Microbiology

Biochemistry

Chemical biology

2010. 07-2017. 03 PhD of Biology, Shanghai Jiao Tong University

2006. 09-2010. 07 Bachelor of Bioengineering, East China University of Science and Techbology

2023. 02-to date Professor, Tianjin Institute of Industrial Biotechnology

2017. 07-2023. 01 Postdoc, Department of Biochemistry and Biomedical Sciences, McMaster University (Prof. Gerard D. Wright)

（1） Streptomyces-based whole-cell biosensors for detecting diverse cell envelope-targeting antibiotics, BIOSENSORS AND BIOELECTRONICS, 2024, co-author (4th)
（2） Cladosporin, A Highly Potent Antimalaria Drug?, CHEMBIOCHEM, 2023, corresponding author
（3） Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus, JOURNAL OF MEDICINAL CHEMISTRY, 2023, co-first author
（4） A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity, CELL CHEMICAL BIOLOGY, 2022, co-author (3rd)
（5） Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics, ACS CENTRAL SCIENCE, 2022, first author
（6） Functional Genome Mining Reveals a Class V Lanthipeptide Containing ad-Amino Acid Introduced by an F420H2-Dependent Reductase, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, co-first author
（7） GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery, NATURE COMMUNICATIONS, 2020, first author
（8） Heterologous expression-facilitated natural products' discovery in actinomycetes, JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2019, first author
（9） Engineered Streptomyces lividans Strains for Optimal Identification and Expression of Cryptic Biosynthetic Gene Clusters, FRONTIERS IN MICROBIOLOGY, 2018, co-author (7th)
（10） Biosynthesis of Tropolones in Streptomyces spp.: Interweaving Biosynthesis and Degradation of Phenylacetic Acid and Hydroxylations on the Tropone Ring, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2018, co-author (2nd)
（11） Reconstitution of Kinamycin Biosynthesis within the Heterologous Host Streptomyces albus J1074, JOURNAL OF NATURAL PRODUCTS, 2018, co-author (3rd)
（12） Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement, CELL CHEMICAL BIOLOGY, 2017, co-author (3rd)
（13） Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, co-author (7th)
（14） Hybrubins: Bipyrrole Tetramic Acids Obtained by Crosstalk between a Truncated Undecylprodigiosin Pathway and Heterologous Tetramic Acid Biosynthetic Genes, ORGANIC LETTERS, 2016, co-author (3rd)
（15） Functional Genome Mining for Metabolites Encoded by Large Gene Clusters through Heterologous Expression of a Whole-Genome Bacterial Artificial Chromosome Library in Streptomyces spp., APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2016, first author
（16） High-Throughput Screening for Streptomyces Antibiotic Biosynthesis Activators, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2012, co-author (4th)

Synthetic biology

Natural product drug discovery and development

Antimicrobial resistance and biosynthesis