​Genetically modified immune cell-based therapy,

Active natural products and their functions.

09/2007- 06/2011  Bachelor student at Department of Pharmaceutical and Pharmacological Sciences, Shandong University, China.

09/2011- 06/2014  Master student at Department of Pharmaceutical and Pharmacological Sciences, Shandong University, China.

09/2014- 09/2018  Doctoral student at Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium.

   

10/2018- 12/2022  Assistant professor at Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, China. 

01/2023- Present  Associate professor at Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, China.

1.        Maoxuan Liu, Jing-Guang Lu, Ming-Rong Yang, Zhi-Hong Jiang, Xiaochun Wan, Walter Luyten. Bioassay-Guided Isolation of Anthelmintic Components from Semen pharbitidis, and the Mechanism of Action of Pharbitin. International Journal of Molecular Sciences, 2022, 23(24), 15739.

2.        Maoxuan Liu^#, Junchen Liu^#, Ziwei Liang, Kun Dai, Jiangyu Gan, Qi Wang, Yang Xu, Youhai H. Chen, Xiaochun Wan. CAR-macrophages and CAR-T Cells Synergistically Kill Tumor Cells in vitro. Cells, 2022, 11(22), 3692.

3.        Maoxuan Liu, Bart Landuyt, Hugo Klaassen, Peter Geldhof, Walter Luyten. Screening of a drug repurposing library with a nematode motility assay identifies promising anthelmintic hits against Cooperia oncophora and other ruminant parasites. Veterinary Parasitology, 2019, 265: 15~18.

4.        Maoxuan Liu, Cedrick Veryser, Jing-Guang Lu, Tom Wenseleers, Wim De Borggraeve, Zhi-Hong Jiang, Walter Luyten. Bioassay-guided isolation of active substances from Semen Torreyae identifies two new anthelmintic compounds with novel mechanism of action. Journal of Ethnopharmacology, 2018, 216: 229~232.

5.        Maoxuan Liu, Daniëlle Copmans, Jing-Guang Lu, Ming-Rong Yang, Jo Sourbron, Annelii Ny, Zhi-Hong Jiang, Peter A.M.de Witte, Walter Luyten. Bioassay-guided isolation of anti-seizure principles from Semen Pharbitidis using a zebrafish pentylenetetrazol seizure model. Journal of Ethnopharmacology, 2019, 232: 130~134.

6.        Maoxuan Liu, Purity Kipanga, Anh Hung Mai, Ineke Dhondt, Bart P. Braeckman, Wim De Borggraeve, Walter Luyten. Bioassay-guided isolation of three anthelmintic compounds from Warburgia ugandensis Sprague subspecies ugandensis, and the mechanism of action of polygodial. International Journal for Parasitology, 2018, 48(11): 833~844.

7.        Maoxuan Liu, Haining Tan, Xinke Zhang, Zhang Liu, Yanna Cheng, Dongliang Wang, Fengshan Wang. Hematopoietic effects and mechanisms of Fufang E'jiao Jiang on radiotherapy and chemotherapy-induced myelosuppressed mice. Journal of Ethnopharmacology, 2014, 152(3): 575~584.

8.        刘茂玄, 罗 洁, 王东亮, 王凤山. 复方阿胶浆对肾性贫血大鼠的治疗作用及其机制. 中草药, 2014, 45(3): 380~385.

9.        Luc Van Puyvelde, Maoxuan Liu^*, Cedrick Veryser, Wim M.De Borggraeve, Joseph Mungarulire, Marie Jeanne Mukazayire, Walter Luyten. Active principles of Tetradenia riparia. IV. Anthelmintic activity of 8(14),15-sandaracopimaradiene-7 alpha,18-diol. Journal of Ethnopharmacology, 2018, 216: 229~232. 

10.     Maoxuan Liu, Sujogya Kumar Panda, Walter Luyten. Plant-Based Natural Products for the Discovery and Development of Novel Anthelmintics against Nematodes. Biomolecules, 2020, 10(3):426.

11.     王琪^#, 刘茂玄^#, 黄明, 许晨光, 万晓春. 两种靶向间皮素的CAR-T细胞杀伤三阴乳腺癌效果的对比研究. 集成技术, 2022, 11(05): 12~22.

12.     Dongliang Wang, Maoxuan Liu, Jichao Cao, Yanna Cheng, Chen Zhuo, Hongyan Xu, Shousheng Tian, Yan Zhang, Jian Zhang, Fengshan Wang. Effect of Colla corii asini (E'jiao) on D-Galactose Induced Aging Mice. Biological and Pharmaceutical Bulletin, 2012, 35(12): 2128~2132.

13.     Sujogya K. Panda, Laxmipriya Padhi, Pieter Leyssen, Maoxuan Liu, Johan Neyts, Walter Luyten. Antimicrobial, Anthelmintic, and Antiviral Activity of Plants Traditionally Used for Treating Infectious Disease in the Similipal Biosphere Reserve, Odisha, India. Frontiers in Pharmacology, 2017, 8: 658.

14.     Qianqian Lian, Wenjie Jiang, Yanna Cheng, Hongzhi Cao, Maoxuan Liu, Jinfeng Wang, Yan Li, Xinlei Song, Fengshan Wang. A novel pentapeptide originated from calf thymus named TIPP shows an inhibitory effect on lung allergic inflammation. International Immunopharmacology, 2015, 24(2): 256~266.

15.     Jian Cheng, Zhao Liu, Tian Deng, Zhen Lu, Maoxuan Liu, Xiaoxu Lu, Funmilayo Oladunni Adeshakin, Dehong Yan, Guizhong Zhang, Xiaochun Wan. CD317 mediates immunocytolysis resistance by RICH2/cytoskeleton-dependent membrane protection. Molecular Immunology, 2021, 129: 94-102.

16.     Purity N Kipanga, Maoxuan Liu, Sujogya K Panda, Anh Hung Mai, Cedrick Veryser, Luc Van Puyvelde, Wim M De Borggraeve, Patrick Van Dijck, Josphat Matasyoh, Walter Luyten. Biofilm inhibiting properties of compounds from the leaves of Warburgia ugandensis Sprague subsp ugandensis against Candida and staphylococcal biofilms. Journal of Ethnopharmacology, 2020, 248:112352.

17.     Bishnu Joshi, Sujogya Kumar Panda, Ramin Saleh Jouneghani, Maoxuan Liu, Niranjan Parajuli, Pieter Leysse, Johan Neyts, Walter Luyten. Antibacterial, Antifungal, Antiviral, and Anthelmintic Activities of Medicinal Plants of Nepal Selected Based on Ethnobotanical Evidence. Evidence-Based Complementary and Alternative Medicine. 2020, 2020:1043471.  

18.     Haiping Zhang, Yang Yang, Junxin Li, Min Wang, Konda Mani Saravanan, Jinli Wei, Justin Tze-Yang Ng, Md Tofazzal Hossain, Maoxuan Liu, Huiling Zhang, Xiaohu Ren, Yi Pan, Yin Peng, Yi Shi, Xiaochun Wan, Yingxia Liu, Yanjie Wei. A novel virtual screening procedure identifies Pralatrexate as inhibitor of SARS-CoV-2 RdRp and it reduces viral replication in vitro. PLOS Computational Biology. 2020, 16(12): e1008489.

19.     Guozheng Cao, Guizhong Zhang, Maoxuan Liu, Junchen Liu, Qi Wang, Lifang Zhu, Xiaochun Wan. GPC3-targeted CAR-T cells secreting B7H3-targeted BiTE exhibit potent cytotoxicity activity against hepatocellular carcinoma cell in the in vitro assay. Biochem Biophys Rep. 2022, 31:101324.

20.     戴昆, 刘骏晨, 刘茂玄, 甘江彧, 王琪, 陈有海, 万晓春, 于广. 靶向NKG2D配体的嵌合抗原受体巨噬细胞具有肿瘤杀伤功能. 免疫学杂志. 2022,38(12): 1090~1099. 

(1) Preparation and application of BiTE-secreting CAR-T, invention patent, 2022, the second author, CN202211150670.2

(2) Dual-targeted CAR-T cells targeting mesothelin and NKG2D ligands and their applications, invention patent, 2022, the second author, CN202211144259.4

(3) A chimeric antigen receptor macrophage and its preparation method and application, invention patent, 2022, the ​third author, CN202210710127.7

(4) Application of the combination of CAR-T and CAR-M in the preparation of anti-tumor drugs, invention patent, 2022, the third author, CN202210703429.1

(5) A chimeric antigen receptor, macrophage expressing chimeric antigen receptor and its application, invention patent, 2022, the third author, CN202210698985.4

(6) Use of benserazide or its derivatives, invention patent, 2020, the second author, CN111743884A

(7) Use of 2-hydroxyestradiol or its derivatives, invention patent, 2020, the second author, CN111743904A

( 8 ) Uses of water silomycin or its derivatives, invention patent, 2020, the second author, CN111743890A

(9) OX40 monoclonal antibody and its application, invention patent, 2020, the fifth author, CN111434690A

(10) A quantitative detection kit for DcR3, invention patent, 2020, the fifth author, CN111435137A