全能型&多能性；构建人类与非人灵长类动物早期胚胎发育与谱系特化模型；再生医学；细胞治疗；类器官

招生专业：细胞生物学专业；生物化学与分子生物学专业；生物信息学专业；生物医药专业

研究方向：全能型&多能性；人与非人灵长类早期胚胎发育；特化谱系模型构建；再生医学；细胞治疗；类器官

2025-01--中国科学院广州生物医药与健康研究院   研究员

2022-12--2024-12   中国科学院广州生物医药与健康研究院   副研究员

2020-04--2022-03   中国科学院广州生物医药与健康研究院   博士后

人才类荣誉

2022 年：国家外国专家个人类项目

2022 年：广州市黄埔区广州开发区精英人才

2020年：中国科学院国际人才计划（CAS-PIFI）- 特需人才

学生类奖励

​2018-2019 年：广州生物医药与健康研究院优秀学生奖

2014 年：中国科学院与发展中国家科学院院长奖学金（CAS-TWAS）

2006-2007 年：UGC 贾纳塔银行优秀奖学金

2003-2006 年：孟加拉国拉杰沙希大学优秀奖学金

（ 1 ） 基于猴原始态多能干细胞定向诱导为下胚层样细胞的培养基及培养方法, 发明专利, 2026, 第 1 作者, 专利号: 2026105021219

（ 2 ） 基于原始态多能干细胞定向诱导为羊膜样细胞的培养基及培养方法, 发明专利, 2026, 第 1 作者, 专利号: 2026102134145

（ 3 ） EMBRYO-LIKE MODEL, AND CONSTRUCTION METHOD THEREFOR AND USE THEREOF , 发明专利, 2023, 第 3 作者, 专利号: PCT/CN2023/118079

（ 4 ） Media and Methods for Producing Human Cells and Tissues from Teratoma, Organoids and Embryoid Bodies, 发明专利, 2022, 第 3 作者, 专利号: PCT/CN2022/081499

（ 5 ） 从畸胎瘤、类器官和拟胚体中产生人细胞和组织的培养基和方法, 发明专利, 2022, 第 3 作者, 专利号: 202211317527.8

（ 6 ） 建立和维持早期胚胎样细胞的培养基和方法, 发明专利, 2020, 第 2 作者, 专利号: 202011256758.3

（ 7 ） Media and Methods for Establishing and Maintaining Early Embryo-Like Cells, 发明专利, 2020, 第 2 作者, 专利号: PCT/CN2020/128091

1. Md. Abdul Mazid^#*, Carl Ward^#, Zhiwei Luo^#, Chuanyu Liu^#, Yunpan Li, Yiwei Lai, Liang Wu, Jinxiu Li, Wenqi Jia, Yu Jiang, Hao Liu, Lixin Fu, Yueli Yang, David P. Ibañez, Junjian Lai, Xiaoyu Wei, Juan An, Pengcheng Guo, Yue Yuan, Qiuting Deng, Yang Wang, Ying Liu, Fei Gao, Junwen Wang, Shahriar Zaman, Baoming Qin, Guangming Wu, Patrick H. Maxwell, Xun Xu, Longqi Liu*, Wenjuan Li*, Miguel A. Esteban* (2022). Rolling back of human pluripotent stem cells to an 8-cell embryo-like stage. Nature 605, 315-324. (Impact Factor = 55). ^#First author, *Corresponding author.
2. Jing Cao^#, Wenjuan Li^#, Jie Li^#, Md. Abdul Mazid^#, Chunyang Li^#, Yu Jiang^#, Wenqi Jia^#, Zhaodi Liao, Shiyu Sun, Jiqiang Fu, Yan Wang, Yong Lu, Yuting Xu, Yanhong Nie, Xinyan Bian, Changshan Gao, Xiaotong Zhang, Liansheng Zhang, Yunpan Li, Lixin Fu, Hao Liu, Junjian Lai, Yang Wang, Yue Yuan, Yiwei Lai, Longqi Liu, Xiaolong Wang, Qiang Sun*, Miguel A. Esteban*, Zhen Liu* (2023). Live Birth of Chimeric Macaque Monkey with High Contribution from Homologous Embryonic Stem Cells. Cell 186, 4996–5014. (Impact Factor = 48.9). ^#First author, *Corresponding author.
3. Yueli Yang^#, Wenqi Jia^#, Zhiwei Luo, Yunpan Li, Hao Liu, Lixin Fu, Jinxiu Li, Yu Jiang, Junjian Lai, Haiwei Li, Babangida Jabir Saeed, Yi Zou, Yuan Lv, Liang Wu, Ting Zhou, Yongli Shan, Chuanyu Liu, Yiwei Lai, Longqi Liu, Andrew P. Hutchins, Miguel A. Esteban*, Md. Abdul Mazid*, Wenjuan Li* (2024). VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification. Nature Communications 15, 583. (Impact Factor = 17.20). ^#First author, *Corresponding author.
4. Mazid Md. Abdul^#, David P. Ibañez, Ping Zhao, Hao Liu, Xiaofen Zhong, Yingying Li, Meng Zhang, Wenjuan Li, Yunpan Li, Carl Ward, Shuhan Chen, Dongye Wang, Baoming Qin, Miguel A. Esteban, Xiwei Wang*, Wenxia Fan*, Zhiwei Luo (2019). Generation of an induced pluripotent stem cell line (GIBHi003-A) from a Parkinson's disease patient with mutant PINK1 (p. I368N). Stem Cell Research, 41. (Impact Factor = 0.8). ^#First author, *Corresponding author.
5. Juan Zhang^#*, Lamisa Ataei, Kirti Mittal, Liang Wu, Lauren Caldwell, Linh Huynh, Shahil Sarajideen, Kevin Tse, Marie-Michelle Simon, Md. Abdul Mazid, David P. Cook, Daniel Trcka, Tony Kwan, Michael M. Hoffman, Jeffrey L. Wrana, Miguel A. Esteban, Miguel Ramalho-Santos* (2025). LINE1 and PRC2 control nucleolar organization and repression of the 8C state in human ESCs. Dev Cell. 60(2), 186-203. (Impact Factor = 10.70). #First author, *Corresponding author.
6. Jinxiu Li^#, Lixin Fu^#, Yunpan Li^#, Wei Sun, Yao Yi, Wenqi Jia, Haiwei Li, Hao Liu, Pengcheng Guo, Yang Wang, Yue Shen, Xiuqing Zhang, Yuan Lv, Baoming Qin, Wenjuan Li, Chuanyu Liu, Longqi Liu, Md Abdul Mazid, Yiwei Lai, Miguel A Esteban, Yu Jiang*, Liang Wu* (2024). A single-cell chromatin accessibility dataset of human primed and naïve pluripotent stem cell-derived teratoma. Sci Data.11(1), 725. (Impact Factor = 6.90). #First author, *Corresponding author.
7. Jiantao Shi^#, Qing Chen, Jianheng Lai,  Jieying Zhu, Ran Zhang, Md Abdul Mazid, Dongwei Li, Huanxing Su*, Dajiang Qin* (2024). Impact of c-JUN deficiency on thalamus development in mice and human neural models. Cell Biosci. 14(1),149. (Impact Factor = 9.606). #First author, *Corresponding author.
8. Jiaowei Wang^#, Wenguang Xie^#, Nan Li^#, Wenjuan Li^#, Zhishuai Zhang^#, Nana Fan, Zhen Ouyang, Yu Zhao, Chengdan Lai, Hao Li, Mengqi Chen, Longquan Quan, Yunpan Li, Yu Jiang, Wenqi Jia, Lixin Fu, Md. Abdul Mazid, Yanling Zhu, Patrick H. Maxwell, Guangjin Pan*, Miguel A. Esteban*, Zhen Dai*, and Liangxue Lai* (2023). Generation of a Humanized Mesonephros in Pigs from Induced Pluripotent Stem Cells via Embryo Complementation. Cell Stem Cell 30(9), 1235-1245. (Impact Factor = 21.80). #First author, *Corresponding author.
9. Jie Li^#, Qingyuan Zhu^#, Jing Cao^#, Ying Liu^#, Yong Lu^#, Yining Sun, Qian Li, Yiming Huang, Shenshen Shang, Xinyan Bian, Chunyang Li, Liansheng Zhang, Yan Wang, Yanhong Nie, Jiqiang Fu, Wenjuan Li, Md. Abdul Mazid, Yu Jiang, Wenqi Jia, Xiaolong Wang, Yidi Sun, Miguel A. Esteban, Qiang Sun*, Fan Zhou*, Zhen Liu* (2023). Cynomolgus monkey embryo model captures gastrulation and early pregnancy. Cell Stem Cell 30(4), 362-377. (Impact Factor = 21.80). #First author, *Corresponding author.
10. Isaac A. Babarinde, Gang Ma, Yuhao Li, Boping Deng, Zhiwei Luo, Hao Liu, Mazid Md. Abdul, Carl Ward, Minchun Chen, Xiuling Fu, Liyang Shi, Martha Duttlinger, Jiangping He, Li Sun, Wenjuan Li, Qiang Zhuang, Guoqing Tong, Jon Frampton, Jean-Baptiste Cazier, Jiekai Chen, Ralf Jauch, Miguel A. Esteban and Andrew P. Hutchins (2021). Transposable element sequence fragments incorporated into coding and noncoding transcripts modulate the transcriptome of human pluripotent stem cells. Nucleic Acids Research, 49(16). (Impact Factor = 16.80). #First author, *Corresponding author.
11. Li Chen, Qiaoqiao Tong, Xiaowen Chen, Penglei Jiang, Hua Yu, Qianbing Zhao, Lingang Sun, Chao Liu, Bin Gu, Yuping Zheng, Lijiang Fei, Xiao Jiang, Wenjuan Li, Giacomo Volpe, Mazid MD. Abdul, Guoji Guo, Jin Zhang, Pengxu Qian, Qiming Sun, Dante Neculai, Miguel A. Esteban, Chen Li, Feiqiu Wen and Junfeng Ji (2021). PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus. Nature Communications, 12(1). (Impact Factor = 17.20). #First author, *Corresponding author.
12. Zhang M, Lai Y, Krupalnik V, Zhou J, Guo P, Xu Y, Yu Z, Guo X, Liu L, Li W, Abdul M M, Ma G, Li N, Fu X, Lv Y, Wang L, Tariq M, Luo Z, Zhang H, Huang Y, Qin X, Chen S, Wang D, Ward C, Zhang X, He M, Ibañez DP, Liu H, Li Y, Kanwal S, Zhou J, Feng Y, Di Vicino U, Bao X, Wu G, Schambach A, Wang H, Gao F, Qin B, Hutchins AP, Hartmann C, Cosma MP, Yan Q, Chen R, Volpe G, Hanna JH, and Esteban MA (2020). β-Catenin safeguards the ground state of mouse pluripotency by strengthening the robustness of the transcriptional apparatus. Science Advances, 6(29). (Impact Factor = 14.10). #First author, *Corresponding author.
13. Yunpan Li, David P. Ibanez, Wenxia Fan, Ping Zhao, Shuhan Chen, Mazid Md. Abdul, Yu Jiang, Lixin Fu, Zhiwei Luo, Zhenhua Liu, Yueli Yang, Jifeng Guo, Giacomo Volpe, Shahzina Kanwal, Dongye Wang, Beisha Tang and Wenjuan Li (2020). Generation of an induced pluripotent stem cell line (GIBHi004-A) from a Parkinson's disease patient with mutant DJ-1/PARK7 (p.L10P). Stem Cell Research, 46. (Impact Factor = 0.8). #First author, *Corresponding author.
14. Meng Zhang, David P. Ibañez, Wenxia Fan, Hao Liu, Xiaofen Zhong, Xiwei Wang, Yingying Li, Mazid Md. Abdul, Wenjuan Li, Yunpan Li, Carl Ward, Shuhan Chen, Dongye Wang, Baoming Qin, Miguel A. Esteban, Ping Zhao, Zhiwei Luo (2019). Generation of a PARK2 homozygous knockout induced pluripotent stem cell line (GIBHi002-A-1) with two common. Stem Cell Research, 41. (Impact Factor = 0.8). #First author, *Corresponding author.
15. He, J, Fu, X, Zhang, M, He, F, Li, W, Abdul, M. M, Zhou, J, Sun, L, Chang, C, Li, Y, Liu, H, Wu, K, Babarinde, I. A, Zhuang, Q, Loh, Y. H, Chen, J, Esteban, M. A, … Hutchins, A. P. (2019). Transposable elements are regulated by context specific patterns of chromatin marks in mouse embryonic stem cells. Nature Communications, 10(1), 34. (Impact Factor = 17.20). #First author, *Corresponding author.
16. Zhuang Qiang, Li Wenjuan, Benda Christina, Huang Zhijian, Ahmed Tanveer, Liu Ping, Guo Xiangpeng, Ibañez David P, Luo Zhiwei, Zhang Meng, Abdul Mazid Md, Yang Zhongzhou, Yang Jiayin, Huang Yinghua, Zhang Hui, Huang Dehao, Zhou Jianguo, Zhong Xiaofen, Zhu Xihua, Fu Xiuling, Fan Wenxia, Liu Yulin, Xu Yan, Ward Carl, Khan Muhammad Jadoon, Kanwal Shahzina, Mirza Bushra, Tortorella Micky D, Tse Hung-Fat, Chen Jiayu, Qin Baoming, Bao Xichen, Gao Shaorong, Hutchins Andrew P, Esteban Miguel A, (2018). NCoR/SMRT co repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming. Nature Cell Biology, 20, 400-412. (Impact Factor = 22.60). #First author, *Corresponding author.

   

（ 1 ） In Vitro Modeling of Human Early Embryo Development from ZGA to Gastrulation Using PSC-Derived Pre-ZGA-Like Cells, 负责人, 国家任务, 2026-01--2027-12
（ 2 ） 建立下胚层样细胞来源的卵黄囊模型研究人类早期造血发生过程, 负责人, 地方任务, 2025-01--2028-12
（ 3 ） 细胞衰老研究专家, 负责人, 中国科学院计划, 2025-01--2026-12
（ 4 ） 器官发育与再生研究组启动经费, 负责人, 研究所自主部署, 2024-12--2029-11

（1）From Decay to Renewal: Harnessing the Potentials of Human Totipotent and Pluripotent Cells for Rejuvenation   2024-06-06
（2）干细胞研究与医疗创新   第15届新加坡干细胞学会研讨会   2023-11-30