基本信息

徐明  研究员
电子邮件: mingxu@rcees.ac.cn
通信地址: 北京市海淀区双清路18号,中国科学院生态环境研究中心
邮政编码: 100085

研究领域

环境污染物的毒性效应与机制

1)发展基于元素质谱的分析新方法;

2)重金属元素的健康风险、毒性效应与作用机理;

(3)纳米材料的生物效应与机制;

招生信息

招生专业
083001-环境科学
070302-分析化学
0703J1-纳米科学与技术

教育背景

2006-09--2011-06   厦门大学,化学化工学院   理学博士
2002-09--2006-06   厦门大学,化学化工学院   理学学士

工作经历

工作经历

2021.2 - 至今,中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,研究员

2016.1 - 2021.1,中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,副研究员

2014.2 - 2015.12,中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,助理研究员

2011.9 - 2013.11,法国国家科学研究院(CNRS),Lab Chim Analyt Bioinorgan & Environm,博士后,合作导师: Prof. Sandra Mounicou,Prof. Ryszard Lobinski


社会兼职

2020.1 - 至今,国科大杭州高等研究院,教授

2020.1 - 至今,Atomic Spectroscopy期刊,编委

2018.12 - 至今,中国毒理学会分析毒理专业委员会,秘书长

教授课程

环境毒理学研究方法
现代生物学技术在环境健康研究中的应用

出版信息

(1)徐明,阚海东*,桑楠,刘思金. 持久性有毒污染物环境健康研究的现状与思考. 中国科学院院刊 2020, 35, 1337–1343.

(2)Chen, Y., Ma, J.* Xu, M.* Liu, S. Antiviral nanoagents: more attention and effort needed? Nano Today 2020, 35, 100976.

(3)Ma, M.,# Wang R.,# Xu, L., Xu, M.,* Liu, S. Emerging health risks and underlying toxicological mechanisms of uranium contamination: lessons from the past two decades. Environment International 2020, 145, 106107.

(4)马明昊,徐明*,刘思金. 氧化石墨烯的表面化学修饰及纳米-生物界面作用机理. 化学学报 2020, 78, 877-887.

(5) Xu, L., Xu, M.,* Wang R., Yin Y., Lynch, I., Liu, S.* The Crucial Role of Environmental Coronas in Determining the Biological Effects of Engineered Nanomaterials. Small 2020, 16, 2003691.

(6)Wang, S., Ren, L., Qi, Y., Chen, Y., Wang R., Ma, M., Xu, M.;* Liu, S.* Chapter 7 - Two-dimensional nanoparticles for the delivery of anticancer drugs and cancer therapy, Frontiers of Nanoscience, Elsevier Ltd., 2020, 16, 151-199.

(7)Xu, M.;* Yang, Q.; Xu, L.; Rao, Z.; Cao, D.; Gao, M.; Liu, S. Protein target identification and toxicological mechanism investigation of silver nanoparticles-induced hepatotoxicity by integrating proteomic and metallomic strategies, Particle and Fibre Toxicology, 2019, 16, 46.

(8) Xu, M., Mohamed Soliman M. G., Sun X., Pelaz B., Feliu N., Parak W. J.,* Liu S.How Entanglement of Different Physicochemical Properties Complicates the Prediction of in Vitro and in Vivo Interactions of Gold Nanoparticles, ACS Nano, 2018, 12, 10104-10113.

(9) Zhu, J.,# Xu, M.,# Wang, F., Gao, M., Zhang, Z., Xu, Y., Chen, W., Liu, S. Low-dose exposure of graphene oxide significantly increases metal toxicity to macrophages by altering their cellular priming state, Nano Research, 2018, 11, 4111-4122.

(10) Wang, X., Cheng, W., Yang, Q., Niu, H., Liu, Q., Liu, Y., Gao, M., Xu, M.,* Xu, A., Liu, S., Huang, X.,* Du, Y. Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles, Journal of Environmental Sciences-China, 2018, 69, 217-226.

(11) 任泉仲#,徐立宁#徐明*,刘思金. 大气细颗粒物导致呼吸系统疾病及相关生物机制的研究进展, 中国科学:化学, 2018, 48, 1260–1268.

(12) Zhu, J., Xu, M.,* Gao, M., Zhang, Z., Xu, Y., Xia T., Liu, S.* Graphene Oxide Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents, ACS Nano, 2017, 11, 2637-2651.

(13) Xu, M., Zhu, J., Wang, F., Xiong, Y., Wu, Y., Wang, Q., Weng, J.,* Zhang, Z.,* Chen, W., Liu, S.* Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation, ACS Nano, 2016, 10, 3267-3281.

(14)徐明,王哲,刘思金*.  纳米银生物过程及影响的研究进展, 中国材料进展, 2016, 35, 28-35.

(15)Guo, W., Zhang, J., Li, W., Xu, M.,* Liu, S.* Disruption of iron homeostasis and resultant health effects upon exposure to various environmental pollutants: A critical review, Journal of Environmental Sciences-China, 2015, 34, 155-164.

(16) 徐明,杨利民,王秋泉*硒-汞双元素标记策略识别硒蛋白/多肽. 分析化学,  2015, 43 (9), 1265-1271.

(17) Xu, M., Frelon, S., Simon, O., Lobinski, R., Mounicou, S.* Development of a non-denaturing 2D gel electrophoresis protocol for screening in vivo uranium-protein targets in Procambarus clarkii with laser ablation ICP MS followed by protein identification by HPLC–Orbitrap MS, Talanta, 2014, 128, 187-195.

(18) Xu, M., Frelon, S., Simon, O., Lobinski, R., Mounicou, S.* Non-denaturating isoelectric focusing gel electrophoresis for uranium–protein complexes quantitative analysis with LA-ICP MS, Analytical and Bioanalytical Chemistry, 2014, 406 (4), 1063-1072.

(19) Xu, M., Bijoux H., Gonzalez P., Mounicou, S.* Investigating the response of cuproproteins from oysters (Crassostrea gigas) after waterborne copper exposure by metallomic and proteomic, Metallomics, 2014, 6 (2), 338-346.

(20) Xu, M., Yang, L. M., Wang, Q. Q.* Chemical interactions of mercury species and some transition and noble metals towards metallothionein (Zn7MT-2) evaluated using SEC/ICP-MS, RP-HPLC/ESI-MS and MALDI-TOF-MS, Metallomics, 2013, 5 (7), 855-860.

(21)Xu, M., Yang, L. M., Wang, Q. Q.* A way to probe the microenvironment of free sulfhydryls in intact proteins with a series of monofunctional organic mercurials, Chemistry - A European Journal, 2012, 18 (44), 13989-13993.

(22) 徐明,严晓文,杨利民,王秋泉*. 化学标记与蛋白质/多肽的识别检测. 中国科学:化学, 2011, 41, 663-677.

(23) Xu, M., Yan, X. W., Xie, Q. Q., Yang, L. M., Wang, Q. Q.* Dynamic labeling strategy with 204Hg-isotopic methylmercurithiosalicylate for absolute peptide and protein quantification, Analytical Chemistry, 2010, 82 (5), 1616-1620.

(24) Xu, M., Deng, G. F., Liu, S. S., Chen, S., Cui, D., Yang, L. M., Wang, Q. Q.* Free cadmium ions released from CdTe-based nanoparticles and their cytotoxicity on Phaeodactylum tricornutum, Metallomics, 2010, 2 (7), 469-473.

(25) Xu, M., Yang, L. M., Wang, Q. Q.* Quantification of selenium-tagged proteins in human plasma using species-unspecific isotope dilution ICP-DRC-qMS coupled on-line with anion exchange chromatography, Journal of Analytical Atomic Spectrometry, 2008, 23 (11), 1545-1549.

(26) 徐明,杨利民,王秋泉*. 人体血浆中硒蛋白P提取方法初探. 南昌大学学报.理科版,  2006, 30S, 621-622.

科研活动

承担科研项目:

( 1 ) 国家基金委优秀青年科学基金,环境污染物的毒性效应与机制,2020-2022,主持.

( 2 ) 国家基金委青年科学基金,基于金属组学揭示纳米银肝细胞毒性的分子机制,2015-2017,主持.

( 3 ) 中国科学院战略性先导科技专项B类子课题,阐明典型污染物对肿瘤恶化和去分化的分子机制,2014-2019,主持.

( 4 ) 科技部973项目,典型人工纳米材料的水环境过程、生物效应及其调控研究,2014-2018,参与.

( 5 ) 科技部973项目,耐极端条件的有机含氟纳米材料的研究,2015-2019,参与.


获奖及荣誉:

( 1 ) 国家基金委优秀青年科学基金(2019)

( 2 ) 中国科学院青年创新促进会会员(2018)

( 3 ) 陈国珍奖学金(2010)

( 4 ) 黄本立奖学金(2009)