基因修饰免疫细胞治疗技术；

天然药物活性物质与功能。

   

086000-生物与医药

基因修饰免疫细胞治疗技术，天然药物活性物质与功能

2014-09--2018-09   鲁汶大学药学院   博士
2011-09--2014-06   山东大学药学院   硕士
2007-09--2011-06   山东大学药学院   学士

   

2023-01~现在, 中国科学院深圳先进技术研究院, 副研究员
2020-09~2022-12,中国科学院深圳先进技术研究院, 助理研究员
2018-10~2020-09,中国科学院深圳先进技术研究院, 博士后

   

（ 1 ） 分泌BiTE的CAR-T的制备及其应用, 发明专利, 2022, 第 2 作者, 专利号: CN202211150670.2

（ 2 ） 靶向间皮素和NKG2D配体的双靶向CAR-T细胞及其应用, 发明专利, 2022, 第 2 作者, 专利号: CN202211144259.4

（ 3 ） 一种嵌合抗原受体巨噬细胞及其制备方法和应用, 发明专利, 2022, 第 3 作者, 专利号: CN202210710127.7

（ 4 ） CAR-T和CAR-M联用在制备抗肿瘤药物中的应用, 发明专利, 2022, 第 3 作者, 专利号: CN202210703429.1

（ 5 ） 一种嵌合抗原受体、表达嵌合抗原受体的巨噬细胞及应用, 发明专利, 2022, 第 3 作者, 专利号: CN202210698985.4

（ 6 ） 苄丝肼或其衍生物的用途, 发明专利, 2020, 第 2 作者, 专利号: CN111743884A

（ 7 ） 2-羟基雌二醇或其衍生物的用途, 发明专利, 2020, 第 2 作者, 专利号: CN111743904A

（ 8 ） 水绫霉素或其衍生物的用途, 发明专利, 2020, 第 2 作者, 专利号: CN111743890A

（ 9 ） OX40单克隆抗体及应用, 发明专利, 2020, 第 5 作者, 专利号: CN111434690A

（ 10 ） 一种DcR3的定量检测试剂盒, 发明专利, 2020, 第 5 作者, 专利号: CN111435137A

   

[1] Saliu, Muhammad Auwal, Wang, Qi, Salisu, Mansur Dabai, Ren, Yuanfeng, Zhang, Pengchao, Suleiman, Rabiatu Bako, Cao, Bingbing, Xu, Yiqiao, Liu, Xudong, Lluis, Frederic, Liu, Maoxuan, Wan, Xiaochun. Mesothelin-targeted CAR-T cells secreting NKG2D-BiTEs exhibit potent efficacy against triple-negative breast cancer. EXPERIMENTAL HEMATOLOGY & ONCOLOGY. 2025, 第 11 作者  通讯作者  14(1): http://dx.doi.org/10.1186/s40164-025-00621-y.
[2] Liu, Junchen, Dai, Kun, Saliu, Muhammad Auwal, Salisu, Mansur Dabai, Gan, Jiangyu, Afolabi, Lukman Olalekan, Yan, Dehong, Zhang, Guizhong, Liu, Maoxuan, Wan, Xiaochun. Sodium valproate enhances efficacy of NKG2D CAR-T cells against glioblastoma. FRONTIERS IN IMMUNOLOGY[J]. 2025, 第 9 作者  通讯作者  15: http://dx.doi.org/10.3389/fimmu.2024.1519777.
[3] Zhang, Zhiyuan, Wu, Haoran, Wang, Shuai, Li, Yuanyuan, Yang, Pei, Xu, Lingchuan, Liu, Yuhong, Liu, Maoxuan. PRG ameliorates cognitive impairment in Alzheimer's disease mice by regulating β-amyloid and targeting the ERK pathway. PHYTOMEDICINE[J]. 2024, 第 8 作者  通讯作者  130: http://dx.doi.org/10.1016/j.phymed.2024.155671.
[4] 戴昆, 刘骏晨, 刘茂玄, 甘江彧, 王琪, 陈有海, 万晓春, 于广. 靶向NKG2D配体的嵌合抗原受体巨噬细胞具有肿瘤杀伤功能. 免疫学杂志[J]. 2022, 第 3 作者38(12): 1090-1099, http://lib.cqvip.com/Qikan/Article/Detail?id=7108675716.
[5] 王琪, 刘茂玄, 黄明, 许晨光, 万晓春. 两种靶向间皮素的CAR-T细胞杀伤三阴乳腺癌效果的对比研究. 集成技术[J]. 2022, 第 2 作者11(5): 12-22, http://lib.cqvip.com/Qikan/Article/Detail?id=7108163829.
[6] Liu, Maoxuan, Liu, Junchen, Liang, Ziwei, Dai, Kun, Gan, Jiangyu, Wang, Qi, Xu, Yang, Chen, Youhai H, Wan, Xiaochun. CAR-Macrophages and CAR-T Cells Synergistically Kill Tumor Cells In Vitro. CELLS[J]. 2022, 第 1 作者11(22): http://dx.doi.org/10.3390/cells11223692.
[7] Liu, Maoxuan, Lu, JingGuang, Yang, MingRong, Jiang, ZhiHong, Wan, Xiaochun, Luyten, Walter. Bioassay-Guided Isolation of Anthelmintic Components from Semen pharbitidis, and the Mechanism of Action of Pharbitin. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2022, 第 1 作者  通讯作者  23(24): http://dx.doi.org/10.3390/ijms232415739.
[8] Guozheng Cao, Guizhong Zhang, Maoxuan Liu, Junchen Liu, Qi Wang, Lifang Zhu, Xiaochun Wan. GPC3-targeted CAR-T cells secreting B7H3-targeted BiTE exhibit potent cytotoxicity activity against hepatocellular carcinoma cell in the in vitro assay. BIOCHEMISTRY AND BIOPHYSICS REPORTS[J]. 2022, 第 3 作者31: 101324, http://dx.doi.org/10.1016/j.bbrep.2022.101324.
[9] 戴昆, 刘骏晨, 刘茂玄, 甘江彧, 王琪, 陈有海, 万晓春, 于广. ������NKG2D���������������������������������������������������������������. 免疫学杂志[J]. 2022, 第 3 作者38(12): 1090-1099, http://lib.cqvip.com/Qikan/Article/Detail?id=7108675716.
[10] 王琪, 刘茂玄, 黄明, 许晨光, 万晓春. ������������������������CAR-T������������������������������������������������. 集成技术[J]. 2022, 第 2 作者11(5): 12-22, http://lib.cqvip.com/Qikan/Article/Detail?id=7108163829.
[11] Liu, Maoxuan, Liu, Junchen, Liang, Ziwei, Dai, Kun, Gan, Jiangyu, Wang, Qi, Xu, Yang, Chen, Youhai H, Wan, Xiaochun. CAR-Macrophages and CAR-T Cells Synergistically Kill Tumor Cells In Vitro. CELLS[J]. 2022, 第 1 作者11(22): http://dx.doi.org/10.3390/cells11223692.
[12] Liu, Maoxuan, Lu, JingGuang, Yang, MingRong, Jiang, ZhiHong, Wan, Xiaochun, Luyten, Walter. Bioassay-Guided Isolation of Anthelmintic Components from Semen pharbitidis, and the Mechanism of Action of Pharbitin. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2022, 第 11 作者23(24): http://dx.doi.org/10.3390/ijms232415739.
[13] Guozheng Cao, Guizhong Zhang, Maoxuan Liu, Junchen Liu, Qi Wang, Lifang Zhu, Xiaochun Wan. GPC3-targeted CAR-T cells secreting B7H3-targeted BiTE exhibit potent cytotoxicity activity against hepatocellular carcinoma cell in the in vitro assay. BIOCHEMISTRY AND BIOPHYSICS REPORTS[J]. 2022, 第 3 作者31: 101324, http://dx.doi.org/10.1016/j.bbrep.2022.101324.
[14] Cheng, Jian, Liu, Zhao, Deng, Tian, Lu, Zhen, Liu, Maoxuan, Lu, Xiaoxu, Adeshakin, Funmilayo Oladunni, Yan, Dehong, Zhang, Guizhong, Wan, Xiaochun. CD317 mediates immunocytolysis resistance by RICH2/cytoskeleton-dependent membrane protection. MOLECULAR IMMUNOLOGY[J]. 2021, 第 5 作者129: 94-102, http://dx.doi.org/10.1016/j.molimm.2020.11.002.
[15] Cheng, Jian, Liu, Zhao, Deng, Tian, Lu, Zhen, Liu, Maoxuan, Lu, Xiaoxu, Adeshakin, Funmilayo Oladunni, Yan, Dehong, Zhang, Guizhong, Wan, Xiaochun. CD317 mediates immunocytolysis resistance by RICH2/cytoskeleton-dependent membrane protection. MOLECULAR IMMUNOLOGY[J]. 2021, 第 5 作者129: 94-102, http://dx.doi.org/10.1016/j.molimm.2020.11.002.
[16] Bishnu Joshi, Sujogya Kumar Panda, Ramin Saleh Jouneghani, Maoxuan Liu, Niranjan Parajuli, Pieter Leyssen, Johan Neyts, Walter Luyten. Antibacterial, Antifungal, Antiviral, and Anthelmintic Activities of Medicinal Plants of Nepal Selected Based on Ethnobotanical Evidence. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE[J]. 2020, 第 4 作者2020: https://doaj.org/article/b80dccd9d1dd487bb50ea780576c4ad4.
[17] Zhang, Haiping, Yang, Yang, Li, Junxin, Wang, Min, Saravanan, Konda Mani, Wei, Jinli, Ng, Justin TzeYang, Hossain, Md Tofazzal, Liu, Maoxuan, Zhang, Huiling, Ren, Xiaohu, Pan, Yi, Peng, Yin, Shi, Yi, Wan, Xiaochun, Liu, Yingxia, Wei, Yanjie. A novel virtual screening procedure identifies Pralatrexate as inhibitor of SARS-CoV-2 RdRp and it reduces viral replication in vitro. PLOS COMPUTATIONAL BIOLOGY[J]. 2020, 第 9 作者16(12): https://doaj.org/article/471cc95322164c9b80d0e64bf5632825.
[18] Liu, Maoxuan, Panda, Sujogya Kumar, Luyten, Walter. Plant-Based Natural Products for the Discovery and Development of Novel Anthelmintics against Nematodes. BIOMOLECULES[J]. 2020, 第 1 作者10(3): https://doaj.org/article/7a87029adaef4ea798fb5b52e2cc94eb.
[19] Kipanga, Purity N, Liu, Maoxuan, Panda, Sujogya K, Anh Hung Mai, Veryser, Cedrick, Van Puyvelde, Luc, De Borggraeve, Wim M, Van Dijck, Patrick, Matasyoh, Josphat, Luyten, Walter. Biofilm inhibiting properties of compounds from the leaves of Warburgia ugandensis Sprague subsp ugandensis against Candida and staphylococcal biofilms. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2020, 第 2 作者248: http://dx.doi.org/10.1016/j.jep.2019.112352.
[20] Bishnu Joshi, Sujogya Kumar Panda, Ramin Saleh Jouneghani, Maoxuan Liu, Niranjan Parajuli, Pieter Leyssen, Johan Neyts, Walter Luyten. Antibacterial, Antifungal, Antiviral, and Anthelmintic Activities of Medicinal Plants of Nepal Selected Based on Ethnobotanical Evidence. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE[J]. 2020, 第 4 作者2020: https://doaj.org/article/b80dccd9d1dd487bb50ea780576c4ad4.
[21] Zhang, Haiping, Yang, Yang, Li, Junxin, Wang, Min, Saravanan, Konda Mani, Wei, Jinli, Ng, Justin TzeYang, Hossain, Md Tofazzal, Liu, Maoxuan, Zhang, Huiling, Ren, Xiaohu, Pan, Yi, Peng, Yin, Shi, Yi, Wan, Xiaochun, Liu, Yingxia, Wei, Yanjie. A novel virtual screening procedure identifies Pralatrexate as inhibitor of SARS-CoV-2 RdRp and it reduces viral replication in vitro. PLOS COMPUTATIONAL BIOLOGY[J]. 2020, 第 9 作者16(12): https://doaj.org/article/471cc95322164c9b80d0e64bf5632825.
[22] Liu, Maoxuan, Panda, Sujogya Kumar, Luyten, Walter. Plant-Based Natural Products for the Discovery and Development of Novel Anthelmintics against Nematodes. BIOMOLECULES[J]. 2020, 第 1 作者10(3): https://doaj.org/article/7a87029adaef4ea798fb5b52e2cc94eb.
[23] Kipanga, Purity N, Liu, Maoxuan, Panda, Sujogya K, Anh Hung Mai, Veryser, Cedrick, Van Puyvelde, Luc, De Borggraeve, Wim M, Van Dijck, Patrick, Matasyoh, Josphat, Luyten, Walter. Biofilm inhibiting properties of compounds from the leaves of Warburgia ugandensis Sprague subsp ugandensis against Candida and staphylococcal biofilms. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2020, 第 2 作者248: http://dx.doi.org/10.1016/j.jep.2019.112352.
[24] Liu, Maoxuan, Landuyt, Bait, Klaassen, Hugo, Geldhof, Peter, Luyten, Walter. Screening of a drug repurposing library with a nematode motility assay identifies promising anthelmintic hits against Cooperia oncophora and other ruminant parasites. VETERINARY PARASITOLOGY[J]. 2019, 第 1 作者  通讯作者  265: 15-18, http://dx.doi.org/10.1016/j.vetpar.2018.11.014.
[25] Liu, Maoxuan, Copmans, Danielle, Lu, JingGuang, Yang, MingRong, Sourbron, Jo, Ny, Annelii, Jiang, ZhiHong, de Witte, Peter A M, Luyten, Walter. Bioassay-guided isolation of anti-seizure principles from Semen Pharbitidis using a zebrafish pentylenetetrazol seizure model. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2019, 第 1 作者  通讯作者  232: 130-134, http://dx.doi.org/10.1016/j.jep.2018.12.024.
[26] Liu, Maoxuan, Landuyt, Bait, Klaassen, Hugo, Geldhof, Peter, Luyten, Walter. Screening of a drug repurposing library with a nematode motility assay identifies promising anthelmintic hits against Cooperia oncophora and other ruminant parasites. VETERINARY PARASITOLOGY[J]. 2019, 第 11 作者265: 15-18, http://dx.doi.org/10.1016/j.vetpar.2018.11.014.
[27] Liu, Maoxuan, Copmans, Danielle, Lu, JingGuang, Yang, MingRong, Sourbron, Jo, Ny, Annelii, Jiang, ZhiHong, de Witte, Peter A M, Luyten, Walter. Bioassay-guided isolation of anti-seizure principles from Semen Pharbitidis using a zebrafish pentylenetetrazol seizure model. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2019, 第 11 作者232: 130-134, http://dx.doi.org/10.1016/j.jep.2018.12.024.
[28] Liu, Maoxuan, Veryser, Cedrick, Lu, JingGuang, Wenseleers, Tom, De Borggraeve, Wim M, Jiang, ZhiHong, Luyten, Walter. Bioassay-guided isolation of active substances from Semen Torreyae identifies two new anthelmintic compounds with novel mechanism of action. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2018, 第 1 作者  通讯作者  224: 421-428, http://dx.doi.org/10.1016/j.jep.2018.06.026.
[29] Van Puyvelde, Luc, Liu, Maoxuan, Veryser, Cedrick, De Borggraeve, Wim M, Mungarulire, Joseph, Mukazayire, Marie Jeanne, Luyten, Walter. Active principles of Tetradenia riparia. IV. Anthelmintic activity of 8(14),15-sandaracopimaradiene-7 alpha,18-diol. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2018, 第 2 作者  通讯作者  216: 229-232, https://www.webofscience.com/wos/woscc/full-record/WOS:000428490000023.
[30] Liu, Maoxuan, Kipanga, Purity, Anh Hung Mai, Dhondt, Ineke, Braeckman, Bart P, De Borggraeve, Wim, Luyten, Walter. Bioassay-guided isolation of three anthelmintic compounds from Warburgia ugandensis Sprague subspecies ugandensis, and the mechanism of action of polygodial. INTERNATIONAL JOURNAL FOR PARASITOLOGY[J]. 2018, 第 1 作者  通讯作者  48(11): 833-844, http://dx.doi.org/10.1016/j.ijpara.2017.11.009.
[31] Liu, Maoxuan, Veryser, Cedrick, Lu, JingGuang, Wenseleers, Tom, De Borggraeve, Wim M, Jiang, ZhiHong, Luyten, Walter. Bioassay-guided isolation of active substances from Semen Torreyae identifies two new anthelmintic compounds with novel mechanism of action. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2018, 第 11 作者224: 421-428, http://dx.doi.org/10.1016/j.jep.2018.06.026.
[32] Van Puyvelde, Luc, Liu, Maoxuan, Veryser, Cedrick, De Borggraeve, Wim M, Mungarulire, Joseph, Mukazayire, Marie Jeanne, Luyten, Walter. Active principles of Tetradenia riparia. IV. Anthelmintic activity of 8(14),15-sandaracopimaradiene-7 alpha,18-diol. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2018, 第 11 作者216: 229-232, https://www.webofscience.com/wos/woscc/full-record/WOS:000428490000023.
[33] Liu, Maoxuan, Kipanga, Purity, Anh Hung Mai, Dhondt, Ineke, Braeckman, Bart P, De Borggraeve, Wim, Luyten, Walter. Bioassay-guided isolation of three anthelmintic compounds from Warburgia ugandensis Sprague subspecies ugandensis, and the mechanism of action of polygodial. INTERNATIONAL JOURNAL FOR PARASITOLOGY[J]. 2018, 第 11 作者48(11): 833-844, http://dx.doi.org/10.1016/j.ijpara.2017.11.009.
[34] Panda, Sujogya K, Padhi, Laxmipriya, Leyssen, Pieter, Liu, Maoxuan, Neyts, Johan, Luyten, Walter. Antimicrobial, Anthelmintic, and Antiviral Activity of Plants Traditionally Used for Treating Infectious Disease in the Similipal Biosphere Reserve, Odisha, India. FRONTIERS IN PHARMACOLOGY[J]. 2017, 第 4 作者8: https://doaj.org/article/ca4edbe6ed604faeaa1eefcf5150d3a0.
[35] Panda, Sujogya K, Padhi, Laxmipriya, Leyssen, Pieter, Liu, Maoxuan, Neyts, Johan, Luyten, Walter. Antimicrobial, Anthelmintic, and Antiviral Activity of Plants Traditionally Used for Treating Infectious Disease in the Similipal Biosphere Reserve, Odisha, India. FRONTIERS IN PHARMACOLOGY[J]. 2017, 第 4 作者8: https://doaj.org/article/ca4edbe6ed604faeaa1eefcf5150d3a0.
[36] Lian, Qianqian, Jiang, Wenjie, Cheng, Yanna, Cao, Hongzhi, Liu, Maoxuan, Wang, Jinfeng, Li, Yan, Song, Xinlei, Wang, Fengshan. A novel pentapeptide originated from calf thymus named TIPP shows an inhibitory effect on lung allergic inflammation. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2015, 第 5 作者24(2): 256-266, http://dx.doi.org/10.1016/j.intimp.2014.12.019.
[37] Lian, Qianqian, Jiang, Wenjie, Cheng, Yanna, Cao, Hongzhi, Liu, Maoxuan, Wang, Jinfeng, Li, Yan, Song, Xinlei, Wang, Fengshan. A novel pentapeptide originated from calf thymus named TIPP shows an inhibitory effect on lung allergic inflammation. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2015, 第 5 作者24(2): 256-266, http://dx.doi.org/10.1016/j.intimp.2014.12.019.
[38] Liu, Maoxuan, Tan, Haining, Zhang, Xinke, Liu, Zhang, Cheng, Yanna, Wang, Dongliang, Wang, Fengshan. Hematopoietic effects and mechanisms of Fufang E'jiao Jiang on radiotherapy and chemotherapy-induced myelosuppressed mice. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2014, 第 1 作者152(3): 575-584, https://www.webofscience.com/wos/woscc/full-record/WOS:000334818100022.
[39] 刘茂玄, 罗洁, 王东亮, 王凤山. 复方阿胶浆对肾性贫血大鼠的治疗作用及其机制. 中草药[J]. 2014, 第 1 作者45(3): 380-385, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5055186&detailType=1.
[40] Liu, Maoxuan, Tan, Haining, Zhang, Xinke, Liu, Zhang, Cheng, Yanna, Wang, Dongliang, Wang, Fengshan. Hematopoietic effects and mechanisms of Fufang E'jiao Jiang on radiotherapy and chemotherapy-induced myelosuppressed mice. JOURNAL OF ETHNOPHARMACOLOGY[J]. 2014, 第 1 作者152(3): 575-584, https://www.webofscience.com/wos/woscc/full-record/WOS:000334818100022.
[41] 刘茂玄, 罗洁, 王东亮, 王凤山. ���������������������������������������������������������������. 中草药[J]. 2014, 第 1 作者45(3): 380-385, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5055186&detailType=1.
[42] Wang, Dongliang, Liu, Maoxuan, Cao, Jichao, Cheng, Yanna, Zhuo, Chen, Xu, Hongyan, Tian, Shousheng, Zhang, Yan, Zhang, Jian, Wang, Fengshan. Effect of Colla corii asini (E'jiao) on D-Galactose Induced Aging Mice. BIOLOGICAL & PHARMACEUTICAL BULLETIN[J]. 2012, 第 2 作者35(12): 2128-2132, https://www.webofscience.com/wos/woscc/full-record/WOS:000311772000004.
[43] Wang, Dongliang, Liu, Maoxuan, Cao, Jichao, Cheng, Yanna, Zhuo, Chen, Xu, Hongyan, Tian, Shousheng, Zhang, Yan, Zhang, Jian, Wang, Fengshan. Effect of Colla corii asini (E'jiao) on D-Galactose Induced Aging Mice. BIOLOGICAL & PHARMACEUTICAL BULLETIN[J]. 2012, 第 2 作者35(12): 2128-2132, https://www.webofscience.com/wos/woscc/full-record/WOS:000311772000004.

   

（ 1 ） 功能增强型CAR-T治疗胰腺癌的效果研究, 负责人, 国家任务, 2023-01--2025-12
（ 2 ） FEJ中促进HSC扩增的活性成分的鉴定及其作用机制, 负责人, 国家任务, 2019-03--2020-10
（ 3 ） CAR-T细胞治疗实体瘤的研究, 负责人, 地方任务, 2021-10--2024-09
（ 4 ） 新型CAR-T细胞治疗胰腺癌的效果及作用机制, 负责人, 地方任务, 2021-10--2024-09
（ 5 ） 新型CAR-T细胞, 负责人, 国家任务, 2024-01--2025-12
（ 6 ） 制备CAR-T细胞的关键技术, 负责人, 地方任务, 2023-07--2025-07