General

State Key Laboratory of Environmental Chemistry and Ecotoxicology

Research Center for Eco-Environmental Sciences

Chinese Academy of Sciences

Beijing, China

E-mail: mingxu@rcees.ac.cn

Research Areas

His research interests focus on the health risks and toxicological mechanisms of heavy metals and nanoparticles.

Education

2002~2006 Bachelor, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China

2006~2011 PhD, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China, Prof. Qiuquan Wang

Experience

   
Work Experience

2002~2006 Bachelor, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China

2006~2011 PhD, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China, Prof. Qiuquan Wang


2011~2013 Postdoctor, Centre national de la recherche scientifique (CNRS), France,  Prof. Sandra Mounicou,Prof. Ryszard Lobinski

2014~2015 Assistant professor, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences (CAS), China

Since 2016 Associate professor, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences (CAS), China

Publications


Papers

(1)马明昊,徐明*,刘思金. 氧化石墨烯的表面化学修饰及纳米-生物界面作用机理. 化学学报 2020.

(2) Xu, L., Xu, M.,* Wang R., Yin Y., Lynch, I., Liu, S.* The Crucial Role of Environmental Coronas in Determining the Biological Effects of Engineered Nanomaterials. Small 2020, 2003691.

(3)Xu, M.;* Yang, Q.; Xu, L.; Rao, Z.; Cao, D.; Gao, M.; Liu, SProtein target identification and toxicological mechanism investigation of silver nanoparticles-induced hepatotoxicity by integrating proteomic and metallomic strategies, Particle and Fibre Toxicology, 2019, 16, 46.

(4) Xu, M., Mohamed Soliman M. G., Sun X., Pelaz B., Feliu N., Parak W. J.,* Liu S.How Entanglement of Different Physicochemical Properties Complicates the Prediction of in Vitro and in Vivo Interactions of Gold Nanoparticles, ACS Nano, 2018, 12, 10104-10113.

(5) Zhu, J.,# Xu, M.,# Wang, F., Gao, M., Zhang, Z., Xu, Y., Chen, W., Liu, S. Low-dose exposure of graphene oxide significantly increases metal toxicity to macrophages by altering their cellular priming state, Nano Research, 2018, 11, 4111-4122.

(6) Wang, X., Cheng, W., Yang, Q., Niu, H., Liu, Q., Liu, Y., Gao, M., Xu, M.,* Xu, A., Liu, S., Huang, X.,* Du, Y. Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles, Journal of Environmental Sciences-China, 2018, 69, 217-226.

(7) 任泉仲#,徐立宁#徐明*,刘思金大气细颗粒物导致呼吸系统疾病及相关生物机制的研究进展, 中国科学:化学, 2018, 48, 1260–1268.

(8) Zhu, J., Xu, M.,* Gao, M., Zhang, Z., Xu, Y., Xia T., Liu, S.* Graphene Oxide Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents, ACS Nano, 2017, 11, 2637-2651.

(9) Xu, M., Zhu, J., Wang, F., Xiong, Y., Wu, Y., Wang, Q., Weng, J.,* Zhang, Z.,* Chen, W., Liu, S.* Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation, ACS Nano, 2016, 10, 3267-3281.

(10)徐明,王哲,刘思金*.  纳米银生物过程及影响的研究进展, 中国材料进展, 2016, 35, 28-35.

(11)Guo, W., Zhang, J., Li, W., Xu, M.,* Liu, S.* Disruption of iron homeostasis and resultant health effects upon exposure to various environmental pollutants: A critical review, Journal of Environmental Sciences-China, 2015, 34, 155-164.

(12) 徐明,杨利民,王秋泉*. 硒-汞双元素标记策略识别硒蛋白/多肽分析化学,  2015, 43 (9), 1265-1271.

(13) Xu, M., Frelon, S., Simon, O., Lobinski, R., Mounicou, S.* Development of a non-denaturing 2D gel electrophoresis protocol for screening in vivo uranium-protein targets in Procambarus clarkii with laser ablation ICP MS followed by protein identification by HPLC–Orbitrap MS, Talanta, 2014, 128, 187-195.

(14) Xu, M., Frelon, S., Simon, O., Lobinski, R., Mounicou, S.* Non-denaturating isoelectric focusing gel electrophoresis for uranium–protein complexes quantitative analysis with LA-ICP MS, Analytical and Bioanalytical Chemistry, 2014, 406 (4), 1063-1072.

(15) Xu, M., Bijoux H., Gonzalez P., Mounicou, S.* Investigating the response of cuproproteins from oysters (Crassostrea gigas) after waterborne copper exposure by metallomic and proteomic, Metallomics, 2014, 6 (2), 338-346.

(16) Xu, M., Yang, L. M., Wang, Q. Q.* Chemical interactions of mercury species and some transition and noble metals towards metallothionein (Zn7MT-2) evaluated using SEC/ICP-MS, RP-HPLC/ESI-MS and MALDI-TOF-MS, Metallomics, 2013, 5 (7), 855-860.

(17)Xu, M., Yang, L. M., Wang, Q. Q.* A way to probe the microenvironment of free sulfhydryls in intact proteins with a series of monofunctional organic mercurials, Chemistry - A European Journal, 2012, 18 (44), 13989-13993.

(18) 徐明,严晓文,杨利民,王秋泉*. 化学标记与蛋白质/多肽的识别检测中国科学:化学, 2011, 41, 663-677.

(19) Xu, M., Yan, X. W., Xie, Q. Q., Yang, L. M., Wang, Q. Q.* Dynamic labeling strategy with 204Hg-isotopic methylmercurithiosalicylate for absolute peptide and protein quantification, Analytical Chemistry, 2010, 82 (5), 1616-1620.

(20) Xu, M., Deng, G. F., Liu, S. S., Chen, S., Cui, D., Yang, L. M., Wang, Q. Q.* Free cadmium ions released from CdTe-based nanoparticles and their cytotoxicity on Phaeodactylum tricornutum, Metallomics, 2010, 2 (7), 469-473.

(21) Xu, M., Yang, L. M., Wang, Q. Q.* Quantification of selenium-tagged proteins in human plasma using species-unspecific isotope dilution ICP-DRC-qMS coupled on-line with anion exchange chromatography, Journal of Analytical Atomic Spectrometry, 2008, 23 (11), 1545-1549.

(22) 徐明,杨利民,王秋泉*. 人体血浆中硒蛋白P提取方法初探. 南昌大学学报.理科版,  2006, 30S, 621-622.