping, Liu, Ningning, Wei, Qian, Jiang, Liangzhen, Tong, Xiaomei, Ye, Xin. Polo-like Kinase 1 (Plk1) Up-regulates Telomerase Activity by Affecting Human Telomerase Reverse Transcriptase (hTERT) Stability. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2015, 第 3 作者290(30): 18865-18873, http://dx.doi.org/10.1074/jbc.M114.635375.
[21] 刘宁宁, 焦童, 叶昕. HBV/HCV相关miRNAs研究进展. 传染病信息[J]. 2013, 第 1 作者373-377, http://lib.cqvip.com/Qikan/Article/Detail?id=48689935.
[22] Hu, Yan, Tang, HongBo, Liu, NingNing, Tong, XiaJing, Dang, Wei, Duan, YiMin, Fu, XiaoHong, Zhang, Yang, Peng, Jing, Meng, FeiLong, Zhou, JinQiu. Telomerase-Null Survivor Screening Identifies Novel Telomere Recombination Regulators. PLOS GENETICS[J]. 2013, 第 3 作者9(1): http://dx.doi.org/10.1371/journal.pgen.1003208.
[23] Liu, Ningning, Zhang, Jinfang, Jiao, Tong, Li, Zhiwei, Peng, Jirun, Cui, Zhuqingqing, Ye, Xin. Hepatitis B Virus Inhibits Apoptosis of Hepatoma Cells by Sponging the MicroRNA 15a/16 Cluster. JOURNAL OF VIROLOGY[J]. 2013, 第 1 作者87(24): 13370-13378, http://dx.doi.org/10.1128/JVI.02130-13.
[24] Liu, NingNing, Han, Tian Xu, Du, LiLin, Zhou, JinQiu. A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length. CELL RESEARCH[J]. 2010, 第 1 作者20(8): 963-965, http://lib.cqvip.com/Qikan/Article/Detail?id=35595949.
[2] Oncogene. 2023, 第 1 作者
[3] Sun, Meiyu, Zhu, Li, Zhang, Yanan, Liu, Ningning, Zhang, Jinzheng, Li, Hui, Bai, Hongtong, Shi, Lei. Creation of new germplasm resources, development of SSR markers, and screening of monoterpene synthases in thyme. BMC PLANT BIOLOGY[J]. 2023, 第 4 作者23(1): http://dx.doi.org/10.1186/s12870-022-04029-2.
[4] Qi, Dandan, Lu, Min, Xu, Pengfei, Yao, Xinli, Chen, Yongchen, Gan, Lipeng, Li, Yong, Cui, Yahua, Tong, Xiaomei, Liu, Shuhong, Zhao, Jingmin, Liu, Ningning, Ye, Xin. Transcription factor ETV4 promotes the development of hepatocellular carcinoma by driving hepatic TNF-a signaling. CANCER COMMUNICATIONS. 2023, 第 12 作者 通讯作者 http://dx.doi.org/10.1002/cac2.12482.
[5] Liu, Ningning, Zhang, Tianpeng, Steer, Clifford J, Song, Guisheng. MicroRNA-378a-3p prevents initiation and growth of colorectal cancer by fine tuning polyamine synthesis. CELL AND BIOSCIENCE[J]. 2022, 第 1 作者12(1):
[6] Ningning Liu, Clifford J. Steer, and Guisheng Song. MicroRNA-15a/16-1 Prevent Hepatocellular Carcinoma by Disrupting the Communication between Kupffer Cells and Regulatory T Cells. Gastroenterology[J]. 2022,
[7] Ningning Liu, Clifford J Steer, Guisheng Song.. MicroRNA-206 Enhances Antitumor Immunity by Disrupting the Communication between Malignant Hepatocytes and Tregs in c-Myc Mice.. HEPTOLOGY[J]. 2022,
[8] 陈永臣, 温金燕, 祁丹丹, 童晓梅, 刘宁宁, 叶昕, , , , , , . 乙型肝炎病毒上调的lnc-HUR1抑制肝癌细胞凋亡. 生物工程学报[J]. 2022, 第 5 作者38(9): 3501-3514, https://cjb.ijournals.cn/cjbcn/article/abstract/gc22093501?st=article_issue.
[9] Ningning Liu, Xiaomei Wang, Clifford J. Steer, and Guisheng Song.. MicroRNA-206 Promotes the Recruitment of CD8+ T Cells by Driving M1 Phase Polarization of Kupffer Cells.. Gut[J]. 2022,
[10] Tianpeng Zhang*, Hongtao Shi*, Ningning Liu, Jing Tian, Clifford J. Steer, Qinghua Han* and Guisheng Song.. Activation of microRNA-378-3p biogenesis by E2F1 facilitates secretion of VLDL by modulating Sortilin-ApoB100 pathway.. Theranostics[J]. 2020,
[11] Qi Liu, Ningning Liu, Qilin Shangguan, Fang Zhang, Wenjia Chai, Xiaomei Tong, Xin Zhao, Zhiwei Li, Dandan Qi, Xin Ye. LncRNA SAMD12-AS1 promotes cell proliferation and inhibits apoptosis by interacting with NPM1. SCIENTIFIC REPORTS[J]. 2019, 第 2 作者9(1): http://dx.doi.org/10.1038/s41598-019-48116-1.
[12] Liu, Ningning, Liu, Qi, Yang, Xiaohai, Zhang, Fang, Li, Xinda, Ma, Yuanwu, Guan, Feifei, Zhao, Xin, Li, Zhiwei, Zhang, Lianfeng, Ye, Xin. Hepatitis B Virus-Upregulated LNC-HUR1 Promotes Cell Proliferation and Tumorigenesis by Blocking p53 Activity. HEPATOLOGY[J]. 2018, 第 1 作者68(6): 2130-2144, http://dx.doi.org/10.1002/hep.30098.
[13] Ma Yuanwu, Zhang Fang, Zhang Lianfeng, Liu Qi, Li Xinda, Li Zhiwei, Yang Xiaohai, Zhao Xin, Guan Feifei, Liu Ningning, Ye Xin. Hepatitis b virus-upregulated lnc-hur1 promotes cell proliferation and tumorigenesis by blocking p53 activity.. HEPATOLOGY (BALTIMORE, MD.)[J]. 2018, 第 10 作者http://www.corc.org.cn/handle/1471x/2157859.
[14] 焦童, 刘宁宁, 叶昕. HBx抑制IGFBP3转录的机制. 微生物学报[J]. 2017, 第 2 作者57(12): 1788-1796, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20171205?st=article_issue.
[15] Liu, Ningning, Zhang, Jinfang, Yang, Xiaohai, Jiao, Tong, Zhao, Xin, Li, Wenxia, Zhu, Jianhua, Yang, Pu, Jin, Jianping, Peng, Jirun, Li, Zhiwei, Ye, Xin. HDM2 Promotes NEDDylation of Hepatitis B Virus HBx To Enhance Its Stability and Function. JOURNAL OF VIROLOGY[J]. 2017, 第 1 作者91(16): http://www.corc.org.cn/handle/1471x/2159331.
[16] Gao, Jiming, Xiao, Shuqi, Xiao, Yihong, Wang, Xiangpeng, Zhang, Chong, Zhao, Qin, Nan, Yuchen, Huang, Baicheng, Liu, Hongliang, Liu, Ningning, Lv, Junhua, Du, Taofeng, Sun, Yani, Mu, Yang, Wang, Gang, Syed, Shahid Faraz, Zhang, Gaiping, Hiscox, Julian A, Goodfellow, Ian, Zhou, EnMin. MYH9 is an Essential Factor for Porcine Reproductive and Respiratory Syndrome Virus Infection. SCIENTIFIC REPORTS[J]. 2016, 第 10 作者6: http://dx.doi.org/10.1038/srep25120.
[17] 王寒, 齐建勋, 刘宁宁, 李燕, 高俊, 张廷虹, 柴彦, 高峰, 张浩. 埃博拉病毒入侵：人TIM分子的结构与结合PS的分子基础. 科学通报[J]. 2015, 第 3 作者60(35): 3438-3453, https://d.wanfangdata.com.cn/periodical/kxtb201535005.
[18] Liu, Ningning, Jiao, Tong, Huang, Yan, Liu, Wenjun, Li, Zhiwei, Ye, Xin. Hepatitis B Virus Regulates Apoptosis and Tumorigenesis through the MicroRNA-15a-Smad7-Transforming Growth Factor Beta Pathway. JOURNAL OF VIROLOGY[J]. 2015, 第 1 作者89(5): 2739-2749, http://dx.doi.org/10.1128/JVI.02784-14.
[19] Wu, Bo, Chu, Xiaoyu, Feng, Cong, Hou, Junwei, Fan, Hongxia, Liu, Ningning, Li, Changfei, Kong, Xianping, Ye, Xin, Meng, Songdong. Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer. CANCER LETTERS[J]. 2015, 第 6 作者359(2): 325-334, http://www.corc.org.cn/handle/1471x/2156254.
[20] Huang, Yan, Sun, Liping, Liu, Ningning, Wei, Qian, Jiang, Liangzhen, Tong, Xiaomei, Ye, Xin. Polo-like Kinase 1 (Plk1) Up-regulates Telomerase Activity by Affecting Human Telomerase Reverse Transcriptase (hTERT) Stability. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2015, 第 3 作者290(30): 18865-18873, http://dx.doi.org/10.1074/jbc.M114.635375.
[21] 刘宁宁, 焦童, 叶昕. HBV/HCV相关miRNAs研究进展. 传染病信息[J]. 2013, 第 1 作者373-377, http://lib.cqvip.com/Qikan/Article/Detail?id=48689935.
[22] Hu, Yan, Tang, HongBo, Liu, NingNing, Tong, XiaJing, Dang, Wei, Duan, YiMin, Fu, XiaoHong, Zhang, Yang, Peng, Jing, Meng, FeiLong, Zhou, JinQiu. Telomerase-Null Survivor Screening Identifies Novel Telomere Recombination Regulators. PLOS GENETICS[J]. 2013, 第 3 作者9(1): http://dx.doi.org/10.1371/journal.pgen.1003208.
[23] Liu, Ningning, Zhang, Jinfang, Jiao, Tong, Li, Zhiwei, Peng, Jirun, Cui, Zhuqingqing, Ye, Xin. Hepatitis B Virus Inhibits Apoptosis of Hepatoma Cells by Sponging the MicroRNA 15a/16 Cluster. JOURNAL OF VIROLOGY[J]. 2013, 第 1 作者87(24): 13370-13378, http://dx.doi.org/10.1128/JVI.02130-13.
[24] Liu, NingNing, Han, Tian Xu, Du, LiLin, Zhou, JinQiu. A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length. CELL RESEARCH[J]. 2010, 第 1 作者20(8): 963-965, http://lib.cqvip.com/Qikan/Article/Detail?id=35595949.