基本信息
徐敏 男 博导 中国科学院天津工业生物技术研究所
电子邮件： xumin@tib.cas.cn
通信地址： 天津市东丽区西十五道21号B404
邮政编码：300308
研究领域
微生物学
生物化学
招生信息
招生专业
071005-微生物学
071010-生物化学与分子生物学
0703Z1-化学生物学
071010-生物化学与分子生物学
0703Z1-化学生物学
招生方向
合成生物学
抗生素发掘，抗生素耐药
生物合成
抗生素发掘，抗生素耐药
生物合成
教育背景
2010-09--2017-03 上海交通大学 博士
2006-09--2010-07 华东理工大学 本科
2006-09--2010-07 华东理工大学 本科
工作经历
工作简历
2023-02~现在, 中国科学院天津工业生物技术研究所, 研究员
2017-07~2023-01,麦克马斯特大学, 博士后
2017-07~2023-01,麦克马斯特大学, 博士后
专利与奖励
专利成果
（ 1 ） 3，7‑二羟基卓酚酮生物合成基因簇及其应用, 专利授权, 2018, 第 3 作者, 专利号: CN107699581A
（ 2 ） 3,7-二羟基卓酚酮高产菌株及其发酵培养方法, 2020, 第 3 作者, 专利号: CN107699532B
（ 3 ） 抗菌肽Lexapeptide及其制备方法和用途, 2020, 第 2 作者, 专利号: CN106188253B
（ 4 ） 羊毛硫肽类抗菌肽及其脱氢衍生物的制备方法, 2020, 第 2 作者, 专利号: CN106366168B
（ 2 ） 3,7-二羟基卓酚酮高产菌株及其发酵培养方法, 2020, 第 3 作者, 专利号: CN107699532B
（ 3 ） 抗菌肽Lexapeptide及其制备方法和用途, 2020, 第 2 作者, 专利号: CN106188253B
（ 4 ） 羊毛硫肽类抗菌肽及其脱氢衍生物的制备方法, 2020, 第 2 作者, 专利号: CN106366168B
出版信息
发表论文
[1] Hengyu Wang, Yong Sheng, Yixin Ou, Min Xu, Meifeng Tao, Shuangjun Lin, Zixin Deng, Linquan Bai, Wei Ding, Qianjin Kang. Streptomyces-based whole-cell biosensors for detecting diverse cell envelope-targeting antibiotics. BIOSENSORS AND BIOELECTRONICS. 2024, 第 4 作者249: http://dx.doi.org/10.1016/j.bios.2024.116004.
[2] Hou, Anwei, Li, Bei, Deng, Zixin, Xu, Min, Dickschat, Jeroen S. Cladosporin, A Highly Potent Antimalaria Drug?. CHEMBIOCHEM[J]. 2023, 第 4 作者 通讯作者 https://doi.org/10.1002/cbic.202300154.
[3] Koteva, Kalinka, Xu, Min, Wang, Wenliang, FiebigComyn, Aline A, Cook, Michael A, Coombes, Brian K, Wright, Gerard D. Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2023, 第 2 作者66(13): 9006-9022, http://dx.doi.org/10.1021/acs.jmedchem.3c00633.
[4] Alder, Arne, Struck, Nicole S, Xu, Min, Johnson, Jarrod W, Wang, Wenliang, Pallant, Daniel, Cook, Michael A, Rambow, Janis, Lemcke, Sarah, Gilberger, Tim W, Wright, Gerard D. A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity. CELL CHEMICAL BIOLOGY[J]. 2022, 第 3 作者29(5): 840-+, http://dx.doi.org/10.1016/j.chembiol.2021.10.005.
[5] Xu, Min, Wang, Wenliang, Waglechner, Nicholas, Culp, Elizabeth J, Guitor, Allison K, Wright, Gerard D. Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics. ACS CENTRAL SCIENCE[J]. 2022, 第 1 作者8(5): 615-626, http://dx.doi.org/10.1021/acscentsci.1c01389.
[6] Xu, Min, Zhang, Fei, Cheng, Zhuo, Bashiri, Ghader, Wang, Jing, Hong, Jiali, Wang, Yemin, Xu, Lijun, Chen, Xuefei, Huang, ShengXiong, Lin, Shuangjun, Deng, Zixin, Tao, Meifeng. Functional Genome Mining Reveals a Class V Lanthipeptide Containing ad-Amino Acid Introduced by an F420H2-Dependent Reductase. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 第 1 作者59(41): 18029-18035, https://www.webofscience.com/wos/woscc/full-record/WOS:000561818000001.
[7] Min Xu, Wenliang Wang, Nicholas Waglechner, Elizabeth J Culp, Allison K Guitor, Gerard D Wright. GPAHex-A synthetic biology platform for Type IV-V glycopeptide antibiotic production and discovery. NATURE COMMUNICATIONS[J]. 2020, 第 1 作者11(1): http://dx.doi.org/10.1038/s41467-020-19138-5.
[8] Xu, Min, Wright, Gerard D. Heterologous expression-facilitated natural products' discovery in actinomycetes. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY[J]. 2019, 第 1 作者46(3-4): 415-431, http://dx.doi.org/10.1007/s10295-018-2097-2.
[9] Peng, Qinying, Gao, Guixi, Lu, Jin, Long, Qingshan, Chen, Xuefei, Zhang, Fei, Xu, Min, Liu, Kai, Wang, Yemin, Deng, Zixin, Li, Zhiyong, Tao, Meifeng. Engineered Streptomyces lividans Strains for Optimal Identification and Expression of Cryptic Biosynthetic Gene Clusters. FRONTIERS IN MICROBIOLOGY[J]. 2018, 第 7 作者9: https://doaj.org/article/2955ad01e267477e808676c5e27246a9.
[10] Chen, Xuefei, Xu, Min, Lu, Jin, Xu, Jianguo, Wang, Yemin, Lin, Shuangjun, Deng, Zixin, Tao, Meifeng. Biosynthesis of Tropolones in Streptomyces spp.: Interweaving Biosynthesis and Degradation of Phenylacetic Acid and Hydroxylations on the Tropone Ring. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2018, 第 2 作者84(12): https://www.webofscience.com/wos/woscc/full-record/WOS:000433902200011.
[11] Liu, Xiangyang, Liu, Dongxu, Xu, Min, Tao, Meifeng, Bai, Linquan, Deng, Zixin, Pfeifer, Blaine A, Jiang, Ming. Reconstitution of Kinamycin Biosynthesis within the Heterologous Host Streptomyces albus J1074. JOURNAL OF NATURAL PRODUCTS[J]. 2018, 第 3 作者81(1): 72-77, https://www.webofscience.com/wos/woscc/full-record/WOS:000423778900011.
[12] Gao, Guixi, Liu, Xiangyang, Xu, Min, Wang, Yemin, Zhang, Fei, Xu, Lijun, Lv, Jin, Long, Qingshan, Kang, Qianjin, Ou, HongYu, Wang, Ying, Rohr, Jurgen, Deng, Zixin, Jiang, Ming, Lin, Shuangjun, Tao, Meifeng. Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement. CELL CHEMICAL BIOLOGY[J]. 2017, 第 3 作者24(7): 881-891, http://dx.doi.org/10.1016/j.chembiol.2017.06.008.
[13] Zheng, Xiaoqing, Cheng, Qiuxiang, Yao, Fen, Wang, Xiaozheng, Kong, Lingxin, Cao, Bo, Xu, Min, Lin, Shuangjun, Deng, Zixin, Chooi, YitHeng, You, Delin. Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 第 7 作者114(16): 4135-4140, http://dx.doi.org/10.1073/pnas.1701361114.
[14] Zhao, Zhilong, Shi, Ting, Xu, Min, Brock, Nelson L, Zhao, YiLei, Wang, Yemin, Deng, Zixin, Pang, Xiuhua, Tao, Meifeng. Hybrubins: Bipyrrole Tetramic Acids Obtained by Crosstalk between a Truncated Undecylprodigiosin Pathway and Heterologous Tetramic Acid Biosynthetic Genes. ORGANIC LETTERS[J]. 2016, 第 3 作者18(3): 572-575, http://dx.doi.org/10.1021/acs.orglett.5b03609.
[15] Xu, Min, Wang, Yemin, Zhao, Zhilong, Gao, Guixi, Huang, ShengXiong, Kang, Qianjin, He, Xinyi, Lin, Shuangjun, Pang, Xiuhua, Deng, Zixin, Tao, Meifeng. Functional Genome Mining for Metabolites Encoded by Large Gene Clusters through Heterologous Expression of a Whole-Genome Bacterial Artificial Chromosome Library in Streptomyces spp.. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2016, 第 1 作者82(19): 5795-5805, http://www.irgrid.ac.cn/handle/1471x/1175698.
[16] Chen, Li, Wang, Yemin, Guo, Hang, Xu, Min, Deng, Zixin, Tao, Meifeng. High-Throughput Screening for Streptomyces Antibiotic Biosynthesis Activators. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2012, 第 4 作者78(12): 4526-4528, http://dx.doi.org/10.1128/AEM.00348-12.
[2] Hou, Anwei, Li, Bei, Deng, Zixin, Xu, Min, Dickschat, Jeroen S. Cladosporin, A Highly Potent Antimalaria Drug?. CHEMBIOCHEM[J]. 2023, 第 4 作者 通讯作者 https://doi.org/10.1002/cbic.202300154.
[3] Koteva, Kalinka, Xu, Min, Wang, Wenliang, FiebigComyn, Aline A, Cook, Michael A, Coombes, Brian K, Wright, Gerard D. Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2023, 第 2 作者66(13): 9006-9022, http://dx.doi.org/10.1021/acs.jmedchem.3c00633.
[4] Alder, Arne, Struck, Nicole S, Xu, Min, Johnson, Jarrod W, Wang, Wenliang, Pallant, Daniel, Cook, Michael A, Rambow, Janis, Lemcke, Sarah, Gilberger, Tim W, Wright, Gerard D. A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity. CELL CHEMICAL BIOLOGY[J]. 2022, 第 3 作者29(5): 840-+, http://dx.doi.org/10.1016/j.chembiol.2021.10.005.
[5] Xu, Min, Wang, Wenliang, Waglechner, Nicholas, Culp, Elizabeth J, Guitor, Allison K, Wright, Gerard D. Phylogeny-Informed Synthetic Biology Reveals Unprecedented Structural Novelty in Type V Glycopeptide Antibiotics. ACS CENTRAL SCIENCE[J]. 2022, 第 1 作者8(5): 615-626, http://dx.doi.org/10.1021/acscentsci.1c01389.
[6] Xu, Min, Zhang, Fei, Cheng, Zhuo, Bashiri, Ghader, Wang, Jing, Hong, Jiali, Wang, Yemin, Xu, Lijun, Chen, Xuefei, Huang, ShengXiong, Lin, Shuangjun, Deng, Zixin, Tao, Meifeng. Functional Genome Mining Reveals a Class V Lanthipeptide Containing ad-Amino Acid Introduced by an F420H2-Dependent Reductase. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 第 1 作者59(41): 18029-18035, https://www.webofscience.com/wos/woscc/full-record/WOS:000561818000001.
[7] Min Xu, Wenliang Wang, Nicholas Waglechner, Elizabeth J Culp, Allison K Guitor, Gerard D Wright. GPAHex-A synthetic biology platform for Type IV-V glycopeptide antibiotic production and discovery. NATURE COMMUNICATIONS[J]. 2020, 第 1 作者11(1): http://dx.doi.org/10.1038/s41467-020-19138-5.
[8] Xu, Min, Wright, Gerard D. Heterologous expression-facilitated natural products' discovery in actinomycetes. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY[J]. 2019, 第 1 作者46(3-4): 415-431, http://dx.doi.org/10.1007/s10295-018-2097-2.
[9] Peng, Qinying, Gao, Guixi, Lu, Jin, Long, Qingshan, Chen, Xuefei, Zhang, Fei, Xu, Min, Liu, Kai, Wang, Yemin, Deng, Zixin, Li, Zhiyong, Tao, Meifeng. Engineered Streptomyces lividans Strains for Optimal Identification and Expression of Cryptic Biosynthetic Gene Clusters. FRONTIERS IN MICROBIOLOGY[J]. 2018, 第 7 作者9: https://doaj.org/article/2955ad01e267477e808676c5e27246a9.
[10] Chen, Xuefei, Xu, Min, Lu, Jin, Xu, Jianguo, Wang, Yemin, Lin, Shuangjun, Deng, Zixin, Tao, Meifeng. Biosynthesis of Tropolones in Streptomyces spp.: Interweaving Biosynthesis and Degradation of Phenylacetic Acid and Hydroxylations on the Tropone Ring. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2018, 第 2 作者84(12): https://www.webofscience.com/wos/woscc/full-record/WOS:000433902200011.
[11] Liu, Xiangyang, Liu, Dongxu, Xu, Min, Tao, Meifeng, Bai, Linquan, Deng, Zixin, Pfeifer, Blaine A, Jiang, Ming. Reconstitution of Kinamycin Biosynthesis within the Heterologous Host Streptomyces albus J1074. JOURNAL OF NATURAL PRODUCTS[J]. 2018, 第 3 作者81(1): 72-77, https://www.webofscience.com/wos/woscc/full-record/WOS:000423778900011.
[12] Gao, Guixi, Liu, Xiangyang, Xu, Min, Wang, Yemin, Zhang, Fei, Xu, Lijun, Lv, Jin, Long, Qingshan, Kang, Qianjin, Ou, HongYu, Wang, Ying, Rohr, Jurgen, Deng, Zixin, Jiang, Ming, Lin, Shuangjun, Tao, Meifeng. Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement. CELL CHEMICAL BIOLOGY[J]. 2017, 第 3 作者24(7): 881-891, http://dx.doi.org/10.1016/j.chembiol.2017.06.008.
[13] Zheng, Xiaoqing, Cheng, Qiuxiang, Yao, Fen, Wang, Xiaozheng, Kong, Lingxin, Cao, Bo, Xu, Min, Lin, Shuangjun, Deng, Zixin, Chooi, YitHeng, You, Delin. Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 第 7 作者114(16): 4135-4140, http://dx.doi.org/10.1073/pnas.1701361114.
[14] Zhao, Zhilong, Shi, Ting, Xu, Min, Brock, Nelson L, Zhao, YiLei, Wang, Yemin, Deng, Zixin, Pang, Xiuhua, Tao, Meifeng. Hybrubins: Bipyrrole Tetramic Acids Obtained by Crosstalk between a Truncated Undecylprodigiosin Pathway and Heterologous Tetramic Acid Biosynthetic Genes. ORGANIC LETTERS[J]. 2016, 第 3 作者18(3): 572-575, http://dx.doi.org/10.1021/acs.orglett.5b03609.
[15] Xu, Min, Wang, Yemin, Zhao, Zhilong, Gao, Guixi, Huang, ShengXiong, Kang, Qianjin, He, Xinyi, Lin, Shuangjun, Pang, Xiuhua, Deng, Zixin, Tao, Meifeng. Functional Genome Mining for Metabolites Encoded by Large Gene Clusters through Heterologous Expression of a Whole-Genome Bacterial Artificial Chromosome Library in Streptomyces spp.. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2016, 第 1 作者82(19): 5795-5805, http://www.irgrid.ac.cn/handle/1471x/1175698.
[16] Chen, Li, Wang, Yemin, Guo, Hang, Xu, Min, Deng, Zixin, Tao, Meifeng. High-Throughput Screening for Streptomyces Antibiotic Biosynthesis Activators. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2012, 第 4 作者78(12): 4526-4528, http://dx.doi.org/10.1128/AEM.00348-12.
发表著作
（1） Chapter fourteen: Glycopeptide antibiotic discovery in the genomic era, Elsevier, 2021-12, 第 1 作者
科研活动
科研项目
（ 1 ） 微生物活性天然产物高效发掘, 负责人, 地方任务, 2022-08--2025-06
（ 2 ） 天然药物的高效发现与合成技术, 参与, 地方任务, 2022-02--2025-01
（ 3 ） 抗感染新型糖肽抗生素的发掘与合成改造, 负责人, 地方任务, 2023-07--2026-07
（ 4 ） 新骨架微生物天然产物的生物合成与高效创制, 负责人, 国家任务, 2023-12--2028-11
（ 5 ） 新率先行动B类, 负责人, 中国科学院计划, 2023-07--2028-12
（ 6 ） 万古霉素生产菌株的探索性研究, 负责人, 境内委托项目, 2024-01--2025-01
（ 2 ） 天然药物的高效发现与合成技术, 参与, 地方任务, 2022-02--2025-01
（ 3 ） 抗感染新型糖肽抗生素的发掘与合成改造, 负责人, 地方任务, 2023-07--2026-07
（ 4 ） 新骨架微生物天然产物的生物合成与高效创制, 负责人, 国家任务, 2023-12--2028-11
（ 5 ） 新率先行动B类, 负责人, 中国科学院计划, 2023-07--2028-12
（ 6 ） 万古霉素生产菌株的探索性研究, 负责人, 境内委托项目, 2024-01--2025-01